Abstract:
BACKGROUND:Perineural invasion (PNI) is correlated with adverse survival in several malignancies, but its significance in esophageal squamous cell carcinoma (ESCC) remains to be clearly defined. The objective of this study was to determine the association between PNI status and clinical outcomes. METHODS:We retrospectively evaluated the PNI of 433 patients with ESCC treated with surgery between 2000 and 2007 at a single academic center. The resulting data were analyzed using Spearman's rank correlation, the Kaplan-Meier method, Cox proportional hazards regression modeling and Harrell's concordance index (C-index). RESULTS:PNI was identified in 209 of the 433 (47.7%) cases of ESCC. The correlation analysis demonstrated that PNI in ESCC was significantly correlated with tumor differentiation, infiltration depth, pN classification and stage (P < 0.05). The five-year overall survival rate was 0.570 for PNI-negative tumors versus 0.326 for PNI-positive tumors. Patients with PNI-negative tumors exhibited a 1.7-fold increase in five-year recurrence-free survival compared with patients with PNI-positive tumors (0.531 v 0.305, respectively; P < 0.0001). In the subset of patients with node-negative disease, PNI was evaluated as a prognostic predictor as well (P < 0.05). In the multivariate analysis, PNI was an independent prognostic factor for overall survival (P = 0.027). The C-index estimate for the combined model (PNI, gender and pN status) was a significant improvement on the C-index estimate of the clinicopathologic model alone (0.739 v 0.706, respectively). CONCLUSIONS:PNI can function as an independent prognostic factor of outcomes in ESCC patients, and the PNI status in primary ESCC specimens should be considered for therapy stratification.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Chen JW,Xie JD,Ling YH,Li P,Yan SM,Xi SY,Luo RZ,Yun JP,Xie D,Cai MYdoi
10.1186/1471-2407-14-313subject
Has Abstractpub_date
2014-05-05 00:00:00pages
313issn
1471-2407pii
1471-2407-14-313journal_volume
14pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the role of mesothelioma stem cells (MSC) in treatment failure and eventually to design specific target...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4354-1
更新日期:2018-04-27 00:00:00
abstract:BACKGROUND:Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-017-3803-6
更新日期:2017-12-14 00:00:00
abstract:BACKGROUND:No scientific consensus has been reached on whether active tobacco smoking causes breast cancer. We examine the association between active smoking and breast cancer risk in Denmark, which has some of the highest smoking and breast cancer rates in women worldwide. METHODS:We used the data from a nationwide D...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3546-4
更新日期:2017-08-22 00:00:00
abstract:BACKGROUND:Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during treatment, or become apparent on re-treatment of the patient. The mechanisms involved are usually inferred from experiments with cell lines, as studies in tumor-derived cells are difficult. Studies of human tumors s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-78
更新日期:2005-07-18 00:00:00
abstract:BACKGROUND:Annually, colorectal cancer (CRC) is diagnosed in >1.4 million subjects worldwide and incidence is increasing. Much effort has therefore been focused on screening, which has proven to reduce cancer-related mortality. The Sept9 DNA-methylation assay is among the most well studied blood-based screening markers...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1832-6
更新日期:2015-10-29 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro-angiogenic transcription factors HIF-1alpha and STAT3 have been implicated in HCC progression, thus representing interesting targets for molecu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-206
更新日期:2008-07-23 00:00:00
abstract:BACKGROUND:Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR1C enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized and advanced prostate adenocarcinoma, and is associated with prostate cancer (PCa) aggressivenes...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-672
更新日期:2010-12-06 00:00:00
abstract:BACKGROUND:Although this effect is well known, tailored treatment methods have not yet been broadly adopted. The aim of this study was to identify those patient characteristics that most influence the impairment of quality of life and thus to identify those patients who need and can benefit most from specific intervent...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2822-z
更新日期:2016-10-10 00:00:00
abstract:BACKGROUND:Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However, the mechanisms involved in lipid modulation of NK cell postoperative anti-tumor function are unkno...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6045-y
更新日期:2019-08-20 00:00:00
abstract:BACKGROUND:MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a hundred of targets. On the other hand, a single protein-coding gene could be targeted by many potent...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-194
更新日期:2009-06-18 00:00:00
abstract:BACKGROUND:Ovarian cancer is the leading cause of death among gynecologic diseases in Western countries. We have previously identified a miR-200-E-cadherin axis that plays an important role in ovarian inclusion cyst formation and tumor invasion. The purpose of this study was to determine if the miR-200 pathway is invol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3417-z
更新日期:2017-06-17 00:00:00
abstract:BACKGROUND:CD73 is one of the critical component in the formation of immunosuppressive microenvironment in cancers. We aimed to provide an overview of the current status of CD73 expression and its relationship with clinicopathlogical features and prognosis in different cancers. METHODS:PubMed, Web of Science, EMBASE a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4073-7
更新日期:2018-03-07 00:00:00
abstract:BACKGROUND:Neuroblastoma are pediatric tumors of the sympathetic nervous system with a poor prognosis. Apoptosis is often deregulated in cancer cells, but only a few defects in apoptotic routes have been identified in neuroblastoma. METHODS:Here we investigated genomic aberrations affecting genes of the intrinsic apop...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-285
更新日期:2012-07-12 00:00:00
abstract:BACKGROUND:Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In this study, we examined the possibility of HemoHIM both to enhance anticancer effect with cisplatin an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-85
更新日期:2009-03-17 00:00:00
abstract:BACKGROUND:Platelets are frequently altered in hepatocellular carcinoma (HCC) patients. Platelet lysates (hPL) can enhance HCC cell growth and decrease apoptosis. The aims were to evaluate whether hPL can modulate the actions of sorafenib or regorafenib, two clinical HCC multikinase antagonists. METHODS:Several human ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-351
更新日期:2014-05-21 00:00:00
abstract:BACKGROUND:In Taiwan, a distinct ethnic group variation in incidence and mortality rates has been suggested for most carcinomas. Our aim is to identify the role of prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan. METHODS:Taiwan Cancer Registry records of 9039 subjects diagnos...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-7-101
更新日期:2007-06-15 00:00:00
abstract:BACKGROUND:High-risk Human Papillomavirus (HPV) testing is replacing cytology in cervical cancer screening as it is more sensitive for preinvasive cervical lesions. However, the bottleneck of HPV testing is the many false positive test results (positive tests without cervical lesions). Here, we evaluated to what extent...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2518-4
更新日期:2016-07-20 00:00:00
abstract:BACKGROUND:Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage. Thus, the concomitant use of novel compounds represents a critical strategy to improve t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2957-y
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:Loss of lean body mass (LBM) is a common occurrence after treatment for breast cancer and is related to deleterious metabolic health outcomes [Clin Oncol, 22(4):281-288, 2010; Appl Physiol Nutr Metab, 34(5):950-956, 2009]. The aim of this research is to determine the effectiveness of long chain omega-3 fatty...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-14-264
更新日期:2014-04-16 00:00:00
abstract:OBJECTIVES:The present study aims to evaluate long-term side-effects and outcomes and confirm prognostic factors after stereotactic body radiotherapy (SBRT) of pulmonary lesions. This is the first work that combines the investigated data from patient charts and patient-reported outcome (PRO) up to 14 years after therap...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6635-8
更新日期:2020-05-19 00:00:00
abstract:BACKGROUND:The cost-effectiveness of human papillomavirus (HPV) vaccination in women pre-sexual debut has been demonstrated in many countries. This study aimed to estimate the cost-effectiveness of a 3-dose bivalent HPV vaccination at ages 12 to 55 year in both rural and urban settings in China. METHODS:The Markov coh...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2207-3
更新日期:2016-02-26 00:00:00
abstract:BACKGROUND:Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will investigate, in individuals with diabetes, an association between glucose control and cancer incide...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-364
更新日期:2012-08-23 00:00:00
abstract:BACKGROUND:The 5-year overall survival rates for head and neck cancer (HNC) relies on distant metastasis. Importantly, the epithelial-mesenchymal transition (EMT) is believed to be an initial step of metastasis. However, the relationship of epigenetic with EMT formation is still unexplored in HNC. This study focuses on...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2468-x
更新日期:2016-07-08 00:00:00
abstract:BACKGROUND:DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG sites of the 5' untrans...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3595-8
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation. PRDM5 has not been ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1011-9
更新日期:2015-01-23 00:00:00
abstract:BACKGROUND:More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncontrolled cell growth. Vemurafenib (PLX4032) is an oral chemotherapeutic agent that targets the specif...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4583-3
更新日期:2018-06-22 00:00:00
abstract:BACKGROUND:This study aimed to identify potential predictive factors for the survival of advanced non small-cell lung cancer (NSCLC) patients undergoing first-line platinum-based chemotherapy. METHODS:A total of 270 advanced NSCLC patients who underwent first-line platinum-based chemotherapy from June, 2011 to June, 2...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5490-y
更新日期:2019-03-29 00:00:00
abstract:BACKGROUND:Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile of sex hormone receptors in gastric cancer and their clinicopathological and prognostic value were de...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-566
更新日期:2012-12-02 00:00:00
abstract:BACKGROUND:Gambogic acid (GA) is a major active ingredient of gamboge, a widely used traditional Chinese medicine that has been reported to be a potent cytotoxic agent against some malignant tumors. Many studies have shown that the NF-kappa B signaling pathway plays an important role in anti-apoptosis and the drug resi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-343
更新日期:2009-09-25 00:00:00
abstract:BACKGROUND:Deciphering the meaning of the human DNA is an outstanding goal which would revolutionize medicine and our way for treating diseases. In recent years, non-coding RNAs have attracted much attention and shown to be functional in part. Yet the importance of these RNAs especially for higher biological functions ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6338-1
更新日期:2019-12-03 00:00:00