Abstract:
BACKGROUND:The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with other four published NTCP models to evaluate its efficacy. METHODS:Medical notes of 174 NPC patients after radiotherapy were reviewed. Biochemical hypothyroidism was defined as an elevated level of serum thyroid-stimulating hormone (TSH) value with a normal or decreased level of serum free thyroxine (fT4) after radiotherapy. Logistic regression with leave-one-out cross-validation was performed to establish the NTCP model. Model performance was evaluated and compared by the area under the receiver operating characteristic curve (AUC) in our NPC cohort. RESULTS:With a median follow-up of 24 months, 39 (22.4%) patients developed biochemical hypothyroidism. Gender, chemotherapy, the percentage thyroid volume receiving more than 50 Gy (V50), and the maximum dose of the pituitary (Pmax) were identified as the most predictive factors for RHT. A NTCP model based on these four parameters were developed. The model comparison was made in our NPC cohort and our NTCP model performed better in RHT prediction than the other four models. CONCLUSIONS:This study developed a four-variable NTCP model for biochemical hypothyroidism in NPC patients post-radiotherapy. Our NTCP model for RHT presents a high prediction capability. TRIAL REGISTRATION:This is a retrospective study without registration.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Luo R,Wu VWC,He B,Gao X,Xu Z,Wang D,Yang Z,Li M,Lin Zdoi
10.1186/s12885-018-4348-zsubject
Has Abstractpub_date
2018-05-18 00:00:00pages
575issue
1issn
1471-2407pii
10.1186/s12885-018-4348-zjournal_volume
18pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Previous studies have found that polymorphisms of the DNA repair gene X-ray repair cross-complementing group 1(XRCC1) and environmental factors are both associated with an increased risk of stomach cancer, but no study has reported on the potential additive effect of these factors among Thai people. The aim ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3675-9
更新日期:2017-10-11 00:00:00
abstract:BACKGROUND:High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach, but previous studies suggest that a combined inhibition of Bcl-2 an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5439-1
更新日期:2019-03-18 00:00:00
abstract:BACKGROUND:DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG sites of the 5' untrans...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3595-8
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:For the expanding population of bladder cancer survivors in Korea, the development of subsequent cancers is a significant concern. Here, we provide the second primary cancer incidence rates and types in Korean patients with bladder cancer. METHODS:Using population-based data from the Korea Central Cancer Re...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4530-3
更新日期:2018-05-31 00:00:00
abstract:BACKGROUND:Hyponatraemia is a common finding in patients with cancer, and has been shown to be associated with poor prognosis in different settings. We have analysed the impact of severe hyponatraemia in patients with cancer. METHODS:A retrospective review of all patients admitted to a specialist cancer hospital with ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1156-6
更新日期:2015-03-22 00:00:00
abstract:BACKGROUND:Standard radiotherapy is the treatment of first choice in patients with symptomatic spinal metastases, but is only moderately effective. Stereotactic body radiation therapy is increasingly used to treat spinal metastases, without randomized evidence of superiority over standard radiotherapy. The VERTICAL stu...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-016-2947-0
更新日期:2016-11-21 00:00:00
abstract:BACKGROUND:It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in patients with HER2-negative metastatic breast cancer. METHODS:We searched Pubmed, Embase, and Cochr...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-020-6674-1
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is a type of neoplasm that is highly prevalent in East Asia and Africa with Epstein-Barr virus (EBV), genetic, and dietary factors implicated as possible aetiologic factors. Previous studies suggested the association of certain cytokines with the invasion and metastatic propert...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-574
更新日期:2010-10-22 00:00:00
abstract:BACKGROUND:In Australia, breast cancer is the most common cancer affecting Australian women. Inequalities in clinical and psychosocial outcomes have existed for some time, affecting particularly women from rural areas and from areas of disadvantage. We have a limited understanding of how individual and area-level facto...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-415
更新日期:2011-09-28 00:00:00
abstract:BACKGROUND:Whether chronic inflammation increases prostate cancer risk remains unclear. This study investigated whether chronic inflammatory diseases (CID) or anti-inflammatory medication use (AIM) were associated with prostate cancer risk. METHODS:Fifty-five thousand nine hundred thirty-seven cases (all prostate canc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5846-3
更新日期:2019-06-21 00:00:00
abstract:BACKGROUND:Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4637-6
更新日期:2018-07-09 00:00:00
abstract:BACKGROUND:To assess the relationship between responses within 1 year and health-related quality of life (HRQoL) outcomes by exploring profiles of patients with CML-CP who were treated with front-line imatinib or nilotinib. METHODS:A prospective, longitudinal, single-center study was conducted to assess the response t...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-018-4699-5
更新日期:2018-08-03 00:00:00
abstract:BACKGROUND:Accurate assessment of HER-2/neu status is crucial for proper prognostic information and to offer direct appropriate treatment for breast cancer patients. Next to immunohistochemistry (IHC) to evaluate HER2 protein overexpression, a second line gene amplification test is generally deemed necessary for cases ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-4
更新日期:2009-01-05 00:00:00
abstract:BACKGROUND:Phase 3 studies suggest that induction chemotherapy (ICT) of cisplatin and 5-fluorouracil plus docetaxel (TPF) is effective but toxic for patients with squamous-cell carcinoma of the head and neck (SCCHN). Dose-dense chemotherapy may yield favorable outcomes compared with standard-dose chemotherapy, yet the ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07347-6
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Molecular alterations occur frequently in T-ALL and the potential impact of those abnormalities on outcome is still controversial. The current study aimed to test whether NOTCH1 mutations and additional molecular abnormalities would impact T-ALL outcome in a series of 138 T-ALL paediatric cases. METHODS:T-A...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-9
更新日期:2012-01-06 00:00:00
abstract:BACKGROUND:In past decades, circular RNAs (circRNAs) have achieved increasing attention because of its regulatory role in different kinds of cancers. However, how circAGFG1 regulates cervical cancer (CC) is still largely undiscovered. This study aims to evaluate the role of a novel circRNAs and related molecular mechan...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6269-x
更新日期:2019-11-08 00:00:00
abstract:BACKGROUND:Long non-coding RNAs have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to gastric cancer remain largely unknown. METHODS:The differential expression of lncRNAs in gastric cancer and paired non-cancerous tissues were identified by microarray and valida...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-932
更新日期:2014-12-11 00:00:00
abstract:BACKGROUND:Higher sunlight exposure is correlated with lower incidence of breast cancer in ecological studies, but findings from prospective studies regarding the association of circulating levels of vitamin D with the risk of breast cancer have been null. The objective of this study was to examine the relation between...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-29
更新日期:2014-01-17 00:00:00
abstract:BACKGROUND:FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative role of this cytokine in prostate tumor progression. METHODS:FAM3B expression was analyzed by quantita...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3950-9
更新日期:2018-01-22 00:00:00
abstract:BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4457-8
更新日期:2018-05-08 00:00:00
abstract:BACKGROUND:Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. The present study aimed to investigate the e...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07350-x
更新日期:2020-09-03 00:00:00
abstract:BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-365
更新日期:2008-12-11 00:00:00
abstract:BACKGROUND:The aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing surgical treatment. METHODS:Between January 1996 and December 2006, a total of 1367 CRC patients who ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-288
更新日期:2009-08-20 00:00:00
abstract:BACKGROUND:Metformin and the thiazolidinediones (TZDs) may have a protective effect against the development of lung cancer. METHODS:Patients with diabetes mellitus (DM) were identified from the electronic medical records of the Cleveland Clinic. Diabetics with lung cancer were identified then verified by direct review...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-410
更新日期:2012-09-14 00:00:00
abstract:BACKGROUND:The Nijmegen Breakage Syndrome is a chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency, and increased frequency of cancers. Familial studies on relatives of these patients indicated that they also appear to be at increased risk of cancer. METHODS:In a candid...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-181
更新日期:2009-06-12 00:00:00
abstract:OBJECTIVE:Crizotinib can target against mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK), which has been considered as a multi-targeted tyrosine kinase inhibitor (TKI). The objective of this study was to explore the efficacy of crizotinib in advanced non-small-cell lung cancer (NSCLC) with c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5078-y
更新日期:2018-11-26 00:00:00
abstract:BACKGROUND:The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multiple tyrosine kinase o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1131-2
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:There is limited real-world safety information on palbociclib for treatment of advanced stage HR+/HER2- breast cancer. METHODS:We conducted a cohort study of breast cancer patients initiating palbociclib and fulvestrant from February 2015 to September 2017 using the HealthCore Integrated Research Database (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-021-07790-z
更新日期:2021-01-25 00:00:00
abstract:BACKGROUND:The numerous side effects of chemotherapy in patients with breast cancer are well known. However, the precise effects of chemotherapy on ovarian function in premenopausal women are poorly investigated. The patients are at risk of developing sexual hormone deficiency and impaired fertility. This prospective c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3593-x
更新日期:2017-09-06 00:00:00
abstract:BACKGROUND:Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population studies. Consequently, very limited information on the disorder is available, making it difficult to ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-3015-5
更新日期:2017-01-05 00:00:00