Abstract:
BACKGROUND:No scientific consensus has been reached on whether active tobacco smoking causes breast cancer. We examine the association between active smoking and breast cancer risk in Denmark, which has some of the highest smoking and breast cancer rates in women worldwide. METHODS:We used the data from a nationwide Danish Nurse Cohort on 21,867 female nurses (age > 44 years) who at recruitment in 1993 or 1999 reported information on smoking status, onset, duration, and intensity, as well as breast cancer risk factors. We obtained data on incidence of breast cancer from Danish Cancer Registry until 2013, and used Cox regression models to analyze the association between smoking and breast cancer. RESULTS:Of 21,831 women (mean age 53.2 years) 1162 developed breast cancer during 15.7 years of follow-up. 33.7% of nurses were current and 30.0% former smokers at cohort baseline. Compared to never smokers, we found increased risk of breast cancer of 18% in ever (hazard ratio and 95% confidence interval: 1.18; 1.04-1.34) and 27% in current (1.27; 1.11-1.46) smokers. We detected a dose-response relationship with smoking intensity with the highest breast cancer risk in women smoking >15 g/day (1.31; 1.11-1.56) or >20 pack-years (1.32; 1.12-1.55). Parous women who smoked heavily (>10 pack-years) before first childbirth had the highest risk of breast cancer (1.58; 1.20-2.10). Association between smoking and breast cancer was not modified by menopausal status, obesity, alcohol or hormone therapy use, and seemed to be limited to the estrogen receptor positive breast cancer subtype. CONCLUSIONS:Active smoking increases risk of breast cancer, with smoking before first birth being the most relevant exposure window.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Andersen ZJ,Jørgensen JT,Grøn R,Brauner EV,Lynge Edoi
10.1186/s12885-017-3546-4subject
Has Abstractpub_date
2017-08-22 00:00:00pages
556issue
1issn
1471-2407pii
10.1186/s12885-017-3546-4journal_volume
17pub_type
杂志文章相关文献
BMC CANCER文献大全abstract::Following publication of the original article [1], the authors notified us of a misleading data presentation in Table 4. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-5029-7
更新日期:2018-11-30 00:00:00
abstract:BACKGROUND:To evaluate radiomics analysis in neuro-oncologic studies according to a radiomics quality score (RQS) system to find room for improvement in clinical use. METHODS:Pubmed and Embase were searched up the terms radiomics or radiogenomics and gliomas or glioblastomas until February 2019. From 189 articles, 51 ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-019-6504-5
更新日期:2020-01-10 00:00:00
abstract:BACKGROUND:Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and asymmetric division of ES cells and several nervous system tumor cells. Th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-108
更新日期:2008-04-18 00:00:00
abstract:BACKGROUND:From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs). We aimed to compare the length of the diagnostic interval in 2010 with the length of the diagnostic interval before (2004/05) and during (2007/08) the implementation of CPPs...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1317-7
更新日期:2015-04-23 00:00:00
abstract:BACKGROUND:It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in patients with HER2-negative metastatic breast cancer. METHODS:We searched Pubmed, Embase, and Cochr...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-020-6674-1
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:To determine the safety and efficacy of transarterial chemoembolization (TACE) combined with radiofrequency ablation (hereafter, TACE-RFA) in treating Barcelona Clinic Liver Cancer (BCLC) Stage A or B (hereafter, BCLC A/B) hepatocellular carcinoma (HCC) patients, and to explore the range of tumor sizes suita...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6237-5
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclea...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07107-6
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:It is known that amino acid oxidation is increased in tumor-bearing rat muscles and that leucine is an important ketogenic amino acid that provides energy to the skeletal muscle. METHODS:To evaluate the effects of a leucine supplemented diet on the intestinal absorption alterations produced by Walker 256, g...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-2-7
更新日期:2002-04-15 00:00:00
abstract:BACKGROUND:Breast cancer mortality steadily declined from the 1990s and this has been attributed to early detection and/or to improvements in therapy. Which of those two has had the greater impact is a subject of contention. METHODS:A database of 386 patients, enrolled in a randomized clinical trial on the effect of a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-702
更新日期:2014-09-24 00:00:00
abstract:BACKGROUND:Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm that involves the bones in only 14% of all cases. The optimal treatment strategy has not been established. We herein report a case of primary PMHE in which denosumab treatment showed activity in both imaging studies and the clinical ou...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6072-8
更新日期:2019-09-03 00:00:00
abstract:BACKGROUND:Our previous study showed that GATA6 plays important roles in cholangiocarcinoma (CCA) cell invasion and metastasis. However, the regulation mechanism of GATA6 in CCA is not clear. In this study, we studied the potential function of miR-124 in CCA and the mechanism of GATA6 regulation. METHODS:The expressio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3166-z
更新日期:2017-03-07 00:00:00
abstract:BACKGROUND:Cetuximab combined with chemotherapy is one of the first-line treatments of metastatic colorectal cancer. Although disease progression inevitably occurs, rechallenge and maintenance therapies using cetuximab-based regimens may be beneficial, particularly for patients with wild-type (WT) KRAS. CASE PRESENTAT...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3133-8
更新日期:2017-02-14 00:00:00
abstract:BACKGROUND:This study was performed to create and validate a scoring system for the survival of patients with malignant spinal cord compression (SCC) from myeloma. METHODS:Of the entire cohort (N = 216), 108 patients were assigned to a test group and 108 patients to a validation group. In the test group, nine pre-trea...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-425
更新日期:2012-09-25 00:00:00
abstract:BACKGROUND:Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association between pre-operative plasma metabolites and risk of biochemical-, local- and metastatic-recurrence,...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6418-2
更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:The phenomenon that malignant cells can acquire stemness under specific stimuli, encompassed under the concept of cancer cell plasticity, has been well-described in epithelial malignancies. To our knowledge, cancer cell plasticity has not yet been described in hematopoietic cancers. To illustrate and study c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4300-2
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response in critical care patients, has been suggested as an independent prognostic factor for several solid malignancies. We investigated the utility of pretreatment NLR as a prognosticator in patients who presented with ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2134-3
更新日期:2016-02-16 00:00:00
abstract:BACKGROUND:Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its fu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3823-2
更新日期:2017-12-06 00:00:00
abstract:BACKGROUND:The 3rd isoform of the metallothionein (MT3) gene family has been shown to be overexpressed in most ductal breast cancers. A previous study has shown that the stable transfection of MCF-7 cells with the MT3 gene inhibits cell growth. The goal of the present study was to determine the role of the unique C-ter...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3355-9
更新日期:2017-05-25 00:00:00
abstract:BACKGROUND:The literature on sexual orientation disclosure is arguably one of the most developed in the field of lesbian, gay and bisexual (LGB) people in healthcare in English speaking countries however, relatively little research has been conducted into disclosure in cancer care. Studies have been mainly undertaken i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5895-7
更新日期:2019-07-10 00:00:00
abstract:OBJECTIVES:The present study aims to evaluate long-term side-effects and outcomes and confirm prognostic factors after stereotactic body radiotherapy (SBRT) of pulmonary lesions. This is the first work that combines the investigated data from patient charts and patient-reported outcome (PRO) up to 14 years after therap...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6635-8
更新日期:2020-05-19 00:00:00
abstract:BACKGROUND:Locally advanced or metastatic adenocarcinoma of the pancreas remains - despite the implementation of new chemotherapy protocols - a disease with short overall survival (OS). METHODS:Eighty-three patients were treated with locally advanced or metastatic adenocarcinoma of the pancreas with either FOLFIRINOX ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5240-6
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:Sexually transmitted Human Papilloma Virus (HPV) infection is a known risk factor for cancer of the anal canal in both men and women. CASE PRESENTATION:We describe a report of synchronous carcinoma of the anal canal in a heterosexual couple. High risk type 16 HPV DNA was detected in both tumors. CONCLUSION...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4785-8
更新日期:2018-09-10 00:00:00
abstract:BACKGROUND:Tyrosine kinase inhibitors (TKIs) are currently approved for the treatment of metastatic renal cell carcinoma (mRCC). The cardiotoxic effects of sorafenib and sunitinib may cause hypertension, left ventricular ejection fraction (LVEF) dysfunction and/or congestive heart failure (CHF), and arterial thrombo-em...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-231
更新日期:2012-06-11 00:00:00
abstract:BACKGROUND:Embryonic Liver Fodrin (ELF) is an adaptor protein of transforming growth factor (TGF-β) signaling cascade. Disruption of ELF results in mislocalization of Smad3 and Smad4, leading to compromised TGF-β signaling. c-Myc is an important oncogenic transcription factor, and the disruption of TGF-β signaling prom...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4379-5
更新日期:2018-04-24 00:00:00
abstract:BACKGROUND:We evaluated the hierarchical risk groups for the estimated survival of WHO grade III glioma patients using recursive partitioning analysis (RPA). To our knowledge, this is the first study to address the results of RPA specifically for WHO grade III gliomas. METHODS:A total of 133 patients with anaplastic a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-450
更新日期:2009-12-18 00:00:00
abstract:BACKGROUND:This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). METHODS:A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database in...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-4670-5
更新日期:2018-07-23 00:00:00
abstract:BACKGROUND:Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna si...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4630-0
更新日期:2018-07-05 00:00:00
abstract:BACKGROUND:SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown. METHODS:We retrieved the expression data of 1168 CRC patients from 3 Gene Expression Omnibus (GEO)...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6484-5
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:It is well known that estrogen receptor α (ERα) participates in the pathogenic progress of breast cancer, hepatocellular carcinoma and head and neck squamous cell carcinoma. In neuroblastoma cells and related cancer clinical specimens, moreover, the ectopic expression of ERα has been identified. However, the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1495-3
更新日期:2015-06-30 00:00:00
abstract:BACKGROUND:To investigate the incidence of gastrointestinal stromal tumors (GISTs) in Taiwan and the impact of imatinib on the overall survival (OS) of GIST patients. METHODS:GISTs were identified from the Taiwan Cancer Registry (TCR) from 1998 to 2008. The age-adjusted incidence rates and the observed OS rates were c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-102
更新日期:2014-02-18 00:00:00