Synchronous anal canal carcinoma in a heterosexual couple.

abstract：BACKGROUND:We investigated the role of the HIPK2-p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments. METHODS:Primary human CRC samples and normal intestinal tissues from patients were analyzed for HIPK2 expression by im...

journal_title：BMC cancer

authors： Zhou L,Feng Y,Jin Y,Liu X,Sui H,Chai N,Chen X,Liu N,Ji Q,Wang Y,Li Q

更新日期：2014-10-05 00:00:00

abstract：BACKGROUND:The incidence of papillary thyroid cancer (PTC) is markedly higher in women than men during the reproductive years. In vitro studies have suggested that estrogen may play an important role in the development and progression of PTC through estrogen receptors (ERs). This study aimed to investigate the expressi...

journal_title：BMC cancer

authors： Huang Y,Dong W,Li J,Zhang H,Shan Z,Teng W

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spectrum of patients with suspected LS in Latin America. METHODS:Eleven LS hereditary cancer registrie...

journal_title：BMC cancer

authors： Rossi BM,Palmero EI,López-Kostner F,Sarroca C,Vaccaro CA,Spirandelli F,Ashton-Prolla P,Rodriguez Y,de Campos Reis Galvão H,Reis RM,Escremim de Paula A,Capochin Romagnolo LG,Alvarez K,Della Valle A,Neffa F,Kalfayan PG,Spir

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/F...

journal_title：BMC cancer

authors： Jiang K,Li Y,Zhu Q,Xu J,Wang Y,Deng W,Liu Q,Zhang G,Meng S

更新日期：2014-07-30 00:00:00

abstract：BACKGROUND:High levels of blood glucose are thought to be associated with colorectal cancer (CRC) and hyperinsulinemia, an interstage in the development of CRC. The purpose of this study was to examine associations between incident CRC and blood glucose; plasma insulin; and the homeostasis model assessment for insulin ...

journal_title：BMC cancer

authors： Vulcan A,Manjer J,Ohlsson B

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:In general, human papillomavirus (HPV) vaccines have demonstrated efficacy in young women worldwide, but there is limited evidence on the efficacy of the quadrivalent HPV6/11/16/18 vaccine in adult women and no evidence of its effectiveness in Japanese adult women in particular. This study aims to evaluate t...

journal_title：BMC cancer

authors： Kurokawa T,Yamamoto M,Onuma T,Tsuyoshi H,Shinagawa A,Chino Y,Yoshida Y

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, water soluble and non-toxic molecule is shown to have potent anti-cancer property. METHODS:In this st...

journal_title：BMC cancer

authors： Ravi M,Tentu S,Baskar G,Rohan Prasad S,Raghavan S,Jayaprakash P,Jeyakanthan J,Rayala SK,Venkatraman G

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Biannual ultrasound (US)-with or without alpha-fetoprotein (AFP)-is recommended by current guidelines for the surveillance of hepatocellular carcinoma (HCC). However, the inadequate sensitivity of US has been a concern. Magnetic resonance imaging (MRI) is known to have high sensitivity in detecting hepatic m...

journal_title：BMC cancer

authors： An C,Kim DY,Choi JY,Han KH,Roh YH,Kim MJ

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:Annonaceous acetogenins are a family of natural products with antitumor activities. Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and induces gastric cancer cell death. However, the mechanisms underlying its cell-death-inducing activity a...

journal_title：BMC cancer

authors： Han B,Wang TD,Shen SM,Yu Y,Mao C,Yao ZJ,Wang LS

更新日期：2015-03-18 00:00:00

abstract：BACKGROUND:Loss of lean body mass (LBM) is a common occurrence after treatment for breast cancer and is related to deleterious metabolic health outcomes [Clin Oncol, 22(4):281-288, 2010; Appl Physiol Nutr Metab, 34(5):950-956, 2009]. The aim of this research is to determine the effectiveness of long chain omega-3 fatty...

journal_title：BMC cancer

authors： McDonald C,Bauer J,Capra S,Coll J

更新日期：2014-04-16 00:00:00

abstract：BACKGROUNDS:There have been conflicting reports about serum golgi protein 73 (GP73) as one of the most promising serum markers for the diagnosis of hepatocellular carcinoma (HCC). This study was to make a systematic review about the diagnostic accuracy of serum GP73 versus alpha-fetoprotein (AFP) for HCC. METHODS:Afte...

journal_title：BMC cancer

authors： Zhou Y,Yin X,Ying J,Zhang B

更新日期：2012-01-16 00:00:00

abstract：BACKGROUND:EndoPredict (EP) is a clinically validated multianalyte gene expression test to predict distant metastasis in ER-positive, HER2-negative breast cancer treated with endocrine therapy alone. The test is based on the combined analysis of 12 genes in formalin-fixed, paraffin-embedded (FFPE) tissue by reverse tra...

journal_title：BMC cancer

authors： Kronenwett R,Bohmann K,Prinzler J,Sinn BV,Haufe F,Roth C,Averdick M,Ropers T,Windbergs C,Brase JC,Weber KE,Fisch K,Müller BM,Schmidt M,Filipits M,Dubsky P,Petry C,Dietel M,Denkert C

更新日期：2012-10-05 00:00:00

abstract：:Recently, Shu-Yu Tai et al. reported that personal hair dye use increased risk of prostate cancer with a dose-response effect. Although hair dyes were identified as carcinogenic in animals and increased risk of some cancers among hairdressers, the existing epidemiological data did not support that personal hair dye us...

journal_title：BMC cancer

authors： Jiann BP

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Spinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life (ADL), reduced clinical performance, the risk of pathological fractures, and neurological deficits. The aim of this randomized, controlled pilot ...

journal_title：BMC cancer

authors： Rief H,Omlor G,Akbar M,Welzel T,Bruckner T,Rieken S,Haefner MF,Schlampp I,Gioules A,Habermehl D,von Nettelbladt F,Debus J

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a role in cancer development. We recently reported that downregulation of TFPI inhibited apoptosis in a b...

journal_title：BMC cancer

authors： Stavik B,Skretting G,Aasheim HC,Tinholt M,Zernichow L,Sletten M,Sandset PM,Iversen N

更新日期：2011-08-17 00:00:00

abstract：BACKGROUND:RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explore...

journal_title：BMC cancer

authors： Xu H,Xu Y,Ouyang T,Li J,Wang T,Fan Z,Fan T,Lin B,Xie Y

更新日期：2018-06-18 00:00:00

abstract：BACKGROUND:In Spain, cervical cancer prevention is based on opportunistic screening, due to the disease's traditionally low incidence and mortality rates. Changes in sexual behaviour, tourism and migration have, however, modified the probability of exposure to human papilloma virus among Spaniards. This study thus soug...

journal_title：BMC cancer

authors： Cervantes-Amat M,López-Abente G,Aragonés N,Pollán M,Pastor-Barriuso R,Pérez-Gómez B

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:The only available predictive models for the outcome of breast cancer patients in New Zealand (NZ) are based on data in other countries. We aimed to develop and validate a predictive model using NZ data for this population, and compare its performance to a widely used overseas model, the Nottingham Prognosti...

journal_title：BMC cancer

authors： Elwood JM,Tawfiq E,TinTin S,Marshall RJ,Phung TM,Campbell I,Harvey V,Lawrenson R

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the...

journal_title：BMC cancer

authors： McEvoy AC,Warburton L,Al-Ogaili Z,Celliers L,Calapre L,Pereira MR,Khattak MA,Meniawy TM,Millward M,Ziman M,Gray ES

更新日期：2018-07-09 00:00:00

abstract：BACKGROUND:Primary central nervous system lymphoma (PCNSL) is a frequent complication in acquired immunodeficiency syndrome (AIDS). The objective of this survey was to investigate incidence, clinical features, radiological findings, histologic diagnosis, treatment and outcome for all patients with histologically verifi...

journal_title：BMC cancer

authors： Haldorsen IS,Kråkenes J,Goplen AK,Dunlop O,Mella O,Espeland A

更新日期：2008-08-06 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) has aggressive progression with poor prognosis and ineffective treatments. Selumetinib is an allosteric, ATP-noncompetitive inhibitor of MEK1/2, which has benn known as effective antineoplastic drugs for several malignant tumors. We hypothesized that Selumetinib might be ...

journal_title：BMC cancer

authors： Zhou Y,Lin S,Tseng KF,Han K,Wang Y,Gan ZH,Min DL,Hu HY

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is a rare cutaneous neoplasm with increasing incidence, aggressive behavior and poor prognosis. Somatostatin receptors (SSTR) are expressed in MCC and represent a potential target for both imaging and treatment. METHODS:To non-invasively assess SSTR expression in MCC using PET an...

journal_title：BMC cancer

authors： Buder K,Lapa C,Kreissl MC,Schirbel A,Herrmann K,Schnack A,Bröcker EB,Goebeler M,Buck AK,Becker JC

更新日期：2014-04-17 00:00:00

abstract：BACKGROUND:Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangemen...

journal_title：BMC cancer

authors： Wang L,Sun Y,Sun Y,Meng L,Xu X

更新日期：2018-04-23 00:00:00

abstract：BACKGROUND:To assess the efficacy of salvage radiotherapy (RT) for persistent or rising PSA after radical prostatectomy and to determine prognostic factors identifying patients who may benefit from salvage RT. METHODS:Between 1990 and 2003, 59 patients underwent RT for PSA recurrence after radical prostatectomy. Patie...

journal_title：BMC cancer

authors： Quero L,Mongiat-Artus P,Ravery V,Maylin C,Desgrandchamps F,Hennequin C

更新日期：2008-01-29 00:00:00

abstract：BACKGROUND:Cyclo-oxygenase-2 (COX-2), the key enzyme in the conversion of arachidonic acid to prostaglandins, is involved in critical steps of tumor onset and progression, and is a strong predictor of chemotherapy resistance and poor outcome in advanced ovarian cancer. To our knowledge, no data has been reported until ...

journal_title：BMC cancer

authors： Ferrandina G,Ranelletti FO,Martinelli E,Paglia A,Zannoni GF,Scambia G

更新日期：2006-07-11 00:00:00

abstract：BACKGROUND:The aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing surgical treatment. METHODS:Between January 1996 and December 2006, a total of 1367 CRC patients who ...

journal_title：BMC cancer

authors： Sun LC,Chu KS,Cheng SC,Lu CY,Kuo CH,Hsieh JS,Shih YL,Chang SJ,Wang JY

更新日期：2009-08-20 00:00:00

abstract：BACKGROUND:Microvascular invasion (MVI) is recognized as a prognostic factor associated with poor outcome in hepatocellular carcinoma (HCC) patients after curative resection. It remains unclear, however, whether MVI can provide prognostic information for patients at a specific tumor stage. METHODS:Consecutive HCC pati...

journal_title：BMC cancer

authors： Huang C,Zhu XD,Ji Y,Ding GY,Shi GM,Shen YH,Zhou J,Fan J,Sun HC

更新日期：2017-01-17 00:00:00

abstract：BACKGROUND:Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various cancers including pancreatic cancer. METHODS:We investigated the anti tumor efficacy of triptolide in ...

journal_title：BMC cancer

authors： Kim ST,Kim SY,Lee J,Kim K,Park SH,Park YS,Lim HY,Kang WK,Park JO

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:The use of high-dose chemotherapy combined with autologous stem cell transplantation has improved the outcome of hematologic malignancies. Nevertheless, this treatment can cause persistent fatigue and a reduced global quality of life, role and physical function. Physical exercise interventions may be benefic...

journal_title：BMC cancer

authors： Persoon S,Kersten MJ,Chinapaw MJ,Buffart LM,Burghout H,Schep G,Brug J,Nollet F

更新日期：2010-12-06 00:00:00

abstract：BACKGROUND:Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant risk of decline in physical wellbeing with oesophagectomy however this has been inadequately quanti...

journal_title：BMC cancer

authors： Guinan EM,Bennett AE,Doyle SL,O'Neill L,Gannon J,Foley G,Elliott JA,O'Sullivan J,Reynolds JV,Hussey J

更新日期：2019-07-12 00:00:00