Salvage radiotherapy for patients with PSA relapse after radical prostatectomy: a single institution experience.

abstract：BACKGROUND:CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 plays its enzymatic function by catalyzing the hydrolysis of AMP into adenosine and phosphate. In addition to this, accumulating data have shown that CD73 is a key regulatory molecule involved in cancer growth and metastasi...

journal_title：BMC cancer

authors： Gao ZW,Wang HP,Lin F,Wang X,Long M,Zhang HZ,Dong K

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less well characterised. This study aimed to address key information gaps by conducting a systematic revi...

journal_title：BMC cancer

authors： Abogunrin S,Di Tanna GL,Keeping S,Carroll S,Iheanacho I

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:The efficacy of immunotherapy targeting the PD-1/PD-L1 pathway has previously been demonstrated in metastatic head and neck squamous cell carcinoma (HNSCC). Stereotactic Body Radiotherapy (SBRT) aims at ablating metastatic lesions and may play a synergistic role with immunotherapy. The purpose of this study ...

journal_title：BMC cancer

authors： Bahig H,Aubin F,Stagg J,Gologan O,Ballivy O,Bissada E,Nguyen-Tan FP,Soulières D,Guertin L,Filion E,Christopoulos A,Lambert L,Tehfe M,Ayad T,Charpentier D,Jamal R,Wong P

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are well recognized as gene regulators and have been implicated in the regulation of development as well as human diseases. miR-143 is located at a fragile site on chromosome 5 frequently deleted in cancer, and has been reported to be down-regulated in several cancers including colon cance...

journal_title：BMC cancer

authors： Gregersen LH,Jacobsen A,Frankel LB,Wen J,Krogh A,Lund AH

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:The discovery of a solitary pulmonary nodule (SPN) on a chest imaging exam is of major clinical concern. However, the incidence rates of SPNs in a general population have not been estimated. The objective of this study was to provide incidence estimates of SPNs in a general population in 5 northeastern regio...

journal_title：BMC cancer

authors： Marrer É,Jolly D,Arveux P,Lejeune C,Woronoff-Lemsi MC,Jégu J,Guillemin F,Velten M

更新日期：2017-01-11 00:00:00

abstract：BACKGROUND:Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In this study, we examined the possibility of HemoHIM both to enhance anticancer effect with cisplatin an...

journal_title：BMC cancer

authors： Park HR,Ju EJ,Jo SK,Jung U,Kim SH,Yee ST

更新日期：2009-03-17 00:00:00

abstract：BACKGROUND:KIAA1199 is a recently identified novel gene that is up-regulated in human cancer with poor survival. Our proteomic study on signaling polarity in chemotactic cells revealed KIAA1199 as a novel protein target that may be involved in cellular chemotaxis and motility. In the present study, we examined the func...

journal_title：BMC cancer

authors： Jami MS,Hou J,Liu M,Varney ML,Hassan H,Dong J,Geng L,Wang J,Yu F,Huang X,Peng H,Fu K,Li Y,Singh RK,Ding SJ

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:Perineural invasion (PNI) is correlated with adverse survival in several malignancies, but its significance in esophageal squamous cell carcinoma (ESCC) remains to be clearly defined. The objective of this study was to determine the association between PNI status and clinical outcomes. METHODS:We retrospect...

journal_title：BMC cancer

authors： Chen JW,Xie JD,Ling YH,Li P,Yan SM,Xi SY,Luo RZ,Yun JP,Xie D,Cai MY

更新日期：2014-05-05 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) have emerged as promising therapeutic agents in non-small cell lung cancer (NSCLC). However, the duration for which ICIs should be continued remains a clinical problem. METHODS:We examined the efficacy of anti-PD-1/PD-L1 inhibitors after the discontinuation of antibodies ...

journal_title：BMC cancer

authors： Tachihara M,Negoro S,Inoue T,Tamiya M,Akazawa Y,Uenami T,Urata Y,Hattori Y,Hata A,Katakami N,Yokota S

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:The role of serine/threonine kinase 33 (STK33) gene in tumorigenesis is still controversial. This study was aimed to investigate whether STK33 had the effect on hypopharyngeal squamous cell carcinoma (HSCC) and relevant genes, as well as the potential relation to ERK1/2 pathway. METHODS:Immunohistochemistry...

journal_title：BMC cancer

authors： Huang L,Chen C,Zhang G,Ju Y,Zhang J,Wang H,Li J

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Uterine carcinosarcoma (UCS) represents a true example of cancer associated with epithelial-mesenchymal transition (EMT), which exhibits cancer stem cell (CSC)-like traits. Both Sox and β-catenin signal transductions play key roles in the regulation of EMT/CSC properties, but little is known about their invo...

journal_title：BMC cancer

authors： Inoue H,Takahashi H,Hashimura M,Eshima K,Akiya M,Matsumoto T,Saegusa M

更新日期：2016-02-03 00:00:00

abstract：BACKGROUND:Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the role of mesothelioma stem cells (MSC) in treatment failure and eventually to design specific target...

journal_title：BMC cancer

authors： Wu L,Blum W,Zhu CQ,Yun Z,Pecze L,Kohno M,Chan ML,Zhao Y,Felley-Bosco E,Schwaller B,de Perrot M

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:Cervical cancer represents an important global public health problem. It is the 2nd most common cancer among women worldwide. Human papillomavirus (HPV) infection is now well-established as a necessary cause of invasive cervical cancer (ICC) development. Only a few studies on HPV prevalence and type-specific...

journal_title：BMC cancer

authors： Mariani L,Monfulleda N,Alemany L,Vizza E,Marandino F,Vocaturo A,Benevolo M,Quirós B,Lloveras B,Klaustermeier JE,Quint W,de Sanjosé S,Bosch FX

更新日期：2010-06-04 00:00:00

abstract：BACKGROUND:New therapeutic principles in clinical oncology require the adjustment of response criteria to govern therapy decisions. For advanced hepatocellular carcinoma (HCC) a new era has recently begun by the approval of the multikinase inhibitor sorafenib. As a unique feature, HCC usually develops in a diseased liv...

journal_title：BMC cancer

authors： Horger M,Lauer UM,Schraml C,Berg CP,Koppenhöfer U,Claussen CD,Gregor M,Bitzer M

更新日期：2009-06-28 00:00:00

abstract：BACKGROUND:Young breast cancer (BC) patients less than 45 years old are at higher risk of dying from the disease when compared to their older counterparts. However, specific risk factors leading to this poorer outcome have not been identified. METHODS:One candidate is iron deficiency, as this is common in young women ...

journal_title：BMC cancer

authors： Jian J,Yang Q,Shao Y,Axelrod D,Smith J,Singh B,Krauter S,Chiriboga L,Yang Z,Li J,Huang X

更新日期：2013-06-24 00:00:00

abstract：BACKGROUND:High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible for treatment with poly(ADP-ribose) polymerase inhibitors (PARPi). The aim of this study was to ...

journal_title：BMC cancer

authors： Gornjec A,Novakovic S,Stegel V,Hocevar M,Pohar Marinsek Z,Gazic B,Krajc M,Skof E

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:This study is designed to investigate the clinical value of systemic chemotherapy combined with bronchoscopic interventional cryotherapy in the treatment of lung cancer. METHODS:A total of 412 lung cancer patients admitted to Cangzhou People's Hospital from March 2018 to March 2020 were collected and divide...

journal_title：BMC cancer

authors： Xu F,Song J,Xu B,Wang J,Mao J,Liu H,Li X,Deng A

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable prognosis compared with HPV-negative OPSCC, leading to investigation and adoption of de-escalation trea...

journal_title：BMC cancer

authors： Nopmaneepaisarn T,Tangjaturonrasme N,Rawangban W,Vinayanuwattikun C,Keelawat S,Bychkov A

更新日期：2019-11-06 00:00:00

abstract：BACKGROUND:The use of combined positron emission tomography/computerised tomography (PET/CT) scanners in oncology has been shown to improve the staging of tumours and the detection of relapses. However, mis-registration errors are increasingly recognised to be a common pitfall of PET/CT studies. CASE PRESENTATION:We r...

journal_title：BMC cancer

authors： Wang J,Cook G,Frank J,Dina R,Livni N,Lynn J,Fleming W,Seckl MJ

更新日期：2007-08-03 00:00:00

abstract：BACKGROUND:The purpose of our study was to investigate the immunohistochemical expression of TGF-beta1 and p27 in pancreatic adenocarcinomas and to compare the findings with the clinicopathological features and survival. We also aimed to evaluate the expression of TGF-beta1 and p27 in the context of other cell cycle an...

journal_title：BMC cancer

authors： Culhaci N,Sagol O,Karademir S,Astarcioglu H,Astarcioglu I,Soyturk M,Oztop I,Obuz F

更新日期：2005-08-08 00:00:00

abstract：:Following publication of the original article [1], the authors reported the following errors in the article. ...

journal_title：BMC cancer

authors： Perez EA,de Haas SL,Eiermann W,Barrios CH,Toi M,Im YH,Conte PF,Martin M,Pienkowski T,Pivot XB,Burris HA 3rd,Stanzel S,Patre M,Ellis PA

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:Treatment of localized gastric cancer (LGC) consists of surgical resection followed by adjuvant treatment. Both chemoradiation (CRT) and chemotherapy (CT) regimens have shown benefit in survival outcomes versus observation. However, there are few data comparing these approaches. METHODS:This study included ...

journal_title：BMC cancer

authors： Girardi DM,de Lima MA,Pereira GCB,Negrão MV,López RVM,Capareli FC,Sabbaga J,Hoff PMG

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Pancreatic cancer remains the deadliest of all cancers, with a mortality rate of 91%. Gemcitabine is considered the gold chemotherapeutic standard, but only marginally improves life-span due to its chemical instability and low cell penetrance. A new paradigm to improve Gemcitabine's therapeutic index is to a...

journal_title：BMC cancer

authors： Papa AL,Basu S,Sengupta P,Banerjee D,Sengupta S,Harfouche R

更新日期：2012-09-22 00:00:00

abstract：BACKGROUND:The effectiveness of cervical cancer screening programs is challenged by suboptimal participation and coverage. Offering cervico-vaginal self-sampling for human papillomavirus testing (HPV self-sampling) to non-participants can increase screening participation. However, the effect varies substantially among ...

journal_title：BMC cancer

authors： Tranberg M,Bech BH,Blaakær J,Jensen JS,Svanholm H,Andersen B

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:Castleman's disease is a rare form of localized lymph node hyperplasia of uncertain etiology. Although the mediastinum is the most common site of involvement, rare cases occurring in lymph node bearing tissue of other localization have been reported, including only a few intramuscular cases. Unicentric and m...

journal_title：BMC cancer

authors： Schaefer IM,Günnel H,Schweyer S,Korenkov M

更新日期：2011-08-12 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive and most likely combines environmental and genetic factors. The Kv2.1 potassium channel encoded by KC...

journal_title：BMC cancer

authors： Barbirou M,Woldu HG,Sghaier I,Bedoui SA,Mokrani A,Aami R,Mezlini A,Yacoubi-Loueslati B,Tonellato PJ,Bouhaouala-Zahar B

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:Tumor associated macrophages (TAMs) are alternatively activated macrophages that enhance tumor progression by promoting tumor cell invasion, migration and angiogenesis. TAMs have an anti-inflammatory function resembling M2 macrophages. CD163 is regarded as a highly specific monocyte/macrophage marker for M2 ...

journal_title：BMC cancer

authors： Medrek C,Pontén F,Jirström K,Leandersson K

更新日期：2012-07-23 00:00:00

abstract：BACKGROUND:The goal of this exploratory study was to develop and assess a prediction model which can potentially be used as a biomarker of breast cancer, based on anthropometric data and parameters which can be gathered in routine blood analysis. METHODS:For each of the 166 participants several clinical features were ...

journal_title：BMC cancer

authors： Patrício M,Pereira J,Crisóstomo J,Matafome P,Gomes M,Seiça R,Caramelo F

更新日期：2018-01-04 00:00:00

abstract：BACKGROUND:Of all female genital tract tumors, 1-3% are stromal malignancies. In 8-10% of cases, these are represented by Müllerian adenosarcoma an extremely rare tumor characterized by a stromal component of usually low-grade malignancy and by a benign glandular epithelial component. Variant that arises in the pouch o...

journal_title：BMC cancer

authors： Patrelli TS,Silini EM,Gizzo S,Berretta R,Franchi L,Thai E,Lukanovic A,Nardelli GB,Modena AB

更新日期：2011-05-15 00:00:00

abstract：BACKGROUND:Hyponatraemia is a common finding in patients with cancer, and has been shown to be associated with poor prognosis in different settings. We have analysed the impact of severe hyponatraemia in patients with cancer. METHODS:A retrospective review of all patients admitted to a specialist cancer hospital with ...

journal_title：BMC cancer

authors： Balachandran K,Okines A,Gunapala R,Morganstein D,Popat S

更新日期：2015-03-22 00:00:00