Clinical study of systemic chemotherapy combined with bronchoscopic interventional cryotherapy in the treatment of lung cancer.

abstract：BACKGROUND:Due to improvements in imaging and radiological techniques as well as the use of chemotherapy, distant metastasis has become the predominant mode of treatment failure in patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Platinum-based systemic chemotherapy has shown survival benefits and is n...

journal_title：BMC cancer

authors： Ke LR,Xia WX,Qiu WZ,Huang XJ,Yang J,Yu YH,Liang H,Liu GY,Ye YF,Xiang YQ,Guo X,Lv X

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth. METHODS:Pancreatic carcinomas were assessed in a syngenei...

journal_title：BMC cancer

authors： Zechner D,Radecke T,Amme J,Bürtin F,Albert AC,Partecke LI,Vollmar B

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its fu...

journal_title：BMC cancer

authors： Benedicto A,Marquez J,Herrero A,Olaso E,Kolaczkowska E,Arteta B

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators ("writer," "eraser," and "reader" proteins), which are associated with cancer occurrence and development. Th...

journal_title：BMC cancer

authors： Qu N,Qin S,Zhang X,Bo X,Liu Z,Tan C,Wen G,Jiang H

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:In past decades, circular RNAs (circRNAs) have achieved increasing attention because of its regulatory role in different kinds of cancers. However, how circAGFG1 regulates cervical cancer (CC) is still largely undiscovered. This study aims to evaluate the role of a novel circRNAs and related molecular mechan...

journal_title：BMC cancer

authors： Wu F,Zhou J

更新日期：2019-11-08 00:00:00

abstract：BACKGROUND:Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study were to see if the national target of 70% of all cancer patients being included in a CPP was met, and ...

journal_title：BMC cancer

authors： Nilssen Y,Brustugun OT,Eriksen MT,Haug ES,Naume B,Møller B

更新日期：2020-05-30 00:00:00

abstract：BACKGROUND:The survival following transarterial chemoembolization (TACE) alone is still low in unresectable hepatocellular carcinoma (HCC) with almost patients developing disease progression after treatment. There is need to investigate additional therapeutic options that would intensify the initial response to TACE. T...

journal_title：BMC cancer

authors： Su TS,Lu HZ,Cheng T,Zhou Y,Huang Y,Gao YC,Tang MY,Jiang HY,Lian ZP,Hou EC,Liang P

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:High-dose (HD) chemotherapy followed by autologous blood stem-cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) patients. However, the collection of sufficient peripheral blood stem cell (PBSC) grafts can be challenging, and the question arises whether reinfusion of low-dose gra...

journal_title：BMC cancer

authors： Sauer S,Pavel P,Schmitt A,Cremer M,Kriegsmann M,Bruckner T,Jordan K,Wuchter P,Müller-Tidow C,Kriegsmann K

更新日期：2020-04-25 00:00:00

abstract：BACKGROUND:Activated pancreatic stellate cells (PaSCs) are the key cellular source of cancer-associated fibroblasts in the pancreatic stroma of patients with pancreatic ductal adenocarcinoma (PDAC), however, the activation mechanism of PaSCs is not yet known. The Notch signaling pathway, components of which are express...

journal_title：BMC cancer

authors： Song H,Zhang Y

更新日期：2018-01-05 00:00:00

abstract：BACKGROUND:Signaling pathways that converge on two different transcription factor complexes, NFkappaB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. METHODS:Two cell line models of tamoxifen-resistant ER-positive breast cancer, MCF7/HER2 and B...

journal_title：BMC cancer

authors： Zhou Y,Yau C,Gray JW,Chew K,Dairkee SH,Moore DH,Eppenberger U,Eppenberger-Castori S,Benz CC

更新日期：2007-04-03 00:00:00

abstract：BACKGROUND:We conducted a case-control study in the greater Toronto area to evaluate potential lung cancer risk factors including environmental tobacco smoke (ETS) exposure, family history of cancer, indoor air pollution, workplace exposures and history of previous respiratory diseases with special consideration given ...

journal_title：BMC cancer

authors： Brenner DR,Hung RJ,Tsao MS,Shepherd FA,Johnston MR,Narod S,Rubenstein W,McLaughlin JR

更新日期：2010-06-14 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the safety and feasibility of self-expanding metallic stent (SEMS) followed by neoadjuvant chemotherapy prior to elective surgery for obstructing left-sided colon cancer. METHODS:Eleven consecutive patients with obstructing left-sided colon cancer between May 2014 and November 2...

journal_title：BMC cancer

authors： Han JG,Wang ZJ,Zeng WG,Wang YB,Wei GH,Zhai ZW,Zhao BC,Yi BQ

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:The origin and development of breast cancer remain complex and obscure. Recently, microRNA (miRNA) has been identified as an important regulator of the initiation and progression of breast cancer, and some studies have shown the essential role of miR-124-3p as a tumor suppressor in breast tumorigenesis. Howe...

journal_title：BMC cancer

authors： Wang Y,Chen L,Wu Z,Wang M,Jin F,Wang N,Hu X,Liu Z,Zhang CY,Zen K,Chen J,Liang H,Zhang Y,Chen X

更新日期：2016-11-15 00:00:00

abstract：BACKGROUND:Ameloblastomas are odontogenic neoplasms characterized by local invasiveness. This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas. METHODS:Plasmids containing either MMP-2 siRNA or tissue inhibitor of metalloproteinase-2 (TIMP-2) cDNA were...

journal_title：BMC cancer

authors： Wang A,Zhang B,Huang H,Zhang L,Zeng D,Tao Q,Wang J,Pan C

更新日期：2008-06-30 00:00:00

abstract：BACKGROUND:There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicating that the immune system is involved in the therapeutic effect of these agents; this finding stron...

journal_title：BMC cancer

authors： Thomas SK,Cha SC,Smith DL,Kim KH,Parshottam SR,Rao S,Popescu M,Lee VY,Neelapu SS,Kwak LW

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The diminished capability of the immune system to control and resolve HPV infection is one of several hyp...

journal_title：BMC cancer

authors： Gillio-Tos A,Bicalho Mda G,Fiano V,Grasso C,Tarallo V,De Marco L,Trevisan M,Xavier M,Slowik R,Carvalho NS,Maestri CA,Lacerda HM,Zugna D,Richiardi L,Merletti F

更新日期：2012-12-24 00:00:00

abstract：BACKGROUND:Needle core biopsy, often in conjunction with ultrasonic or stereotactic guided techniques, is frequently used to diagnose breast carcinoma in women. Confocal scanning laser microscopy (CSLM) is a technology that provides real-time digital images of tissues with cellular resolution. This paper reports the pr...

journal_title：BMC cancer

authors： Schiffhauer LM,Boger JN,Bonfiglio TA,Zavislan JM,Zuley M,Fox CA

更新日期：2009-08-03 00:00:00

abstract：BACKGROUND:Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significanc...

journal_title：BMC cancer

authors： Song Y,Song S,Zhang D,Zhang Y,Chen L,Qian L,Shi M,Zhao H,Jiang Z,Guo N

更新日期：2006-12-28 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal as standard size-related response criteria do not necessarily accurately reflect clinical benefit, ...

journal_title：BMC cancer

authors： Kelly-Morland C,Rudman S,Nathan P,Mallett S,Montana G,Cook G,Goh V

更新日期：2017-06-02 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various efforts in detection and treatment, many patients with AML die of this cancer. That is why it is impo...

journal_title：BMC cancer

authors： Gil-Kulik P,Dudzińska E,Radzikowska-Büchner E,Wawer J,Jojczuk M,Nogalski A,Wawer GA,Feldo M,Kocki W,Cioch M,Bogucka-Kocka A,Rahnama M,Kocki J

更新日期：2020-05-18 00:00:00

abstract：BACKGROUND:Solid tumours are less oxygenated than normal tissues. This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. The molecular mechanisms underlying such resistance have been investigated in a range of tumour types, including the adult brain tumours glioblastoma, yet little is k...

journal_title：BMC cancer

authors： Cowman S,Fan YN,Pizer B,Sée V

更新日期：2019-04-03 00:00:00

abstract：BACKGROUND:There is no consensus regarding resection of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastatic colorectal cancer (CRC). A potential benefit of resection of the primary tumour is to prevent complications of the primary tumour in later stages of the disease. We...

journal_title：BMC cancer

authors： 't Lam-Boer J,Mol L,Verhoef C,de Haan AF,Yilmaz M,Punt CJ,de Wilt JH,Koopman M

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynaecological cancers as well, since upregulation of SERBP1 was described in ova...

journal_title：BMC cancer

authors： Serce NB,Boesl A,Klaman I,von Serényi S,Noetzel E,Press MF,Dimmler A,Hartmann A,Sehouli J,Knuechel R,Beckmann MW,Fasching PA,Dahl E

更新日期：2012-12-13 00:00:00

abstract：BACKGROUND:This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC). METHODS:A total of 303 TNBC patients who underwent weekly paclitaxel plus carboplatin treatments followed by surgical resection were ...

journal_title：BMC cancer

authors： Wang RX,Chen S,Huang L,Shao ZM

更新日期：2018-09-21 00:00:00

abstract：BACKGROUND:3,3'-diindolylmethane (DIM) is an acid-catalyzed dimer of idole-3-carbinol (I3C), a phytochemical found in cruciferous vegetables that include broccoli, Brussels sprouts and cabbage. DIM is an aryl hydrocarbon receptor (AhR) ligand and a potential anticancer agent, namely for the treatment of breast cancer. ...

journal_title：BMC cancer

authors： Marques M,Laflamme L,Benassou I,Cissokho C,Guillemette B,Gaudreau L

更新日期：2014-07-21 00:00:00

abstract：BACKGROUND:Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient. MicroRNAs (miRNAs) play a role in the regulation of the tumor cell response to hypoxia, however, not much is known ab...

journal_title：BMC cancer

authors： Gits CM,van Kuijk PF,de Rijck JC,Muskens N,Jonkers MB,van IJcken WF,Mathijssen RH,Verweij J,Sleijfer S,Wiemer EA

更新日期：2014-06-13 00:00:00

abstract：BACKGROUND:Despite the increase in cancer incidence in the last years in Serbia, no nation-wide, population-based cancer epidemiology data have been reported. In this study cancer incidence and mortality rates for Serbia are presented using nation-wide data from two population-based cancer registries. These rates are a...

journal_title：BMC cancer

authors： Mihajlović J,Pechlivanoglou P,Miladinov-Mikov M,Zivković S,Postma MJ

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:Recent large trials have shown the survival benefits of 10-year use of tamoxifen by reducing late recurrence compared with 5-year therapy in estrogen receptor(ER)-positive breast cancer. We tried to identify clinical factors associated with the late recurrence. METHODS:We reviewed our database of ER-positiv...

journal_title：BMC cancer

authors： Lee ES,Han W,Kim MK,Kim J,Yoo TK,Lee MH,Lee KH,Kim TY,Moon HG,Im SA,Noh DY,Lee ES

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in monocular patients. METHODS:In this retrospective case series, intravitreal chemotherapy-assisted en...

journal_title：BMC cancer

authors： Yu X,Li X,Xing Y,Lu S,Tanumiharjo S,Ma J

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:It has been previously demonstrated in several cancer models, that Dronabinol (THC) may have anti-tumor activity--however, controversial data exists for acute leukemia. We have anecdotal evidence that THC may have contributed to disease control in a patient with acute undifferentiated leukemia. METHODS:To t...

journal_title：BMC cancer

authors： Kampa-Schittenhelm KM,Salitzky O,Akmut F,Illing B,Kanz L,Salih HR,Schittenhelm MM

更新日期：2016-01-16 00:00:00