Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma.

abstract：BACKGROUND:Epidemiological studies show that cigarette smoking increase the risk of nasopharyngeal carcinoma (NPC), however, whether other common, potentially adverse household inhalants increase NPC risk remains uncertain. METHODS:We conducted a large case-control study to explore the effects of household inhalants, ...

journal_title：BMC cancer

authors： He YQ,Xue WQ,Shen GP,Tang LL,Zeng YX,Jia WH

更新日期：2015-12-29 00:00:00

abstract：BACKGROUND:Although adjuvant chemotherapy with S-1 after curative gastrectomy has been performed as a standard treatment for Stage II and III gastric cancer (GC) in Japan, patients with Stage III GC still have a high incidence of recurrence and a poor prognostic outcome. The aim of this study was to investigate risk fa...

journal_title：BMC cancer

authors： Nishibeppu K,Komatsu S,Ichikawa D,Imamura T,Kosuga T,Okamoto K,Konishi H,Shiozaki A,Fujiwara H,Otsuji E

更新日期：2018-01-30 00:00:00

abstract：BACKGROUND:Squamous cell carcinoma of the head and neck (SCCHN) often contain highly radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality for these tumours. Reoxygenation during fractionated radiotherapy is desired to render these hypoxic tumour regions more radiosensitive. Hypoxia a...

journal_title：BMC cancer

authors： Schilling D,Bayer C,Geurts-Moespot A,Sweep FC,Pruschy M,Mengele K,Sprague LD,Molls M

更新日期：2007-07-30 00:00:00

abstract：BACKGROUND:In past decades, circular RNAs (circRNAs) have achieved increasing attention because of its regulatory role in different kinds of cancers. However, how circAGFG1 regulates cervical cancer (CC) is still largely undiscovered. This study aims to evaluate the role of a novel circRNAs and related molecular mechan...

journal_title：BMC cancer

authors： Wu F,Zhou J

更新日期：2019-11-08 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM) tumors exhibit strong phenotypic differences that can be quantified using magnetic resonance imaging (MRI), but the underlying biological drivers of these imaging phenotypes remain largely unknown. An Imaging-Genomics analysis was performed to reveal the mechanistic associations between MR...

journal_title：BMC cancer

authors： Grossmann P,Gutman DA,Dunn WD Jr,Holder CA,Aerts HJ

更新日期：2016-08-08 00:00:00

abstract：BACKGROUND:Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellular compartments in vitro, we evaluated a well-established hepatic tumor cell line, HepG2, and an adul...

journal_title：BMC cancer

authors： Rangwala F,Williams KP,Smith GR,Thomas Z,Allensworth JL,Lyerly HK,Diehl AM,Morse MA,Devi GR

更新日期：2012-09-10 00:00:00

abstract：BACKGROUND:Lung cancer patients with an activating mutation in the EGFR (epidermal growth factor receptor) can develop resistance to erlotinib treatment, which is often mediated by the T790M resistance mutation in EGFR. The difficulties in obtaining biopsies at progression make it challenging to investigate the appeara...

journal_title：BMC cancer

authors： Demuth C,Madsen AT,Weber B,Wu L,Meldgaard P,Sorensen BS

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:IMMUNEPOTENT CRP (ICRP) can be cytotoxic to cancer cell lines. However, its widespread use in cancer patients has been limited by the absence of conclusive data on the molecular mechanism of its action. Here, we evaluated the mechanism of cell death induced by ICRP in HeLa and MCF-7 cells. METHODS:Cell deat...

journal_title：BMC cancer

authors： Martínez-Torres AC,Reyes-Ruiz A,Calvillo-Rodriguez KM,Alvarez-Valadez KM,Uscanga-Palomeque AC,Tamez-Guerra RS,Rodríguez-Padilla C

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells, and its expression has been correlated with increased tumour angiogenesis. Although numerous publications dealing with the measurement of circulating VEGF for diagnostic and therapeutic monitoring have been published, the re...

journal_title：BMC cancer

authors： Cressey R,Wattananupong O,Lertprasertsuke N,Vinitketkumnuen U

更新日期：2005-10-04 00:00:00

abstract：BACKGROUND:A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. METHODS:In order to evaluate the NuMa gene for breast cancer sus...

journal_title：BMC cancer

authors： Kilpivaara O,Rantanen M,Tamminen A,Aittomäki K,Blomqvist C,Nevanlinna H

更新日期：2008-03-10 00:00:00

abstract：BACKGROUND:Knowledge about the expression and thus a role of enzymes that produce endogenous H2S - cystathionine-β-synthase, cystathionine γ-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controversial. In this study we aimed to determine the expression of these enzymes relatively to the expres...

journal_title：BMC cancer

authors： Breza J Jr,Soltysova A,Hudecova S,Penesova A,Szadvari I,Babula P,Chovancova B,Lencesova L,Pos O,Breza J,Ondrias K,Krizanova O

更新日期：2018-05-24 00:00:00

abstract：BACKGROUND:Pancreatic cancer remains the deadliest of all cancers, with a mortality rate of 91%. Gemcitabine is considered the gold chemotherapeutic standard, but only marginally improves life-span due to its chemical instability and low cell penetrance. A new paradigm to improve Gemcitabine's therapeutic index is to a...

journal_title：BMC cancer

authors： Papa AL,Basu S,Sengupta P,Banerjee D,Sengupta S,Harfouche R

更新日期：2012-09-22 00:00:00

abstract：BACKGROUND:The APC tumor suppressor is mutated or downregulated in many tumor types, and is prominently localized to punctate clusters at protrusion tips in migratory cells, such as in astrocytes where it has been implicated in directed cell motility. Although APC loss is considered an initiating event in colorectal ca...

journal_title：BMC cancer

authors： Odenwald MA,Prosperi JR,Goss KH

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:Early life social environment may influence breast cancer through shaping risk factors operating in early life, adolescence and adulthood, or may be associated with breast cancer risk independent of known risk factors. We investigated the associations between early life socioeconomic status (SES) and mammogr...

journal_title：BMC cancer

authors： Tehranifar P,Cohn BA,Flom JD,Protacio A,Cirillo P,Lumey LH,Michels KB,Terry MB

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:The number of circulating tumor cells (CTCs) in metastatic prostate cancer patients provides prognostic and predictive information. However, it is the molecular characterization of CTCs that offers insight into the biology of these tumor cells in the context of personalized treatment. METHODS:We developed a...

journal_title：BMC cancer

authors： Magbanua MJ,Sosa EV,Scott JH,Simko J,Collins C,Pinkel D,Ryan CJ,Park JW

更新日期：2012-02-28 00:00:00

abstract：BACKGROUND:The prognostic value of histone γ-H2AX and 53BP1 proteins to predict the radiotherapy (RT) outcome of patients with rectal carcinoma (RC) was evaluated in a prospective study. High expression of the constitutive histone γ-H2AX is indicative of defective DNA repair pathway and/or genomic instability, whereas ...

journal_title：BMC cancer

authors： Djuzenova CS,Zimmermann M,Katzer A,Fiedler V,Distel LV,Gasser M,Waaga-Gasser AM,Flentje M,Polat B

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Histone acetyltransferase p300 is a crucial transcriptional coactivator and has been implicated as a poor prognostic factor in human cancers. However, little is known about the substantial functions and mechanisms of p300 in NSCLC proliferation and distant metastasis. METHODS:We constructed p300 down-regula...

journal_title：BMC cancer

authors： Hou X,Gong R,Zhan J,Zhou T,Ma Y,Zhao Y,Zhang Y,Chen G,Zhang Z,Ma S,Chen X,Gao F,Hong S,Luo F,Fang W,Yang Y,Huang Y,Chen L,Yang H,Zhang L

更新日期：2018-06-07 00:00:00

abstract：BACKGROUND:Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. However, preclinical experimental data explaining the interaction mechanism(s) are lacking. Our objective is to investig...

journal_title：BMC cancer

authors： Deng L,Ren Z,Jia Q,Wu W,Shen H,Wang Y

更新日期：2013-07-29 00:00:00

abstract：BACKGROUND:Our previous study showed that GATA6 plays important roles in cholangiocarcinoma (CCA) cell invasion and metastasis. However, the regulation mechanism of GATA6 in CCA is not clear. In this study, we studied the potential function of miR-124 in CCA and the mechanism of GATA6 regulation. METHODS:The expressio...

journal_title：BMC cancer

authors： Tian F,Chen J,Zheng S,Li D,Zhao X,Jiang P,Li J,Wang S

更新日期：2017-03-07 00:00:00

abstract：BACKGROUND:RASSF1A gene silencing by DNA methylation has been suggested as a major event in pancreatic endocrine tumor (PET) but RASSF1A expression has never been studied. The RASSF1 locus contains two CpG islands (A and C) and generates seven transcripts (RASSF1A-RASSF1G) by differential promoter usage and alternative...

journal_title：BMC cancer

authors： Malpeli G,Amato E,Dandrea M,Fumagalli C,Debattisti V,Boninsegna L,Pelosi G,Falconi M,Scarpa A

更新日期：2011-08-12 00:00:00

abstract：BACKGROUND:The five-year survival rates for head and neck squamous cell carcinoma (HNSCC) patients are less than 50%, and the prognosis has not improved, despite advancements in standard multi-modality therapies. Hence major emphasis is being laid on identification of novel molecular targets and development of multi-ta...

journal_title：BMC cancer

authors： Macha MA,Matta A,Chauhan S,Siu KM,Ralhan R

更新日期：2010-11-30 00:00:00

abstract：BACKGROUND:Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant risk of decline in physical wellbeing with oesophagectomy however this has been inadequately quanti...

journal_title：BMC cancer

authors： Guinan EM,Bennett AE,Doyle SL,O'Neill L,Gannon J,Foley G,Elliott JA,O'Sullivan J,Reynolds JV,Hussey J

更新日期：2019-07-12 00:00:00

abstract：BACKGROUND:Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relationship between the margin-negative (R0) resection rate and findings indicating peripancreatic vascular...

journal_title：BMC cancer

authors： Yasuta S,Kobayashi T,Aizawa H,Takahashi S,Ikeda M,Konishi M,Kojima M,Kuno H,Uesaka K,Morinaga S,Miyamoto A,Toyama H,Takakura N,Sugimachi K,Takayama W

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Treatment with recombinant human granulocyte-colony stimulating factor (G-CSF) is accepted standard for prevention of chemotherapy-induced neutropenia. RGB-02 (Gedeon Richter) is a proposed biosimilar to pegylated G-CSF (Neulasta®, Amgen) with sustained release properties. This is a randomized, comparative, ...

journal_title：BMC cancer

authors： Kahan Z,Grecea D,Smakal M,Tjulandin S,Bondarenko I,Perjesi L,Illes A,Horvat-Karajz K,Aradi I

更新日期：2019-02-06 00:00:00

abstract：BACKGROUND:Pseudomonas fluorescens lectin (PFL) belongs to a recently discovered anti-HIV lectin family and induces anoikis-like cell death of MKN28 gastric cancer cells by causing α2 integrin internalization through recognition of high mannose glycans; however, the detailed anti-cancer mechanism is not fully elucidate...

journal_title：BMC cancer

authors： Sato Y,Kubo T,Morimoto K,Yanagihara K,Seyama T

更新日期：2016-02-06 00:00:00

abstract：BACKGROUND:Gene-gene and gene-environment interactions involved in the metabolism of carcinogens may increase the risk of cancer. Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC). METHODS:...

journal_title：BMC cancer

authors： Fan C,Jin M,Chen K,Zhang Y,Zhang S,Liu B

更新日期：2007-06-30 00:00:00

abstract：BACKGROUND:To investigate the incidence of gastrointestinal stromal tumors (GISTs) in Taiwan and the impact of imatinib on the overall survival (OS) of GIST patients. METHODS:GISTs were identified from the Taiwan Cancer Registry (TCR) from 1998 to 2008. The age-adjusted incidence rates and the observed OS rates were c...

journal_title：BMC cancer

authors： Chiang NJ,Chen LT,Tsai CR,Chang JS

更新日期：2014-02-18 00:00:00

abstract：BACKGROUND:Classical in vitro wound-healing assays and other techniques designed to study cell migration and invasion have been used for many years to elucidate the various mechanisms associated with metastasis. However, many of these methods are limited in their ability to achieve reproducible, quantitative results th...

journal_title：BMC cancer

authors： Kam Y,Guess C,Estrada L,Weidow B,Quaranta V

更新日期：2008-07-14 00:00:00

abstract：BACKGROUND:Molecular alterations occur frequently in T-ALL and the potential impact of those abnormalities on outcome is still controversial. The current study aimed to test whether NOTCH1 mutations and additional molecular abnormalities would impact T-ALL outcome in a series of 138 T-ALL paediatric cases. METHODS:T-A...

journal_title：BMC cancer

authors： Mansur MB,Hassan R,Barbosa TC,Splendore A,Jotta PY,Yunes JA,Wiemels JL,Pombo-de-Oliveira MS

更新日期：2012-01-06 00:00:00

abstract：BACKGROUND:Median OS after surgery in curative intent for non-metastasized pancreas cancer ranges under study conditions from 17.9 months to 23.6 months. Tumor recurrence occurs locally, at distant sites (liver, peritoneum, lungs), or both. Observational and autopsy series report local recurrence rates of up to 87% eve...

journal_title：BMC cancer

authors： Tachezy M,Gebauer F,Petersen C,Arnold D,Trepel M,Wegscheider K,Schafhausen P,Bockhorn M,Izbicki JR,Yekebas E

更新日期：2014-06-07 00:00:00