Abstract:
BACKGROUND:Despite the increase in cancer incidence in the last years in Serbia, no nation-wide, population-based cancer epidemiology data have been reported. In this study cancer incidence and mortality rates for Serbia are presented using nation-wide data from two population-based cancer registries. These rates are additionally compared to European and global cancer epidemiology estimates. Finally, predictions on Serbian cancer incidence and mortality rates are provided. METHODS:Cancer incidence and mortality was collected from the cancer registries of Central Serbia and Vojvodina from 1999 to 2009. Using age-specific regression models, we estimated time trends and predictions for cancer incidence and mortality for the following five years (2010-2014). The comparison of Serbian with European and global cancer incidence/mortality rates, adjusted to the world population (ASR-W) was performed using Serbian population-based data and estimates from GLOBOCAN 2008. RESULTS:Increasing trends in both overall cancer incidence and mortality rates were identified for Serbia. In men, lung cancer showed the highest incidence (ASR-W 2009: 70.8/100,000), followed by colorectal (ASR-W 2009: 39.9/100,000), prostate (ASR-W 2009: 29.1/100,000) and bladder cancer (ASR-W 2009: 16.2/100,000). Breast cancer was the most common form of cancer in women (ASR-W 2009: 70.8/100,000) followed by cervical (ASR-W 2009: 25.5/100,000), colorectal (ASR-W 2009: 21.1/100,000) and lung cancer (ASR-W 2009: 19.4/100,000). Prostate and colorectal cancers have been significantly increasing over the last years in men, while this was also observed for breast cancer incidence and lung cancer mortality in women. In 2008 Serbia had the highest mortality rate from breast cancer (ASR-W 2008: 22.7/100,000), among all European countries while incidence and mortality of cervical, lung and colorectal cancer were well above European estimates. CONCLUSION:Cancer incidence and mortality in Serbia has been generally increasing over the past years. For a number of cancer sites, incidence and mortality is alarmingly higher than in the majority of European regions. For this increasing trend to be controlled, the management of risk factors that are present among the Serbian population is necessary. Additionally, prevention and early diagnosis are areas where significant improvements could still be made.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Mihajlović J,Pechlivanoglou P,Miladinov-Mikov M,Zivković S,Postma MJdoi
10.1186/1471-2407-13-18subject
Has Abstractpub_date
2013-01-15 00:00:00pages
18issn
1471-2407pii
1471-2407-13-18journal_volume
13pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:The EphB4 receptor tyrosine kinase has been reported as increased in tumours originating from several different tissues and its expression in a prostate cancer xenograft model has been reported. METHODS:RT-PCR, western blotting and immunohistochemical techniques were used to examine EphB4 expression and pro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-119
更新日期:2005-09-20 00:00:00
abstract:BACKGROUND:Deaf people represent 0.1% of the French population and their access to public health campaigns is limited due to their frequent illiteracy and the infrequent use of sign language in campaigns. There is also a lack of general health knowledge in spite of the existence of French Deaf Care Units (UASS). The ai...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3972-3
更新日期:2018-01-23 00:00:00
abstract:BACKGROUND:Heterogeneous nuclear ribonucleoproteins (hnRNPs) of the A/B type (hnRNP A1, A2/B1, A3) are highly related multifunctional proteins participating in alternative splicing by antagonising other splicing factors, notably ASF/SF2. The altered expression pattern of hnRNP A2/B1 and/or splicing variant B1 alone in ...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-10-434
更新日期:2010-08-17 00:00:00
abstract:BACKGROUND:Treatment of solid malignancies has been revolutionized with the introduction of immune checkpoint inhibitors (ICIs) and their use is being expanded in therapy of different cancers. However, immune related adverse events (IRAEs) can occur during treatment. These side effects occur due to stimulation of the i...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-019-5661-x
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are well recognized as gene regulators and have been implicated in the regulation of development as well as human diseases. miR-143 is located at a fragile site on chromosome 5 frequently deleted in cancer, and has been reported to be down-regulated in several cancers including colon cance...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-232
更新日期:2012-06-12 00:00:00
abstract:BACKGROUND:ZFP36 is an mRNA binding protein that exerts anti-tumor activity in glioblastoma by triggering cell death, associated to an increase in the stability of the kinase RIP1. METHODS:We used cell death assays, size exclusion chromatography, Co-Immunoprecipitation, shRNA lentivectors and glioma neural stem cells ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1388-5
更新日期:2015-05-06 00:00:00
abstract:BACKGROUND:Gene-gene and gene-environment interactions involved in the metabolism of carcinogens may increase the risk of cancer. Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC). METHODS:...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-115
更新日期:2007-06-30 00:00:00
abstract:BACKGROUND:From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs). We aimed to compare the length of the diagnostic interval in 2010 with the length of the diagnostic interval before (2004/05) and during (2007/08) the implementation of CPPs...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1317-7
更新日期:2015-04-23 00:00:00
abstract:BACKGROUND:Primary central nervous system lymphoma (PCNSL) is a frequent complication in acquired immunodeficiency syndrome (AIDS). The objective of this survey was to investigate incidence, clinical features, radiological findings, histologic diagnosis, treatment and outcome for all patients with histologically verifi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-225
更新日期:2008-08-06 00:00:00
abstract:BACKGROUND:Large number of patients with colorectal liver metastasis show recurrent disease after curative surgical resection. Identification of these high-risk patients may guide therapeutic strategies. The aim of this study was to evaluate whether the presence of disseminated tumor cells in bone marrow from patients ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-153
更新日期:2010-04-20 00:00:00
abstract:BACKGROUND:Understanding the complex, multistep process of metastasis remains a major challenge in cancer research. Metastasis models can reveal insights in tumor development and progression and provide tools to test new intervention strategies. METHODS:To develop a new cancer metastasis model, we used DU145 human pro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-387
更新日期:2014-05-30 00:00:00
abstract:BACKGROUND:Cancer cells exhibit increased glycolysis for ATP production (the Warburg effect) and macromolecular biosynthesis; it is also linked with therapeutic resistance that is generally associated with compromised respiratory metabolism. Molecular mechanisms underlying radio-resistance linked to elevated glycolysis...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1368-9
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Pancreatic adenocarcinoma is one of the most dreaded cancers with very low survival rate and poor prognosis to the existing frontline chemotherapeutic drugs. Gene therapy in combination with a cytotoxic agent could be a promising approach to circumvent the limitations of previously attempted therapeutic inte...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-75
更新日期:2014-02-08 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available treating options have prolonged patient's survival. However, BRAF-mutated CRC patients remain unres...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6586-0
更新日期:2020-02-17 00:00:00
abstract:BACKGROUND:Associations between polycyclic aromatic hydrocarbons (PAHs) and colorectal cancer have been reported previously but few studies have characterized PAH exposure using biological measurements. We evaluated colorectal cancer risk in relation to urinary concentration of 1-hydroxypyrene glucuronide (1-OHPG), a p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-282
更新日期:2013-06-11 00:00:00
abstract:BACKGROUND:Phase 3 studies suggest that induction chemotherapy (ICT) of cisplatin and 5-fluorouracil plus docetaxel (TPF) is effective but toxic for patients with squamous-cell carcinoma of the head and neck (SCCHN). Dose-dense chemotherapy may yield favorable outcomes compared with standard-dose chemotherapy, yet the ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07347-6
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:There are large ethnic differences in cervical cancer survival in New Zealand that are only partly explained by stage at diagnosis. We investigated the association of comorbidity with cervical cancer survival, and whether comorbidity accounted for the previously observed ethnic differences in survival. METH...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-132
更新日期:2011-04-12 00:00:00
abstract:BACKGROUND:Oncotype DX® (ODX) is used to assess risk of disease recurrence in hormone receptor positive, HER2-negative breast cancer and to guide decisions regarding adjuvant chemotherapy. Little is known about how physician factors impact treatment decisions. The purpose of this study was to examine patient and physic...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07355-6
更新日期:2020-09-03 00:00:00
abstract:BACKGROUND:Amphiregulin (AREG) and Epiregulin (EREG), ligands of EGFR, are reported to be predictive biomarkers of colorectal cancer patients treated with Cetuximab, an anti-EGFR antibody. The purpose of this study is to determine the correlation of AREG and EREG expression between primary colorectal cancer and corresp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-88
更新日期:2012-03-13 00:00:00
abstract:BACKGROUND:The clinical implication of Ras/Raf/ERK pathway activity in breast cancer tissue and its association with response to chemotherapy is controversial. We aimed to explore the value of p90RSK phosphorylation, a downstram molecule of the pathway, in predicting chemotherapy response in breast cancer. METHODS:The...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-585
更新日期:2012-12-10 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative morbidity, reduced TME quality or better pathological response. Aim of this study ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6538-8
更新日期:2020-01-20 00:00:00
abstract:BACKGROUND:To assess the diagnostic value of retrospective PET-MRI fusion and to compare the results with side-by-side analysis and single modality use of PET and of MRI alone for locoregional tumour and nodal staging of head-and-neck cancer. METHODS:Thirty-three patients with head-and-neck cancer underwent preoperati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-846
更新日期:2014-11-19 00:00:00
abstract:BACKGROUND:HtrA1 is expressed in a variety of normal human tissues and seems to be involved in numerous physiological processes as well as tumorigenesis. This study reports the results of a meta-analysis that was performed: to compare HtrA1 expression as mRNA and protein, in cancer tissue versus non-cancer tissue and t...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-4041-2
更新日期:2018-02-06 00:00:00
abstract:BACKGROUND:Ongoing improvements in technique and instruments for video-assisted thoracoscopic surgery (VATS) have made minimally-invasive uniportal VATS lobectomy a reality. However, the outcomes of the procedure are still under investigation, and at present, uniportal VATS lobectomy is performed infrequently at most h...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3069-z
更新日期:2017-01-25 00:00:00
abstract:BACKGROUND:There is limited real-world safety information on palbociclib for treatment of advanced stage HR+/HER2- breast cancer. METHODS:We conducted a cohort study of breast cancer patients initiating palbociclib and fulvestrant from February 2015 to September 2017 using the HealthCore Integrated Research Database (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-021-07790-z
更新日期:2021-01-25 00:00:00
abstract:BACKGROUND:BAG-1 is a multifunctional co-chaperone of heat shock proteins (Hsc70/Hsp70) that is expressed in most cells. It interacts with Bcl-2 and Raf indicating that it might connect protein folding with other signaling pathways. Evidence that BAG-1 expression is frequently altered in human cancers, in particular in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-4-85
更新日期:2004-11-24 00:00:00
abstract:BACKGROUND:A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. METHODS:In order to evaluate the NuMa gene for breast cancer sus...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-71
更新日期:2008-03-10 00:00:00
abstract:BACKGROUND:To determine the safety and efficacy of transarterial chemoembolization (TACE) combined with radiofrequency ablation (hereafter, TACE-RFA) in treating Barcelona Clinic Liver Cancer (BCLC) Stage A or B (hereafter, BCLC A/B) hepatocellular carcinoma (HCC) patients, and to explore the range of tumor sizes suita...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6237-5
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:Data concerning incidence and prevalence of cancer in the different regions of Russia have traditionally not been provided on a basis that facilitated comparison with data from countries in western parts of Europe. The oncological hospital in Arkhangelsk, in co-operation with Universitetet i Tromsø (Norway),...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-82
更新日期:2005-07-19 00:00:00
abstract:BACKGROUND:Immune checkpoint inhibitors (ICIs) have emerged as promising therapeutic agents in non-small cell lung cancer (NSCLC). However, the duration for which ICIs should be continued remains a clinical problem. METHODS:We examined the efficacy of anti-PD-1/PD-L1 inhibitors after the discontinuation of antibodies ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4819-2
更新日期:2018-10-03 00:00:00