Efficacy of anti-PD-1/PD-L1 antibodies after discontinuation due to adverse events in non-small cell lung cancer patients (HANSHIN 0316).

abstract：BACKGROUND:Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. Several studies have demonstrated discordant HER2 status in the primary and metastatic tumour. However, rates of discordance vary considerably in published report...

journal_title：BMC cancer

authors： Chan A,Morey A,Brown B,Hastrich D,Willsher P,Ingram D

更新日期：2012-11-24 00:00:00

abstract：BACKGROUND:The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker...

journal_title：BMC cancer

authors： Ikenberg K,Fritzsche FR,Zuerrer-Haerdi U,Hofmann I,Hermanns T,Seifert H,Müntener M,Provenzano M,Sulser T,Behnke S,Gerhardt J,Mortezavi A,Wild P,Hofstädter F,Burger M,Moch H,Kristiansen G

更新日期：2010-06-30 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynaecological cancers as well, since upregulation of SERBP1 was described in ova...

journal_title：BMC cancer

authors： Serce NB,Boesl A,Klaman I,von Serényi S,Noetzel E,Press MF,Dimmler A,Hartmann A,Sehouli J,Knuechel R,Beckmann MW,Fasching PA,Dahl E

更新日期：2012-12-13 00:00:00

abstract：BACKGROUND:The association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenomatous polyposis coli (APC) gene has been reported to have a "gatekeeper" function in the colonic muc...

journal_title：BMC cancer

authors： Sarebø M,Skjelbred CF,Breistein R,Lothe IM,Hagen PC,Bock G,Hansteen IL,Kure EH

更新日期：2006-03-17 00:00:00

abstract：BACKGROUND:Mantle Cell Lymphoma (MCL) is often associated with progression, temporary response to therapy and a high relapse rate over time resulting in a poor long-term prognosis. Because MCL is classified as an incurable disease, therapeutic resistance is of great interest. However, knowledge about the biological mec...

journal_title：BMC cancer

authors： Hanf M,Chiron D,de Visme S,Touzeau C,Maisonneuve H,Jardel H,Pellat-Deceunynck C,Amiot M,le Gouill S

更新日期：2016-10-14 00:00:00

abstract：BACKGROUND:It is well known that osteopontin (OPN) plays an important role in tumor progression and that a high OPN expression level in several tumor entities correlates with poor prognosis in cancer patients. However, little is known about the prognostic relevance of the OPN mRNA splice variants. METHODS:We analyzed ...

journal_title：BMC cancer

authors： Hahnel A,Wichmann H,Greither T,Kappler M,Würl P,Kotzsch M,Taubert H,Vordermark D,Bache M

更新日期：2012-04-02 00:00:00

abstract：BACKGROUND:Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve long-term outcome after transplantation. We wanted to prospectively assess feasibility of systemic ant...

journal_title：BMC cancer

authors： Eilard MS,Andersson M,Naredi P,Geronymakis C,Lindnér P,Cahlin C,Bennet W,Rizell M

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:Staging of B-cell non Hodgkin's lymphoma (NHL) routinely involves bone marrow (BM) examination by trephine biopsy (BM-TB). The evidence of disease in the BM-TB results in a clinical stage IV classification affecting therapeutic strategies for NHL patients. BM immunophenotyping by flow cytometry (FC) is also ...

journal_title：BMC cancer

authors： Mancuso P,Calleri A,Antoniotti P,Quarna J,Pruneri G,Bertolini F

更新日期：2010-11-24 00:00:00

abstract：BACKGROUND:The effectiveness of cervical cancer screening programs is challenged by suboptimal participation and coverage. Offering cervico-vaginal self-sampling for human papillomavirus testing (HPV self-sampling) to non-participants can increase screening participation. However, the effect varies substantially among ...

journal_title：BMC cancer

authors： Tranberg M,Bech BH,Blaakær J,Jensen JS,Svanholm H,Andersen B

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. METHODS:In order to evaluate the NuMa gene for breast cancer sus...

journal_title：BMC cancer

authors： Kilpivaara O,Rantanen M,Tamminen A,Aittomäki K,Blomqvist C,Nevanlinna H

更新日期：2008-03-10 00:00:00

abstract：BACKGROUND:The development of non-small cell lung carcinoma proceeds through a series of well-defined pathological steps before the appearance of invasive lung carcinoma. The molecular changes that correspond with pathology changes are not well defined and identification of the molecular events may provide clues on the...

journal_title：BMC cancer

authors： Tichelaar JW,Zhang Y,leRiche JC,Biddinger PW,Lam S,Anderson MW

更新日期：2005-12-06 00:00:00

abstract：BACKGROUND:Cysteine-rich 61 (Cyr61), a member of the CCN protein family, possesses diverse functionality in cellular processes such as adhesion, migration, proliferation, and survival. Cyr61 can also function as an oncogene or a tumour suppressor, depending on the origin of the cancer. Only a few studies have reported ...

journal_title：BMC cancer

authors： Jeong D,Heo S,Sung Ahn T,Lee S,Park S,Kim H,Park D,Byung Bae S,Lee SS,Soo Lee M,Kim CJ,Jun Baek M

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src homology) domain-containing adaptor protein. CRKL is tightly linked ...

journal_title：BMC cancer

authors： Song Q,Yi F,Zhang Y,Jun Li DK,Wei Y,Yu H,Zhang Y

更新日期：2019-05-27 00:00:00

abstract：BACKGROUND:Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior history, who face a life-long risk of reoccurrence. The objective of the current study was to identify ...

journal_title：BMC cancer

authors： Coroiu A,Moran C,Bergeron C,Drapeau M,Wang B,Kezouh A,Ernst J,Batist G,Körner A

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as the gold standard for prostate cancer (PCa) diagnosis. In this paper, we present a targeted PCa imagi...

journal_title：BMC cancer

authors： Qiu C,Bai Y,Yin T,Miao X,Gao R,Zhou H,Ren J,Song L,Liu C,Zheng H,Zheng R

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expressed in the kidneys, little is known about their influence on human renal cancer. METHODS:To clarify...

journal_title：BMC cancer

authors： Betsunoh H,Fukuda T,Anzai N,Nishihara D,Mizuno T,Yuki H,Masuda A,Yamaguchi Y,Abe H,Yashi M,Fukabori Y,Yoshida K,Kamai T

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:Recruitment of cofactors in the interaction of the androgen receptor (AR) and AR ligands plays a critical role in determining androgenic/antiandrogenic effects of the AR ligand on signaling, but the functions of key cofactors, including nuclear receptor coactivator (NCOA), remain poorly understood in prostat...

journal_title：BMC cancer

authors： Takeda K,Hara N,Nishiyama T,Tasaki M,Ishizaki F,Tomita Y

更新日期：2016-05-25 00:00:00

abstract：BACKGROUND:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune system. However, the roles and clinical relevance of the collective or individual NADPH oxidase (NO...

journal_title：BMC cancer

authors： Cho SY,Kim S,Son MJ,Kim G,Singh P,Kim HN,Choi HG,Yoo HJ,Ko YB,Lee BS,Eun HS

更新日期：2019-11-09 00:00:00

abstract：BACKGROUNDS:There have been conflicting reports about serum golgi protein 73 (GP73) as one of the most promising serum markers for the diagnosis of hepatocellular carcinoma (HCC). This study was to make a systematic review about the diagnostic accuracy of serum GP73 versus alpha-fetoprotein (AFP) for HCC. METHODS:Afte...

journal_title：BMC cancer

authors： Zhou Y,Yin X,Ying J,Zhang B

更新日期：2012-01-16 00:00:00

abstract：BACKGROUND:The primary aim of treatment of a patient who has developed metastatic disease is palliation. The objectives of the current study are to describe and quantify the clinical management of women with metastatic breast cancer from the diagnosis of metastatic disease until death and to analyze differences between...

journal_title：BMC cancer

authors： Manders K,van de Poll-Franse LV,Creemers GJ,Vreugdenhil G,van der Sangen MJ,Nieuwenhuijzen GA,Roumen RM,Voogd AC

更新日期：2006-07-06 00:00:00

abstract：BACKGROUND:According to the very limited cancer registry, incidence and mortality rates for female breast cancer in China are regarded to be increasing especially in the metropolitan areas. Representative data on the breast cancer profile of Chinese women and its time trend over years are relatively rare. The aims of t...

journal_title：BMC cancer

authors： Li J,Zhang BN,Fan JH,Pang Y,Zhang P,Wang SL,Zheng S,Zhang B,Yang HJ,Xie XM,Tang ZH,Li H,Li JY,He JJ,Qiao YL

更新日期：2011-08-22 00:00:00

abstract：BACKGROUND:Ovarian epithelial cancer (OEC) usually presents in the later stages of the disease. Factors, especially those associated with cell-cycle genes, affecting the genesis and tumour progression for ovarian cancer are largely unknown. We hypothesized that over-expressed transcription factors (TFs), as well as tho...

journal_title：BMC cancer

authors： Kothandaraman N,Bajic VB,Brendan PN,Huak CY,Keow PB,Razvi K,Salto-Tellez M,Choolani M

更新日期：2010-02-24 00:00:00

abstract：BACKGROUND:To provide estimations of partial and total prevalence of 24 cancer sites in France in 2008. The estimations of partial prevalence were compared with the previous estimations for 2002. METHODS:Nationwide estimations of incidence and survival data from cancer registries were used for partial prevalence. Nati...

journal_title：BMC cancer

authors： Colonna M,Mitton N,Bossard N,Belot A,Grosclaude P,French Network of Cancer Registries (FRANCIM).

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:We investigated the role of the HIPK2-p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments. METHODS:Primary human CRC samples and normal intestinal tissues from patients were analyzed for HIPK2 expression by im...

journal_title：BMC cancer

authors： Zhou L,Feng Y,Jin Y,Liu X,Sui H,Chai N,Chen X,Liu N,Ji Q,Wang Y,Li Q

更新日期：2014-10-05 00:00:00

abstract：BACKGROUND:Small cell cervical carcinoma (SCCC) is a rare, aggressive tumor with a poor prognosis. However, information in relation to its treatment is scarce due to the limited numbers of patients. The aim of this study was to establish whether platinum-based combination chemotherapy may by beneficial in this patient ...

journal_title：BMC cancer

authors： Huang L,Liao LM,Liu AW,Wu JB,Cheng XL,Lin JX,Zheng M

更新日期：2014-02-27 00:00:00

abstract：BACKGROUND:Neuroblastoma are pediatric tumors of the sympathetic nervous system with a poor prognosis. Apoptosis is often deregulated in cancer cells, but only a few defects in apoptotic routes have been identified in neuroblastoma. METHODS:Here we investigated genomic aberrations affecting genes of the intrinsic apop...

journal_title：BMC cancer

authors： Lamers F,Schild L,Koster J,Speleman F,Øra I,Westerhout EM,van Sluis P,Versteeg R,Caron HN,Molenaar JJ

更新日期：2012-07-12 00:00:00

abstract：BACKGROUND:Cancer services are inaccessible in many low-income countries, and few published examples describe oncology programs within the public sector. In 2011, the Rwanda Ministry of Health (RMOH) established Butaro Cancer Center of Excellence (BCCOE) to expand cancer services nationally. In hopes of informing cance...

journal_title：BMC cancer

authors： Tapela NM,Mpunga T,Hedt-Gauthier B,Moore M,Mpanumusingo E,Xu MJ,Nzayisenga I,Hategekimana V,Umuhizi DG,Pace LE,Bigirimana JB,Wang J,Driscoll C,Uwizeye FR,Drobac PC,Ngoga G,Shyirambere C,Muhayimana C,Lehmann L,Shulma

更新日期：2016-03-18 00:00:00

abstract：BACKGROUND:High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible for treatment with poly(ADP-ribose) polymerase inhibitors (PARPi). The aim of this study was to ...

journal_title：BMC cancer

authors： Gornjec A,Novakovic S,Stegel V,Hocevar M,Pohar Marinsek Z,Gazic B,Krajc M,Skof E

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Utilisation of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and guide sheath (EBUS-GS) for diagnosis and staging of lung cancer is gaining popularity, however, its impact on clinical practice is unclear. This study aimed to determine the impact of the introduction of endobronc...

journal_title：BMC cancer

authors： Slavova-Azmanova NS,Lizama C,Johnson CE,Ludewick HP,Lester L,Karunarathne S,Phillips M

更新日期：2016-01-28 00:00:00

abstract：BACKGROUND:Bone mineral density (BMD) and lean mass (LM) may both decrease in breast cancer survivors, thereby increasing risk of falls and fractures. Research is needed to determine whether lean mass (LM) and fat mass (FM) independently relate to BMD in this patient group. METHODS:The Health, Eating, Activity, and Li...

journal_title：BMC cancer

authors： George SM,McTiernan A,Villaseñor A,Alfano CM,Irwin ML,Neuhouser ML,Baumgartner RN,Baumgartner KB,Bernstein L,Smith AW,Ballard-Barbash R

更新日期：2013-10-25 00:00:00