Abstract:
BACKGROUND:Small cell cervical carcinoma (SCCC) is a rare, aggressive tumor with a poor prognosis. However, information in relation to its treatment is scarce due to the limited numbers of patients. The aim of this study was to establish whether platinum-based combination chemotherapy may by beneficial in this patient population. METHODS:We carried out a multicenter, retrospective study comprising of 72 Chinese patients with SCCC. The patients were treated between 1995 and 2010 at Sun Yat-sen Memorial Hospital or the Cancer Center of Sun Yat-Sen University, and at the First Affiliated Hospital of Shantou University Medical College, China. RESULTS:Of the 72 patients, 46/72 (63.9%) had Federation of Gynecology and Obstetrics (FIGO) stage Ia-Ib2 and 26/72 (36.1%) had stage IIa-IV disease. Surgery was performed in 63/72 (87.5%) patients, 61/72 (84.7%) patients received chemoradiotherapy and 35/72 (48.6%) received radiotherapy. The 3-year overall survival (OS) and disease-free survival (DFS) rates were as follows: Ia (100%, 100%); Ib1 (62%, 57%); Ib2 (53%, 48%); IIa (36%, 23%); IIb (29%, 21%); IIIb (50%, 50%); and IV (0%, 0%), respectively. The estimated 3-year OS and DFS rates in patients who received platinum-based combination chemotherapy (etoposide + cisplatin [EP], or paclitaxel + cisplatin [TP]) as part of their adjuvant treatment were 64.8% and 63.0%, respectively, compared to 25.2% and 22.0% in those who did not (P = 0.0003; P = 0.0003). Univariate analysis showed that platinum-based combination chemotherapy was associated with improved survival compared to other chemotherapy techniques or no chemotherapy (OS: HR = 0.227; 95% CI, 0.099-0.524; P = 0.001; DFS: HR = 0.210; 95% CI, 0.087-0.506; P = 0.001). Multivariate analysis identified FIGO stage, lymphatic metastasis and platinum-based combination chemotherapy as independent prognostic factors for improved survival in patients with SCCC. CONCLUSIONS:Platinum-based combination chemotherapy (with EP or TP) can improve the 3-year survival outcomes in patients with SCCC. Therefore, it should be considered an important component in a future standardized treatment strategy for SCCC.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Huang L,Liao LM,Liu AW,Wu JB,Cheng XL,Lin JX,Zheng Mdoi
10.1186/1471-2407-14-140subject
Has Abstractpub_date
2014-02-27 00:00:00pages
140issn
1471-2407pii
1471-2407-14-140journal_volume
14pub_type
杂志文章,多中心研究相关文献
BMC CANCER文献大全abstract:BACKGROUND:To investigate the diagnostic reliability of selective microdochectomy after direct ductoscopic wire marking of suspect lesions in patients with pathological nipple discharge. METHODS:Selective microdochectomy due to pathological discharge was performed in 33 patients with mean age of 51.7 years. Ductoscope...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-151
更新日期:2009-05-17 00:00:00
abstract:BACKGROUND:Recent studies suggested that cancer stem-like cells contribute to tumor vasculogenesis by differentiating into endothelial cells. However, such process is governed by still undefined mechanism. METHODS:At varying differentiation levels, three representative colon cancer cells were cultured in endothelial-i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3578-9
更新日期:2017-08-30 00:00:00
abstract:BACKGROUND:An imbalance between proliferation and apoptosis is one of the main features of carcinogenesis. TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis upon binding to the TRAIL death receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2, whereas binding to TRAIL-R3 and TRAIL-R4 might promote cell surv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-532
更新日期:2013-11-09 00:00:00
abstract:BACKGROUND:Characterization of the linkage disequilibrium (LD) structure of candidate genes is the basis for an effective association study of complex diseases such as cancer. In this study, we report the LD and haplotype architecture and tagging-single nucleotide polymorphisms (tSNPs) for five DNA repair genes: ATM, M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-99
更新日期:2005-08-09 00:00:00
abstract:BACKGROUND:This paper describes the development of a Cancer Awareness Measure for colorectal (CRC) cancer (Bowel/Colorectal CAMa) (study 1) and presents key results from a population-representative survey using the measure (study 2). METHODS:STUDY 1: Items were taken from the literature and reviewed by expert groups. ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-366
更新日期:2011-08-23 00:00:00
abstract:BACKGROUND:It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme of sequentially occurring Copy Number Alterations (CNAs). METHODS:In this work we set to determine ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-121
更新日期:2014-02-22 00:00:00
abstract:BACKGROUND:Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase domain including the activating V599E and V599K transitions. METHODS:We here investigated a represent...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-58
更新日期:2005-06-03 00:00:00
abstract:BACKGROUND:Adoptive immunotherapy with cytotoxic T lymphocytes (CTL) represents an alternative approach to treating solid tumors. Ideally, this would confer long-term protection against tumor. We previously demonstrated that in vitro-generated tumor-specific CTL from the ovalbumin (OVA)-specific OT-I T cell receptor tr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-3-21
更新日期:2003-07-28 00:00:00
abstract:BACKGROUND:Mammographic breast density and parenchymal patterns are well-established risk factors for breast cancer. We aimed to report inter-observer agreement on three different subjective ways of assessing mammographic density and parenchymal pattern, and secondarily to examine what potential impact reproducibility ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1256-3
更新日期:2015-04-12 00:00:00
abstract:BACKGROUND:The aim of this study was to compare surgical treatment received by Aboriginal and non-Aboriginal people with non-small cell lung cancer (NSCLC) in New South Wales (NSW), Australia and to examine whether patient and disease characteristics are associated with any disparities found. An additional objective wa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2322-1
更新日期:2016-04-25 00:00:00
abstract:BACKGROUND:There is a large body of evidence which suggests that bile acids increase the risk of colon cancer and act as tumor promoters, however, the mechanism(s) of bile acids mediated tumorigenesis is not clear. Previously we showed that deoxycholic acid (DCA), a tumorogenic bile acid, and ursodeoxycholic acid (UDCA...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-219
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:To access the prognostic significance of HER-2 overexpression, the effect of trastuzumab and the cause of death in patients with brain metastases (BM) from breast cancer (BC). METHODS:We analyzed the outcome of 130 patients with BM from BC who received whole-brain radiotherapy (WBRT) (without surgery or rad...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-395
更新日期:2011-09-19 00:00:00
abstract:BACKGROUND:Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src homology) domain-containing adaptor protein. CRKL is tightly linked ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5671-8
更新日期:2019-05-27 00:00:00
abstract:BACKGROUND:Cancer of unknown primary remains a mallignancy of elusive biology and grim prognosis that lacks effective therapeutic options. We investigated angiogenesis in cancer of unknown primary to expand our knowledge on the biology of these tumors and identify potential therapeutic targets. METHODS:Paraffin embedd...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-25
更新日期:2005-03-03 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy (NAC) is one of the standard care regimens for patients with resectable early-stage breast cancer. It would be advantageous to determine the chemosensitivity of tumors before initiating NAC. One of the parameters potentially compromising such chemosensitivity would be a hypoxic micro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-400
更新日期:2014-06-04 00:00:00
abstract:BACKGROUND:The number of Nigerian men presenting with benign prostatic hyperplasia is on the rise because of increase awareness about the ailment. With the renewed effort by the national health insurance scheme to cover the informal sector, it becomes imperative to determine the cost implication for managing Benign Pro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2431-x
更新日期:2016-07-07 00:00:00
abstract:BACKGROUND:The biological relevance of nuclear ErbB-2/HER2 (NuclErbB-2) presence in breast tumors remains unexplored. In this study we assessed the clinical significance of ErbB-2 nuclear localization in primary invasive breast cancer. The reporting recommendations for tumor marker prognostic studies (REMARK) guideline...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-74
更新日期:2012-02-22 00:00:00
abstract:BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4457-8
更新日期:2018-05-08 00:00:00
abstract:BACKGROUND:p53 (encoded by TP53) is involved in DNA damage repair, cell cycle regulation, apoptosis, aging and cellular senescence. TP53 is mutated in around 50% of human cancers. Nevertheless, the consequences of p53 inactivation in colon cancer outcome remain unclear. Recently, a new role of p53 together with CSNK1A1...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-277
更新日期:2013-06-05 00:00:00
abstract:BACKGROUND:For the expanding population of bladder cancer survivors in Korea, the development of subsequent cancers is a significant concern. Here, we provide the second primary cancer incidence rates and types in Korean patients with bladder cancer. METHODS:Using population-based data from the Korea Central Cancer Re...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4530-3
更新日期:2018-05-31 00:00:00
abstract:BACKGROUND:Metformin and the thiazolidinediones (TZDs) may have a protective effect against the development of lung cancer. METHODS:Patients with diabetes mellitus (DM) were identified from the electronic medical records of the Cleveland Clinic. Diabetics with lung cancer were identified then verified by direct review...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-410
更新日期:2012-09-14 00:00:00
abstract:BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3762-y
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizer-replete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and induction of an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1994-2
更新日期:2015-12-26 00:00:00
abstract:BACKGROUND:The aim of this population-based study was to assess independent prognostic factors in ovarian cancer using relative survival (RS) and to investigate changes in RS rates from 1982 to 2005. METHODS:Data on 748 patients with ovarian cancer were provided by the Côte d'Or gynaecologic cancer registry. The RS wa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-622
更新日期:2010-11-10 00:00:00
abstract:BACKGROUND:Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an important role in tumor-associated angiogenesis. However, the effects of simultaneously targeting on VE...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2834-8
更新日期:2016-10-12 00:00:00
abstract:BACKGROUND:RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explore...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4585-1
更新日期:2018-06-18 00:00:00
abstract:BACKGROUND:The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements character...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-195
更新日期:2014-03-15 00:00:00
abstract:BACKGROUND:Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. Several studies have demonstrated discordant HER2 status in the primary and metastatic tumour. However, rates of discordance vary considerably in published report...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-555
更新日期:2012-11-24 00:00:00
abstract:BACKGROUND:Of all female genital tract tumors, 1-3% are stromal malignancies. In 8-10% of cases, these are represented by Müllerian adenosarcoma an extremely rare tumor characterized by a stromal component of usually low-grade malignancy and by a benign glandular epithelial component. Variant that arises in the pouch o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-171
更新日期:2011-05-15 00:00:00
abstract:BACKGROUND:5-fluorouracil, leucovorin, irinotecan and oxaliplatin (FOLFIRINOX) is superior to gemcitabine in patients with metastatic pancreatic cancer who have a good performance status. We investigated this combination as neoadjuvant therapy for locally advanced pancreatic cancer (LAPC). METHODS:In this retrospectiv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-199
更新日期:2012-05-29 00:00:00