Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer.

abstract：BACKGROUND:Breast metastasis from extramammary malignancy is uncommon and often presents diagnostic challenges. Herein, we report a case of a patient with metachronous isolated breast metastasis from pulmonary adenocarcinoma with micropapillary component. CASE PRESENTATION:A 47-year-old woman presented with left breas...

journal_title：BMC cancer

authors： Jeong YJ,Bong JG,Oh HK,Park SH,Kang SM,Bae SH

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging can be biased due to the anatomic complexity of this region. Recently, several markers related to canc...

journal_title：BMC cancer

authors： Chong Y,Thakur N,Paik KY,Lee EJ,Kang CS

更新日期：2020-03-14 00:00:00

abstract：BACKGROUND:TGFβ signaling has typically been associated with suppression of tumor initiation while the role it plays in metastasis is generally associated with progression of malignancy. However, we present evidence here for an anti-metastatic role of TGFβ signaling. METHODS:To test the importance of TGFβ signaling to...

journal_title：BMC cancer

authors： Simms NA,Rajput A,Sharratt EA,Ongchin M,Teggart CA,Wang J,Brattain MG

更新日期：2012-06-06 00:00:00

abstract：BACKGROUND:Microvascular invasion (MVI) is recognized as a prognostic factor associated with poor outcome in hepatocellular carcinoma (HCC) patients after curative resection. It remains unclear, however, whether MVI can provide prognostic information for patients at a specific tumor stage. METHODS:Consecutive HCC pati...

journal_title：BMC cancer

authors： Huang C,Zhu XD,Ji Y,Ding GY,Shi GM,Shen YH,Zhou J,Fan J,Sun HC

更新日期：2017-01-17 00:00:00

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been identified as an oncoprotein in various human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. We examined GOLPH3 expression levels and relationship with survival in patients with PDAC to establish the significance of GOLPH3 in the dev...

journal_title：BMC cancer

authors： Zhang LJ,Wang KB,Liu LS,Chen LZ,Peng BG,Liang LJ,Li Z,Xue L,Li W,Xia JT

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence. The aim of this study was to identify new mechanisms responsible for hypoxia-induced resistance in breast cancer cells. METHODS:MDA-MB-231...

journal_title：BMC cancer

authors： Flamant L,Roegiers E,Pierre M,Hayez A,Sterpin C,De Backer O,Arnould T,Poumay Y,Michiels C

更新日期：2012-09-06 00:00:00

abstract：BACKGROUND:Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple dis...

journal_title：BMC cancer

authors： Ozaki A,Nomura S,Leppold C,Tsubokura M,Tanimoto T,Yokota T,Saji S,Sawano T,Tsukada M,Morita T,Ochi S,Kato S,Kami M,Nemoto T,Kanazawa Y,Ohira H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:Renal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis (FSGS) or its morphological v...

journal_title：BMC cancer

authors： Jia N,Cormack FC,Xie B,Shiue Z,Najafian B,Gralow JR

更新日期：2015-07-22 00:00:00

abstract：:Following publication of the original article [1], the authors notified us of a misleading data presentation in Table 4. ...

journal_title：BMC cancer

authors： Martínez-González NA,Neuner-Jehle S,Plate A,Rosemann T,Senn O

更新日期：2018-11-30 00:00:00

abstract：BACKGROUND:We have recently described the correlation between quantitative measures of HER2 expression or HER2 homodimers by the HERmark assay and objective response (RR), time-to progression (TTP), and overall survival (OS) in an expanded access cohort of trastuzumab-treated HER2-positive patients with metastatic brea...

journal_title：BMC cancer

authors： Toi M,Sperinde J,Huang W,Saji S,Winslow J,Jin X,Tan Y,Ohno S,Nakamura S,Iwata H,Masuda N,Aogi K,Morita S,Petropoulos C,Bates M

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Stereotactic radiotherapy is an emerging treatment option for patients with inoperable renal cell carcinoma (RCC). Haemorrhage has not previously been reported to occur as a result of Stereotactic Body Radiotherapy (SBRT) to the kidney for primary RCC. We report an acute haemorrhage in a patient who received...

journal_title：BMC cancer

authors： Hilleary LA,Wratten C,Siva S,Hilleary J,Martin JM

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association between pre-operative plasma metabolites and risk of biochemical-, local- and metastatic-recurrence,...

journal_title：BMC cancer

authors： Zoni E,Minoli M,Bovet C,Wehrhan A,Piscuoglio S,Ng CKY,Gray PC,Spahn M,Thalmann GN,Kruithof-de Julio M

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:Several lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC) is implicated in the initiation and progression of malignancies and thus gained attraction as druggable target. Since data on the role of Sirt1 in pancreatic ductal adenocarcinoma (PDAC) are sparse, we investigated the expr...

journal_title：BMC cancer

authors： Stenzinger A,Endris V,Klauschen F,Sinn B,Lorenz K,Warth A,Goeppert B,Ehemann V,Muckenhuber A,Kamphues C,Bahra M,Neuhaus P,Weichert W

更新日期：2013-10-02 00:00:00

abstract：BACKGROUND:The preoperative characterization of thyroid nodules is a challenge for the clinicians. Fine-needle aspiration (FNA) is the commonly used pre-operative technique for diagnosis of malignant thyroid tumor. However, many benign lesions, with indeterminate diagnosis following FNA, are referred to surgery. There ...

journal_title：BMC cancer

authors： Arcolia V,Paci P,Dhont L,Chantrain G,Sirtaine N,Decaestecker C,Remmelink M,Belayew A,Saussez S

更新日期：2014-07-08 00:00:00

abstract：BACKGROUND:Young breast cancer (BC) patients less than 45 years old are at higher risk of dying from the disease when compared to their older counterparts. However, specific risk factors leading to this poorer outcome have not been identified. METHODS:One candidate is iron deficiency, as this is common in young women ...

journal_title：BMC cancer

authors： Jian J,Yang Q,Shao Y,Axelrod D,Smith J,Singh B,Krauter S,Chiriboga L,Yang Z,Li J,Huang X

更新日期：2013-06-24 00:00:00

abstract：BACKGROUND:It has been previously demonstrated in several cancer models, that Dronabinol (THC) may have anti-tumor activity--however, controversial data exists for acute leukemia. We have anecdotal evidence that THC may have contributed to disease control in a patient with acute undifferentiated leukemia. METHODS:To t...

journal_title：BMC cancer

authors： Kampa-Schittenhelm KM,Salitzky O,Akmut F,Illing B,Kanz L,Salih HR,Schittenhelm MM

更新日期：2016-01-16 00:00:00

abstract：BACKGROUND:Neuroblastoma patients show heterogeneous clinical courses ranging from life-threatening progression to spontaneous regression. Recently, gene expression profiles of neuroblastoma tumours were associated with clinically different phenotypes. However, such data is still rare for important patient subgroups, s...

journal_title：BMC cancer

authors： Warnat P,Oberthuer A,Fischer M,Westermann F,Eils R,Brors B

更新日期：2007-05-25 00:00:00

abstract：BACKGROUND:Colorectal-cancer is a leading cause of cancer death in the United States, and Latinos have particularly low rates of screening. Strategies and Opportunities to STOP Colon Cancer in Priority Populations (STOP CRC) is a partnership among two research institutions and a network of safety net clinics to promote...

journal_title：BMC cancer

authors： Coronado GD,Vollmer WM,Petrik A,Aguirre J,Kapka T,Devoe J,Puro J,Miers T,Lembach J,Turner A,Sanchez J,Retecki S,Nelson C,Green B

更新日期：2014-02-26 00:00:00

abstract：BACKGROUND:To investigate on expressions and clinical significances of CD133 protein and vasculogenic mimicry (VM) in primary non-small cell lung cancer (NSCLC). METHODS:The specimens of NSCLC from 305 Chinese patients with follow-up were analyzed for CD133 protein expression and VM by immunohistochemical and histoche...

journal_title：BMC cancer

authors： Wu S,Yu L,Wang D,Zhou L,Cheng Z,Chai D,Ma L,Tao Y

更新日期：2012-11-21 00:00:00

abstract：BACKGROUND:Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary lesion may not match with its...

journal_title：BMC cancer

authors： Zhao J,Hu C,Wang C,Yu W,Guo Y,Shi M,Shui Y,Wei Q

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL) is a heterogeneous group of malignant disorders derived from B- or T-cell lymphoid progenitor cells. ALL often is refractory to or relapses after treatment; thus, novel targeted therapy for ALL is urgently needed. In the present study, we initially found that the level of S...

journal_title：BMC cancer

authors： Jin Y,Cao Q,Chen C,Du X,Jin B,Pan J

更新日期：2015-04-07 00:00:00

abstract：BACKGROUND:Oesophageal squamous cell carcinoma (OSCC) is a major health burden in Sub-Saharan Africa, and novel chemotherapies are urgently required to combat this disease. The heat shock protein 90 (HSP90) inhibitor 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) has previously been proposed as a possible candidate ...

journal_title：BMC cancer

authors： Hadley KE,Hendricks DT

更新日期：2014-05-15 00:00:00

abstract：BACKGROUND:Earlier studies have reported the production of histamine in colorectal cancers (CRCs). The effect of histamine is largely determined locally by the histamine receptor expression pattern. Recent evidence suggests that the expression level of histamine receptor H4 (HRH4) is abnormal in colorectal cancer tissu...

journal_title：BMC cancer

authors： Fang Z,Yao W,Xiong Y,Li J,Liu L,Shi L,Zhang W,Zhang C,Nie L,Wan J

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:The Michigan Prevention Research Center, the University of Michigan Schools of Nursing, Public Health, and Medicine, and the Michigan Department of Community Health propose a multidisciplinary academic-clinical practice three-year project to increase breast cancer screening among young breast cancer survivor...

journal_title：BMC cancer

authors： Katapodi MC,Northouse LL,Schafenacker AM,Duquette D,Duffy SA,Ronis DL,Anderson B,Janz NK,McLosky J,Milliron KJ,Merajver SD,Duong LM,Copeland G

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:A functional polymorphism within MDM2, SNP309 T>G, has been linked to early onset cancer. This study examined clinical associations of breast cancer with SNP309 in a Scottish Caucasian population and investigated additional MDM2 intron 1 polymorphisms. METHODS:Intron 1 of MDM2 was PCR amplified and direct...

journal_title：BMC cancer

authors： Paulin FE,O'Neill M,McGregor G,Cassidy A,Ashfield A,Ali CW,Munro AJ,Baker L,Purdie CA,Lane DP,Thompson AM

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Amyloid-β precursor protein (APP) is a highly conserved single transmembrane protein that has been linked to Alzheimer disease. Recently, the increased expression of APP in multiple types of cancers has been reported where it has significant correlation with the cancer cell proliferation. However, the functi...

journal_title：BMC cancer

authors： Lim S,Yoo BK,Kim HS,Gilmore HL,Lee Y,Lee HP,Kim SJ,Letterio J,Lee HG

更新日期：2014-12-10 00:00:00

abstract：BACKGROUND:Aboriginal status has been unreliably and incompletely recorded in health and vital registration data collections for the most populous areas of Australia, including NSW where 29% of Australian Aboriginal people reside. This paper reports an assessment of Aboriginal status recording in NSW cancer registratio...

journal_title：BMC cancer

authors： Morrell S,You H,Baker D

更新日期：2012-05-06 00:00:00

abstract：BACKGROUND:Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by its combination with other microtubule-binding agents. METHODS:The interactions between ABZ and micro...

journal_title：BMC cancer

authors： Ehteda A,Galettis P,Pillai K,Morris DL

更新日期：2013-02-23 00:00:00

abstract：BACKGROUND:Helicobacter pylori (H. pylori) is thought to have an oncogenic effect on the development of gastric malignancies. However, the effect of H. pylori status on the prognosis of gastric diffuse large B-cell lymphoma (DLBCL) remains unconfirmed. This study aimed to identify the prognostic importance of H. pylori...

journal_title：BMC cancer

authors： Cheng Y,Xiao Y,Zhou R,Liao Y,Zhou J,Ma X

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:18F-FDG PET/CT could satisfactorily show pancreatic and extra-pancreatic lesions in AIP, which can be mistaken for pancreatic cancer (PC). This study aimed to identify 18F-FDG PET/CT findings that might differentiate AIP from PC. METHODS:FDG-PET/CT findings of 26 AIP and 40 PC patients were reviewed. Pancre...

journal_title：BMC cancer

authors： Zhang J,Jia G,Zuo C,Jia N,Wang H

更新日期：2017-10-23 00:00:00