Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer.

abstract：BACKGROUND:Although modest improvements in the survival of patients with non-small cell lung cancer (NSCLC) can be achieved with cisplatin-based chemotherapy (CT), its value is disputed in the geriatric setting. In this study, we evaluate the feasibility of vinorelbine/cisplatin CT for elderly NSCLC patients. METHODS:...

journal_title：BMC cancer

authors： Pereira JR,Martins SJ,Nikaedo SM,Ikari FK

更新日期：2004-09-29 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related death in the world with a five-year survival rate of less than 5%. Not all PDAC are the same, because there exist intra-tumoral heterogeneity between PDAC, which poses a great challenge to personalized treatments for PDAC. ...

journal_title：BMC cancer

authors： Zhao L,Zhao H,Yan H

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artificial intelligence models for 5-year overall survival prediction in patients with cervical cancer tre...

journal_title：BMC cancer

authors： Obrzut B,Kusy M,Semczuk A,Obrzut M,Kluska J

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:Oncotype DX® (ODX) is used to assess risk of disease recurrence in hormone receptor positive, HER2-negative breast cancer and to guide decisions regarding adjuvant chemotherapy. Little is known about how physician factors impact treatment decisions. The purpose of this study was to examine patient and physic...

journal_title：BMC cancer

authors： Schwedhelm TM,Rees JR,Onega T,Zipkin RJ,Schaefer A,Celaya MO,Moen EL

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:Human papillomaviruses (HPV) are the aetiological agents of certain benign and malignant tumours of skin and mucosae; the most important of which is cervical cancer. Also, the incidence of ano-genital warts, HPV-anal cancer and oropharyngeal cancers are rising. To help ascertain a useful PCR detection protoc...

journal_title：BMC cancer

authors： Winder DM,Ball SL,Vaughan K,Hanna N,Woo YL,Fränzer JT,Sterling JC,Stanley MA,Sudhoff H,Goon PK

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Nasopharyngeal carcinoma (NPC) is a type of head-neck cancer with a distinguishable geographic and racial distribution worldwide. Increasing evidence supports that the accumulation of additional genetic and epigenetic abnormalities is important in driving the NPC tumorigenic process. In this study, we aim to...

journal_title：BMC cancer

authors： Huang PY,Zeng TT,Ban X,Li MQ,Zhang BZ,Zhu YH,Hua WF,Mai HQ,Zhang L,Guan XY,Li Y

更新日期：2016-08-22 00:00:00

abstract：BACKGROUND:To compare the survival outcomes and acute toxicities of concurrent chemoradiotherapy (CCRT), induction chemotherapy (IC) plus radiotherapy (RT), and IC plus CCRT in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated using intensity-modulated radiotherapy (IMRT). METHODS:Patients w...

journal_title：BMC cancer

authors： Li WF,Li YQ,Chen L,Zhang Y,Guo R,Zhang F,Peng H,Sun Y,Ma J

更新日期：2015-10-27 00:00:00

abstract：BACKGROUND:Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involved in human cancer. However, there is limited information regarding the clinical significance of cyt...

journal_title：BMC cancer

authors： Dai SD,Wang Y,Miao Y,Zhao Y,Zhang Y,Jiang GY,Zhang PX,Yang ZQ,Wang EH

更新日期：2009-06-09 00:00:00

abstract：BACKGROUND:FOXM1 regulates expression of cell cycle related genes that are essential for progression into DNA replication and mitosis. Consistent with its role in proliferation, elevated expression of FOXM1 has been reported in a variety of human tumour entities. FOXM1 is a gene of interest because recently chemical in...

journal_title：BMC cancer

authors： Bektas N,Haaf At,Veeck J,Wild PJ,Lüscher-Firzlaff J,Hartmann A,Knüchel R,Dahl E

更新日期：2008-02-06 00:00:00

abstract：BACKGROUND:The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative breast cancer (TNBC). METHODS:A systematic search of the MEDLINE, EMBASE, and Web of Science databas...

journal_title：BMC cancer

authors： Gao G,Wang Z,Qu X,Zhang Z

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Extramammary Paget's disease (EMPD) remains a rare condition with only a limited number of cases reported in the literature. EMPD is mainly composed of intraepidermal Paget cells, and possesses variable clinical behaviors and histological appearances, leading to difficulty in the diagnosis of this disease. ...

journal_title：BMC cancer

authors： Wang X,Yang W,Yang J

更新日期：2010-08-04 00:00:00

abstract：BACKGROUND:Prognostic factors aid in the stratification and treatment of cancer. This study evaluated prognostic importance of tumor infiltrating immune cell in patients with oral squamous cell carcinoma. METHODS:Profiles of infiltrating immune cells and clinicopathological data were available for 78 OSCC patients wit...

journal_title：BMC cancer

authors： Fang J,Li X,Ma D,Liu X,Chen Y,Wang Y,Lui VWY,Xia J,Cheng B,Wang Z

更新日期：2017-05-26 00:00:00

abstract：BACKGROUND:In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization) in PWA in 10 cities in Togo in 2019. METHODS:This is a cross...

journal_title：BMC cancer

authors： Saka B,Akakpo SA,Teclessou JN,Gnossike P,Adam S,Mahamadou G,Kassang P,Elegbede Y,Mouhari-Toure A,Darre T,Kombate K,Pitché P

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:Pancreatic adenocarcinoma is one of the most dreaded cancers with very low survival rate and poor prognosis to the existing frontline chemotherapeutic drugs. Gene therapy in combination with a cytotoxic agent could be a promising approach to circumvent the limitations of previously attempted therapeutic inte...

journal_title：BMC cancer

authors： Xu J,Singh A,Amiji MM

更新日期：2014-02-08 00:00:00

abstract：BACKGROUND:More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncontrolled cell growth. Vemurafenib (PLX4032) is an oral chemotherapeutic agent that targets the specif...

journal_title：BMC cancer

authors： Xiao J,Egger ME,McMasters KM,Hao H

更新日期：2018-06-22 00:00:00

abstract：BACKGROUND:We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth. METHODS:Pancreatic carcinomas were assessed in a syngenei...

journal_title：BMC cancer

authors： Zechner D,Radecke T,Amme J,Bürtin F,Albert AC,Partecke LI,Vollmar B

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellent rates of local control for primary tumors or metastases. A recent randomized phase II trial evalua...

journal_title：BMC cancer

authors： Palma DA,Olson R,Harrow S,Correa RJM,Schneiders F,Haasbeek CJA,Rodrigues GB,Lock M,Yaremko BP,Bauman GS,Ahmad B,Schellenberg D,Liu M,Gaede S,Laba J,Mulroy L,Senthi S,Louie AV,Swaminath A,Chalmers A,Warner A,Slot

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Annually, colorectal cancer (CRC) is diagnosed in >1.4 million subjects worldwide and incidence is increasing. Much effort has therefore been focused on screening, which has proven to reduce cancer-related mortality. The Sept9 DNA-methylation assay is among the most well studied blood-based screening markers...

journal_title：BMC cancer

authors： Ørntoft MB,Nielsen HJ,Ørntoft TF,Andersen CL,Danish Study Group on Early Detection of Colorectal Cancer.

更新日期：2015-10-29 00:00:00

abstract：BACKGROUND:To the best of our knowledge, no study has reported mediastinal shift accompanied with obstructive atelectasis due to bulky primary esophageal tumor components treated with adaptive radiotherapy and concurrent chemotherapy. CASE PRESENTATION:Here we report the case of a 65-year-old male patient diagnosed wi...

journal_title：BMC cancer

authors： Sakanaka K,Fujii K,Mizowaki T

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and par...

journal_title：BMC cancer

authors： Haffner MC,Petridou B,Peyrat JP,Révillion F,Müller-Holzner E,Daxenbichler G,Marth C,Doppler W

更新日期：2007-07-25 00:00:00

abstract：BACKGROUND:Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary lesion may not match with its...

journal_title：BMC cancer

authors： Zhao J,Hu C,Wang C,Yu W,Guo Y,Shi M,Shui Y,Wei Q

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. However, the lack of accuracy in identifying HR patients with conventional risk factors (large, deep, ...

journal_title：BMC cancer

authors： Filleron T,Le Guellec S,Chevreau C,Cabarrou B,Lesluyes T,Lodin S,Massoubre A,Mounier M,Poublanc M,Chibon F,Valentin T

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND:Abundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors. Therefore, it is very important that finding the agents that increase the death receptors of cancer cells. In this study, we demonstrated that the snake venom toxin...

journal_title：BMC cancer

authors： Park MH,Jo M,Won D,Song HS,Han SB,Song MJ,Hong JT

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:To provide estimations of partial and total prevalence of 24 cancer sites in France in 2008. The estimations of partial prevalence were compared with the previous estimations for 2002. METHODS:Nationwide estimations of incidence and survival data from cancer registries were used for partial prevalence. Nati...

journal_title：BMC cancer

authors： Colonna M,Mitton N,Bossard N,Belot A,Grosclaude P,French Network of Cancer Registries (FRANCIM).

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:The lymphocytes played an important role in the natural history of cancer. The aim of this study was to explore the prognostic value of lymphocyte count and percentage for survival in advanced cancer patients receiving palliative care. METHODS:A retrospective review of clinicopathological data from 378 cons...

journal_title：BMC cancer

authors： Zhao W,Wang P,Jia H,Chen M,Gu X,Liu M,Zhang Z,Cheng W,Wu Z

更新日期：2017-08-02 00:00:00

abstract：BACKGROUND:Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major ro...

journal_title：BMC cancer

authors： Cegolon L,Salata C,Weiderpass E,Vineis P,Palù G,Mastrangelo G

更新日期：2013-01-03 00:00:00

abstract：BACKGROUND:Most currently known breast cancer predisposition genes play a role in DNA repair by homologous recombination. Recent studies conducted on RAD51 paralogs, involved in the same DNA repair pathway, have identified rare germline mutations conferring breast and/or ovarian cancer predisposition in the RAD51C, RAD...

journal_title：BMC cancer

authors： Golmard L,Caux-Moncoutier V,Davy G,Al Ageeli E,Poirot B,Tirapo C,Michaux D,Barbaroux C,d'Enghien CD,Nicolas A,Castéra L,Sastre-Garau X,Stern MH,Houdayer C,Stoppa-Lyonnet D

更新日期：2013-10-19 00:00:00

abstract：BACKGROUND:Oncolytic viruses, including vaccinia virus (VACV), are a promising alternative to classical mono-cancer treatment methods such as surgery, chemo- or radiotherapy. However, combined therapeutic modalities may be more effective than mono-therapies. In this study, we enhanced the effectiveness of oncolytic vir...

journal_title：BMC cancer

authors： Schäfer S,Weibel S,Donat U,Zhang Q,Aguilar RJ,Chen NG,Szalay AA

更新日期：2012-08-23 00:00:00

abstract：BACKGROUND:Mounting evidence shows that microRNA-34a (miR-34a) is involved in cancer prognosis. Therefore, we summarize the predictive role of miR-34a for survival in patients with gastrointestinal cancers (GICs). METHODS:All eligible studies were found by searching PubMed, Web of Science and EMBASE, and survival resu...

journal_title：BMC cancer

authors： Chen YL,Liu XL,Li L

更新日期：2021-01-14 00:00:00

abstract：CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...

journal_title：BMC cancer

authors： Wang X,Chen J,Wang J,Yu F,Zhao S,Zhang Y,Tang H,Peng Z

更新日期：2018-01-11 00:00:00