Snake venom toxin from Vipera lebetina turanica induces apoptosis of colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expression.

abstract：BACKGROUND:High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible for treatment with poly(ADP-ribose) polymerase inhibitors (PARPi). The aim of this study was to ...

journal_title：BMC cancer

authors： Gornjec A,Novakovic S,Stegel V,Hocevar M,Pohar Marinsek Z,Gazic B,Krajc M,Skof E

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the feasibility and potential benefit of a brief psychosocial intervention based on cognitive-behavioral therapy performed in addition to early palliative care (PC) in the reduction of depressive symptoms among patients with advanced cancer. METHODS:An open-label randomiz...

journal_title：BMC cancer

authors： do Carmo TM,Paiva BSR,de Oliveira CZ,Nascimento MSA,Paiva CE

更新日期：2017-08-23 00:00:00

abstract：BACKGROUND:The bone scan index (BSI) using a computer-aided diagnosis system for bone scans is expected to be an objective and quantitative clinical tool for evaluating bone metastatic prostate cancer. This study aimed to evaluate the pretreatment BSI as a prognostic factor in hormone-naive prostate cancer patients wit...

journal_title：BMC cancer

authors： Miyoshi Y,Yoneyama S,Kawahara T,Hattori Y,Teranishi J,Kondo K,Moriyama M,Takebayashi S,Yokomizo Y,Yao M,Uemura H,Noguchi K

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Chondrosarcoma is a malignant cartilage forming bone tumour for which no effective systemic treatment is available. Previous studies illustrate the need for a better understanding of the role of the IGF pathway in chondrosarcoma to determine if it can be a target for therapy, which was therefore explored in ...

journal_title：BMC cancer

authors： Peterse EF,Cleven AH,De Jong Y,Briaire-de Bruijn I,Fletcher JA,Danen EH,Cleton-Jansen AM,Bovée JV

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:The present study evaluated the expression of hepcidin mRNA in hepatocellular carcinoma (HCC). METHODS:Samples of cancerous and non-cancerous liver tissue were taken from 40 patients with HCC who underwent hepatectomy. Expression of hepcidin mRNA was evaluated by real-time PCR, and compared in tumors differ...

journal_title：BMC cancer

authors： Kijima H,Sawada T,Tomosugi N,Kubota K

更新日期：2008-06-09 00:00:00

abstract：BACKGROUND:We sought to determine the comparative diagnostic performance of standard b-value (800-1000 s/mm2) versus low b-value (400-500 s/mm2) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of renal cell carcinoma (RCC). METHOD:After a systematic review of the available literature, studies w...

journal_title：BMC cancer

authors： Tang Y,Zhou Y,Du W,Liu N,Zhang C,Ouyang T,Hu J

更新日期：2014-11-18 00:00:00

abstract：BACKGROUND:High levels of blood glucose are thought to be associated with colorectal cancer (CRC) and hyperinsulinemia, an interstage in the development of CRC. The purpose of this study was to examine associations between incident CRC and blood glucose; plasma insulin; and the homeostasis model assessment for insulin ...

journal_title：BMC cancer

authors： Vulcan A,Manjer J,Ohlsson B

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:Subsyndromal delirium, a condition in which patients exhibit some, but not all, of the symptoms of delirium, can negatively affect the outcomes of patients with cancer. However, the incidence of subsyndromal delirium in patients with gastric cancer is unknown. Here, we investigated the incidence and risk fac...

journal_title：BMC cancer

authors： Hwang H,Lee KM,Son KL,Jung D,Kim WH,Lee JY,Kong SH,Suh YS,Lee HJ,Yang HK,Hahm BJ

更新日期：2018-07-27 00:00:00

abstract：BACKGROUND:Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the prognostic value of MDSCs ...

journal_title：BMC cancer

authors： Ai L,Mu S,Wang Y,Wang H,Cai L,Li W,Hu Y

更新日期：2018-12-05 00:00:00

abstract：BACKGROUND:Brain tumor vasculature can be significantly compromised and leakier than that of normal brain blood vessels. Little is known if there are vascular permeability alterations in the brain adjacent to tumor (BAT). Changes in BAT permeability may also lead to increased drug permeation in the BAT, which may exert...

journal_title：BMC cancer

authors： Mohammad AS,Adkins CE,Shah N,Aljammal R,Griffith JIG,Tallman RM,Jarrell KL,Lockman PR

更新日期：2018-12-07 00:00:00

abstract：BACKGROUND:MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a hundred of targets. On the other hand, a single protein-coding gene could be targeted by many potent...

journal_title：BMC cancer

authors： Jiang Q,Feng MG,Mo YY

更新日期：2009-06-18 00:00:00

abstract：BACKGROUND:MicroRNA-21 (miR-21) is up-regulated in many cancers, including colorectal cancer (CRC). Nevertheless, the function of miR-21 in CRC and the mechanism underlying that function is still unclear. METHODS:After analyzing the expression of miR-21 and Sec23A in CRC cell lines, we transfected the highest miR-21 e...

journal_title：BMC cancer

authors： Li C,Zhao L,Chen Y,He T,Chen X,Mao J,Li C,Lyu J,Meng QH

更新日期：2016-08-05 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate whether p503S, p504S and p510S gene expression in peripheral-blood be useful as a diagnostic or prognostic marker of prostatic cancer. METHODS:Circulating cells were identified by reverse transcription-polymerase chain reaction (RT-PCR) to detect p503S, p504S and p510...

journal_title：BMC cancer

authors： Cardillo MR,Gentile V,Ceccariello A,Giacomelli L,Messinetti S,Di Silverio F

更新日期：2005-09-05 00:00:00

abstract：BACKGROUND:The incidence and survival rates for colorectal cancer in Australia are among the highest in the world. With population growth and ageing there are increasing numbers of colorectal cancer survivors in the community, yet little is known of their ongoing follow up and survivorship care experiences. This study ...

journal_title：BMC cancer

authors： Young JM,Durcinoska I,DeLoyde K,Solomon MJ

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Currently the majority of cancer patients are considered ineligible for intensive care treatment and oncologists are struggling to get their patients admitted to intensive care units. Critical care and oncology are frequently two separate worlds that communicate rarely and thus do not share novel development...

journal_title：BMC cancer

authors： von Bergwelt-Baildon M,Hallek MJ,Shimabukuro-Vornhagen AA,Kochanek M

更新日期：2010-11-08 00:00:00

abstract：BACKGROUND:There are racial/ethnic disparities in breast cancer mortality may be attributed to differences in receipt of adjuvant cancer treatment. Our purpose was to determine whether the mortality disparities could be explained by racial/ethnic differences in long-term adherence to adjuvant endocrine therapy (AET). ...

journal_title：BMC cancer

authors： Farias AJ,Wu WH,Du XL

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Despite the excellent results obtained with hormone therapy, the long treatment period and the side effects associated with its use make patient adherence difficult. Moreover, certain aspects of health care can mitigate or exacerbate non-adherence. This study aimed to identify the factors associated with adh...

journal_title：BMC cancer

authors： Brito C,Portela MC,de Vasconcellos MT

更新日期：2014-06-03 00:00:00

abstract：BACKGROUND:Alcohol consumption is associated with increased risk of breast cancer (BC), and the underlying mechanism is thought to be sex-hormone driven. In vitro and observational studies suggest a mechanism involving peroxisome proliferator-activated receptor gamma (PPARγ) in a complex with peroxisome proliferator-ac...

journal_title：BMC cancer

authors： Kopp TI,Jensen DM,Ravn-Haren G,Cohen A,Sommer HM,Dragsted LO,Tjonneland A,Hougaard DM,Vogel U

更新日期：2016-04-21 00:00:00

abstract：BACKGROUND:Comorbidity has a well documented detrimental effect on cancer survival. However it is difficult to disentangle the direct effects of comorbidity on survival from indirect effects via the influence of comorbidity on treatment choice. This study aimed to assess the impact of comorbidity on colon cancer patien...

journal_title：BMC cancer

authors： Sarfati D,Hill S,Blakely T,Robson B,Purdie G,Dennett E,Cormack D,Dew K

更新日期：2009-04-20 00:00:00

abstract：:Following definitive chemoradiation for anal squamous cell carcinoma (ASCC), patients face a variety of chronic issues including: bowel dysfunction, accelerated bone loss, sexual dysfunction, and psychosocial distress. The increasing incidence of this disease, high cure rates, and significant long-term sequelae warran...

journal_title：BMC cancer

authors： Savoie MB,Laffan A,Brickman C,Daniels B,Levin A,Rowen T,Smith J,Van Blarigan EL,Hope TA,Berry-Lawhorn JM,Anwar M,Van Loon K

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different next-generation sequencing (NGS) pipelines in paired cerebrospinal fluid (CSF) and plasma samples fr...

journal_title：BMC cancer

authors： Ge M,Zhan Q,Zhang Z,Ji X,Zhou X,Huang R,Liang X

更新日期：2019-02-12 00:00:00

abstract：BACKGROUND:Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, aging and cancer. The modified guanine, 7,8-dihydro-8-oxoguanine (also known as 8-hydroxyguanine) is one of the major oxidized bases generated in DNA by reactive oxygen species and has ...

journal_title：BMC cancer

authors： Chatterjee A,Mambo E,Zhang Y,Deweese T,Sidransky D

更新日期：2006-10-03 00:00:00

abstract：BACKGROUND:There is international interest in risk-stratification of breast screening programmes to allow women at higher risk to benefit from more frequent screening and chemoprevention. Risk-stratification also identifies women at low-risk who could be screened less frequently, as the harms of breast screening may ou...

journal_title：BMC cancer

authors： McWilliams L,Woof VG,Donnelly LS,Howell A,Evans DG,French DP

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this disease. However, the mechanism of miRNA-induced mRNA cleavage remains to be investigated. METHOD:In...

journal_title：BMC cancer

authors： Zhou F,Tang D,Xu Y,He H,Wu Y,Lin L,Dong J,Tan W,Dai Y

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:The immune system plays an important role in the multifactorial biologic system during the development of neoplasias. However, the involvement of the inflammatory response in the promotion/control of malignant cells is still controversial, and the cell subsets and the mechanisms involved are poorly investiga...

journal_title：BMC cancer

authors： Estrela-Lima A,Araújo MS,Costa-Neto JM,Teixeira-Carvalho A,Barrouin-Melo SM,Cardoso SV,Martins-Filho OA,Serakides R,Cassali GD

更新日期：2010-06-04 00:00:00

abstract：BACKGROUND:Distress in patients with cancer influences their quality of life. Worldwide, screening on distress with the Distress Thermometer (DT) in patients with cancer is recommended. However, the effects of the use of the DT on the psychosocial wellbeing of the patient are unknown. A study to assess the psychosocial...

journal_title：BMC cancer

authors： Ploos van Amstel FK,Prins JB,van der Graaf WT,Peters ME,Ottevanger PB

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small cell lung cancer (NSCLC) who harbor EGFR mutations. However, little is known about the popu...

journal_title：BMC cancer

authors： Yoshimura A,Yamada T,Okura N,Takeda T,Furutani W,Kubota Y,Shiotsu S,Hiranuma O,Nishioka N,Chihara Y,Tamiya N,Kaneko Y,Uchino J,Takayama K

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported the correlation between the prognosis of COAD and the immune system. The current study aimed to deve...

journal_title：BMC cancer

authors： Luo J,Liu P,Wang L,Huang Y,Wang Y,Geng W,Chen D,Bai Y,Yang Z

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:Cancer cells release exosomes and can be taken up by mast cells (MCs), but the potential functional effects of MCs on tumor metastasis remain unknown. METHOD:Exosomes were isolated from the lung adenocarcinoma cell line A549, and the uptake of PKH26-labeled exosomes by bone marrow MCs was examined via flow ...

journal_title：BMC cancer

authors： Xiao H,He M,Xie G,Liu Y,Zhao Y,Ye X,Li X,Zhang M

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) have emerged as promising therapeutic agents in non-small cell lung cancer (NSCLC). However, the duration for which ICIs should be continued remains a clinical problem. METHODS:We examined the efficacy of anti-PD-1/PD-L1 inhibitors after the discontinuation of antibodies ...

journal_title：BMC cancer

authors： Tachihara M,Negoro S,Inoue T,Tamiya M,Akazawa Y,Uenami T,Urata Y,Hattori Y,Hata A,Katakami N,Yokota S

更新日期：2018-10-03 00:00:00