The release of tryptase from mast cells promote tumor cell metastasis via exosomes.

abstract：BACKGROUND:Prostate cancer is the second leading cause of male cancer death in developed countries. Although the role of angiogenesis in its progression is well established, the efficacy of anti-angiogenic therapy is not clearly proved. Whether this could depend on differential responses between tumor and normal endoth...

journal_title：BMC cancer

authors： Fiorio Pla A,Brossa A,Bernardini M,Genova T,Grolez G,Villers A,Leroy X,Prevarskaya N,Gkika D,Bussolati B

更新日期：2014-12-12 00:00:00

abstract：BACKGROUND:It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in patients with HER2-negative metastatic breast cancer. METHODS:We searched Pubmed, Embase, and Cochr...

journal_title：BMC cancer

authors： Sun Z,Lan X,Xu S,Li S,Xi Y

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody used in association with chemotherapy in met...

journal_title：BMC cancer

authors： Lereclus E,Tout M,Girault A,Baroukh N,Caulet M,Borg C,Bouché O,Ternant D,Paintaud G,Lecomte T,Raoul W

更新日期：2017-03-27 00:00:00

abstract：BACKGROUND:The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections. This margin should be evaluated by serial perpendicular sectioning. The aim of the study was to determine whether retroperitoneal margin involvement independently predicts surviva...

journal_title：BMC cancer

authors： Westgaard A,Tafjord S,Farstad IN,Cvancarova M,Eide TJ,Mathisen O,Clausen OP,Gladhaug IP

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:For decades, planar bone scintigraphy has been the standard practice for detection of bone metastases in prostate cancer and has been endorsed by recent oncology/urology guidelines. It is a sensitive method with modest specificity. (18)F-fluoride positron emission tomography/computed tomography has shown imp...

journal_title：BMC cancer

authors： Fonager RF,Zacho HD,Langkilde NC,Petersen LJ

更新日期：2016-01-11 00:00:00

abstract：BACKGROUND:A substantial number of patients will develop further biochemical progression after radical prostatectomy (RP) and salvage radiotherapy (sRT). Recently published data using prostate-specific membrane antigen ligand positron emission tomography (PSMA - PET) for re-staging suggest that those recurrences are of...

journal_title：BMC cancer

authors： Oehus AK,Kroeze SGC,Schmidt-Hegemann NS,Vogel MME,Kirste S,Becker J,Burger IA,Derlin T,Bartenstein P,Eiber M,Mix M,la Fougère C,Belka C,Combs SE,Grosu AL,Müller AC,Guckenberger M,Christiansen H,Henkenberens C

更新日期：2020-04-29 00:00:00

abstract：BACKGROUND:Bladder cancer is the ninth most common type of cancer worldwide. In the past, radical cystectomy via open surgery has been considered the gold-standard treatment for muscle invasive bladder cancer. However, in recent years there has been a progressive increase in the use of robot-assisted laparoscopic radic...

journal_title：BMC cancer

authors： Porreca A,Palmer K,Artibani W,Antonelli A,Bianchi L,Brunocilla E,Bocciardi AM,Brausi M,Busetto GM,Carini M,Carrieri G,Celia A,Cindolo L,Cochetti G,Colombo R,De Berardinis E,De Cobelli O,Di Maida F,Ercolino A,Gaboard

更新日期：2021-01-11 00:00:00

abstract：BACKGROUND:Classical in vitro wound-healing assays and other techniques designed to study cell migration and invasion have been used for many years to elucidate the various mechanisms associated with metastasis. However, many of these methods are limited in their ability to achieve reproducible, quantitative results th...

journal_title：BMC cancer

authors： Kam Y,Guess C,Estrada L,Weidow B,Quaranta V

更新日期：2008-07-14 00:00:00

abstract：BACKGROUND:Human Papillomavirus (HPV) genotyping has an increasingly important role in cervical cancer screening and vaccination monitoring, however, without an internationally agreed standard reference assay. The test results from the most widely used genotyping assays are read manually and hence prone to inter-observ...

journal_title：BMC cancer

authors： Ejegod DM,Rebolj M,Bonde J

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is involved in the occurrence and progression of several malignant tumors. However, its potential role in esophageal squamous cell carcinoma (ESCC) is still unknown. METHODS:PRAF2 mRNA expression was determined in 77 frozen ESCC samples by quantitati...

journal_title：BMC cancer

authors： Qian Z,Wei B,Zhou Y,Wang Q,Wang J,Sun Y,Gao Y,Chen X

更新日期：2019-06-14 00:00:00

abstract：BACKGROUND:Along with the marked increase in early gastric cancer (EGC) in the Eastern countries, there has been an effort to adopt the sentinel node concept in EGC to preserve gastric function and reduce the occurrence of postoperative complications. Based on promising results from a previous quality control study, th...

journal_title：BMC cancer

authors： Park JY,Kim YW,Ryu KW,Nam BH,Lee YJ,Jeong SH,Park JH,Hur H,Han SU,Min JS,An JY,Hyung WJ,Cho GS,Jeong GA,Jeong O,Park YK,Jung MR,Yoon HM,Eom BW

更新日期：2016-05-31 00:00:00

abstract：BACKGROUND:Previous studies have found that polymorphisms of the DNA repair gene X-ray repair cross-complementing group 1(XRCC1) and environmental factors are both associated with an increased risk of stomach cancer, but no study has reported on the potential additive effect of these factors among Thai people. The aim ...

journal_title：BMC cancer

authors： Putthanachote N,Promthet S,Hurst C,Suwanrungruang K,Chopjitt P,Wiangnon S,Chen SL,Yen AM,Chen TH

更新日期：2017-10-11 00:00:00

abstract：BACKGROUND:Deciphering the meaning of the human DNA is an outstanding goal which would revolutionize medicine and our way for treating diseases. In recent years, non-coding RNAs have attracted much attention and shown to be functional in part. Yet the importance of these RNAs especially for higher biological functions ...

journal_title：BMC cancer

authors： Smolander J,Stupnikov A,Glazko G,Dehmer M,Emmert-Streib F

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Despite the increase in cancer incidence in the last years in Serbia, no nation-wide, population-based cancer epidemiology data have been reported. In this study cancer incidence and mortality rates for Serbia are presented using nation-wide data from two population-based cancer registries. These rates are a...

journal_title：BMC cancer

authors： Mihajlović J,Pechlivanoglou P,Miladinov-Mikov M,Zivković S,Postma MJ

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:"Biomarker-driven targeted therapy," the practice of tailoring patients' treatment to the expression/activity levels of disease-specific genes/proteins, remains challenging. For example, while the anti-ERBB2 monoclonal antibody, trastuzumab, was first developed using well-characterized, diverse in vitro brea...

journal_title：BMC cancer

authors： Chang HR,Park HS,Ahn YZ,Nam S,Jung HR,Park S,Lee SJ,Balch C,Powis G,Ku JL,Kim YH

更新日期：2016-03-09 00:00:00

abstract：BACKGROUND:Recurrence of colorectal cancer (CRC) may arise due to the persistence of drug-resistant and cancer-initiating cells that survive exposure to chemotherapy. Proteins responsible for this recurrence include the chemokine receptor CXCR4, which is known to enable CRC metastasis, as well as the cancer-initiating ...

journal_title：BMC cancer

authors： Cutler MJ,Lowthers EL,Richard CL,Hajducek DM,Spagnuolo PA,Blay J

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:To assess the clinical value of peritoneal washing cytology (PWC) in women with BRCA1 or BRCA2 mutations and women from a family with hereditary breast and/or ovarian cancer (HBOC) undergoing risk-reducing salpingo-oophorectomy (RRSO) in detecting primary peritoneal cancer (PPC) or occult ovarian/fallopian t...

journal_title：BMC cancer

authors： Blok F,Roes EM,van Leenders GJ,van Beekhuizen HJ

更新日期：2016-01-14 00:00:00

abstract：BACKGROUND:Pancreatic cancer is poorly characterized at genetic and non-genetic levels. The current study evaluates in a large cohort of patients the prognostic relevance of molecular subtypes and key transcription factors in pancreatic ductal adenocarcinoma (PDAC). METHODS:We performed gene expression analysis of who...

journal_title：BMC cancer

authors： Janky R,Binda MM,Allemeersch J,Van den Broeck A,Govaere O,Swinnen JV,Roskams T,Aerts S,Topal B

更新日期：2016-08-12 00:00:00

abstract：BACKGROUND:Over-expression of HER2 in a subset of breast cancers (HER2+) is associated with high histological grade and aggressive clinical course. Despite these distinctive features, the differences in response of HER2+ patients to both adjuvant cytotoxic chemotherapy and targeted therapy (e.g. trastuzumab) suggests t...

journal_title：BMC cancer

authors： Hicks DG,Janarthanan BR,Vardarajan R,Kulkarni SA,Khoury T,Dim D,Budd GT,Yoder BJ,Tubbs R,Schreeder MT,Estopinal NC,Beck RA,Wang Y,Ring BZ,Seitz RS,Ross DT

更新日期：2010-03-22 00:00:00

abstract：BACKGROUND:Standard radiotherapy is the treatment of first choice in patients with symptomatic spinal metastases, but is only moderately effective. Stereotactic body radiation therapy is increasingly used to treat spinal metastases, without randomized evidence of superiority over standard radiotherapy. The VERTICAL stu...

journal_title：BMC cancer

authors： van der Velden JM,Verkooijen HM,Seravalli E,Hes J,Gerlich AS,Kasperts N,Eppinga WS,Verlaan JJ,van Vulpen M

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Toll-like receptor 3 (TLR3) is a critical component of the innate immune response to dsRNA viruses, which was considered to be mainly expressed in immune cells and some endothelial cells. In this study, we investigated the expression and proapoptotic activity of TLR3 in human and murine tumor cell lines. ME...

journal_title：BMC cancer

authors： Jiang Q,Wei H,Tian Z

更新日期：2008-01-17 00:00:00

abstract：BACKGROUND:Breast cancer is the most common malignancy in women world-wide. Triple negative breast cancer (TNBC) is a highly aggressive subtype that lacks expression of hormone receptors for estrogen, progesterone and human epidermal growth factor 2; and is associated with a high propensity for metastatic spread. Sever...

journal_title：BMC cancer

authors： Avery-Kiejda KA,Braye SG,Forbes JF,Scott RJ

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:To determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted (DW) MR imaging in patients with breast lesions. METHODS:English and Chinese studies published prior to June 2009 to assess the diagnostic performance of quantitative DWI in patients with breast lesions were revi...

journal_title：BMC cancer

authors： Chen X,Li WL,Zhang YL,Wu Q,Guo YM,Bai ZL

更新日期：2010-12-29 00:00:00

abstract：BACKGROUND:Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to be functionally silent and evolutionarily ...

journal_title：BMC cancer

authors： Chu D,Wei L

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:The prognostic value of p53 protein expression in esophageal cancer has been evaluated, but the results remain inconclusive and no consensus has yet been achieved. This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in esophageal cancer. METHODS:Publicatio...

journal_title：BMC cancer

authors： Wang L,Yu X,Li J,Zhang Z,Hou J,Li F

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme of sequentially occurring Copy Number Alterations (CNAs). METHODS:In this work we set to determine ...

journal_title：BMC cancer

authors： Orsetti B,Selves J,Bascoul-Mollevi C,Lasorsa L,Gordien K,Bibeau F,Massemin B,Paraf F,Soubeyran I,Hostein I,Dapremont V,Guimbaud R,Cazaux C,Longy M,Theillet C

更新日期：2014-02-22 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is a lethal disease, while the precise underlying molecular mechanisms of HCC pathogenesis remain to be defined. MicroRNA (miRNA), a class of non-coding small RNAs, can post-transcriptionally regulate gene expression. Altered miRNA expression has been reported in HCCs. This stu...

journal_title：BMC cancer

authors： Zhu Q,Gong L,Wang J,Tu Q,Yao L,Zhang JR,Han XJ,Zhu SJ,Wang SM,Li YH,Zhang W

更新日期：2016-10-18 00:00:00

abstract：BACKGROUND:Oncolytic viruses, including vaccinia virus (VACV), are a promising alternative to classical mono-cancer treatment methods such as surgery, chemo- or radiotherapy. However, combined therapeutic modalities may be more effective than mono-therapies. In this study, we enhanced the effectiveness of oncolytic vir...

journal_title：BMC cancer

authors： Schäfer S,Weibel S,Donat U,Zhang Q,Aguilar RJ,Chen NG,Szalay AA

更新日期：2012-08-23 00:00:00

abstract：BACKGROUND:Population attributable risks (PARs) are useful tool to estimate the burden of risk factors in cancer incidence. Few studies estimated the PARs of oral cavity cancer to tobacco smoking alone, alcohol drinking alone and their joint consumption but none performed analysis stratified by subsite, gender or age. ...

journal_title：BMC cancer

authors： Radoï L,Menvielle G,Cyr D,Lapôtre-Ledoux B,Stücker I,Luce D,ICARE Study Group.

更新日期：2015-10-31 00:00:00

abstract：BACKGROUND:Aquaporins (AQPs) have been recognized to promote tumor progression, invasion, and metastasis and are therefore recognized as promising targets for novel anti-cancer therapies. Potentially relevant AQPs in distinct cancer entities can be determined by a comprehensive expression analysis of the 13 human AQPs....

journal_title：BMC cancer

authors： Warth A,Muley T,Meister M,Herpel E,Pathil A,Hoffmann H,Schnabel PA,Bender C,Buness A,Schirmacher P,Kuner R

更新日期：2011-05-06 00:00:00