Cytology material is equivalent to tumor tissue in determining mutations of BRCA 1/2 genes in patients with tubo-ovarian high grade serous carcinoma.

abstract：BACKGROUND:Higher sunlight exposure is correlated with lower incidence of breast cancer in ecological studies, but findings from prospective studies regarding the association of circulating levels of vitamin D with the risk of breast cancer have been null. The objective of this study was to examine the relation between...

journal_title：BMC cancer

authors： Kim Y,Franke AA,Shvetsov YB,Wilkens LR,Cooney RV,Lurie G,Maskarinec G,Hernandez BY,Le Marchand L,Henderson BE,Kolonel LN,Goodman MT

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP are ubiquitous glycopeptidases closely linked to tumor pathogenesis and development, and they are use...

journal_title：BMC cancer

authors： Varona A,Blanco L,Perez I,Gil J,Irazusta J,López JI,Candenas ML,Pinto FM,Larrinaga G

更新日期：2010-05-11 00:00:00

abstract：BACKGROUND:High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogran...

journal_title：BMC cancer

authors： Nielsen K,Binderup T,Langer SW,Kjaer A,Knigge P,Grøndahl V,Melchior L,Federspiel B,Knigge U

更新日期：2020-01-10 00:00:00

abstract：:... ...

journal_title：BMC cancer

authors： Knoerl R,Weller E,Halpenny B,Berry D

更新日期：2019-05-13 00:00:00

abstract：BACKGROUND:Advances in the knowledge of renal neoplasms have demonstrated the implication of several proteases in their genesis, growth and dissemination. Glutamyl-aminopeptidase (GAP) (EC. 3.4.11.7) is a zinc metallopeptidase with angiotensinase activity highly expressed in kidney tissues and its expression and activi...

journal_title：BMC cancer

authors： Blanco L,Sanz B,Perez I,Sánchez CE,Cándenas ML,Pinto FM,Gil J,Casis L,López JI,Larrinaga G

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of TOP2A seems different among different subtypes of breast cancer. The current study evaluated the prognostic impact of TOP2A protein on luminal breast cancer....

journal_title：BMC cancer

authors： An X,Xu F,Luo R,Zheng Q,Lu J,Yang Y,Qin T,Yuan Z,Shi Y,Jiang W,Wang S

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:The nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills cancer cells and has the ability to perturb angiogenesis in vitro. In this study, the mechanism of action of ARC was further investigated by comparing in vitro and in vivo activity with other ...

journal_title：BMC cancer

authors： Stockwin LH,Yu SX,Stotler H,Hollingshead MG,Newton DL

更新日期：2009-02-20 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are short, non-coding RNAs (~22 nt) that play important roles in the pathogenesis of human diseases by negatively regulating gene expression. Although miR-196a has been implicated in several other cancers, its role in non-small cell lung cancer (NSCLC) is unknown. The aim of the present st...

journal_title：BMC cancer

authors： Liu XH,Lu KH,Wang KM,Sun M,Zhang EB,Yang JS,Yin DD,Liu ZL,Zhou J,Liu ZJ,De W,Wang ZX

更新日期：2012-08-09 00:00:00

abstract：BACKGROUND:Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatment of hypercholesterolemia and have been shown to trigger apoptosis in a tumor-specific manner. Rec...

journal_title：BMC cancer

authors： Martirosyan A,Clendening JW,Goard CA,Penn LZ

更新日期：2010-03-18 00:00:00

abstract：BACKGROUND:A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION:In 1987 a caucasian man, then 38 years ol...

journal_title：BMC cancer

authors： Osipov V,Ho KC,Krouwer HG,Meyer G,Shidham VB

更新日期：2002-12-03 00:00:00

abstract：BACKGROUND:Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the progesterone receptor (PR). Invasiveness and metastasis of L-BCa cells is supported by the short PR isofor...

journal_title：BMC cancer

authors： Rosati R,Oppat K,Huang Y,Kim S,Ratnam M

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Loss of DNA mismatch repair (MMR) in humans, mainly due to mutations in the hMLH1 gene, is linked to hereditary nonpolyposis colorectal cancer (HNPCC). Because not all MLH1 alterations result in loss of MMR function, accurate characterization of variants and their classification in terms of their effect on M...

journal_title：BMC cancer

authors： Vogelsang M,Comino A,Zupanec N,Hudler P,Komel R

更新日期：2009-10-28 00:00:00

abstract：BACKGROUND:Treatment of locally advanced non-small-cell lung cancer is based on a combined approach. To study the impact of trimodal therapy for stage III-N2 NSCLC a single centre retrospective evaluation focusing on survival and therapy-related toxicity was performed. METHODS:71 patients diagnosed between March 2001 ...

journal_title：BMC cancer

authors： Askoxylakis V,Tanner J,Kappes J,Hoffmann H,Nicolay NH,Rief H,Debus J,Thomas M,Bischof M

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Modeling the relationship between age and mortality for breast cancer patients may have important prognostic and therapeutic implications. METHODS:Data from 9 registries of the Surveillance, Epidemiology, and End Results Program (SEER) of the United States were used. This study employed proportional hazards...

journal_title：BMC cancer

authors： Tai P,Cserni G,Van De Steene J,Vlastos G,Voordeckers M,Royce M,Lee SJ,Vinh-Hung V,Storme G

更新日期：2005-10-08 00:00:00

abstract：BACKGROUND:Sarcomas are rare malignant tumors. Accurate initial histological diagnosis is essential for adequate management. We prospectively assessed the medical management of all patients diagnosed with sarcoma in a European region over a one-year period to identify the quantity of first diagnosis compared to central...

journal_title：BMC cancer

authors： Lurkin A,Ducimetière F,Vince DR,Decouvelaere AV,Cellier D,Gilly FN,Salameire D,Biron P,de Laroche G,Blay JY,Ray-Coquard I

更新日期：2010-04-19 00:00:00

abstract：BACKGROUND:The radiopharmaceutical (131)I-meta-iodobenzylguanidine ((131)I-MIBG) is an effective treatment for neuroblastoma. However, maximal therapeutic benefit from (131)I-MIBG is likely to be obtained by its combination with chemotherapy. We previously reported enhanced antitumour efficacy of (131)I-MIBG by inhibit...

journal_title：BMC cancer

authors： Nile DL,Rae C,Hyndman IJ,Gaze MN,Mairs RJ

更新日期：2016-08-11 00:00:00

abstract：BACKGROUND:Vinflunine is recommended in the European guideline for the treatment of advanced or metastatic urothelial cell carcinoma (UCC) after failure of platinum-based therapy. METHODS:This prospective, non-interventional study investigated the safety and efficacy of vinflunine in platinum-pretreated UCC patients i...

journal_title：BMC cancer

authors： Retz M,de Geeter P,Goebell PJ,Matz U,de Schultz W,Hegele A

更新日期：2015-06-04 00:00:00

abstract：BACKGROUND:Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17beta-estradiol. These findings suggest that E6 performs critical functions in normal adult cervix and skin, highli...

journal_title：BMC cancer

authors： Mendoza-Villanueva D,Diaz-Chavez J,Uribe-Figueroa L,Rangel-Escareão C,Hidalgo-Miranda A,March-Mifsut S,Jimenez-Sanchez G,Lambert P,Gariglio P

更新日期：2008-11-26 00:00:00

abstract：BACKGROUND:Severe toxicity to 5-fluorouracil (5-FU) based chemotherapy in gastrointestinal cancer has been associated with constitutional genetic alterations of the dihydropyrimidine dehydrogenase gene (DPYD). METHODS:In this study, we evaluated DPYD promoter methylation through quantitative methylation-specific PCR a...

journal_title：BMC cancer

authors： Savva-Bordalo J,Ramalho-Carvalho J,Pinheiro M,Costa VL,Rodrigues A,Dias PC,Veiga I,Machado M,Teixeira MR,Henrique R,Jerónimo C

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Cancer cells release exosomes and can be taken up by mast cells (MCs), but the potential functional effects of MCs on tumor metastasis remain unknown. METHOD:Exosomes were isolated from the lung adenocarcinoma cell line A549, and the uptake of PKH26-labeled exosomes by bone marrow MCs was examined via flow ...

journal_title：BMC cancer

authors： Xiao H,He M,Xie G,Liu Y,Zhao Y,Ye X,Li X,Zhang M

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:Pancreatic paragangliomas are rare tumors, with only 16 reported cases to date. One of these cases demonstrates metastasis to lymph node, while another case was functional, however, none of these cases showed malignant and large, pancreatic paraganglioma with marked invasion. Also another unique feature was ...

journal_title：BMC cancer

authors： Al-Jiffry BO,Alnemary Y,Khayat SH,Haiba M,Hatem M

更新日期：2013-10-20 00:00:00

abstract：BACKGROUND:FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative role of this cytokine in prostate tumor progression. METHODS:FAM3B expression was analyzed by quantita...

journal_title：BMC cancer

authors： Maciel-Silva P,Caldeira I,de Assis Santos I,Carreira ACO,Siqueira FR,Antonioli E,Goldberg AC,Belizário JE,Garay-Malpartida HM

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involved in human cancer. However, there is limited information regarding the clinical significance of cyt...

journal_title：BMC cancer

authors： Dai SD,Wang Y,Miao Y,Zhao Y,Zhang Y,Jiang GY,Zhang PX,Yang ZQ,Wang EH

更新日期：2009-06-09 00:00:00

abstract：BACKGROUND:In Chile, more than 500 women die every year from cervical cancer, and a majority of Chilean women are not up-to-date with their Papanicolau (Pap) test. Mobile health has great potential in many health areas, particularly in health promotion and prevention. There are no randomized controlled trials in Latin ...

journal_title：BMC cancer

authors： Momany MC,Martinez-Gutierrez J,Soto M,Capurro D,Ciampi F,Thompson B,Puschel K

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC). METHODS:Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a ...

journal_title：BMC cancer

authors： Gremel G,Djureinovic D,Niinivirta M,Laird A,Ljungqvist O,Johannesson H,Bergman J,Edqvist PH,Navani S,Khan N,Patil T,Sivertsson Å,Uhlén M,Harrison DJ,Ullenhag GJ,Stewart GD,Pontén F

更新日期：2017-01-04 00:00:00

abstract：BACKGROUND:Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant risk of decline in physical wellbeing with oesophagectomy however this has been inadequately quanti...

journal_title：BMC cancer

authors： Guinan EM,Bennett AE,Doyle SL,O'Neill L,Gannon J,Foley G,Elliott JA,O'Sullivan J,Reynolds JV,Hussey J

更新日期：2019-07-12 00:00:00

abstract：BACKGROUND:Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome that is commonly associated with a germline mutation in the tumor suppressor gene p53. Loss of p53 results in increased expression of CD44, a cancer stem cell (CSC) marker, which is involved in the scavenging of reactive oxygen species...

journal_title：BMC cancer

authors： Yoshida GJ,Fuchimoto Y,Osumi T,Shimada H,Hosaka S,Morioka H,Mukai M,Masugi Y,Sakamoto M,Kuroda T

更新日期：2012-10-02 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) not only confers tumor cells with a distinct advantage for metastatic dissemination, but also it provides those cells with cancer stem cell-like characters for proliferation and drug resistance. However, the molecular mechanism for maintenance of these stem cell-like t...

journal_title：BMC cancer

authors： Li J,Zhou BP

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Molecular targeted therapy has emerged as a promising treatment of Hepatocellular carcinoma (HCC). One potential target is the Src family Kinase (SFK). C-Src, a non-receptor tyrosine kinase is a critical link of multiple signal pathways that regulate proliferation, invasion, survival, metastasis, and angioge...

journal_title：BMC cancer

authors： Chang AY,Wang M

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...

journal_title：BMC cancer

authors： Dillon MF,Mohd Nazri SR,Nasir S,McDermott EW,Evoy D,Crotty TB,O'Higgins N,Hill AD

更新日期：2006-06-23 00:00:00