Abstract:
:...
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Knoerl R,Weller E,Halpenny B,Berry Ddoi
10.1186/s12885-019-5669-2subject
Has Abstractpub_date
2019-05-13 00:00:00pages
438issue
1issn
1471-2407pii
10.1186/s12885-019-5669-2journal_volume
19pub_type
杂志文章,已发布勘误相关文献
BMC CANCER文献大全abstract:BACKGROUND:Mantle Cell Lymphoma (MCL) is often associated with progression, temporary response to therapy and a high relapse rate over time resulting in a poor long-term prognosis. Because MCL is classified as an incurable disease, therapeutic resistance is of great interest. However, knowledge about the biological mec...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-016-2844-6
更新日期:2016-10-14 00:00:00
abstract:BACKGROUND:MicroRNA-21 (miR-21) is up-regulated in many cancers, including colorectal cancer (CRC). Nevertheless, the function of miR-21 in CRC and the mechanism underlying that function is still unclear. METHODS:After analyzing the expression of miR-21 and Sec23A in CRC cell lines, we transfected the highest miR-21 e...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2628-z
更新日期:2016-08-05 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07766-5
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:H. pylori, whose infection increases tumor invasiveness and metastasis, is generally labelled as the strongest risk factor for the development of gastric cancer. It appears not to be a coincidence that there is also an overexpression of CXCR4 and an obvious involvement in gastric cancer metastasis. The aim o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-419
更新日期:2010-08-11 00:00:00
abstract:BACKGROUND:As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an additional risk factor for cancer development and the SPCs appearing beyond 5 years after radiotherapy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06960-9
更新日期:2020-05-20 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available treating options have prolonged patient's survival. However, BRAF-mutated CRC patients remain unres...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6586-0
更新日期:2020-02-17 00:00:00
abstract:BACKGROUND:Improved insight into the molecular characteristics of the different ovarian cancer subgroups is needed for developing a more individualized and optimized treatment regimen. The aim of this study was to a) identify differentially expressed miRNAs in high-grade serous ovarian carcinoma (HGSC), clear cell ovar...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-80
更新日期:2014-02-11 00:00:00
abstract:BACKGROUND:Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However, genetically engineered T cells have been associated with serious side-effects due to off-target tox...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3539-3
更新日期:2017-08-17 00:00:00
abstract:BACKGROUND:Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms. METHODS:The response of breast cancer cell lines (MCF-7 and MDA-MB-231) to doxorubicin was ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3953-6
更新日期:2018-01-06 00:00:00
abstract:BACKGROUND:Temozolomide (TMZ)-induced side effects and drug tolerance to human gliomas are still challenging issues now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houpo), is safe for normal brain cells and can kill human glioma cells. This study was further aimed ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4267-z
更新日期:2018-04-03 00:00:00
abstract:BACKGROUND:Malignant pleural mesothelioma (MPM) is a tumor known to be resistant to conventional therapies. Thus, an in vivo model can represent an important tool for assessing the efficacy of novel approaches in the treatment of MPM.Presently, human MPM cells have been grown orthotopically in mice upon transplantation...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-130
更新日期:2006-05-17 00:00:00
abstract:BACKGROUND:The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expressed in the kidneys, little is known about their influence on human renal cancer. METHODS:To clarify...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-509
更新日期:2013-10-30 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the safety and efficacy of fractionated stereotactic radiotherapy (SRT) in combination with systemic therapies (ST) for brain metastases (BM). METHODS:Ninety-nine patients (171 BM) received SRT and concurrent ST (group 1) and 95 patients (131 BM) received SRT alone wit...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07491-z
更新日期:2020-10-13 00:00:00
abstract:BACKGROUND:Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of thi...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-019-5579-3
更新日期:2019-04-16 00:00:00
abstract:BACKGROUND:To characterize prognostic and risk factors of central nervous system (CNS) metastases in patients with epithelial ovarian cancer (EOC). METHODS:A retrospective analysis of Xijing Hospital electronic medical records was conducted to identify patients with pathologically confirmed EOC and CNS metastases. In ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-829
更新日期:2014-11-17 00:00:00
abstract:BACKGROUND:This study was performed to create and validate a scoring system for the survival of patients with malignant spinal cord compression (SCC) from myeloma. METHODS:Of the entire cohort (N = 216), 108 patients were assigned to a test group and 108 patients to a validation group. In the test group, nine pre-trea...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-425
更新日期:2012-09-25 00:00:00
abstract:BACKGROUND:Cytokines are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play key role in tumor dissemination and are an independent survival predictor in breast cancer patients. The aim of this study was to assess correlation between CTCs and plasma cytokines in primary breast cancer (PBC) p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2143-2
更新日期:2016-02-19 00:00:00
abstract:BACKGROUND:To date, no single colorectal cancer (CRC) screening strategy has been determined to be applicable worldwide. In China, a CRC screening protocol that combines double fecal immunochemical tests (FITs) and a high-risk factor questionnaire (HRFQ) as the first stage of screening and colonoscopy as the second sta...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5191-y
更新日期:2019-01-10 00:00:00
abstract:BACKGROUND:Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis model of gastric cancer using VX2 tumor, and analyze the clinico-pathological features. METHODS:VX...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-124
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:As one of the malignant tumors most often affecting children and young adults, Ewing sarcoma (ES) is characterized by early metastasis contributing to unfavorable prognosis. However, the molecular mechanisms responsible for ES metastasis remain poorly understood. In this study, we aimed to explore whether Wn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-480
更新日期:2012-10-18 00:00:00
abstract:BACKGROUND:The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC). METHODS:Between 2002 and 2007, a population-based case-contro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-344
更新日期:2012-08-08 00:00:00
abstract:BACKGROUND:Less than 1% of all breast cancer cases are found in men, who reportedly have inferior outcomes compared with matched women patients. Ethnic differences may also affect their prognosis. Here, we investigated overall survival (OS) and major prognostic factors for male breast cancer (MBC) in a cohort of Egypti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-227
更新日期:2014-03-28 00:00:00
abstract:BACKGROUND:The aim of the study was to investigate whether p503S, p504S and p510S gene expression in peripheral-blood be useful as a diagnostic or prognostic marker of prostatic cancer. METHODS:Circulating cells were identified by reverse transcription-polymerase chain reaction (RT-PCR) to detect p503S, p504S and p510...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-111
更新日期:2005-09-05 00:00:00
abstract:BACKGROUND:Clinical studies implying the sunitinib multi-kinase inhibitor have led to disappointing results for breast cancer care but mostly focused on HER2-negative subtypes. Preclinical researches involving this drug mostly concern Triple Negative Breast Cancer (TNBC) murine models. Here, we explored the therapeutic...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1540-2
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:XELOX (capecitabine + oxaliplatin) and FOLFOX 4 (5-FU + folinic acid + oxaliplatin) have shown similar improvements in survival in patients with metastatic colorectal cancer (MCRC). A US cost-minimization study found that the two regimens had similar costs from a healthcare provider perspective but XELOX had...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-11-288
更新日期:2011-07-09 00:00:00
abstract:BACKGROUND:Colorectal-cancer is a leading cause of cancer death in the United States, and Latinos have particularly low rates of screening. Strategies and Opportunities to STOP Colon Cancer in Priority Populations (STOP CRC) is a partnership among two research institutions and a network of safety net clinics to promote...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/1471-2407-14-55
更新日期:2014-02-26 00:00:00
abstract:BACKGROUND:Metastatic renal cell carcinoma (mRCC) had been a chemo-refractory disease, but recent advances in multiple kinase inhibitors such as sunitinib have dramatically changed the clinical course of mRCC. Sunitinib is used for mRCC chemotherapy based on the favorable results of a recent clinical trial, but specifi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1443-2
更新日期:2015-05-22 00:00:00
abstract:BACKGROUND:Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior of gliomas are still poorly understood. The aim of this study was ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-607
更新日期:2012-12-19 00:00:00
abstract:BACKGROUND:CD73 is one of the critical component in the formation of immunosuppressive microenvironment in cancers. We aimed to provide an overview of the current status of CD73 expression and its relationship with clinicopathlogical features and prognosis in different cancers. METHODS:PubMed, Web of Science, EMBASE a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4073-7
更新日期:2018-03-07 00:00:00
abstract:BACKGROUND:A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, characterization of a key ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07081-z
更新日期:2020-06-26 00:00:00