Establishment of an immune-related gene pair model to predict colon adenocarcinoma prognosis.

abstract：BACKGROUND:The objective of this study was to evaluate the efficacy and toxicity of infusional 5-fluorouracil (5-FU), folinic acid and oxaliplatin (modified FOLFOX-6) in patients with advanced gastric cancer (AGC), as first-line palliative combination chemotherapy. We also analyzed the predictive or prognostic value of...

journal_title：BMC cancer

authors： Keam B,Im SA,Han SW,Ham HS,Kim MA,Oh DY,Lee SH,Kim JH,Kim DW,Kim TY,Heo DS,Kim WH,Bang YJ

更新日期：2008-05-27 00:00:00

abstract：BACKGROUNDS:Preoperative chemotherapy (PCT) and chemoradiotherapy (PCRT) showed promising results for gastric cancers. However, the influence of preoperative adverse events (AEs) on postoperative complications remains unknown. The aim of this study was to identify correlations between them. METHODS:Clinical data and l...

journal_title：BMC cancer

authors： Li SX,Seo SH,Choi YY,Nakagawa M,An JY,Kim HI,Cheong JH,Hyung WJ,Noh SH

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:BRAF-activated noncoding RNA (BANCR) is aberrantly expressed in various tumor tissues and has been confirmed to function as a tumor suppressor or oncogene in many types of cancers. Considering the conflicting results and insufficient sampling, a meta-analysis was performed to explore the prognostic value of ...

journal_title：BMC cancer

authors： Fang S,Liu Z,Guo Q,Chen C,Ke X,Xu G

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:In the presence of both HIV infection and cervical intraepithelial neoplasia (CIN), the risk of cancer development despite treatment may be greater. We investigated clinical predictors of persistent cytological abnormalities in women who had had a large loop excision of the transformation zone (LLETZ). METH...

journal_title：BMC cancer

authors： Adam Y,van Gelderen CJ,de Bruyn G,McIntyre JA,Turton DA,Martinson NA

更新日期：2008-07-25 00:00:00

abstract：BACKGROUND:Metastasis is the main cause of death for lung cancer patients. The ex vivo 4D acellular lung model has been shown to mimic this metastatic process. However, the main concern is the model's lack of cellular components of the tumor's microenvironment. In this study, we aim to determine if the intact lung micr...

journal_title：BMC cancer

authors： Mishra DK,Miller RA,Pence KA,Kim MP

更新日期：2018-04-18 00:00:00

abstract：BACKGROUND:Estrogen receptor positive breast cancers have high recurrence rates despite tamoxifen therapy. Breast cancer stem/progenitor cells (BCSCs) initiate tumors, but expression of estrogen (ER) or progesterone receptors (PR) and response to tamoxifen is unknown. Interleukin-6 (IL-6) and interleukin-8 (IL-8) may i...

journal_title：BMC cancer

authors： Schillace RV,Skinner AM,Pommier RF,O'Neill S,Muller PJ,Naik AM,Hansen JE,Pommier SJ

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Patients with metastatic renal cell cancer (mRCC) are commonly treated with the tyrosine kinase inhibitor sunitinib, which blocks signalling from vascular endothelial growth factor (VEGF) - and platelet-derived growth factor-receptors, inhibiting development of new blood vessels. There are currently no predi...

journal_title：BMC cancer

authors： Niinivirta M,Georganaki M,Enblad G,Lindskog C,Dimberg A,Ullenhag GJ

更新日期：2020-04-22 00:00:00

abstract：BACKGROUND:Despite all benefit provided by established therapies prognosis of gastric cancer remains poor. Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and amplify chemotherapeutic effects. METHODS:This phase I study evaluated dose limiting toxicity (DLT...

journal_title：BMC cancer

authors： Mayr M,Becker K,Schulte N,Belle S,Hofheinz R,Krause A,Schmid RM,Röcken C,Ebert MP

更新日期：2012-12-10 00:00:00

abstract：BACKGROUND:In Spain, cervical cancer prevention is based on opportunistic screening, due to the disease's traditionally low incidence and mortality rates. Changes in sexual behaviour, tourism and migration have, however, modified the probability of exposure to human papilloma virus among Spaniards. This study thus soug...

journal_title：BMC cancer

authors： Cervantes-Amat M,López-Abente G,Aragonés N,Pollán M,Pastor-Barriuso R,Pérez-Gómez B

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:The primary aim of treatment of a patient who has developed metastatic disease is palliation. The objectives of the current study are to describe and quantify the clinical management of women with metastatic breast cancer from the diagnosis of metastatic disease until death and to analyze differences between...

journal_title：BMC cancer

authors： Manders K,van de Poll-Franse LV,Creemers GJ,Vreugdenhil G,van der Sangen MJ,Nieuwenhuijzen GA,Roumen RM,Voogd AC

更新日期：2006-07-06 00:00:00

abstract：BACKGROUND:Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers. METHODS:To assess the frequenci...

journal_title：BMC cancer

authors： Letessier A,Sircoulomb F,Ginestier C,Cervera N,Monville F,Gelsi-Boyer V,Esterni B,Geneix J,Finetti P,Zemmour C,Viens P,Charafe-Jauffret E,Jacquemier J,Birnbaum D,Chaffanet M

更新日期：2006-10-13 00:00:00

abstract：BACKGROUND:Local control in malignant salivary gland tumours is dose dependent. High local control rates in adenoid cystic carcinomas could be achieved by highly conformal radiotherapy techniques and particle (neutron/carbon ion) therapy. Considering high doses are needed to achieve local control, all malignant salivar...

journal_title：BMC cancer

authors： Jensen AD,Nikoghosyan A,Windemuth-Kieselbach C,Debus J,Münter MW

更新日期：2010-10-11 00:00:00

abstract：BACKGROUND:Metastatic breast cancer carries a poor prognosis despite the success of newly targeted therapies. Treatment options remain especially limited for the subtype of triple negative breast cancer (TNBC). Several signaling pathways, including NF-κB, are altered in TNBC, and the complexity of this disease implies ...

journal_title：BMC cancer

authors： House CD,Grajales V,Ozaki M,Jordan E,Wubneh H,Kimble DC,James JM,Kim MK,Annunziata CM

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:Mantle Cell Lymphoma (MCL) is often associated with progression, temporary response to therapy and a high relapse rate over time resulting in a poor long-term prognosis. Because MCL is classified as an incurable disease, therapeutic resistance is of great interest. However, knowledge about the biological mec...

journal_title：BMC cancer

authors： Hanf M,Chiron D,de Visme S,Touzeau C,Maisonneuve H,Jardel H,Pellat-Deceunynck C,Amiot M,le Gouill S

更新日期：2016-10-14 00:00:00

abstract：BACKGROUND:Sentinel lymph node (SLN) biopsy is an effective tool for axillary staging in patients with invasive breast cancer. This procedure has been recently proposed as part of the treatment for patients with ductal carcinoma in situ (DCIS), because cases of undetected invasive foci and nodal metastases occasionally...

journal_title：BMC cancer

authors： Zavagno G,Carcoforo P,Marconato R,Franchini Z,Scalco G,Burelli P,Pietrarota P,Lise M,Mencarelli R,Capitanio G,Ballarin A,Pierobon ME,Marconato G,Nitti D

更新日期：2005-03-11 00:00:00

abstract：BACKGROUND:KAI1 was initially identified as a metastasis-suppressor gene in prostate cancer. It is a member of the tetraspan transmembrane superfamily (TM4SF) of membrane glycoproteins. As part of a tetraspanin-enriched microdomain (TEM), KAI1 inhibits tumor metastasis by negative regulation of Src. However, the underl...

journal_title：BMC cancer

authors： Park JJ,Jin YB,Lee YJ,Lee JS,Lee YS,Ko YG,Lee M

更新日期：2012-03-06 00:00:00

abstract：BACKGROUND:MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a hundred of targets. On the other hand, a single protein-coding gene could be targeted by many potent...

journal_title：BMC cancer

authors： Jiang Q,Feng MG,Mo YY

更新日期：2009-06-18 00:00:00

abstract：BACKGROUND:Tobacco smoke exposure may be associated with increased breast cancer risk, although the evidence supporting the association is inconclusive. We conducted a case-control study in Delaware, incorporating detailed exposure assessment for active and secondhand smoke at home and in the workplace. METHODS:Primar...

journal_title：BMC cancer

authors： Rollison DE,Brownson RC,Hathcock HL,Newschaffer CJ

更新日期：2008-06-02 00:00:00

abstract：BACKGROUND:Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its fu...

journal_title：BMC cancer

authors： Benedicto A,Marquez J,Herrero A,Olaso E,Kolaczkowska E,Arteta B

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is one of the most aggressive types of cancer. However, resistance to cisplatin (CDDP) remains a major challenge in NSCLC treatment. The purpose of this study was to investigate the ability of EHD1 [Eps15 homology (EH) domain - containing protein 1] to confer CDDP resistanc...

journal_title：BMC cancer

authors： Gao J,Meng Q,Zhao Y,Chen X,Cai L

更新日期：2016-07-13 00:00:00

abstract：BACKGROUND:About 85% of breast cancer patients attending Komfo Anokye Teaching Hospital (KATH), Ghana, present with stage III/IV disease. In spite of great investments into the early diagnosis and management of breast cancer, late presentation persists and poses a barrier to realising the possible benefits of the gains...

journal_title：BMC cancer

authors： Agbeko AE,Arthur J,Bayuo J,Kaburi BB,Kyei I

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In this study, we examined the possibility of HemoHIM both to enhance anticancer effect with cisplatin an...

journal_title：BMC cancer

authors： Park HR,Ju EJ,Jo SK,Jung U,Kim SH,Yee ST

更新日期：2009-03-17 00:00:00

abstract：BACKGROUND:This study was performed to create and validate a scoring system for the survival of patients with malignant spinal cord compression (SCC) from myeloma. METHODS:Of the entire cohort (N = 216), 108 patients were assigned to a test group and 108 patients to a validation group. In the test group, nine pre-trea...

journal_title：BMC cancer

authors： Douglas S,Schild SE,Rades D

更新日期：2012-09-25 00:00:00

abstract：BACKGROUND:Ectopic TSH-secreting pituitary adenoma (TSH-oma) is a very unusual disorder. To date, there are only four cases reported. It is difficult to distinguish ectopic cases from both regular TSH-omas and resistance to thyroid hormone (RTH). CASE PRESENTATION:A newly identified case of ectopic TSH-oma arising fro...

journal_title：BMC cancer

authors： Song M,Wang H,Song L,Tian H,Ge Q,Li J,Zhu Y,Li J,Zhao R,Ji HL

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:In high-income countries (HICs), increased rates of survival among pediatric cancer patients are achieved through the use of protocol-driven treatment. Compared to HICs, differences in infrastructure, supportive care, and human resources, make compliance with protocol-driven treatment challenging in low- and...

journal_title：BMC cancer

authors： Vasudevan L,Schroeder K,Raveendran Y,Goel K,Makarushka C,Masalu N,Zullig LL

更新日期：2020-03-29 00:00:00

abstract：BACKGROUND:We investigated the role of the HIPK2-p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments. METHODS:Primary human CRC samples and normal intestinal tissues from patients were analyzed for HIPK2 expression by im...

journal_title：BMC cancer

authors： Zhou L,Feng Y,Jin Y,Liu X,Sui H,Chai N,Chen X,Liu N,Ji Q,Wang Y,Li Q

更新日期：2014-10-05 00:00:00

abstract：BACKGROUND:Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectomy (RAE). Previous studies had demonstrated the better short-term outcomes in MIE or RAE when compare...

journal_title：BMC cancer

authors： Yang Y,Zhang X,Li B,Li Z,Sun Y,Mao T,Hua R,Yang Y,Guo X,He Y,Li H,Chen H,Tan L

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior of gliomas are still poorly understood. The aim of this study was ...

journal_title：BMC cancer

authors： Lu R,Wu C,Guo L,Liu Y,Mo W,Wang H,Ding J,Wong ET,Yu M

更新日期：2012-12-19 00:00:00

abstract：BACKGROUND:Alterations in the redox balance are involved in the origin, promotion and progression of cancer. Inter-individual differences in the oxidative stress regulation can explain a part of the variability in cancer susceptibility.The aim of this study was to evaluate if polymorphisms in genes codifying for the di...

journal_title：BMC cancer

authors： Rodrigues P,de Marco G,Furriol J,Mansego ML,Pineda-Alonso M,Gonzalez-Neira A,Martin-Escudero JC,Benitez J,Lluch A,Chaves FJ,Eroles P

更新日期：2014-11-21 00:00:00

abstract：BACKGROUND:CD26/dipeptidyl peptidase IV (DPPIV) is a multifunctional membrane protein with a key role in T-cell biology and also serves as a marker of aggressive cancers, including T-cell malignancies. METHODS:Versican expression was measured by real-time RT-PCR and Western blots. Gene silencing of versican in parenta...

journal_title：BMC cancer

authors： Havre PA,Dang LH,Ohnuma K,Iwata S,Morimoto C,Dang NH

更新日期：2013-11-01 00:00:00