Abstract:
BACKGROUND:Alcohol consumption is associated with increased risk of breast cancer (BC), and the underlying mechanism is thought to be sex-hormone driven. In vitro and observational studies suggest a mechanism involving peroxisome proliferator-activated receptor gamma (PPARγ) in a complex with peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α) and interaction with aromatase (encoded by CYP19A1). Use of non-steroidal anti-inflammatory drugs (NSAID) may also affect circulating sex-hormone levels by modifying PPARγ activity. METHODS:In the present study we assessed whether genetic variation in CYP19A1 is associated with risk of BC in a case-control study group nested within the Danish "Diet, Cancer and Health" cohort (ncases = 687 and ncontrols = 687) and searched for gene-gene interaction between CYP19A1 and PPARGC1A, and CYP19A1 and PPARG, and gene-alcohol and gene-NSAID interactions. Association between the CYP19A1 polymorphisms and hormone levels was also examined among 339 non-HRT users. Incidence rate ratios were calculated based on Cox' proportional hazards model. Furthermore, we performed a pilot randomised controlled trial to determine the effect of the PPARG Pro(12)Ala polymorphism and the PPARγ stimulator Ibuprofen on sex-hormone levels following alcohol intake in postmenopausal women (n = 25) using linear regression. RESULTS:Genetic variations in CYP19A1 were associated with hormone levels (estrone: P rs11070844 = 0.009, estrone sulphate: P rs11070844 = 0.01, P rs749292 = 0.004, P rs1062033 = 0.007 and P rs10519297 = 0.03, and sex hormone-binding globulin (SHBG): P rs3751591 = 0.03) and interacted with alcohol intake in relation to hormone levels (estrone sulphate: P interaction/rs2008691 = 0.02 and P interaction/rs1062033= 0.03, and SHBG: P interaction/rs11070844 = 0.03). CYP19A1/rs3751591 was both associated with SHBG levels (P = 0.03) and with risk of BC (Incidence Rate Ratio = 2.12; 95 % Confidence Interval: 1.02-4.43) such that homozygous variant allele carriers had increased levels of serum SHBG and were at increased risk of BC. Acute intake of alcohol decreased blood estrone (P = <0.0001), estrone sulphate (P = <0.0001), and SHBG (P = 0.009) levels, whereas Ibuprofen intake and PPARG Pro(12)Ala genotype had no effect on hormone levels. CONCLUSIONS:Our results suggest that genetically determined variation in CYP19A1 is associated with differences in sex hormone levels. However, the genetically determined differences in sex hormone levels were not convincingly associated with BC risk. The results therefore indicate that the genetically determined variation in CYP19A1 contributes little to BC risk and to alcohol-mediated BC risk. TRIAL REGISTRATION:NCT02463383, June 3, 2015.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Kopp TI,Jensen DM,Ravn-Haren G,Cohen A,Sommer HM,Dragsted LO,Tjonneland A,Hougaard DM,Vogel Udoi
10.1186/s12885-016-2317-ysubject
Has Abstractpub_date
2016-04-21 00:00:00pages
283issn
1471-2407pii
10.1186/s12885-016-2317-yjournal_volume
16pub_type
杂志文章,随机对照试验相关文献
BMC CANCER文献大全abstract:BACKGROUND:After neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer, high pathologically complete response (pCR) rates are being achieved especially in patients with squamous cell carcinoma (SCC). An active surveillance strategy has been proposed for SCC patients with clinically complete response (cCR) after nC...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12885-020-6669-y
更新日期:2020-03-06 00:00:00
abstract:BACKGROUND:Abundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors. Therefore, it is very important that finding the agents that increase the death receptors of cancer cells. In this study, we demonstrated that the snake venom toxin...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-228
更新日期:2012-06-08 00:00:00
abstract:BACKGROUND:Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the prognostic value of MDSCs ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-5086-y
更新日期:2018-12-05 00:00:00
abstract:BACKGROUND:Tumor testing for mutations in the epidermal growth factor receptor (EGFR) gene is indicated for all newly diagnosed, metastatic lung cancer patients, who may be candidates for first-line treatment with an EGFR tyrosine kinase inhibitor. Few studies have analyzed population-level testing. METHODS:We identif...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4190-3
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:It is urgent to find some biochemical markers for predicting the radiochemotherapy sensitivity. microRNAs have a huge potential as a predictive biomarker in gastric cancer. The current study aims to identify the microRNAs related to the radiochemotherapy sensitivity in gastric cancer. METHODS:From April 201...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4967-4
更新日期:2018-10-29 00:00:00
abstract:BACKGROUND:KAI1 was initially identified as a metastasis-suppressor gene in prostate cancer. It is a member of the tetraspan transmembrane superfamily (TM4SF) of membrane glycoproteins. As part of a tetraspanin-enriched microdomain (TEM), KAI1 inhibits tumor metastasis by negative regulation of Src. However, the underl...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-81
更新日期:2012-03-06 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether radiation (RT)-induced inflammatory responses and organ damage might be modulated by androgen deprivation therapies. METHODS:The mRNA and tissue sections obtained from the lungs, intestines and livers of irradiated mice with or without androgen deprivation were...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-92
更新日期:2009-03-25 00:00:00
abstract:BACKGROUND:High levels of blood glucose are thought to be associated with colorectal cancer (CRC) and hyperinsulinemia, an interstage in the development of CRC. The purpose of this study was to examine associations between incident CRC and blood glucose; plasma insulin; and the homeostasis model assessment for insulin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3874-4
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening with mammography played a role in the decline in mortality. Evaluating the contribution of these int...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-98
更新日期:2009-03-30 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) represent the majority of cellular transcripts and play pivotal roles in hematopoiesis. However, their clinical relevance in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) remains largely unknown. Here, we investigated the functions of HOXB-AS3, a lncRNA locate...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5822-y
更新日期:2019-06-24 00:00:00
abstract:BACKGROUND:MicroRNAs in solid malignancies can behave as predictors of either good or poor outcome. This is the case with members of the miR-200 family, which are the primary regulators of the epithelial to mesenchymal transition and have been reported to act as both oncogenes and tumor suppressors. This study assessed...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-72
更新日期:2013-02-08 00:00:00
abstract:BACKGROUND:MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. To investigate the progn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2869-x
更新日期:2016-10-28 00:00:00
abstract:BACKGROUND:Ethyl carbamate (EC) is a multi-site carcinogen in experimental animals and probably carcinogenic to humans (IARC group 2A). Traces of EC below health-relevant ranges naturally occur in several fermented foods and beverages, while higher concentrations above 1 mg/l are regularly detected in only certain spir...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-10-266
更新日期:2010-06-08 00:00:00
abstract:BACKGROUND:Increasing evidence revealed that high expression level of lncRNA SNHG1 was associated with the unfavorable prognosis of cancer and maybe used as a valuable biomarker for cancer patients. The present meta->analysis is to analyze existing data to reveal potential clinical application of SNHG1 on cancer progno...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-019-5987-4
更新日期:2019-08-07 00:00:00
abstract:BACKGROUND:It is well known that estrogen receptor α (ERα) participates in the pathogenic progress of breast cancer, hepatocellular carcinoma and head and neck squamous cell carcinoma. In neuroblastoma cells and related cancer clinical specimens, moreover, the ectopic expression of ERα has been identified. However, the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1495-3
更新日期:2015-06-30 00:00:00
abstract:BACKGROUND:Metformin is a biguanide oral hypoglycaemic agent commonly used for the treatment of type 2 diabetes mellitus. In addition to its anti-diabetic effect, metformin has also been associated with a reduced risk of cancer incidence of a number of solid tumours, including prostate cancer (PCa). However, the underl...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-017-3458-3
更新日期:2017-07-21 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07766-5
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) constitute a heterogenous group of tumors arising from the neuroendocrine system at diverse anatomic si...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07121-8
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by its combination with other microtubule-binding agents. METHODS:The interactions between ABZ and micro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-86
更新日期:2013-02-23 00:00:00
abstract:BACKGROUND:The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, results with N-terminal inhibitors from initial clinical trials have been disappointing, as toxicity an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-468
更新日期:2011-10-31 00:00:00
abstract:BACKGROUND:Wilms' tumor is also called nephroblastoma and is the most common pediatric renal cancer. Several genetic and epigenetic factors have been found to account for the development of Wilms' tumor. MiRNAs play important roles in this tumorigenic process. In the present study, we aimed to investigate the role of m...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5609-1
更新日期:2019-04-29 00:00:00
abstract:BACKGROUND:Improving the coordination of cancer care is a priority area for service improvement. However, quality improvement initiatives are hindered by the lack of accurate and reliable measures of this aspect of cancer care. This study was conducted to develop a questionnaire to measures patients' experience of canc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-298
更新日期:2011-07-15 00:00:00
abstract:BACKGROUND:One of the basic prerequisites for generating evidence-based data is the availability of classification systems. Attempts to date to classify breast cancer operations have focussed on specific problems, e.g. the avoidance of secondary corrective surgery for surgical defects, rather than taking a generic appr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-108
更新日期:2009-04-08 00:00:00
abstract:BACKGROUND:Overweight and weight gain throughout adult life have been associated with increased risk of breast cancer after the menopause. However the role of body weight at a young age and of the timing of weight gain over the lifetime in postmenopausal breast cancer is not well documented. METHODS:We conducted a pop...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2793-0
更新日期:2016-09-29 00:00:00
abstract:BACKGROUND:To investigate the implications of prophylactic intraoperative Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with D2 radical gastrectomy for locally advanced Gastric Cancer (AGC) in a randomized case control study. METHOD:Eighty consecutive patients with locally AGC were randomly separated into 2 groups...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6125-z
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND:In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer development in Tunisia. We have also tried to evaluate whether these variants affect the bladder tumor...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-101
更新日期:2011-03-22 00:00:00
abstract:BACKGROUND:The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multiple tyrosine kinase o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1131-2
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:Cervical cancer is the fourth most common cancer among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage and underutilization of screening facilities. This study aims to assess knowledge and attitude towards cervical cancer and its prevention, as well as prac...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07060-4
更新日期:2020-06-17 00:00:00
abstract:BACKGROUND:We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of any individual gene with traditional predictors of prognosis. METHODS:Patients with T1-T3 primary ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-55
更新日期:2008-02-20 00:00:00
abstract:BACKGROUND:It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in patients with HER2-negative metastatic breast cancer. METHODS:We searched Pubmed, Embase, and Cochr...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-020-6674-1
更新日期:2020-03-04 00:00:00