Abstract:
BACKGROUND:The lymphocytes played an important role in the natural history of cancer. The aim of this study was to explore the prognostic value of lymphocyte count and percentage for survival in advanced cancer patients receiving palliative care. METHODS:A retrospective review of clinicopathological data from 378 consecutive advanced cancer patients and 106 extended follow-up patients treated with palliative care was conducted. Kaplan-Meier curves and multivariate cox regression analyses were used to evaluate the relationships of peripheral lymphocyte count (LC) and lymphocyte to white blood cell ratio (LWR) with overall survival (OS). RESULTS:The median values for pretreatment LC and LWR were 1.1 (IQR, 0.8 ~ 1.5 × 109/L) and 0.138 (IQR, 0.086 ~ 0.208). The median survival times across LWR quartiles were 19, 47, 79, and 101 days (P < 0.001). Multivariate analysis indicated that patients in the highest quartiles of LC and LWR had an HR of 1.082 (95% CI 0.777 ~ 1.506, P = 0.642) and 0.466 (95% CI 0.328 ~ 0.661, P < 0.001), respectively, compared with patients in the lowest quartiles. Furthermore, only the dynamic changes of LWR were confirmed as an independent prognostic factor for overall survival during the follow-up (HR = 0.396, 95% CI 0.243 ~ 0.668; P = 0.001), as were primary tumor site and ECOG. No effect was observed for the dynamic changes of LC. CONCLUSIONS:Our findings demonstrate that measurement of the dynamic changes of LWR prior to treatment and during follow-up may represent a simple and new powerful prognostic factor for patients with advanced cancer, unlike measurement of LC. As a bedside marker of immune status, the prognostic role of LWR should be further evaluated in prospective studies.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Zhao W,Wang P,Jia H,Chen M,Gu X,Liu M,Zhang Z,Cheng W,Wu Zdoi
10.1186/s12885-017-3498-8subject
Has Abstractpub_date
2017-08-02 00:00:00pages
514issue
1issn
1471-2407pii
10.1186/s12885-017-3498-8journal_volume
17pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:RNA from exosomes and other microvesicles contain transcripts of tumour origin. In this study we sought to identify biomarkers of glioblastoma multiforme in microvesicle RNA from serum of affected patients. METHODS:Microvesicle RNA from serum from patients with de-novo primary glioblastoma multiforme (N = 9...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-22
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy (NAC) is a standard treatment for stage II/III breast cancer patients, and response to NAC is a useful prognostic marker. Since its introduction, 6-8 cycles of NAC has become the standard regimen to improve the outcome of these patients. The purpose of this study is to evaluate the p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2500-1
更新日期:2016-07-21 00:00:00
abstract::Following publication of the original article [1], the authors reported an error in Fig. 6c and in the figure legends for Fig. 5c and Fig. 6c. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-020-6552-x
更新日期:2020-01-23 00:00:00
abstract:BACKGROUND:Interleukin 12 (IL-12) is a cytokine that has been reported to exhibit potent tumoricidal effects in animal tumor models. A combined approach using Paclitaxel and platinum-based doublet chemotherapy is the most commonly used backbone regimen for treating lung cancer. Despite numerous studies regarding the an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2701-7
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival. METHODS:Analysis was car...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-487
更新日期:2012-10-22 00:00:00
abstract:BACKGROUNDS:There have been conflicting reports about serum golgi protein 73 (GP73) as one of the most promising serum markers for the diagnosis of hepatocellular carcinoma (HCC). This study was to make a systematic review about the diagnostic accuracy of serum GP73 versus alpha-fetoprotein (AFP) for HCC. METHODS:Afte...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-12-17
更新日期:2012-01-16 00:00:00
abstract:BACKGROUND:The historical basis and contemporary evidence for the use of immune strategies for prevention of malignancies are reviewed. Emphasis is focussed on the Febrile Infections and Melanoma (FEBIM) study on melanoma and on malignancies that seem to be related to an overexpression of human endogenous retrovirus K ...
journal_title:BMC cancer
pub_type: 历史文章,杂志文章,评审
doi:10.1186/1471-2407-14-595
更新日期:2014-08-16 00:00:00
abstract:BACKGROUND:Magnetic resonance imaging (MRI) may guide breast cancer surgery by measuring residual tumor size post-neoadjuvant chemotherapy (NAC). Accurate measurement may avoid overly radical surgery or reduce the need for repeat surgery. This individual patient data (IPD) meta-analysis examines MRI's agreement with pa...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-015-1664-4
更新日期:2015-10-08 00:00:00
abstract:BACKGROUND:Nivestim™ (filgrastim) is a follow-on biologic agent licensed in the EU for the treatment of neutropenia and febrile neutropenia induced by myelosuppressive chemotherapy. Nivestim™ has been studied in phase 2 and 3 clinical trials where its efficacy and safety was found to be similar to its reference product...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-547
更新日期:2013-11-16 00:00:00
abstract:BACKGROUND:Doxorubicin-based chemotherapy is currently the most frequently used treatment for triple negative breast cancer (TNBC), yet the response rate is not high due to the lack of a biomarker allowing identification of responsive patients before the chemotherapy is initiated. We have demonstrated that doxorubicin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4724-8
更新日期:2018-08-13 00:00:00
abstract:BACKGROUND:Spinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life (ADL), reduced clinical performance, the risk of pathological fractures, and neurological deficits. The aim of this randomized, controlled pilot ...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-14-67
更新日期:2014-02-05 00:00:00
abstract:BACKGROUND:There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable prognosis compared with HPV-negative OPSCC, leading to investigation and adoption of de-escalation trea...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6266-0
更新日期:2019-11-06 00:00:00
abstract:BACKGROUND:We evaluated possible diagnostic and prognostic values of serum midkine in malignant pleural mesothelioma in comparison with those of serum mesothelin, a well-established diagnostic biomarker. METHODS:Serum mesothelin and midkine levels were determined with an enzyme-linked immunosorbent assay. We examined ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3209-5
更新日期:2017-03-23 00:00:00
abstract:BACKGROUND:Afaitnib has shown anti-tumor activity against metastatic EGFR-mutated NSCLC after prior failure to first generation EGFR-TKI and chemotherapy. We prospectively evaluated the efficacy and safety of afatinib in Chinese patients who previously failed first-generation TKI and chemotherapy under a compassionate ...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-016-2201-9
更新日期:2016-02-24 00:00:00
abstract:BACKGROUND:Both diabetes and glucose-lowering medications have been associated with an increased risk of cancer incidence. This study will compare cancer incidence rates in individuals with and without diabetes; and will investigate, in individuals with diabetes, an association between glucose control and cancer incide...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-364
更新日期:2012-08-23 00:00:00
abstract:BACKGROUND:Recent studies suggested that cancer stem-like cells contribute to tumor vasculogenesis by differentiating into endothelial cells. However, such process is governed by still undefined mechanism. METHODS:At varying differentiation levels, three representative colon cancer cells were cultured in endothelial-i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3578-9
更新日期:2017-08-30 00:00:00
abstract::ABSTRACT: BACKGROUND: The aim of this study was to assess the extent of knowledge of primary health care (PHC) patients about colorectal cancer (CRC), their attitudes toward population-based screening for this disease and gender differences in these respects. METHODS: A questionnaire-based survey of PHC patients in t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-408
更新日期:2011-09-25 00:00:00
abstract:BACKGROUND:Serine-threonine kinases of the Raf family (A-Raf, B-Raf, C-Raf) are central players in cellular signal transduction, and thus often causally involved in the development of cancer when mutated or over-expressed. Therefore these proteins are potential targets for immunotherapy and a possible basis for vaccine...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-15
更新日期:2005-02-09 00:00:00
abstract:BACKGROUND:Bevacizumab, a humanized antibody to vascular endothelial growth factor (VEGF), shows clinical activity against human cancer, with its addition to standard chemotherapy having been found to improve outcome in patients with advanced nonsquamous non-small cell lung cancer (NSCLC). However, there have been no e...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-12-327
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Women with ovarian cancer can present with a variety of symptoms and signs, and an increasing range of tests are available for their investigation. A number of international guidelines provide advice for the initial assessment of possible ovarian cancer in symptomatic women. We systematically identified and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6211-2
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell infiltration and prostate cancer recurrence and tried to provide new ideas for the treatment of prostat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6391-9
更新日期:2019-12-03 00:00:00
abstract:BACKGROUND:The transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2; previously known as NRF2) is a crucial regulator of the intracellular antioxidant response. It controls the expression of genes involved in the detoxification and elimination of reactive oxidants and electrophilic agents. The role ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2840-x
更新日期:2016-10-22 00:00:00
abstract:BACKGROUND:In a phase I study of angiotensin-(1-7) [Ang-(1-7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1-7) induced changes in biomarkers according to cancer type and investigates mechanisms of action engaged in vitro. MET...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-404
更新日期:2012-09-11 00:00:00
abstract:BACKGROUND:Improving the coordination of cancer care is a priority area for service improvement. However, quality improvement initiatives are hindered by the lack of accurate and reliable measures of this aspect of cancer care. This study was conducted to develop a questionnaire to measures patients' experience of canc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-298
更新日期:2011-07-15 00:00:00
abstract:BACKGROUND:Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the selective killing efficacy of a lentivirus-mediated cytosine deaminase-thymidine kinase (CDglyTK) gene in transplanted breast cancer deli...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6111-5
更新日期:2019-09-14 00:00:00
abstract:BACKGROUND:Survival rates for upper gastrointestinal (GI) cancer are poor since many are diagnosed at advanced stages. Fast track endoscopy has been introduced to prompt diagnosis for patients with alarm symptoms that could be indicative of upper GI cancer. However, these symptoms may represent benign conditions and li...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4376-8
更新日期:2018-04-18 00:00:00
abstract:BACKGROUND:Cancer is a major public health issue and represents a significant economic burden to health care systems worldwide. The objective of this analysis was to estimate phase-specific, 5-year and lifetime net costs for the 21 most prevalent cancer sites, and remaining tumour sites combined, in Ontario, Canada. M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2835-7
更新日期:2016-10-18 00:00:00
abstract:BACKGROUND:Primary angiosarcomas of the right atrium are extremely rare, often resulted in missed diagnosis or misdiagnosis with routine examination tools. These malignant cardiac tumors are highly aggressive with generally poor prognosis. Surgical excision is the mainstay of treatment as it is essentially not responsi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6450-2
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/F...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-551
更新日期:2014-07-30 00:00:00
abstract:BACKGROUND:Many patients diagnosed with oesophageal adenocarcinoma (OAC) present with advanced disease and approximately half present with metastatic disease. Patients with localised disease, who are managed with curative intent, frequently undergo neoadjuvant chemoradiotherapy. Unfortunately, ~ 70% of patients have li...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5996-3
更新日期:2019-08-07 00:00:00