Efficacy and safety of self-expanding metallic stent placement followed by neoadjuvant chemotherapy and scheduled surgery for treatment of obstructing left-sided colonic cancer.

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been identified as an oncoprotein in various human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. We examined GOLPH3 expression levels and relationship with survival in patients with PDAC to establish the significance of GOLPH3 in the dev...

journal_title：BMC cancer

authors： Zhang LJ,Wang KB,Liu LS,Chen LZ,Peng BG,Liang LJ,Li Z,Xue L,Li W,Xia JT

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Cancer survivors and their caregivers may have various unmet needs that are medically difficult to solve. Previous studies have suggested the relations between individuals' backgrounds and their unmet needs. We conducted a large-scale analysis to clarify the influence of individuals' backgrounds, primarily c...

journal_title：BMC cancer

authors： Watanabe K,Katayama K,Yoshioka T,Narimatsu H

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Long-term survival in numerous cancers often correlates with specific whole transcriptome profiles or the expression patterns of smaller numbers of transcripts. In some instances, these are better predictors of survival than are standard classification methods such as clinical stage or hormone receptor statu...

journal_title：BMC cancer

authors： Mandel J,Avula R,Prochownik EV

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation. PRDM5 has not been ex...

journal_title：BMC cancer

authors： Bond CE,Bettington ML,Pearson SA,McKeone DM,Leggett BA,Whitehall VL

更新日期：2015-01-23 00:00:00

abstract：BACKGROUND:Earlier studies have reported the production of histamine in colorectal cancers (CRCs). The effect of histamine is largely determined locally by the histamine receptor expression pattern. Recent evidence suggests that the expression level of histamine receptor H4 (HRH4) is abnormal in colorectal cancer tissu...

journal_title：BMC cancer

authors： Fang Z,Yao W,Xiong Y,Li J,Liu L,Shi L,Zhang W,Zhang C,Nie L,Wan J

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:Standard radiotherapy is the treatment of first choice in patients with symptomatic spinal metastases, but is only moderately effective. Stereotactic body radiation therapy is increasingly used to treat spinal metastases, without randomized evidence of superiority over standard radiotherapy. The VERTICAL stu...

journal_title：BMC cancer

authors： van der Velden JM,Verkooijen HM,Seravalli E,Hes J,Gerlich AS,Kasperts N,Eppinga WS,Verlaan JJ,van Vulpen M

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different next-generation sequencing (NGS) pipelines in paired cerebrospinal fluid (CSF) and plasma samples fr...

journal_title：BMC cancer

authors： Ge M,Zhan Q,Zhang Z,Ji X,Zhou X,Huang R,Liang X

更新日期：2019-02-12 00:00:00

abstract：BACKGROUND:The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast cancer-specific mortality in women with breast cancer. Our study will add to the knowledge on whether...

journal_title：BMC cancer

authors： Borch KB,Braaten T,Lund E,Weiderpass E

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Breast cancer is the most common malignancy in women world-wide. Triple negative breast cancer (TNBC) is a highly aggressive subtype that lacks expression of hormone receptors for estrogen, progesterone and human epidermal growth factor 2; and is associated with a high propensity for metastatic spread. Sever...

journal_title：BMC cancer

authors： Avery-Kiejda KA,Braye SG,Forbes JF,Scott RJ

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:To date, the clinical benefit of topical steroid use has only been demonstrated for radiation dermatitis induced by 50-60 Gy irradiation in breast cancer. However, these agents are also often used clinically for the control of radiation dermatitis induced by high-dose (>60Gy) irradiation with chemotherapy in...

journal_title：BMC cancer

authors： Zenda S,Yamaguchi T,Yokota T,Miyaji T,Mashiko T,Tanaka M,Yonemura M,Takeno M,Okano T,Kawasaki T,Nakamori Y,Ishii S,Shimada S,Kanamaru M,Uchitomi Y

更新日期：2018-09-06 00:00:00

abstract：BACKGROUND:Prostate cancer displays different morphologies which, in turn, affect patient outcome. This fact prompted questions about the lineage relationship between differentiated, more treatable prostate adenocarcinoma and poorly differentiated, less treatable non-adenocarcinoma including small cell carcinoma, and t...

journal_title：BMC cancer

authors： Kanan AD,Corey E,Vêncio RZN,Ishwar A,Liu AY

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:Metformin is a biguanide oral hypoglycaemic agent commonly used for the treatment of type 2 diabetes mellitus. In addition to its anti-diabetic effect, metformin has also been associated with a reduced risk of cancer incidence of a number of solid tumours, including prostate cancer (PCa). However, the underl...

journal_title：BMC cancer

authors： Crawley D,Chandra A,Loda M,Gillett C,Cathcart P,Challacombe B,Cook G,Cahill D,Santa Olalla A,Cahill F,George G,Rudman S,Van Hemelrijck M

更新日期：2017-07-21 00:00:00

abstract：BACKGROUND:Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior history, who face a life-long risk of reoccurrence. The objective of the current study was to identify ...

journal_title：BMC cancer

authors： Coroiu A,Moran C,Bergeron C,Drapeau M,Wang B,Kezouh A,Ernst J,Batist G,Körner A

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:We analyzed the influence of 8 germinal polymorphisms of candidate genes potentially related to EGFR signalling (EGFR, EGF, CCND1) or antibody-directed cell cytotoxicity (FCGR2A and FCGR3A) on outcome of colorectal cancer (CRC) patients receiving cetuximab-based therapy. METHODS:Fifty-eight advanced CRC pat...

journal_title：BMC cancer

authors： Dahan L,Norguet E,Etienne-Grimaldi MC,Formento JL,Gasmi M,Nanni I,Gaudart J,Garcia S,Ouafik L,Seitz JF,Milano G

更新日期：2011-11-25 00:00:00

abstract：BACKGROUND:Immunotherapies have advanced the treatment of metastatic melanoma; however, they are associated with immune-related toxicities. Patients with pre-existing autoimmune comorbidities are commonly excluded from clinical trials investigating immunotherapies in metastatic melanoma. Since information on pre-existi...

journal_title：BMC cancer

authors： Ma Q,Shilkrut M,Zhao Z,Li M,Batty N,Barber B

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various efforts in detection and treatment, many patients with AML die of this cancer. That is why it is impo...

journal_title：BMC cancer

authors： Gil-Kulik P,Dudzińska E,Radzikowska-Büchner E,Wawer J,Jojczuk M,Nogalski A,Wawer GA,Feldo M,Kocki W,Cioch M,Bogucka-Kocka A,Rahnama M,Kocki J

更新日期：2020-05-18 00:00:00

abstract：BACKGROUND:The purpose of the PROLUCA study is to investigate the efficacy of preoperative and early postoperative rehabilitation in a non-hospital setting in patients with operable lung cancer with special focus on exercise. METHODS:Using a 2 x 2 factorial design with continuous effect endpoint (Maximal Oxygen Uptake...

journal_title：BMC cancer

authors： Sommer MS,Trier K,Vibe-Petersen J,Missel M,Christensen M,Larsen KR,Langer SW,Hendriksen C,Clementsen P,Pedersen JH,Langberg H

更新日期：2014-06-04 00:00:00

abstract：BACKGROUND:Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major ro...

journal_title：BMC cancer

authors： Cegolon L,Salata C,Weiderpass E,Vineis P,Palù G,Mastrangelo G

更新日期：2013-01-03 00:00:00

abstract：BACKGROUND:The influence of the tumor microenvironment and tumor-stromal interactions on the heterogeneity of response within breast cancer subtypes have just begun to be explored. This study focuses on patients with estrogen receptor-positive/human epidermal growth factor receptor 2-positive (ER+/HER2+) breast cancer ...

journal_title：BMC cancer

authors： Brodsky AS,Xiong J,Yang D,Schorl C,Fenton MA,Graves TA,Sikov WM,Resnick MB,Wang Y

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:Colon cancer patients with the same stage show diverse clinical behavior due to tumor heterogeneity. We aimed to discover distinct classes of tumors based on microarray expression patterns, to analyze whether the molecular classification correlated with the histopathological stages or other clinical paramete...

journal_title：BMC cancer

authors： Perez-Villamil B,Romera-Lopez A,Hernandez-Prieto S,Lopez-Campos G,Calles A,Lopez-Asenjo JA,Sanz-Ortega J,Fernandez-Perez C,Sastre J,Alfonso R,Caldes T,Martin-Sanchez F,Diaz-Rubio E

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:18F-FDG PET/CT could satisfactorily show pancreatic and extra-pancreatic lesions in AIP, which can be mistaken for pancreatic cancer (PC). This study aimed to identify 18F-FDG PET/CT findings that might differentiate AIP from PC. METHODS:FDG-PET/CT findings of 26 AIP and 40 PC patients were reviewed. Pancre...

journal_title：BMC cancer

authors： Zhang J,Jia G,Zuo C,Jia N,Wang H

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors for which no effective therapies are currently available. Oncolytic Newcastle disease virus (NDV) has shown the potential to induce oncolytic cell death in a variety of cancer cells of diverse origins. However, whether oncolyti...

journal_title：BMC cancer

authors： Jiang K,Song C,Kong L,Hu L,Lin G,Ye T,Yao G,Wang Y,Chen H,Cheng W,Barr MP,Liu Q,Zhang G,Ding C,Meng S

更新日期：2018-07-18 00:00:00

abstract：:Following publication of the original article [1], the authors reported the following error is the article. ...

journal_title：BMC cancer

authors： Ye S,Hao X,Zhou T,Wu M,Wei J,Wang Y,Zhou L,Jiang X,Ji L,Chen Y,You L,Zhang Y,Xu G,Zhou J,Ma D,Wang S

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is associated with poorer outcomes in some cancers. Its effect on ovarian cancer is less clear. We consider the effect of DM on overall survival (OS) and progression free survival (PFS) in patients with epithelial ovarian cancer (EOC). METHODS:A retrospective cohort study of 215 patie...

journal_title：BMC cancer

authors： Akhavan S,Ghahghaei-Nezamabadi A,Modaresgilani M,Mousavi AS,Sepidarkish M,Tehranian A,Rezayof E

更新日期：2018-12-12 00:00:00

abstract：BACKGROUND:Gene-gene and gene-environment interactions involved in the metabolism of carcinogens may increase the risk of cancer. Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC). METHODS:...

journal_title：BMC cancer

authors： Fan C,Jin M,Chen K,Zhang Y,Zhang S,Liu B

更新日期：2007-06-30 00:00:00

abstract：BACKGROUND:During the last two decades the use of laparoscopic resection and a multimodal approach known as an enhanced recovery programme, have been major changes in colorectal perioperative care. Clinical outcome improves using laparoscopic surgery to resect colorectal cancer but until recently no multicentre trial e...

journal_title：BMC cancer

authors： Kennedy RH,Francis A,Dutton S,Love S,Pearson S,Blazeby JM,Quirke P,Franks PJ,Kerr DJ

更新日期：2012-05-16 00:00:00

abstract：BACKGROUND:We studied the cases of single and multiple HPV infection and analyzed the correlation with negative cases, and preneoplastic and neoplastic lesions of the uterine cervix with the aim of making a contribution to the prognostic factor under discussion. METHODS:Nine hundred nine women undergoing second level ...

journal_title：BMC cancer

authors： Bruno MT,Scalia G,Cassaro N,Boemi S

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:To access the prognostic significance of HER-2 overexpression, the effect of trastuzumab and the cause of death in patients with brain metastases (BM) from breast cancer (BC). METHODS:We analyzed the outcome of 130 patients with BM from BC who received whole-brain radiotherapy (WBRT) (without surgery or rad...

journal_title：BMC cancer

authors： Le Scodan R,Jouanneau L,Massard C,Gutierrez M,Kirova Y,Cherel P,Gachet J,Labib A,Mouret-Fourme E

更新日期：2011-09-19 00:00:00

abstract：BACKGROUND:The serine/threonine kinase PIM1 has been implicated as an oncogene in various human cancers including lymphomas, gastric, colorectal and prostate carcinomas. In mouse models, Pim1 is known to cooperate with c-Myc to promote tumorigenicity. However, there has been limited analysis of the tumorigenic potentia...

journal_title：BMC cancer

authors： Kim J,Roh M,Abdulkadir SA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Breast cancer has been poorly studied in women with intellectual disability (ID), which makes designing a policy for screening the nearly 70 million women with ID in the world difficult. As no data is available in the literature, we evaluated breast cancer at diagnosis in women with ID. METHODS:Women with I...

journal_title：BMC cancer

authors： Satgé D,Sauleau EA,Jacot W,Raffi F,Azéma B,Bouyat JC,El Hage Assaf N

更新日期：2014-03-04 00:00:00