Abstract:
BACKGROUND:To date, the clinical benefit of topical steroid use has only been demonstrated for radiation dermatitis induced by 50-60 Gy irradiation in breast cancer. However, these agents are also often used clinically for the control of radiation dermatitis induced by high-dose (>60Gy) irradiation with chemotherapy in head and neck cancer. Despite this, the prophylactic efficacy of topical steroids for radiation dermatitis induced by high-dose irradiation is still unclear. The aim of this study is to clarify the benefit of topical steroids in basic nursing care for radiation dermatitis induced by chemoradiotherapy in patients with head and neck cancer. METHODS:The study is being conducted as a multicenter 2-arm randomized double-blinded placebo-controlled Phase 3 trial in Japan. The study was started in May 2017, with participant enrollment between May 2017 and April 2019. Patients scheduled to receive definitive or postoperative chemoradiotherapy for head and neck cancer are eligible for enrollment. All patients will receive chemoradiotherapy, consisting of single agent CDDP and 70-Gy irradiation. Bilateral neck irradiation is mandatory. Supportive care for radiation dermatitis will consist of basic nursing care with topical steroid or placebo. When radiation dermatitis grade 1 is seen or total radiation dose reaches 30 Gy, minimally required intervention will be started as a first step. If radiation dermatitis worsens to grade 2, the irradiated area will be covered with a moderately absorbent surgical pad and steroid or placebo topical cream. The primary endpoint is a comparison of the proportion of patients with ≥ grade 2 radiation dermatitis by NCI Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. Ethical approval has been obtained from all participating sites. The results of this study will be submitted for publication in international peer-reviewed journals and the key findings will be presented at international scientific conferences. DISCUSSION:Evidence supporting the benefit of adding topical steroids in general nursing care for radiation dermatitis induced by high-dose irradiation with chemotherapy is insufficient. This trial aims to clarify the clinical benefit of topical steroid for radiation dermatitis induced by high-dose irradiation with chemotherapy. The trial is ongoing and is currently recruiting. TRIAL REGISTRATION NUMBER:UMIN000027161 . Protocol version 3.0, 18 April 2017.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Zenda S,Yamaguchi T,Yokota T,Miyaji T,Mashiko T,Tanaka M,Yonemura M,Takeno M,Okano T,Kawasaki T,Nakamori Y,Ishii S,Shimada S,Kanamaru M,Uchitomi Ydoi
10.1186/s12885-018-4763-1subject
Has Abstractpub_date
2018-09-06 00:00:00pages
873issue
1issn
1471-2407pii
10.1186/s12885-018-4763-1journal_volume
18pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. METHODS:To investigate the effects and mechanisms of genistein on EMT of colon cancer ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3829-9
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear. METHODS:The methods of im...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-133
更新日期:2010-04-08 00:00:00
abstract:BACKGROUND:Cancer is a major public health issue and represents a significant economic burden to health care systems worldwide. The objective of this analysis was to estimate phase-specific, 5-year and lifetime net costs for the 21 most prevalent cancer sites, and remaining tumour sites combined, in Ontario, Canada. M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2835-7
更新日期:2016-10-18 00:00:00
abstract:BACKGROUND:Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is involved in the occurrence and progression of several malignant tumors. However, its potential role in esophageal squamous cell carcinoma (ESCC) is still unknown. METHODS:PRAF2 mRNA expression was determined in 77 frozen ESCC samples by quantitati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5818-7
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether radiation (RT)-induced inflammatory responses and organ damage might be modulated by androgen deprivation therapies. METHODS:The mRNA and tissue sections obtained from the lungs, intestines and livers of irradiated mice with or without androgen deprivation were...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-92
更新日期:2009-03-25 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive and most likely combines environmental and genetic factors. The Kv2.1 potassium channel encoded by KC...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07605-7
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic disease who might benefit from adjuvant therapies. The aim was to examine if cellular immune markers...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3577-x
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:The Nijmegen Breakage Syndrome is a chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency, and increased frequency of cancers. Familial studies on relatives of these patients indicated that they also appear to be at increased risk of cancer. METHODS:In a candid...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-181
更新日期:2009-06-12 00:00:00
abstract:BACKGROUND:During the last two decades the use of laparoscopic resection and a multimodal approach known as an enhanced recovery programme, have been major changes in colorectal perioperative care. Clinical outcome improves using laparoscopic surgery to resect colorectal cancer but until recently no multicentre trial e...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-12-181
更新日期:2012-05-16 00:00:00
abstract:BACKGROUND:The effects of exposure to ultraviolet radiation are a significant concern in Australia which has one of the highest incidences of skin cancer in the world. Despite most skin cancers being preventable by encouraging consistent adoption of sun-protective behaviours, incidence rates are not decreasing. There i...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1471-2407-14-162
更新日期:2014-03-07 00:00:00
abstract:BACKGROUND:Ectopic TSH-secreting pituitary adenoma (TSH-oma) is a very unusual disorder. To date, there are only four cases reported. It is difficult to distinguish ectopic cases from both regular TSH-omas and resistance to thyroid hormone (RTH). CASE PRESENTATION:A newly identified case of ectopic TSH-oma arising fro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-544
更新日期:2014-07-28 00:00:00
abstract:BACKGROUND:We examined 15 years of key performance indicators (KPIs) of the population-based mammography screening programme (PMSP) in Flanders, Belgium. METHODS:Individual screening data were linked to the national cancer registry to obtain oncological follow-up. We benchmarked crude KPI results against KPI-targets s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6230-z
更新日期:2019-10-28 00:00:00
abstract:BACKGROUND:The EphB4 receptor tyrosine kinase has been reported as increased in tumours originating from several different tissues and its expression in a prostate cancer xenograft model has been reported. METHODS:RT-PCR, western blotting and immunohistochemical techniques were used to examine EphB4 expression and pro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-119
更新日期:2005-09-20 00:00:00
abstract:BACKGROUND:SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown. METHODS:We retrieved the expression data of 1168 CRC patients from 3 Gene Expression Omnibus (GEO)...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6484-5
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:Papillary renal cell carcinoma (pRCC) is the 2nd most frequent histological type of kidney cancer and accounts for approximately 15% of all renal cell carcinoma. It has a poorer prognosis than clear cell RCC (ccRCC) with a lack of standard treatments. CASE PRESENTATION:We report the case of a 51 year old ma...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-018-5049-3
更新日期:2018-11-22 00:00:00
abstract:BACKGROUND:Novel biomarkers and molecular monitoring tools hold potential to improve outcome for patients following resection of pancreatic ductal adenocarcinoma (PDAC). We hypothesized that the combined longitudinal analysis of mutated cell-free plasma KRAS (cfKRASmut) and CA 19-9 during adjuvant treatment and follow-...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07736-x
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND:The cost-effectiveness of human papillomavirus (HPV) vaccination in women pre-sexual debut has been demonstrated in many countries. This study aimed to estimate the cost-effectiveness of a 3-dose bivalent HPV vaccination at ages 12 to 55 year in both rural and urban settings in China. METHODS:The Markov coh...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2207-3
更新日期:2016-02-26 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate epigenetic status of cyclin A1 in human papillomavirus-associated cervical cancer. Y. Tokumaru et al., Cancer Res 64, 5982-7 (Sep 1, 2004)demonstrated in head and neck squamous-cell cancer an inverse correlation between cyclin A1 promoter hypermethylation and TP53 mutati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-55
更新日期:2006-03-08 00:00:00
abstract:BACKGROUND:Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However, genetically engineered T cells have been associated with serious side-effects due to off-target tox...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3539-3
更新日期:2017-08-17 00:00:00
abstract:BACKGROUND:Myeloid sarcoma (MS), also known as chloroma, is an extramedullary manifestation of malignant primitive myeloid cells. Previously, only small studies investigated clinical and imaging features of MS. The purpose of this study was to elucidate clinical and imaging features of MS based upon a multicenter patie...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-019-6357-y
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:Advanced biliary tract carcinomas (BTCs) have poor prognosis and limited therapeutic options. Therefore, it is crucial to combine standard therapies with molecular targeting. In this study EGFR, HER2, and their molecular transducers were analysed in terms of mutations, amplifications and over-expression in a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-631
更新日期:2010-11-18 00:00:00
abstract:BACKGROUND:The transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2; previously known as NRF2) is a crucial regulator of the intracellular antioxidant response. It controls the expression of genes involved in the detoxification and elimination of reactive oxidants and electrophilic agents. The role ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2840-x
更新日期:2016-10-22 00:00:00
abstract:: ...
journal_title:BMC cancer
pub_type: 社论,历史文章
doi:10.1186/s12885-018-5020-3
更新日期:2018-11-12 00:00:00
abstract::... ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-019-5669-2
更新日期:2019-05-13 00:00:00
abstract:BACKGROUND:A substantial number of patients will develop further biochemical progression after radical prostatectomy (RP) and salvage radiotherapy (sRT). Recently published data using prostate-specific membrane antigen ligand positron emission tomography (PSMA - PET) for re-staging suggest that those recurrences are of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06883-5
更新日期:2020-04-29 00:00:00
abstract:BACKGROUND:CD26/dipeptidyl peptidase IV (DPPIV) is a multifunctional membrane protein with a key role in T-cell biology and also serves as a marker of aggressive cancers, including T-cell malignancies. METHODS:Versican expression was measured by real-time RT-PCR and Western blots. Gene silencing of versican in parenta...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-517
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:The feasibility of submandibular gland (SMG) preservation in oral squamous cell carcinoma (SCC) has occasionally been analyzed, but the differences in survival associated with the presence or absence of SMG preservation remain unknown. We aimed to prospectively evaluate the oncologic results of SMG preservat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07534-5
更新日期:2020-10-27 00:00:00
abstract:BACKGROUND:The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. However, the lack of accuracy in identifying HR patients with conventional risk factors (large, deep, ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07207-3
更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, water soluble and non-toxic molecule is shown to have potent anti-cancer property. METHODS:In this st...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1784-x
更新日期:2015-10-23 00:00:00
abstract:BACKGROUND:Activation of caspase-9 in response to treatment with cytotoxic drugs is inhibited in NSCLC cells, which may contribute to the clinical resistance to chemotherapy shown in this type of tumor. The aim of the present study was to investigate the mechanism of caspase-9 inhibition, with a focus on a possible rol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-166
更新日期:2006-06-23 00:00:00