Abstract:
BACKGROUND:Castleman's disease is a rare form of localized lymph node hyperplasia of uncertain etiology. Although the mediastinum is the most common site of involvement, rare cases occurring in lymph node bearing tissue of other localization have been reported, including only a few intramuscular cases. Unicentric and multicentric Castleman's disease are being distinguished, the latter harboring an unfavorable prognosis. CASE PRESENTATION:Here, we present a case of unicentric Castleman's disease in a 37-year-old woman without associated neoplastic, autoimmune or infectious diseases. The lesion was located in the femoral region of the right lower extremity and surgically resected after radiographic workup and excisional biopsy examinations. The tumor comprised lymphoid tissue with numerous germinal centers with central fibrosis, onion-skinning and rich interfollicular vascularization. CD23-positive follicular dendritic cells were detected in the germinal centers and numerous CD138-positive plasma cells in interfollicular areas. The diagnosis of mixed cellularity type Castleman's disease was established and the patient recovered well. CONCLUSIONS:In conclusion, the differential diagnosis of Castleman's disease should be considered when evaluating a sharply demarcated, hypervascularized lymphatic tumor located in the extremities. However, the developmental etiology of Castleman's disease remains to be further examined.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Schaefer IM,Günnel H,Schweyer S,Korenkov Mdoi
10.1186/1471-2407-11-352subject
Has Abstractpub_date
2011-08-12 00:00:00pages
352issn
1471-2407pii
1471-2407-11-352journal_volume
11pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the two diseases, we have analyzed the oncogene HER-2 status at both the protein and the gene levels. ME...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-179
更新日期:2007-09-20 00:00:00
abstract:BACKGROUND:Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTOR inhibitors in small cell lung cancer (SCLC) cells and sought to clarify the mechanism of resistanc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1202-4
更新日期:2015-04-09 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the short- and long-term outcomes after laparoscopic resection for low rectal cancer (LRC) compared with mid/high rectal cancer (M/HRC). METHODS:Patients with rectal cancer undergoing laparoscopic resection with curative intent were retrospectively reviewed between 2009 and 2015...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07255-9
更新日期:2020-08-14 00:00:00
abstract:BACKGROUND:Platelet to Lymphocyte ratio (PLR) is thought to be associated with a worse outcome in multiple types of cancer. However, the prognostic significance of PLR has not been investigated in the prostate cancer (PCa) patients receiving hormonal therapy. The objective of this study was to determine the prognostic ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2363-5
更新日期:2016-05-24 00:00:00
abstract:BACKGROUND:Despite all benefit provided by established therapies prognosis of gastric cancer remains poor. Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and amplify chemotherapeutic effects. METHODS:This phase I study evaluated dose limiting toxicity (DLT...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-12-587
更新日期:2012-12-10 00:00:00
abstract:BACKGROUND:Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion. CA IX ectodomain (ECD) is shed from the tumor cell surface to serum/plasma of patients, where it can signify cancer p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2267-4
更新日期:2016-03-19 00:00:00
abstract:BACKGROUND:Genome wide association studies (GWAS) have identified several genetic variants that are associated with prostate cancer. Most of these variants, like other GWAS association signals, are located in non-coding regions of potential candidate genes, and thus could act at the level of the mRNA transcript. METHO...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-315
更新日期:2010-06-22 00:00:00
abstract:BACKGROUND:Clinical trials where cancer patients were treated with protease inhibitors have suggested that the serine protease, prostasin, may act as a tumour suppressor. Prostasin is proteolytically activated by the serine protease, matriptase, which has a very high oncogenic potential. Prostasin is inhibited by prote...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-201
更新日期:2009-06-25 00:00:00
abstract:BACKGROUND:Ovarian carcinoma is a common, and often deadly, gynecological cancer. Mutations in BRCA1 and BRCA2 genes are present in at least a fifth of patients. Uncovering other genes that become mutated subsequent to BRCA1/BRCA2 inactivation during cancer development will be helpful for more effective treatments. ME...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-146
更新日期:2013-03-22 00:00:00
abstract:BACKGROUND:Women with ovarian cancer can present with a variety of symptoms and signs, and an increasing range of tests are available for their investigation. A number of international guidelines provide advice for the initial assessment of possible ovarian cancer in symptomatic women. We systematically identified and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6211-2
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer development in Tunisia. We have also tried to evaluate whether these variants affect the bladder tumor...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-101
更新日期:2011-03-22 00:00:00
abstract:BACKGROUND:Cancer has a lot of consequences on patients' quality of life (such as cancer-related fatigue (CRF), sleep difficulties and emotional distress) and on patients' partners and their relationship, such as distress and communication difficulties. These consequences are undertreated, and interventions based on hy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5046-6
更新日期:2018-11-15 00:00:00
abstract:BACKGROUND:Treatment options for advanced head and neck adenoid cystic carcinoma (AdCC) are limited. Prostate-Specific Membrane Antigen (PSMA), a transmembrane protein that is known for its use in diagnostics and targeted therapy in prostate cancer, is also expressed by AdCC. This study aimed to analyse PSMA expression...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06847-9
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigated the BSI in mCRPC and its relationship with prognosis. METHODS:The PubMed, Cochrane, and Embase da...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-020-06739-y
更新日期:2020-03-20 00:00:00
abstract:BACKGROUND:Thymosin β10 (Tβ10) expression is associated with malignant phenotypes in many cancers. However, the role and mechanisms of Tβ10 in liver fluke-associated cholangiocarcinoma (CCA) are not fully understood. In this study, we investigated the expression of Tβ10 in CCA tumor tissues and cell lines as well as mo...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-430
更新日期:2013-09-23 00:00:00
abstract:BACKGROUND:Several GI peptides linked to intestinal barrier function could be involved in the modification of intestinal permeability and the onset of diarrhea during adjuvant chemotherapy. The aim of the study was to evaluate the circulating levels of zonulin, glucagon-like peptide-2 (GLP-2), epidermal growth factor (...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-13-56
更新日期:2013-02-04 00:00:00
abstract:BACKGROUND:Glioblastoma relapses in the vast majority of cases within 1 year. Maximum safe resection of the recurrent glioblastoma can be offered in some cases. Re-irradiation has been established for the treatment of recurrent glioblastoma, too. In both cases, adjuvant treatment, mostly using temozolomide, can improve...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-017-3928-7
更新日期:2018-01-03 00:00:00
abstract:BACKGROUND:Biannual ultrasound (US)-with or without alpha-fetoprotein (AFP)-is recommended by current guidelines for the surveillance of hepatocellular carcinoma (HCC). However, the inadequate sensitivity of US has been a concern. Magnetic resonance imaging (MRI) is known to have high sensitivity in detecting hepatic m...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/s12885-018-4827-2
更新日期:2018-09-24 00:00:00
abstract:BACKGROUND:Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination. Pseudoperipheral hand palsy is the best known of ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4857-9
更新日期:2018-10-03 00:00:00
abstract:BACKGROUND:Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with similar HER2 status, given similar treatments, suggests that the effects of amplification of HER2 can ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-297
更新日期:2008-10-14 00:00:00
abstract:BACKGROUND:PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation. PRDM5 has not been ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1011-9
更新日期:2015-01-23 00:00:00
abstract:BACKGROUND:RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explore...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4585-1
更新日期:2018-06-18 00:00:00
abstract:BACKGROUND:We investigated the role of the HIPK2-p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments. METHODS:Primary human CRC samples and normal intestinal tissues from patients were analyzed for HIPK2 expression by im...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-747
更新日期:2014-10-05 00:00:00
abstract:BACKGROUND:Combinations of trastuzumab with either docetaxel or vinorelbine are considered valuable treatment options for HER2-positive metastatic breast cancer patients. We performed a retrospective comparison of the clinical outcomes associated with either one of these combinations. METHODS:From a multi-institutiona...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-10-28
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:TGFβ signaling has typically been associated with suppression of tumor initiation while the role it plays in metastasis is generally associated with progression of malignancy. However, we present evidence here for an anti-metastatic role of TGFβ signaling. METHODS:To test the importance of TGFβ signaling to...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-221
更新日期:2012-06-06 00:00:00
abstract:BACKGROUND:To assess the clinical value of peritoneal washing cytology (PWC) in women with BRCA1 or BRCA2 mutations and women from a family with hereditary breast and/or ovarian cancer (HBOC) undergoing risk-reducing salpingo-oophorectomy (RRSO) in detecting primary peritoneal cancer (PPC) or occult ovarian/fallopian t...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12885-015-2011-5
更新日期:2016-01-14 00:00:00
abstract:BACKGROUND:Several studies show that the regulatory impact of microRNAs (miRNAs) is an essential contribution to the pathogenesis of colorectal cancer (CRC). The expression levels of diverse miRNAs are associated with specific clinical diagnoses and prognoses of CRC. However, this association reveals very little action...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1437-0
更新日期:2015-06-18 00:00:00
abstract:BACKGROUND:Accurate assessment of HER-2/neu status is crucial for proper prognostic information and to offer direct appropriate treatment for breast cancer patients. Next to immunohistochemistry (IHC) to evaluate HER2 protein overexpression, a second line gene amplification test is generally deemed necessary for cases ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-4
更新日期:2009-01-05 00:00:00
abstract:BACKGROUND:Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP are ubiquitous glycopeptidases closely linked to tumor pathogenesis and development, and they are use...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-193
更新日期:2010-05-11 00:00:00
abstract:BACKGROUND:SUMOylation, an important post-translational modification, associates with the development of hepatocellular carcinoma (HCC). p65, one of the most important subunits of NF-κB, is a key regulator in the development of HCC and has been reported to be SUMOylated by exogenous small ubiquitin-related modifier 3 (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1665-3
更新日期:2015-10-12 00:00:00