Abstract:
BACKGROUND:Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigated the BSI in mCRPC and its relationship with prognosis. METHODS:The PubMed, Cochrane, and Embase databases were searched systematically for relevant articles published before September 1, 2019. Hazard ratios (HRs) were used to investigate the prognostic value. RESULTS:This study finally identified 9 eligible studies. The results suggested that high baseline BSI predicted poor OS (HR = 1.331, 95% CI: 1.081-1.640) and that elevated ΔBSI also predicted poor OS (HR = 1.220, 95% CI: 1.015-1.467). The subgroup analysis stratified by ethnicity showed that the baseline BSI and ΔBSI predicted poor OS in the Asian population but not in the Caucasian population. We also performed a subgroup analysis based on the different cut-off values of baseline BSI. The subgroup of ≤1 showed a significant association with OS in mCRPC patients. CONCLUSION:Our study demonstrated that high baseline BSI and elevated ΔBSI predicted poor OS in patients with mCRPC. Hence, the BSI can serve as a prognostic indicator for mCRPC patients and may therefore guide clinical treatment in the future.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Song H,Jin S,Xiang P,Hu S,Jin Jdoi
10.1186/s12885-020-06739-ysubject
Has Abstractpub_date
2020-03-20 00:00:00pages
238issue
1issn
1471-2407pii
10.1186/s12885-020-06739-yjournal_volume
20pub_type
杂志文章,meta分析相关文献
BMC CANCER文献大全abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked to ESCC development and prognosis, the genetic alterations have not gained clinical applicability. We applied array-based compara...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-98
更新日期:2008-04-11 00:00:00
abstract:BACKGROUND:Glioblastoma multiforme (GBM) is the most aggressive of the primary brain tumors, with a grim prognosis despite intensive treatment. In the past decades, progress in research has not significantly increased overall survival rate. METHODS:The in vitro antineoplastic effect and mechanism of action of Casiopei...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-156
更新日期:2012-04-27 00:00:00
abstract:BACKGROUND:Cervical cancer represents an important global public health problem. It is the 2nd most common cancer among women worldwide. Human papillomavirus (HPV) infection is now well-established as a necessary cause of invasive cervical cancer (ICC) development. Only a few studies on HPV prevalence and type-specific...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-259
更新日期:2010-06-04 00:00:00
abstract:BACKGROUND:Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage. Thus, the concomitant use of novel compounds represents a critical strategy to improve t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2957-y
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:Oesophageal squamous cell carcinoma (OSCC) is a major health burden in Sub-Saharan Africa, and novel chemotherapies are urgently required to combat this disease. The heat shock protein 90 (HSP90) inhibitor 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) has previously been proposed as a possible candidate ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-334
更新日期:2014-05-15 00:00:00
abstract::It has been highlighted that the original manuscript [1] contains a typesetting error in the surname of Jesson Butcon. This was incorrectly captured as Jessica Butcon in the original manuscript which has since been updated. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-4105-3
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testi...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-017-3485-0
更新日期:2017-07-18 00:00:00
abstract:BACKGROUND:Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is thought to be a precursor to most invasive and metastatic breast cancers. Understanding the mechanisms regulating the invasive transition of DCIS is critical in order to better understand how some types of DCIS become invasive. W...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1007-5
更新日期:2015-01-21 00:00:00
abstract:BACKGROUND:Breast cancer is the second leading cause of cancer deaths in women in the United States. Although the causes of this disease are incompletely understood, oxidative DNA damage is presumed to play a critical role in breast carcinogenesis. A common oxidatively induced DNA lesion is 8-hydroxyguanine (8-OH-Gua),...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-297
更新日期:2006-12-27 00:00:00
abstract:BACKGROUND:This study aims to evaluate the impact of colony stimulating factor-1 (CSF-1) expression on recurrence and survival of patients with clear-cell renal cell carcinoma (ccRCC) following surgery. METHODS:We retrospectively enrolled 267 patients (195 in the training cohort and 72 in the validation cohort) with c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1076-5
更新日期:2015-02-18 00:00:00
abstract:BACKGROUND:Long-term survival in numerous cancers often correlates with specific whole transcriptome profiles or the expression patterns of smaller numbers of transcripts. In some instances, these are better predictors of survival than are standard classification methods such as clinical stage or hormone receptor statu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06756-x
更新日期:2020-04-07 00:00:00
abstract:BACKGROUND:MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aimed to investigate the mechanism of miR-200c targets fucosyltransferase 4 (FUT4) on the proliferation...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07670-y
更新日期:2021-01-04 00:00:00
abstract:BACKGROUND:Locally advanced or metastatic adenocarcinoma of the pancreas remains - despite the implementation of new chemotherapy protocols - a disease with short overall survival (OS). METHODS:Eighty-three patients were treated with locally advanced or metastatic adenocarcinoma of the pancreas with either FOLFIRINOX ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5240-6
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:The epithelial cell adhesion molecule (EpCAM) has been shown to be overexpressed in breast cancer and stem cells and has emerged as an attractive target for immunotherapy of breast cancer patients. This study analyzes the effects of EpCAM on breast cancer cell lines with epithelial or mesenchymal phenotype. ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-501
更新日期:2012-10-30 00:00:00
abstract:BACKGROUND:Worldwide, acute leukemia is the most common type of childhood cancer. It is particularly common in the Hispanic populations residing in the United States, Costa Rica, and Mexico City. The objective of this study was to determine the incidence of acute leukemia in children who were diagnosed and treated in p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-355
更新日期:2011-08-17 00:00:00
abstract:BACKGROUND:Genome wide association studies (GWAS) have identified several genetic variants that are associated with prostate cancer. Most of these variants, like other GWAS association signals, are located in non-coding regions of potential candidate genes, and thus could act at the level of the mRNA transcript. METHO...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-315
更新日期:2010-06-22 00:00:00
abstract:BACKGROUND:We report updated progression-free survival (PFS) and overall survival (OS) data from a trial that compared capecitabine plus oxaliplatin (CapeOX) versus S-1 plus oxaliplatin (SOX) for the first-line treatment of metastatic colorectal cancer. METHODS:This trial was a randomized, two-armed, non-inferiority p...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-14-883
更新日期:2014-11-26 00:00:00
abstract:BACKGROUND:Preclinical evidence suggests that aspirin may inhibit lung cancer progression. In a large cohort of lung cancer patients, we investigated whether low-dose aspirin use was associated with a reduction in the risk of lung cancer-specific mortality. METHODS:We identified lung cancer patients from English cance...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1910-9
更新日期:2015-11-17 00:00:00
abstract:BACKGROUND:Breast cancer is the most common form of malignancy affecting women worldwide. It is also the leading cancer in females in Cyprus, with approximately 400 new cases diagnosed annually. It is well recognized that genetic variation as well as environmental factors modulate breast cancer risk. The main aim of th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-447
更新日期:2010-08-23 00:00:00
abstract:BACKGROUND:To investigate the association between physical activity (PA) and quality of life (QoL) among breast and colorectal cancer survivors in Korea. METHODS:A total of 224 cancer survivors (151 breast and 73 colorectal cancers) who completed treatments were recruited. We measured PA level with Godin Leisure-Time ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06819-z
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Increasing the biological effective dose (BED) of radiotherapy for non-small cell lung cancer (NSCLC) can increase local control rates and improve overall survival. Compared with conventional fractionated radiotherapy, accelerated hypofractionated radiotherapy can yield higher BED, shorten the total treatmen...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2314-1
更新日期:2016-04-23 00:00:00
abstract:BACKGROUND:We sought to determine the comparative diagnostic performance of standard b-value (800-1000 s/mm2) versus low b-value (400-500 s/mm2) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of renal cell carcinoma (RCC). METHOD:After a systematic review of the available literature, studies w...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-14-843
更新日期:2014-11-18 00:00:00
abstract:BACKGROUND:The tumor microenvironment plays a determinative role in stimulating tumor progression and metastasis. Notably, tumor-stroma signals affect the pattern of infiltrated immune cells and the profile of tumor-released cytokines. Among the known molecules that are engaged in stimulating the metastatic spread of t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1034-2
更新日期:2015-02-12 00:00:00
abstract:BACKGROUND:Cysteine-rich 61 (Cyr61), a member of the CCN protein family, possesses diverse functionality in cellular processes such as adhesion, migration, proliferation, and survival. Cyr61 can also function as an oncogene or a tumour suppressor, depending on the origin of the cancer. Only a few studies have reported ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-164
更新日期:2014-03-07 00:00:00
abstract:BACKGROUND:Breast cancer is the leading cause of cancer mortality among women in Malaysia. Delayed diagnosis is preventable and has major effects on patients' prognosis and survival. The objectives of our study were to identify the magnitude of delayed diagnosis and its associated factors in women with breast cancer in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-141
更新日期:2011-04-17 00:00:00
abstract:BACKGROUND:Cationic antimicrobial peptides (CAPs) with antitumor activity constitute a promising group of novel anticancer agents. These peptides induce lysis of cancer cells through interactions with the plasma membrane. It is not known which cancer cell membrane components influence their susceptibility to CAPs. We h...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-183
更新日期:2009-06-15 00:00:00
abstract:BACKGROUND:Treatment of solid malignancies has been revolutionized with the introduction of immune checkpoint inhibitors (ICIs) and their use is being expanded in therapy of different cancers. However, immune related adverse events (IRAEs) can occur during treatment. These side effects occur due to stimulation of the i...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-019-5661-x
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in triple-negative breast cancer (TNBC) and their predictive role in determining the patient's outcome are u...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1151-y
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:Survival rates of lung cancer remains poor and the impact of comorbidities on the prognosis is discussed. The objective of this study was to assess if the Charlson Comorbidity Index (CCI) was associated with 8-year survival rates by histological type. METHODS:A cohort study was conducted using randomly sele...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5000-7
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:Genome-wide changes in DNA methylation are an epigenetic phenomenon that can lead to the development of disease. The study of global DNA methylation utilizes technology that requires both expensive equipment and highly specialized skill sets. METHODS:We have designed and developed an assay, CpGlobal, which ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-222
更新日期:2008-08-03 00:00:00