Abstract：
BACKGROUND:Genome wide association studies (GWAS) have identified several genetic variants that are associated with prostate cancer. Most of these variants, like other GWAS association signals, are located in non-coding regions of potential candidate genes, and thus could act at the level of the mRNA transcript. METHODS:We measured the expression and isoform usage of seven prostate cancer candidate genes in benign and malignant prostate by real-time PCR, and correlated these factors with cancer status and genotype at the GWAS risk variants. RESULTS:We determined that levels of LMTK2 transcripts in prostate adenocarcinomas were only 32% of those in benign tissues (p = 3.2 x 10(-7)), and that an independent effect of genotype at variant rs6465657 on LMTK2 expression in benign (n = 39) and malignant tissues (n = 21) was also evident (P = 0.002). We also identified that whilst HNF1B(C) and MSMB2 comprised the predominant isoforms in benign tissues (90% and 98% of total HNF1B or MSMB expression), HNF1B(B) and MSMB1 were predominant in malignant tissue (95% and 96% of total HNF1B or MSMB expression; P = 1.7 x 10(-7) and 4 x 10(-4) respectively), indicating major shifts in isoform usage. CONCLUSIONS:Our results indicate that the amount or nature of mRNA transcripts expressed from the LMTK2, HNF1B and MSMB candidate genes is altered in prostate cancer, and provides further evidence for a role for these genes in this disorder. The alterations in isoform usage we detect highlights the potential importance of alternative mRNA processing and moderation of mRNA stability as potentially important disease mechanisms.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Harries LW,Perry JR,McCullagh P,Crundwell Mdoi
10.1186/1471-2407-10-315subject
Has Abstractpub_date
2010-06-22 00:00:00pages
315issn
1471-2407pii
1471-2407-10-315journal_volume
10pub_type
杂志文章相关文献
BMC CANCER文献大全abstract：BACKGROUND:The predictive value of thymidylate synthase (TS) for clinical sensitivity to pemetrexed-containing chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis is performed to provide an assessment of whether expression variations of TS are associated with objec...
journal_title：BMC cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1471-2407-14-205
更新日期：2014-03-19 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is a lethal disease, while the precise underlying molecular mechanisms of HCC pathogenesis remain to be defined. MicroRNA (miRNA), a class of non-coding small RNAs, can post-transcriptionally regulate gene expression. Altered miRNA expression has been reported in HCCs. This stu...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2801-4
更新日期：2016-10-18 00:00:00
abstract：BACKGROUND:It has been previously demonstrated in several cancer models, that Dronabinol (THC) may have anti-tumor activity--however, controversial data exists for acute leukemia. We have anecdotal evidence that THC may have contributed to disease control in a patient with acute undifferentiated leukemia. METHODS:To t...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-2029-8
更新日期：2016-01-16 00:00:00
abstract：BACKGROUND:Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR1C enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized and advanced prostate adenocarcinoma, and is associated with prostate cancer (PCa) aggressivenes...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-672
更新日期：2010-12-06 00:00:00
abstract：BACKGROUND:Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many parts of the body and the skin ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-324
更新日期：2010-06-23 00:00:00
abstract：BACKGROUND:Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major ro...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-4
更新日期：2013-01-03 00:00:00
abstract：BACKGROUND:The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic disease who might benefit from adjuvant therapies. The aim was to examine if cellular immune markers...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3577-x
更新日期：2017-08-29 00:00:00
abstract：BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-807
更新日期：2014-11-04 00:00:00
abstract：BACKGROUND:Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with similar HER2 status, given similar treatments, suggests that the effects of amplification of HER2 can ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-297
更新日期：2008-10-14 00:00:00
abstract：BACKGROUND:In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer development in Tunisia. We have also tried to evaluate whether these variants affect the bladder tumor...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-11-101
更新日期：2011-03-22 00:00:00
abstract：BACKGROUND:The main objective of this study was to evaluate the safety of second-line pemetrexed in Stage IIIB or IV NSCLC. METHODS:Overall, 95 patients received pemetrexed 500 mg/m2 i.v. over Day 1 of a 21-day cycle. Patients also received oral dexamethasone, oral folic acid and i.m. vitamin B12 supplementation to re...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-216
更新日期：2008-07-31 00:00:00
abstract：BACKGROUND:RhoC is a small G protein/GTPase and involved in tumor mobility, invasion and metastasis. Previously, up-regulated RhoC expression is found to play an important role in ovarian carcinogenesis and subsequent progression by modulating proliferation, apoptosis, migration and invasion. METHODS:We transfected Rh...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-477
更新日期：2014-07-01 00:00:00
abstract：:Autologous stem cell transplantation (ASCT) is a well-established approach to treatment of patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) recommended by both the European Society for Medical Oncology and the National Comprehensive Cancer Network based on the results from randomized controlled studies. H...
journal_title：BMC cancer
pub_type： 杂志文章,评审
doi：10.1186/s12885-020-07561-2
更新日期：2020-11-10 00:00:00
abstract：BACKGROUND:Clinical studies implying the sunitinib multi-kinase inhibitor have led to disappointing results for breast cancer care but mostly focused on HER2-negative subtypes. Preclinical researches involving this drug mostly concern Triple Negative Breast Cancer (TNBC) murine models. Here, we explored the therapeutic...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1540-2
更新日期：2015-07-22 00:00:00
abstract：BACKGROUND:The epithelial-mesenchymal transition (EMT) plays a pivotal role in various physiological processes, such as embryonic development, tissue morphogenesis, and wound healing. EMT also plays an important role in cancer invasion, metastasis, and chemoresistance. Additionally, EMT is partially responsible for che...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07615-5
更新日期：2020-11-23 00:00:00
abstract：BACKGROUND:Many patients diagnosed with oesophageal adenocarcinoma (OAC) present with advanced disease and approximately half present with metastatic disease. Patients with localised disease, who are managed with curative intent, frequently undergo neoadjuvant chemoradiotherapy. Unfortunately, ~ 70% of patients have li...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-5996-3
更新日期：2019-08-07 00:00:00
abstract：BACKGROUND:Neuroblastoma are pediatric tumors of the sympathetic nervous system with a poor prognosis. Apoptosis is often deregulated in cancer cells, but only a few defects in apoptotic routes have been identified in neuroblastoma. METHODS:Here we investigated genomic aberrations affecting genes of the intrinsic apop...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-285
更新日期：2012-07-12 00:00:00
abstract：BACKGROUND:Prostate cancer displays different morphologies which, in turn, affect patient outcome. This fact prompted questions about the lineage relationship between differentiated, more treatable prostate adenocarcinoma and poorly differentiated, less treatable non-adenocarcinoma including small cell carcinoma, and t...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-5680-7
更新日期：2019-05-30 00:00:00
abstract：BACKGROUND:Renal cell carcinoma (RCC) is a malignant disease that demonstrates resistance to standard chemotherapeutic agents. Yet Active immunization using genetically modified dendritic cells holds promise for the adjuvant treatment of malignancies to eradicate or control residual disease. Cytokine-induced killer (CI...
journal_title：BMC cancer
pub_type： 临床试验,杂志文章
doi：10.1186/1471-2407-14-251
更新日期：2014-04-10 00:00:00
abstract：BACKGROUND:Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence. The aim of this study was to identify new mechanisms responsible for hypoxia-induced resistance in breast cancer cells. METHODS:MDA-MB-231...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-391
更新日期：2012-09-06 00:00:00
abstract：BACKGROUND:The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. However, the lack of accuracy in identifying HR patients with conventional risk factors (large, deep, ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07207-3
更新日期：2020-07-31 00:00:00
abstract：BACKGROUND:It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-5082-2
更新日期：2018-11-27 00:00:00
abstract：BACKGROUND:To provide estimations of partial and total prevalence of 24 cancer sites in France in 2008. The estimations of partial prevalence were compared with the previous estimations for 2002. METHODS:Nationwide estimations of incidence and survival data from cancer registries were used for partial prevalence. Nati...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1168-2
更新日期：2015-03-19 00:00:00
abstract：BACKGROUND:Liver resection had been regarded as a standard treatment for primary hepatocellular carcinoma (HCC). However, early mortality and recurrence after surgery were still of major concern. RAM (Risk Assessment for early Mortality) scoring system is a newly developed tool for assessing early mortality after hepat...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3748-9
更新日期：2017-11-09 00:00:00
abstract：BACKGROUND:Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical trials. Recently, it became clear that intracellular dsRNA is more effective than extracellular dsR...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-11-110
更新日期：2011-03-28 00:00:00
abstract：BACKGROUND:DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG sites of the 5' untrans...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3595-8
更新日期：2017-08-29 00:00:00
abstract：BACKGROUND:The discovery of a solitary pulmonary nodule (SPN) on a chest imaging exam is of major clinical concern. However, the incidence rates of SPNs in a general population have not been estimated. The objective of this study was to provide incidence estimates of SPNs in a general population in 5 northeastern regio...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-3029-z
更新日期：2017-01-11 00:00:00
abstract：BACKGROUND:Histological phenotype and clinical behaviour of malignant tumours are not only dependent on alterations in the epithelial cell compartment, but are affected by their interaction with inflammatory cells and tumour-associated stroma. Studies in animal models have shown influence of tumour-associated macrophag...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-7-156
更新日期：2007-08-10 00:00:00
abstract：BACKGROUND:Standard therapy for borderline-resectable pancreatic cancer in the UK is surgery with adjuvant chemotherapy, but rates of resection with clear margins are unsatisfactory and overall survival remains poor. Meta-analysis of single-arm studies shows the potential of neo-adjuvant chemo-radiotherapy but the rela...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/s12885-016-2765-4
更新日期：2016-09-13 00:00:00
abstract：BACKGROUND:It has been shown that peroxisome proliferator-activated receptors (PPAR) have physiological and pharmacological ligands. The objective is to assess the association between thiazolidinediones (TZDs) and the occurrence of gastric cancer. METHODS:We conducted a population-based nested case-control study. Data...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-420
更新日期：2013-09-17 00:00:00
