Abstract：
BACKGROUND:It has been shown that peroxisome proliferator-activated receptors (PPAR) have physiological and pharmacological ligands. The objective is to assess the association between thiazolidinediones (TZDs) and the occurrence of gastric cancer. METHODS:We conducted a population-based nested case-control study. Data were retrospectively collected from the National Health Insurance Research Database (NHIRD). The cases consisted of all diabetes mellitus (DM) patients aged 30 to 99 years, and who had a first time diagnosis of gastric cancer in the study cohort. The controls were matched to cases by age, sex, and index date. The adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated by using multiple logistic regression. RESULTS:Records from 357 gastric cancer and 1,428 selected matched controls were included in the analyses of gastric cancer risk. A total of 7% or 9.5% of the cases and 10.8% or 14.8% of the controls had used any quantity of at least 2 prescriptions for pioglitazone or rosiglitazone, respectively. After adjusting for possible confounders, pioglitazone (OR = 0.93, P > 0.05) and rosiglitazone (OR = 1.21, P > 0.05), had no significant association of decreasing gastric cancer. After adjusting for possible confounders, pioglitazone (OR = 0.70, P > 0.05) or rosiglitazone (OR = 0.79, P > 0.05), had no significant trend toward decreasing gastric cancer risk with increasing cumulative doses ≥ 260 defined daily doses (DDDs), respectively. Moreover, adjusting for possible confounders pioglitazone (OR = 0.68, P > 0.05) or rosiglitazone (OR = 0.74, P > 0.05) had no significant trend toward decreasing gastric cancer risk with increasing cumulative doses ≥ 1 year, respectively. CONCLUSIONS:Our results did not show evidence to support that TZD derivatives in DM patients reduces gastric cancer occurrence.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Chang SS,Hu HYdoi
10.1186/1471-2407-13-420subject
Has Abstractpub_date
2013-09-17 00:00:00pages
420issn
1471-2407pii
1471-2407-13-420journal_volume
13pub_type
杂志文章相关文献
BMC CANCER文献大全abstract：BACKGROUND:Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immunoproteomics approach, for the detection of 'tumor-associated antigens (TAAs) that elicit humoral resp...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07676-6
更新日期：2020-12-01 00:00:00
abstract：:Fasting in disease prevention and treatment has recently become a popular topic, particularly in the context of oncology. Unfortunately, the growing attention paid by the media has created a background of speculations and ambiguous messages. The attitude towards the role of fasting in cancer patients should be very ca...
journal_title：BMC cancer
pub_type： 杂志文章,评审
doi：10.1186/s12885-018-4245-5
更新日期：2018-03-27 00:00:00
abstract：BACKGROUND:Aberrant expression and activation of the IGF-IR have been reported in a variety of human cancers and have been associated with resistance to HER targeted therapy. In this study, we investigated the effect of simultaneous targeting of IGF-IR and HER (erbB) family, with NVP-AEW541 and afatinib, on proliferati...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-41
更新日期：2013-01-31 00:00:00
abstract：BACKGROUND:Well-designed clinical trials are of great importance in validating novel treatments and ensuring an evidence-based approach for sarcoma. This study aimed to provide a comprehensive landscape of the characteristics of metastatic or advanced sarcoma clinical trials using the substantial resource of the Clinci...
journal_title：BMC cancer
pub_type： 杂志文章,meta分析
doi：10.1186/s12885-018-5163-2
更新日期：2018-12-13 00:00:00
abstract：BACKGROUND:Merkel cell carcinoma (MCC) is a rare cutaneous neoplasm with increasing incidence, aggressive behavior and poor prognosis. Somatostatin receptors (SSTR) are expressed in MCC and represent a potential target for both imaging and treatment. METHODS:To non-invasively assess SSTR expression in MCC using PET an...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-268
更新日期：2014-04-17 00:00:00
abstract：BACKGROUND:SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. Aberrant expression of SLIT-ROBO genes was repeatedly shown in a wide variety of cancers, yet data about their collective behavior in hepatocellular carcinoma (HCC) is missing. Hence, we qua...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-392
更新日期：2008-12-29 00:00:00
abstract：BACKGROUND:Recent randomized controlled trials comparing neoadjuvant chemoradiation plus surgery or perioperative chemotherapy plus surgery with surgery alone showed significant survival benefits for combined modality treatment of patients with localized esophageal adenocarcinoma. However, head-to-head comparisons of n...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12885-016-2564-y
更新日期：2016-07-19 00:00:00
abstract：BACKGROUND:The literature on sexual orientation disclosure is arguably one of the most developed in the field of lesbian, gay and bisexual (LGB) people in healthcare in English speaking countries however, relatively little research has been conducted into disclosure in cancer care. Studies have been mainly undertaken i...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-5895-7
更新日期：2019-07-10 00:00:00
abstract：BACKGROUND:Less than 1% of all breast cancer cases are found in men, who reportedly have inferior outcomes compared with matched women patients. Ethnic differences may also affect their prognosis. Here, we investigated overall survival (OS) and major prognostic factors for male breast cancer (MBC) in a cohort of Egypti...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-227
更新日期：2014-03-28 00:00:00
abstract：BACKGROUND:Metastasis is the main cause of death for lung cancer patients. The ex vivo 4D acellular lung model has been shown to mimic this metastatic process. However, the main concern is the model's lack of cellular components of the tumor's microenvironment. In this study, we aim to determine if the intact lung micr...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4358-x
更新日期：2018-04-18 00:00:00
abstract：:ABSTRACT: BACKGROUND: The aim of this study was to assess the extent of knowledge of primary health care (PHC) patients about colorectal cancer (CRC), their attitudes toward population-based screening for this disease and gender differences in these respects. METHODS: A questionnaire-based survey of PHC patients in t...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-11-408
更新日期：2011-09-25 00:00:00
abstract：BACKGROUND:Some breast cancer patients receiving anti-angiogenic treatment show increased metastases, possibly as a result of induced hypoxia. The effect of hypoxia on tumor cell migration was assessed in selected luminal, post-EMT and basal-like breast carcinoma cell lines. METHODS:Migration was assessed in luminal (...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-11-158
更新日期：2011-05-02 00:00:00
abstract：BACKGROUND:The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative breast cancer (TNBC). METHODS:A systematic search of the MEDLINE, EMBASE, and Web of Science databas...
journal_title：BMC cancer
pub_type： 杂志文章,meta分析
doi：10.1186/s12885-020-6668-z
更新日期：2020-03-04 00:00:00
abstract：BACKGROUND:Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/F...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-551
更新日期：2014-07-30 00:00:00
abstract：BACKGROUND:Ovarian cancer (OV) is one of the most common malignant tumors of gynecology oncology. The lack of effective early diagnosis methods and treatment strategies result in a low five-year survival rate. Also, immunotherapy plays an important auxiliary role in the treatment of advanced OV patient, so it is of gre...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07695-3
更新日期：2020-12-07 00:00:00
abstract：BACKGROUND:Currently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether a marker of systemic inflammation, the neutrophil-to-lymphocyte ratio (NLR), was predictive of clin...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2089-4
更新日期：2016-02-18 00:00:00
abstract：BACKGROUND:Clinical trials where cancer patients were treated with protease inhibitors have suggested that the serine protease, prostasin, may act as a tumour suppressor. Prostasin is proteolytically activated by the serine protease, matriptase, which has a very high oncogenic potential. Prostasin is inhibited by prote...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-9-201
更新日期：2009-06-25 00:00:00
abstract：BACKGROUND:A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, characterization of a key ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07081-z
更新日期：2020-06-26 00:00:00
abstract：BACKGROUND:Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine tumours (NETs). Herein, we investigate the use of these treatment combinations in clinical practice. METHO...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1512-6
更新日期：2015-07-04 00:00:00
abstract：BACKGROUND:The platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) reflect the systematic inflammatory response, with some evidence revealing that they are associated with poorer survival in patients with gastric cancer. However, the effect of the white blood...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-6213-0
更新日期：2019-11-21 00:00:00
abstract：BACKGROUND:One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-11-77
更新日期：2011-02-17 00:00:00
abstract：BACKGROUND:Currently the majority of cancer patients are considered ineligible for intensive care treatment and oncologists are struggling to get their patients admitted to intensive care units. Critical care and oncology are frequently two separate worlds that communicate rarely and thus do not share novel development...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-612
更新日期：2010-11-08 00:00:00
abstract：BACKGOUND:Oropharyngeal cancer (OPC) associated with human papilloma virus (HPV OPC) shows better treatment outcomes than non-HPV OPC. We investigated the expression of p53, β-tubulin, bcl-2 and ERCC 1, which are well-known biomarkers to predict the chemotherapy response, according to HPV status in OPC patients. METHO...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-824
更新日期：2014-11-07 00:00:00
abstract：BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-365
更新日期：2008-12-11 00:00:00
abstract：BACKGROUND:Molecular targeted therapy has emerged as a promising treatment of Hepatocellular carcinoma (HCC). One potential target is the Src family Kinase (SFK). C-Src, a non-receptor tyrosine kinase is a critical link of multiple signal pathways that regulate proliferation, invasion, survival, metastasis, and angioge...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-267
更新日期：2013-05-30 00:00:00
abstract：BACKGROUND:Mucosal melanomas represent about 1% of all melanoma cases and classically have a worse prognosis than cutaneous melanomas. Due to the rarity of mucosal melanomas, only limited clinical studies with metastatic mucosal melanoma are available. Mucosal melanomas most commonly contain mutations in the gene CKIT,...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-516
更新日期：2014-07-16 00:00:00
abstract：BACKGROUND:Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) constitute a heterogenous group of tumors arising from the neuroendocrine system at diverse anatomic si...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07121-8
更新日期：2020-07-06 00:00:00
abstract：BACKGROUND:Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient. MicroRNAs (miRNAs) play a role in the regulation of the tumor cell response to hypoxia, however, not much is known ab...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-429
更新日期：2014-06-13 00:00:00
abstract：BACKGROUND:Resilience has been linked to psychological adaptation to many challenging life events. The present study aims to explore the level of resilience in oral cancer patients and the key factors associated with resilience, and to evaluate the relationship between resilience and anxiety. METHODS:A multiple center...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/s12885-019-5679-0
更新日期：2019-05-14 00:00:00
abstract：BACKGROUND:FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative role of this cytokine in prostate tumor progression. METHODS:FAM3B expression was analyzed by quantita...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3950-9
更新日期：2018-01-22 00:00:00
