Abstract:
BACKGROUND:Breast cancer is the most common form of malignancy affecting women worldwide. It is also the leading cancer in females in Cyprus, with approximately 400 new cases diagnosed annually. It is well recognized that genetic variation as well as environmental factors modulate breast cancer risk. The main aim of this study was to assess the strength of associations between recognized risk factors and breast cancer among Cypriot women. This is the first epidemiological investigation on risk factors of breast cancer among the Cypriot female population. METHODS:We carried out a case-control study, involving 1,109 breast cancer patients and a group of 1,177 controls who were recruited while participating in the National screening programme for breast cancer. Information on demographic characteristics and potential risk factors were collected from both groups during a standardized interview. Logistic regression analysis was used to assess the strength of the association between each risk factor and breast cancer risk, before and after adjusting for the possible confounding effect of other factors. RESULTS:In multivariable models, family history of breast cancer (OR 1.64, 95% CI 1.23, 2.19) was the strongest predictor of breast cancer risk in the Cypriot population. Late menarche (OR 0.64, 95% CI 0.45, 0.92 among women reaching menarche after the age of 15 vs. before the age of 12) and breastfeeding (OR 0.74, 95% CI 0.59, 0.92) exhibited a strong protective effect. In the case of breastfeeding, the observed effect appeared stronger than the effect of pregnancy alone. Surprisingly, we also observed an inverse association between hormone replacement therapy (HRT) although this may be a product of the retrospective nature of this study. CONCLUSION:Overall the findings of our study corroborate with the results of previous investigations on descriptive epidemiology of risk factors for breast cancer. This investigation provides important background information for designing detailed studies that aim to improve our understanding of the epidemiology of breast cancer in the Cypriot population, including the study of gene-environment interactions. Furthermore, our study provides the first scientific evidence for formulating targeted campaigns for prevention and early diagnosis of breast cancer in Cyprus.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Hadjisavvas A,Loizidou MA,Middleton N,Michael T,Papachristoforou R,Kakouri E,Daniel M,Papadopoulos P,Malas S,Marcou Y,Kyriacou Kdoi
10.1186/1471-2407-10-447subject
Has Abstractpub_date
2010-08-23 00:00:00pages
447issn
1471-2407pii
1471-2407-10-447journal_volume
10pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION:In 1987 a caucasian man, then 38 years ol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-2-34
更新日期:2002-12-03 00:00:00
abstract:BACKGROUND:The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation. Recently, a study has demonstrated that the presence or absence of all isomiRs could efficiently discriminate amongst 32 TCGA cancer t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5340-y
更新日期:2019-02-07 00:00:00
abstract:BACKGROUND:In Spain, cervical cancer prevention is based on opportunistic screening, due to the disease's traditionally low incidence and mortality rates. Changes in sexual behaviour, tourism and migration have, however, modified the probability of exposure to human papilloma virus among Spaniards. This study thus soug...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1306-x
更新日期:2015-04-15 00:00:00
abstract:BACKGROUND:Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. METHODS:To investigate the effects and mechanisms of genistein on EMT of colon cancer ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3829-9
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:Patients with metastatic renal carcinoma frequently have pre-existing renal impairment and not infrequently develop worsening renal function as a complication of their treatment. The presence of pancreatic metastases in patients with metastatic renal carcinoma, often confers a more favourable prognosis and a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6215-y
更新日期:2019-10-17 00:00:00
abstract:BACKGROUND:Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumor cells. We investigated whether these MTHFR SNPs were associated with breast cancer survival in African-A...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-257
更新日期:2006-10-27 00:00:00
abstract:BACKGROUND:Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage. Thus, the concomitant use of novel compounds represents a critical strategy to improve t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2957-y
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:The main objective of this study was to evaluate the safety of second-line pemetrexed in Stage IIIB or IV NSCLC. METHODS:Overall, 95 patients received pemetrexed 500 mg/m2 i.v. over Day 1 of a 21-day cycle. Patients also received oral dexamethasone, oral folic acid and i.m. vitamin B12 supplementation to re...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-216
更新日期:2008-07-31 00:00:00
abstract:BACKGROUND:The human pancreatic cancer cell line A818-6 can be grown in vitro either as a highly malignant, undifferentiated monolayer (ML) or as three-dimensional (3D) single layer hollow spheres (HS) simulating a benign, highly differentiated, duct-like pancreatic epithelial structure. This characteristic allowing A8...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06773-w
更新日期:2020-03-30 00:00:00
abstract:BACKGROUND:The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expressed in the kidneys, little is known about their influence on human renal cancer. METHODS:To clarify...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-509
更新日期:2013-10-30 00:00:00
abstract:BACKGROUND:Alcohol consumption is associated with higher breast cancer risk. While studies suggest a modest association between alcohol intake and mammographic density, few studies have examined the association in racial/ethnic minority populations. METHODS:We assessed dense breast area and total breast area from digi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1094-3
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an additional risk factor for cancer development and the SPCs appearing beyond 5 years after radiotherapy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06960-9
更新日期:2020-05-20 00:00:00
abstract:BACKGROUND:Myxoid liposarcoma (MLS) has the tendency to metastasize extrapulmonary. Although prognostic factors at the initial diagnosis of MLS have been reported, those at diagnosis of metastasis remain unclear. The purpose of this study was to investigate the prognostic factors for disease-specific survival at the in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07384-1
更新日期:2020-09-14 00:00:00
abstract::After publication of the original article [1] the authors found that the article contained an incorrect version of Fig. 4. This does not affect the results and conclusions of the article. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-017-3766-7
更新日期:2018-01-16 00:00:00
abstract:BACKGROUND:It is often difficult to diagnose inflammatory bowel disease (IBD)-associated neoplasia endoscopically due to background inflammation. In addition, due to the absence of sensitive tumor biomarkers, countermeasures against IBD-associated neoplasia are crucial. The purpose of this study is to develop a new dia...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07699-z
更新日期:2020-12-03 00:00:00
abstract:BACKGROUND:Gene-gene and gene-environment interactions involved in the metabolism of carcinogens may increase the risk of cancer. Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC). METHODS:...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-115
更新日期:2007-06-30 00:00:00
abstract:BACKGROUND:For most patients, pancreatic adenocarcinoma responds poorly to treatment, and novel therapeutic approaches are needed. Standard-of-care paclitaxel (PTX), combined with birinapant (BRP), a bivalent mimetic of the apoptosis antagonist SMAC (second mitochondria-derived activator of caspases), exerts synergisti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07398-9
更新日期:2020-10-23 00:00:00
abstract:BACKGROUND:Associations between polycyclic aromatic hydrocarbons (PAHs) and colorectal cancer have been reported previously but few studies have characterized PAH exposure using biological measurements. We evaluated colorectal cancer risk in relation to urinary concentration of 1-hydroxypyrene glucuronide (1-OHPG), a p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-282
更新日期:2013-06-11 00:00:00
abstract:BACKGROUND:Oesophageal squamous cell carcinoma (OSCC) is a major health burden in Sub-Saharan Africa, and novel chemotherapies are urgently required to combat this disease. The heat shock protein 90 (HSP90) inhibitor 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) has previously been proposed as a possible candidate ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-334
更新日期:2014-05-15 00:00:00
abstract:BACKGROUND:Sentinel lymph node (SLN) biopsy is an effective tool for axillary staging in patients with invasive breast cancer. This procedure has been recently proposed as part of the treatment for patients with ductal carcinoma in situ (DCIS), because cases of undetected invasive foci and nodal metastases occasionally...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-28
更新日期:2005-03-11 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of decitabine (DAC) in the European Union (EU) in 2012 for the treatment of patients with AML ≥65 years marks the potential for hypomethylating agents in elderly AML. Nevertheless the situation ...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-015-1432-5
更新日期:2015-05-26 00:00:00
abstract:BACKGROUND:Neoadjuvant systemic therapy (NST) is increasingly used in the treatment of breast cancer, yet it is clear that there is significant geographical variation in its use in the UK. This study aimed to examine stated practice across UK breast units, in terms of indications for use, radiological monitoring, patho...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07757-6
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND:Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line chemotherapy is demonstrated to be effective. Thus, there is an urgent need to identify new alterna...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-918
更新日期:2014-12-05 00:00:00
abstract:BACKGROUND:Currently the majority of cancer patients are considered ineligible for intensive care treatment and oncologists are struggling to get their patients admitted to intensive care units. Critical care and oncology are frequently two separate worlds that communicate rarely and thus do not share novel development...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-612
更新日期:2010-11-08 00:00:00
abstract:BACKGROUND:Pembrolizumab is effective as first-line therapy against advanced non-small cell lung cancer (NSCLC) in patients with programmed death ligand-1 (PD-L1) expression levels ≥50% [1]. However, it is not effective in all patients, and the factors predicting responses among this population remain unknown. METHODS...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-020-6582-4
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:Accumulation of tumor-infiltrating mast cells (MCs) predicts poor survival in several cancers after resection. However, its effect on the prognosis of patients with colorectal liver metastases (CRLM) is not known. METHODS:Our retrospective study included 135 patients who underwent potentially curative resec...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1863-z
更新日期:2015-11-04 00:00:00
abstract:BACKGROUND:Methylentetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism and consequently could be an important factor for the efficacy of a treatment with 5-fluorouracil. Our aim was to evaluate the prognostic and predictive value of two well characterized constitutional MTHFR gene polymorphisms f...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-58
更新日期:2014-02-03 00:00:00
abstract:BACKGROUND:The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC). METHODS:Between 2002 and 2007, a population-based case-contro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-344
更新日期:2012-08-08 00:00:00
abstract:BACKGROUND:Patients with BRAF mutation-positive advanced melanoma respond well to matched therapy with BRAF or MEK inhibitors, but often quickly develop resistance. METHODS:Tumor tissue from ten patients with advanced BRAF mutation-positive melanoma who achieved partial response (PR) or complete response (CR) on BRAF ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1029-z
更新日期:2015-02-18 00:00:00
abstract:BACKGROUND:FMS-like tyrosine kinase 3 (FLT3) is a commonly mutated protein in a variety of human acute leukemias. Mutations leading to constitutively active FLT3, including internal tandem duplications of the juxtamembrane domain (ITD), result in continuous cellular proliferation, resistance to apoptotic cell death, an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-38
更新日期:2011-01-27 00:00:00