Abstract:
BACKGROUND:Although this effect is well known, tailored treatment methods have not yet been broadly adopted. The aim of this study was to identify those patient characteristics that most influence the impairment of quality of life and thus to identify those patients who need and can benefit most from specific intervention treatment. METHODS:1879 cancer patients were given the EORTC QLQ C-30 questionnaire at the beginning and end of their inpatient rehabilitation. Patients' scores were compared to those of 2081 healthy adults (Schwarz and Hinz, Eur J Cancer 37:1345-1351, 2001). Furthermore, differences in quality of life corresponding to sex, age, tumor site, TNM stage, interval between diagnosis and rehabilitation, and therapy method were examined. RESULTS:Compared to the healthy population, the study group showed a decreased quality of life in all analyzed domains. This difference diminished with increasing age. Women reported a lower quality of life then men in general. Patients with prostate cancer showed the least impairment in several domains. Patients having undergone chemotherapy as well as radiotherapy were impaired the most. Surprisingly, TNM stage and interval between diagnosis and rehabilitation did not significantly influence quality of life. Global quality of life and all functional domains significantly improved after a 3-week rehabilitation program. CONCLUSIONS:Despite an individualized and increasingly better tolerable therapy, the quality of life of cancer patients is still considerably impaired. However, systematic screening of psychosocial aspects of cancer, e.g. quality of life, could enable improved intervention.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Peters E,Mendoza Schulz L,Reuss-Borst Mdoi
10.1186/s12885-016-2822-zsubject
Has Abstractpub_date
2016-10-10 00:00:00pages
787issue
1issn
1471-2407pii
10.1186/s12885-016-2822-zjournal_volume
16pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclea...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07107-6
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumor cells. We investigated whether these MTHFR SNPs were associated with breast cancer survival in African-A...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-257
更新日期:2006-10-27 00:00:00
abstract:BACKGROUND:Aboriginal status has been unreliably and incompletely recorded in health and vital registration data collections for the most populous areas of Australia, including NSW where 29% of Australian Aboriginal people reside. This paper reports an assessment of Aboriginal status recording in NSW cancer registratio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-168
更新日期:2012-05-06 00:00:00
abstract:BACKGROUND:Several studies have reported the role of CYP2A6 genetic polymorphisms in smoking and lung cancer risk with some contradictory results in different populations. The purpose of the current study is to assess the contribution of the CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 gene polymorphisms and tobacco smok...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4342-5
更新日期:2018-05-03 00:00:00
abstract:BACKGROUND:Aquaporins (AQPs) have been recognized to promote tumor progression, invasion, and metastasis and are therefore recognized as promising targets for novel anti-cancer therapies. Potentially relevant AQPs in distinct cancer entities can be determined by a comprehensive expression analysis of the 13 human AQPs....
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-161
更新日期:2011-05-06 00:00:00
abstract:BACKGROUND:The purpose of the PROLUCA study is to investigate the efficacy of preoperative and early postoperative rehabilitation in a non-hospital setting in patients with operable lung cancer with special focus on exercise. METHODS:Using a 2 x 2 factorial design with continuous effect endpoint (Maximal Oxygen Uptake...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-14-404
更新日期:2014-06-04 00:00:00
abstract:BACKGROUND:Cholangiocarcinoma (CC) is a primary liver cancer with increasing incidence worldwide. Despite all efforts made in past years, prognosis remains to be poor. At least in part, this might be explained by a pronounced resistance of CC cells to undergo apoptosis. Thus, new therapeutic strategies are imperatively...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-466
更新日期:2012-10-11 00:00:00
abstract:BACKGROUND:Cytokines are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play key role in tumor dissemination and are an independent survival predictor in breast cancer patients. The aim of this study was to assess correlation between CTCs and plasma cytokines in primary breast cancer (PBC) p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2143-2
更新日期:2016-02-19 00:00:00
abstract:BACKGROUND:Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis. The arginine-lowering agent PEGylated arginine deiminase (ADI-PEG 20) has shown efficacy as a monot...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-621
更新日期:2014-08-28 00:00:00
abstract:BACKGROUND:The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements character...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-195
更新日期:2014-03-15 00:00:00
abstract:BACKGROUND:We analyzed the influence of 8 germinal polymorphisms of candidate genes potentially related to EGFR signalling (EGFR, EGF, CCND1) or antibody-directed cell cytotoxicity (FCGR2A and FCGR3A) on outcome of colorectal cancer (CRC) patients receiving cetuximab-based therapy. METHODS:Fifty-eight advanced CRC pat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-496
更新日期:2011-11-25 00:00:00
abstract:BACKGROUND:Tamoxifen has dramatically reduced the recurrence and mortality rate of estrogen receptor positive breast cancer. However, the efficacy of tamoxifen varies between individuals and 40% of patients will have a recurrence despite adjuvant tamoxifen treatment. Factors that predict tamoxifen efficacy would be hel...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-612
更新日期:2013-12-28 00:00:00
abstract:BACKGROUND:This study investigated potential prognostic factors in patients treated with whole-brain irradiation (WBI) alone for brain metastases from relatively radioresistant tumors such as malignant melanoma, renal cell carcinoma, and colorectal cancer. Additionally, a potential benefit from escalating the radiation...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-582
更新日期:2010-10-26 00:00:00
abstract:BACKGROUND:It has been shown that peroxisome proliferator-activated receptors (PPAR) have physiological and pharmacological ligands. The objective is to assess the association between thiazolidinediones (TZDs) and the occurrence of gastric cancer. METHODS:We conducted a population-based nested case-control study. Data...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-420
更新日期:2013-09-17 00:00:00
abstract:BACKGROUND:Reports on childhood cancer survivors estimated cumulative probability of developing secondary neoplasms vary from 3.3% to 25% at 25 years from diagnosis, and the risk of developing another cancer to several times greater than in the general population. METHODS:In our retrospective study, we have used the c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-27
更新日期:2007-02-02 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the perioperative outcomes and prognostic impact of the consecutive steps of imaging, frailty assessment, and diagnostic laparoscopy (DLS) in patients with advanced epithelial ovarian cancer (EOC). METHODS:Patients diagnosed with EOC during 2012-2015 were analyzed retrospectivel...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3476-1
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:Knowledge about the expression and thus a role of enzymes that produce endogenous H2S - cystathionine-β-synthase, cystathionine γ-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controversial. In this study we aimed to determine the expression of these enzymes relatively to the expres...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4508-1
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good candidate for targeted therapy in gastric cancer. Herein, we report our newly synthesized c-Met ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2058-y
更新日期:2016-01-22 00:00:00
abstract:BACKGROUND:SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown. METHODS:We retrieved the expression data of 1168 CRC patients from 3 Gene Expression Omnibus (GEO)...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6484-5
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:HOXA family genes were crucial transcription factors involving cell proliferation and apoptosis. While few studies have focused on HOXA10 in AML. We aimed to investigate the prognostic significance of HOXA10. METHODS:We downloaded datasets from GEO and BeatAML database, to compare HOXA expression level betw...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07088-6
更新日期:2020-06-22 00:00:00
abstract:BACKGROUND:Median OS after surgery in curative intent for non-metastasized pancreas cancer ranges under study conditions from 17.9 months to 23.6 months. Tumor recurrence occurs locally, at distant sites (liver, peritoneum, lungs), or both. Observational and autopsy series report local recurrence rates of up to 87% eve...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-14-411
更新日期:2014-06-07 00:00:00
abstract:BACKGROUND:Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutational signature. METHODS:We systematically analyzed the smoking-related DNA methylation sites reported ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07368-1
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:The International Agency for Research on Cancer classified radon and its decay-products as Group-1-human-carcinogens, and with the current knowledge they are linked specifically to lung cancer. Biokinetic models predict that radon could deliver a carcinogenic dose to breast tissue. Our previous work suggeste...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07184-7
更新日期:2020-07-28 00:00:00
abstract:BACKGROUND:Many studies have combined sorafenib with transcatheter arterial chemoembolization (TACE) to treat patients with advanced hepatocellular carcinoma (HCC), but the results are disputable. Thus, we conducted this meta-analysis to assess the efficacy and safety of the combination treatment in patients with advan...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-017-3707-5
更新日期:2017-11-06 00:00:00
abstract:BACKGROUND:Colorectal cancer is the second most common cause of cancer deaths for both men and women, and the third most common cause of cancer in the U.S. Toxicity of current chemotherapeutic agents for colorectal cancer, and emergence of drug resistance underscore the need to develop new, potentially less toxic alter...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2861-5
更新日期:2016-12-08 00:00:00
abstract:BACKGROUND:Previous study reported that resveratrol has anti-tumor activity. In this study, we investigated the involvement of autophagy in the resveratrol-induced apoptotic death of human U251 glioma cells. METHODS:The growth inhibition of U251 cells induced by resveratrol was assessed with methyl thiazolyl tetrazoli...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-215
更新日期:2009-06-30 00:00:00
abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related death in the world with a five-year survival rate of less than 5%. Not all PDAC are the same, because there exist intra-tumoral heterogeneity between PDAC, which poses a great challenge to personalized treatments for PDAC. ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-4546-8
更新日期:2018-05-29 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate epigenetic status of cyclin A1 in human papillomavirus-associated cervical cancer. Y. Tokumaru et al., Cancer Res 64, 5982-7 (Sep 1, 2004)demonstrated in head and neck squamous-cell cancer an inverse correlation between cyclin A1 promoter hypermethylation and TP53 mutati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-55
更新日期:2006-03-08 00:00:00
abstract:BACKGROUND:Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less well characterised. This study aimed to address key information gaps by conducting a systematic revi...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-14-968
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:Humans are exposed to an array of both harmful and beneficial hormonally active compounds in the environment and through diet. Two such chemicals are Bisphenol A (BPA), a plasticizer, and genistein, a component of soy. Prepubertal exposure to BPA increased mammary carcinogenesis, while genistein suppressed c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-379
更新日期:2014-05-29 00:00:00