Abstract:
BACKGROUND:Tamoxifen has dramatically reduced the recurrence and mortality rate of estrogen receptor positive breast cancer. However, the efficacy of tamoxifen varies between individuals and 40% of patients will have a recurrence despite adjuvant tamoxifen treatment. Factors that predict tamoxifen efficacy would be helpful for optimizing treatment. Serum concentrations of the active metabolite, endoxifen, may be positively related to treatment outcome. In addition, hot flashes are suggested to be positively associated with tamoxifen treatment outcome. METHODS:We investigated in a series of 109 patients whether the frequency and severity of hot flashes were related to concentrations of tamoxifen and its metabolites. A serum sample of all patients was analyzed for the concentration of tamoxifen, N-desmethyltamoxifen, endoxifen and 4-hydroxytamoxifen, as well as for estradiol concentrations and several single nucleotide polymorphisms in CYP2D6. Additionally, these patients completed a questionnaire concerning biometric data and treatment side effects. RESULTS:We found no evidence supporting an association between concentrations of tamoxifen or metabolites and either the frequency or severity of hot flashes in the covariate unadjusted analyses. However, including interactions with menopausal status and pre-treatment hot flash (PTHF) history indicated that post-menopausal women with PTHF experienced an increasing frequency of hot flashes with increasing serum concentrations of tamoxifen and its metabolites. This finding was not altered when adjusting for potential confounding factors (duration of tamoxifen treatment, CYP2D6 phenotype, estradiol serum concentration, age and body mass index). In addition we observed a positive association between body mass index and both hot flash frequency (p = 0.04) and severity (p < 0.0001). We also observed that patients with lower estradiol levels reported more severe hot flashes (p = 0.02). CONCLUSIONS:No univariate associations were observed between concentrations of active tamoxifen metabolites and either the frequency or severity of hot flashes during treatment. However, the frequency of hot flashes may be exacerbated by higher serum concentrations of tamoxifen and its metabolites in post-menopausal women with a history of hot flashes prior to tamoxifen treatment.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Jager NG,Koornstra RH,Vincent AD,van Schaik RH,Huitema AD,Korse TM,Schellens JH,Linn SC,Beijnen JHdoi
10.1186/1471-2407-13-612subject
Has Abstractpub_date
2013-12-28 00:00:00pages
612issn
1471-2407pii
1471-2407-13-612journal_volume
13pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:In general, human papillomavirus (HPV) vaccines have demonstrated efficacy in young women worldwide, but there is limited evidence on the efficacy of the quadrivalent HPV6/11/16/18 vaccine in adult women and no evidence of its effectiveness in Japanese adult women in particular. This study aims to evaluate t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07563-0
更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:Breast cancer incidence varies between social groups, but differences have not been thoroughly examined in New Zealand. The objectives of this study are to determine whether trends in breast cancer incidence varied by ethnicity and socioeconomic position between 1981 and 2004 in New Zealand, and to assess po...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-674
更新日期:2010-12-07 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the efficacy and safety of everolimus in patients with progressive unresectable adenoid cystic carcinoma (ACC). METHODS:Histologically confirmed ACC patients with documented disease progression within 12 months prior to the study entry were eligible. Everolimus was given...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-795
更新日期:2014-11-03 00:00:00
abstract:BACKGROUND:Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4637-6
更新日期:2018-07-09 00:00:00
abstract:BACKGROUND:Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major ro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-4
更新日期:2013-01-03 00:00:00
abstract:BACKGROUND:The aim of the trial was to compare two active adjuvant chemotherapy regimens in patients with early stage colorectal cancer (CRC). METHODS:Patients were assigned to oxaliplatin, leucovorin and 5-FU for 12 cycles (group A, FOLFOX6) or oxaliplatin and capecitabine for eight cycles (group B, CAPOX). Primary e...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-015-1406-7
更新日期:2015-05-10 00:00:00
abstract:BACKGROUND:Humans are exposed to an array of both harmful and beneficial hormonally active compounds in the environment and through diet. Two such chemicals are Bisphenol A (BPA), a plasticizer, and genistein, a component of soy. Prepubertal exposure to BPA increased mammary carcinogenesis, while genistein suppressed c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-379
更新日期:2014-05-29 00:00:00
abstract:BACKGROUND:In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization) in PWA in 10 cities in Togo in 2019. METHODS:This is a cross...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07747-8
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:Colon cancer patients with the same stage show diverse clinical behavior due to tumor heterogeneity. We aimed to discover distinct classes of tumors based on microarray expression patterns, to analyze whether the molecular classification correlated with the histopathological stages or other clinical paramete...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-260
更新日期:2012-06-19 00:00:00
abstract:BACKGROUND:Despite the excellent results obtained with hormone therapy, the long treatment period and the side effects associated with its use make patient adherence difficult. Moreover, certain aspects of health care can mitigate or exacerbate non-adherence. This study aimed to identify the factors associated with adh...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-397
更新日期:2014-06-03 00:00:00
abstract:BACKGROUND:Worldwide cervical cancer is the third most common malignancy in women. It usually arises from the cervical area which is susceptible to Human Papilloma virus induced malignancy changes. In low-resource setting visual inspection with acetic acid (VIA) is an alternative sensitive cervical screening method. Th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07344-9
更新日期:2020-09-07 00:00:00
abstract:BACKGROUND:Early treatment of patients at risk for developing aggressive prostate cancer is able to delay metastasis and reduce mortality; as such, up-front identification of these patients is critical. Several risk classification systems, including CAPRA-S, are currently used for disease prognostication. However, high...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07438-4
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND:Cetuximab combined with chemotherapy is one of the first-line treatments of metastatic colorectal cancer. Although disease progression inevitably occurs, rechallenge and maintenance therapies using cetuximab-based regimens may be beneficial, particularly for patients with wild-type (WT) KRAS. CASE PRESENTAT...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3133-8
更新日期:2017-02-14 00:00:00
abstract:BACKGROUND:High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible for treatment with poly(ADP-ribose) polymerase inhibitors (PARPi). The aim of this study was to ...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-019-5535-2
更新日期:2019-04-02 00:00:00
abstract:BACKGROUND:We evaluated the hierarchical risk groups for the estimated survival of WHO grade III glioma patients using recursive partitioning analysis (RPA). To our knowledge, this is the first study to address the results of RPA specifically for WHO grade III gliomas. METHODS:A total of 133 patients with anaplastic a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-450
更新日期:2009-12-18 00:00:00
abstract:BACKGROUND:Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to endothelial cells. It requires interactions between adhesion receptors on endothelial cells and their counter-receptors on cancer cells. Notably, E-selectin, a major endot...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-285
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Previous studies have suggested that metformin may be useful for preventing and treating endometrial cancer (EC), while the results have been inconsistent. This systematic review and meta-analysis aimed to investigate the association between metformin use and risk and prognosis of patients with EC. METHODS:...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12885-018-4334-5
更新日期:2018-04-18 00:00:00
abstract:BACKGROUND:Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such approach. Here we investigated the concordance between mutations found in the primary tumor and pancre...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5195-7
更新日期:2019-01-05 00:00:00
abstract:BACKGROUND:Gynecologic cancer is one of the most common malignant diseases in working-age women. This study investigated whether several characteristics influence return to work after treatment of gynecologic cancer. METHODS:We investigated the correlations between return to work and several other characteristics in 1...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2627-0
更新日期:2016-07-29 00:00:00
abstract:BACKGROUND:Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the role of mesothelioma stem cells (MSC) in treatment failure and eventually to design specific target...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4354-1
更新日期:2018-04-27 00:00:00
abstract:BACKGROUND:Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is involved in the occurrence and progression of several malignant tumors. However, its potential role in esophageal squamous cell carcinoma (ESCC) is still unknown. METHODS:PRAF2 mRNA expression was determined in 77 frozen ESCC samples by quantitati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5818-7
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:The development of targeted therapies has undoubtedly broadened therapeutic options for patients with colorectal cancer (CRC). The use of bevacizumab to reduce angiogenesis has been associated with improved clinical outcomes. However, an urgent need for prognostic/predictive biomarkers for anti-angiogenic th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1648-4
更新日期:2015-09-22 00:00:00
abstract:BACKGROUND:Overweight and weight gain throughout adult life have been associated with increased risk of breast cancer after the menopause. However the role of body weight at a young age and of the timing of weight gain over the lifetime in postmenopausal breast cancer is not well documented. METHODS:We conducted a pop...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2793-0
更新日期:2016-09-29 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the incidence and prognostic value of disseminated tumor cells in bone marrow of breast carcinoma patients with early disease, and to analyze this finding in relation to lymph node involvement, determined by sentinel lymph node (SLN) biopsy analysis, and to prognostic...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-11-252
更新日期:2011-06-16 00:00:00
abstract:BACKGROUND:F-18- fluorodeoxyglucose Positron emission tomography (18FDG-PET) has been widely used in clinical practice. However, the prognostic value of the pretreatment standardized uptake value (SUV) for patients with gastric cancer remains controversial. METHODS:Major databases were systematically searched. The qua...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-017-3271-z
更新日期:2017-04-17 00:00:00
abstract:BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3762-y
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth. METHODS:Pancreatic carcinomas were assessed in a syngenei...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1047-x
更新日期:2015-02-13 00:00:00
abstract:BACKGROUND:Data on cancers is a challenge in most developing countries. Population-based cancer registries are also not common in developing countries despite the usefulness of such registries in informing cancer prevention and control programmes. The availability of population-based data on cancers in Africa varies ac...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-362
更新日期:2014-05-23 00:00:00
abstract:BACKGROUND:Catumaxomab, the first anti-EpCAM antibody, was approved in 2009 for the treatment of malignant ascites in cancer patients with EpCAM positive tumors. We consider this case of interest as treatment with catumaxomab not only prolonged the puncture-free interval but also showed a systemic effect in a patient w...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-618
更新日期:2013-12-31 00:00:00
abstract:BACKGROUND:Papillary renal cell carcinoma (pRCC) is the 2nd most frequent histological type of kidney cancer and accounts for approximately 15% of all renal cell carcinoma. It has a poorer prognosis than clear cell RCC (ccRCC) with a lack of standard treatments. CASE PRESENTATION:We report the case of a 51 year old ma...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-018-5049-3
更新日期:2018-11-22 00:00:00