Abstract：
BACKGROUND:The aim of this study was to examine the efficacy and safety of everolimus in patients with progressive unresectable adenoid cystic carcinoma (ACC). METHODS:Histologically confirmed ACC patients with documented disease progression within 12 months prior to the study entry were eligible. Everolimus was given at a dose of 10 mg daily until progression or occurrence of unacceptable toxicities. The primary endpoint was a 4-month progression-free survival (PFS). RESULTS:A total of 34 patients were enrolled. The 4-month PFS probability was 65.5% (95% one-sided confidence interval [CI], 47.7 to infinity). Median PFS duration was 11.2 months (95% CI, 3.6 to 15.8). Complete or partial response was not achieved. Twenty-seven (79.4%, 95% CI, 63.2 to 89.6) patients showed stable disease (SD). Tumor shrinkage within SD criteria was observed in 15 patients (44.1%) and SD lasting 6 months was observed in 13 patients (38.2%). Four patients had disease progression. Among the 18 patients with both pre- and post-treatment (at 8 weeks) FDG-PET scans available, 8 patients (44.4%) showed a partial metabolic response, defined as a ≥25% reduction in maximum standardized uptake values (SUVmax). The most common adverse events were stomatitis, anemia, asthenia, and leukopenia. No unexpected everolimus related toxicities were reported. CONCLUSIONS:Everolimus showed promising efficacy and good tolerability in progressive unresectable ACC. TRIAL REGISTRATION:ClinicalTrials.gov identifier, NCT01152840.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Kim DW,Oh DY,Shin SH,Kang JH,Cho BC,Chung JS,Kim H,Park KU,Kwon JH,Han JY,Kim MJ,Bang YJdoi
10.1186/1471-2407-14-795subject
Has Abstractpub_date
2014-11-03 00:00:00pages
795issn
1471-2407pii
1471-2407-14-795journal_volume
14pub_type
杂志文章,多中心研究相关文献
BMC CANCER文献大全abstract：BACKGROUND:Metastatic melanoma is an incurable disease with an average survival of less than one year. Talabostat is a novel dipeptidyl peptidase inhibitor with immunostimulatory properties. METHODS:This phase II, open label, single arm study was conducted to evaluate the safety and efficacy of 75-100 mg/m2 cisplatin ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-9-263
更新日期：2009-07-30 00:00:00
abstract：BACKGROUND:Cell lines constitute a powerful model to study cancer, and here we describe three new epithelial ovarian cancer (EOC) cell lines derived from poorly differentiated serous solid tumors (TOV-1946, and TOV-2223G), as well as the matched ascites for one case (OV-1946). METHODS:In addition to growth parameters,...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-152
更新日期：2008-05-28 00:00:00
abstract：BACKGROUND:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune system. However, the roles and clinical relevance of the collective or individual NADPH oxidase (NO...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-6202-3
更新日期：2019-11-09 00:00:00
abstract：BACKGROUND:During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening with mammography played a role in the decline in mortality. Evaluating the contribution of these int...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-9-98
更新日期：2009-03-30 00:00:00
abstract：BACKGROUND:Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and asymmetric division of ES cells and several nervous system tumor cells. Th...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-108
更新日期：2008-04-18 00:00:00
abstract：BACKGROUND:The use of chemotherapy regimens with moderate or high risk of febrile neutropenia (defined as having a FN incidence of 10% or more) and the respective incidence and clinical management of FN in breast cancer and NHL has not been studied in Belgium. The existence of a medical need for G-CSF primary and secon...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2407-10-642
更新日期：2010-11-23 00:00:00
abstract：BACKGROUND:The development and evaluation of new therapeutic approaches for malignant mesothelioma has been sparse due, in part, to lack of suitable tumor models. METHODS:We established primary mesothelioma cultures from pleural and ascitic fluids of five patients with advanced mesothelioma. Electron microscopy and im...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1362-2
更新日期：2015-05-08 00:00:00
abstract：BACKGROUND:To compare the value of two dynamic contrast-enhanced Magnetic Resonance Images (DCE-MRI) reconstruction approaches, namely golden-angle radial sparse parallel (GRASP) and view-sharing with golden-angle radial profile (VS-GR) reconstruction, and evaluate their values in assessing response to neoadjuvant chem...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-6247-3
更新日期：2019-10-24 00:00:00
abstract：BACKGROUND:Long-term survival in numerous cancers often correlates with specific whole transcriptome profiles or the expression patterns of smaller numbers of transcripts. In some instances, these are better predictors of survival than are standard classification methods such as clinical stage or hormone receptor statu...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-06756-x
更新日期：2020-04-07 00:00:00
abstract：BACKGROUND:Interpretation of comparative health-related quality of life (HRQOL) studies following different prostate cancer treatments is often difficult due to differing patient ages. Furthermore, age-related changes can hardly be discriminated from therapy-related changes. The evaluation of age-and comorbidity-relate...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-9-296
更新日期：2009-08-24 00:00:00
abstract：BACKGROUND:Treatment standard for patients with primary glioblastoma (GBM) is combined radiochemotherapy with temozolomide (TMZ). Radiation is delivered up to a total dose of 60 Gy using photons. Using this treatment regimen, overall survival could be extended significantly however, median overall survival is still onl...
journal_title：BMC cancer
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2407-10-478
更新日期：2010-09-06 00:00:00
abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL), the most common childhood malignancy, is characterized by recurring structural chromosomal alterations and genetic alterations, whose detection is critical in diagnosis, risk stratification and prognostication. However, the genetic mechanisms that give rise to ALL remain p...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-6709-7
更新日期：2020-03-12 00:00:00
abstract：BACKGROUND:We sought to determine the comparative diagnostic performance of standard b-value (800-1000 s/mm2) versus low b-value (400-500 s/mm2) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of renal cell carcinoma (RCC). METHOD:After a systematic review of the available literature, studies w...
journal_title：BMC cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1471-2407-14-843
更新日期：2014-11-18 00:00:00
abstract：BACKGROUND:Plenty of studies have demonstrated the prognostic value of various inflammation-based indexes in cancer. This study was designed to investigate the prognostic value of the C-reactive protein/albumin (CRP/Alb) ratio in esophageal squamous cell carcinoma. METHODS:A retrospective study of 423 cases with newly...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1379-6
更新日期：2015-05-02 00:00:00
abstract：BACKGROUND:Fast-track colonoscopy to detect patients with colorectal cancer based on high-risk symptoms is associated with low sensitivity and specificity. The aim was to derive a predictive score of advanced colonic neoplasia in symptomatic patients in fast-track programs. METHODS:All patients referred for fast-track...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/s12885-019-5926-4
更新日期：2019-07-25 00:00:00
abstract：BACKGROUND:Isothiocyanates are natural compounds found in consumable cruciferous vegetables. They have been shown to inhibit chemical carcinogenesis by a wide variety of chemical carcinogens in animal models. Recent studies have also shown that isothiocyanates have antitumor activity, inhibiting the growth of several t...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-269
更新日期：2010-06-09 00:00:00
abstract：BACKGROUND:The role of serine/threonine kinase 33 (STK33) gene in tumorigenesis is still controversial. This study was aimed to investigate whether STK33 had the effect on hypopharyngeal squamous cell carcinoma (HSCC) and relevant genes, as well as the potential relation to ERK1/2 pathway. METHODS:Immunohistochemistry...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1009-3
更新日期：2015-01-21 00:00:00
abstract：BACKGROUND:Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In consequence NO-donors could be of special interest for the treatment of deregulated androgen receptor(AR)-signaling...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-130
更新日期：2012-03-30 00:00:00
abstract：BACKGROUND:Early life social environment may influence breast cancer through shaping risk factors operating in early life, adolescence and adulthood, or may be associated with breast cancer risk independent of known risk factors. We investigated the associations between early life socioeconomic status (SES) and mammogr...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-3010-x
更新日期：2017-01-10 00:00:00
abstract：BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-6-164
更新日期：2006-06-23 00:00:00
abstract：BACKGROUND:Cyclooxygenases (COX) play a key role in prostaglandin metabolism and are important for tumor development and progression. The aim of this study was to analyze the prognostic impact of COX-2 expression in a cohort of lymph node-negative breast cancer patients not treated in the adjuvant setting. METHODS:COX...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-952
更新日期：2014-12-15 00:00:00
abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells, and its expression has been correlated with increased tumour angiogenesis. Although numerous publications dealing with the measurement of circulating VEGF for diagnostic and therapeutic monitoring have been published, the re...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-5-128
更新日期：2005-10-04 00:00:00
abstract：BACKGROUND:CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 plays its enzymatic function by catalyzing the hydrolysis of AMP into adenosine and phosphate. In addition to this, accumulating data have shown that CD73 is a key regulatory molecule involved in cancer growth and metastasi...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3128-5
更新日期：2017-02-15 00:00:00
abstract：BACKGROUND:Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association between pre-operative plasma metabolites and risk of biochemical-, local- and metastatic-recurrence,...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-6418-2
更新日期：2019-12-16 00:00:00
abstract：BACKGROUND:The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle. We have previously demonstrated using RNA interference that cells lacking VHR arrest in the G1 and G2 phases...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-147
更新日期：2008-05-27 00:00:00
abstract：BACKGROUND:Brain tumor vasculature can be significantly compromised and leakier than that of normal brain blood vessels. Little is known if there are vascular permeability alterations in the brain adjacent to tumor (BAT). Changes in BAT permeability may also lead to increased drug permeation in the BAT, which may exert...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-5115-x
更新日期：2018-12-07 00:00:00
abstract：BACKGROUND:Several GI peptides linked to intestinal barrier function could be involved in the modification of intestinal permeability and the onset of diarrhea during adjuvant chemotherapy. The aim of the study was to evaluate the circulating levels of zonulin, glucagon-like peptide-2 (GLP-2), epidermal growth factor (...
journal_title：BMC cancer
pub_type： 临床试验,杂志文章
doi：10.1186/1471-2407-13-56
更新日期：2013-02-04 00:00:00
abstract：BACKGROUND:The centralisation of specialist cancer surgical services across London Cancer and Greater Manchester Cancer, England, may significantly change how patients experience care. These centres are changing specialist surgical pathways for several cancers including prostate, bladder, kidney, and oesophago-gastric ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4137-8
更新日期：2018-02-27 00:00:00
abstract：BACKGROUND:Pancreatic cancer is the fourth-leading cause of cancer deaths in the United States. The silent nature of the disease and its poor prognosis, the need for further research, along with the need to assess the outcomes of current approaches necessitate an ongoing evaluation of the epidemiology and mortality-tre...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4610-4
更新日期：2018-06-25 00:00:00
abstract：BACKGROUND:Genetics-based basket trials have emerged to test targeted therapeutics across multiple cancer types. However, while vemurafenib is FDA-approved for BRAF-V600E melanomas, the non-melanoma basket trial was unsuccessful, suggesting mutation status is insufficient to predict response. We hypothesized that prote...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-6175-2
更新日期：2019-10-31 00:00:00
