Ethnic and socioeconomic trends in breast cancer incidence in New Zealand.

abstract：BACKGROUND:KAI1 was initially identified as a metastasis-suppressor gene in prostate cancer. It is a member of the tetraspan transmembrane superfamily (TM4SF) of membrane glycoproteins. As part of a tetraspanin-enriched microdomain (TEM), KAI1 inhibits tumor metastasis by negative regulation of Src. However, the underl...

journal_title：BMC cancer

authors： Park JJ,Jin YB,Lee YJ,Lee JS,Lee YS,Ko YG,Lee M

更新日期：2012-03-06 00:00:00

abstract：BACKGROUND:Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nu...

journal_title：BMC cancer

authors： Sáenz-López P,Carretero R,Cózar JM,Romero JM,Canton J,Vilchez JR,Tallada M,Garrido F,Ruiz-Cabello F

更新日期：2008-12-19 00:00:00

abstract：BACKGROUND:Less than 20% of familial breast cancer patients who undergo genetic testing for BRCA1 and BRCA2 carry a pathogenic mutation in one of these two genes. The GENESIS (GENE SISter) study was designed to identify new breast cancer susceptibility genes in women attending cancer genetics clinics and with no BRCA1/...

journal_title：BMC cancer

authors： Sinilnikova OM,Dondon MG,Eon-Marchais S,Damiola F,Barjhoux L,Marcou M,Verny-Pierre C,Sornin V,Toulemonde L,Beauvallet J,Le Gal D,Mebirouk N,Belotti M,Caron O,Gauthier-Villars M,Coupier I,Buecher B,Lortholary A,Dugast

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:Prostate tumours are commonly poorly oxygenated which is associated with tumour progression and development of resistance to chemotherapeutic drugs and radiotherapy. Fibroblast growth factor 8b (FGF8b) is a mitogenic and angiogenic factor, which is expressed at an increased level in human prostate tumours an...

journal_title：BMC cancer

authors： Tuomela J,Grönroos TJ,Valta MP,Sandholm J,Schrey A,Seppänen J,Marjamäki P,Forsback S,Kinnunen I,Solin O,Minn H,Härkönen PL

更新日期：2010-10-30 00:00:00

abstract：BACKGROUND:It has been shown that peroxisome proliferator-activated receptors (PPAR) have physiological and pharmacological ligands. The objective is to assess the association between thiazolidinediones (TZDs) and the occurrence of gastric cancer. METHODS:We conducted a population-based nested case-control study. Data...

journal_title：BMC cancer

authors： Chang SS,Hu HY

更新日期：2013-09-17 00:00:00

abstract：BACKGROUND:Uridine 5'-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT2B15, UGT2B17, and UGT2B28 enzymes has not been evaluated in prostate...

journal_title：BMC cancer

authors： Grant DJ,Chen Z,Howard LE,Wiggins E,De Hoedt A,Vidal AC,Carney ST,Squires J,Magyar CE,Huang J,Freedland SJ

更新日期：2017-07-03 00:00:00

abstract：BACKGROUND:FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative role of this cytokine in prostate tumor progression. METHODS:FAM3B expression was analyzed by quantita...

journal_title：BMC cancer

authors： Maciel-Silva P,Caldeira I,de Assis Santos I,Carreira ACO,Siqueira FR,Antonioli E,Goldberg AC,Belizário JE,Garay-Malpartida HM

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous ...

journal_title：BMC cancer

authors： Glockzin G,Gerken M,Lang SA,Klinkhammer-Schalke M,Piso P,Schlitt HJ

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:The discovery of a solitary pulmonary nodule (SPN) on a chest imaging exam is of major clinical concern. However, the incidence rates of SPNs in a general population have not been estimated. The objective of this study was to provide incidence estimates of SPNs in a general population in 5 northeastern regio...

journal_title：BMC cancer

authors： Marrer É,Jolly D,Arveux P,Lejeune C,Woronoff-Lemsi MC,Jégu J,Guillemin F,Velten M

更新日期：2017-01-11 00:00:00

abstract：BACKGROUND:High-dose (HD) chemotherapy followed by autologous blood stem-cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) patients. However, the collection of sufficient peripheral blood stem cell (PBSC) grafts can be challenging, and the question arises whether reinfusion of low-dose gra...

journal_title：BMC cancer

authors： Sauer S,Pavel P,Schmitt A,Cremer M,Kriegsmann M,Bruckner T,Jordan K,Wuchter P,Müller-Tidow C,Kriegsmann K

更新日期：2020-04-25 00:00:00

abstract：BACKGROUND:Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification. METHODS:Three hundred twenty-nine EAC cases were available in Tissue Microarrays (TMA) format. A discovery cohort of 166 EAC cases ...

journal_title：BMC cancer

authors： Humphries MP,Craig SG,Kacprzyk R,Fisher NC,Bingham V,McQuaid S,Murray GI,McManus D,Turkington RC,James J,Salto-Tellez M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangemen...

journal_title：BMC cancer

authors： Wang L,Sun Y,Sun Y,Meng L,Xu X

更新日期：2018-04-23 00:00:00

abstract：BACKGROUND:Cervical cancer is the 4th highest cause of female reproductive tract malignancies. Multiple loci have been identified as important determinant factors for tumor susceptibility. In this report, we aimed to explore the roles of gene polymorphisms affecting x-ray repair cross complementing 1 (XRCC1), the tumor...

journal_title：BMC cancer

authors： Liu GC,Zhou YF,Su XC,Zhang J

更新日期：2019-01-07 00:00:00

abstract：BACKGROUND:F-18- fluorodeoxyglucose Positron emission tomography (18FDG-PET) has been widely used in clinical practice. However, the prognostic value of the pretreatment standardized uptake value (SUV) for patients with gastric cancer remains controversial. METHODS:Major databases were systematically searched. The qua...

journal_title：BMC cancer

authors： Wu Z,Zhao J,Gao P,Song Y,Sun J,Chen X,Ma B,Wang Z

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:Appropriate assessment is essential for the management of chemotherapy-induced peripheral neuropathy (CIPN), an intractable symptom that cannot yet be palliated, which is high on the list of causes of distress for cancer patients. However, objective assessment by medical staff makes it easy to underestimate ...

journal_title：BMC cancer

authors： Kanda K,Fujimoto K,Mochizuki R,Ishida K,Lee B

更新日期：2019-09-10 00:00:00

abstract：BACKGROUND:Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody used in association with chemotherapy in met...

journal_title：BMC cancer

authors： Lereclus E,Tout M,Girault A,Baroukh N,Caulet M,Borg C,Bouché O,Ternant D,Paintaud G,Lecomte T,Raoul W

更新日期：2017-03-27 00:00:00

abstract：BACKGROUND:Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatment of hypercholesterolemia and have been shown to trigger apoptosis in a tumor-specific manner. Rec...

journal_title：BMC cancer

authors： Martirosyan A,Clendening JW,Goard CA,Penn LZ

更新日期：2010-03-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：BMC cancer

authors： Al-Khayal K,Vaali-Mohammed MA,Elwatidy M,Traiki TB,Al-Obeed O,Azam M,Khan Z,Abdulla M,Ahmad R

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer deaths. Radiation therapy (RT), alone or in combination with chemotherapy, is the standard of care for curative intent treatment of patients with locally advanced or inoperable NSCLC. The ability to intens...

journal_title：BMC cancer

authors： Siva S,Callahan J,Kron T,Martin OA,MacManus MP,Ball DL,Hicks RJ,Hofman MS

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) are thought to play important roles in therapy-resistance. In this study, we induced cancer stem-like cells from hepatocellular carcinoma (HCC) cell lines using a unique medium, and examined their potential for resistance to anti-cancer drugs. METHODS:The human HCC cell lines SK-HEP...

journal_title：BMC cancer

authors： Hashimoto N,Tsunedomi R,Yoshimura K,Watanabe Y,Hazama S,Oka M

更新日期：2014-09-27 00:00:00

abstract：BACKGROUND:Breast cancer is the second leading cause of cancer deaths in women in the United States. Although the causes of this disease are incompletely understood, oxidative DNA damage is presumed to play a critical role in breast carcinogenesis. A common oxidatively induced DNA lesion is 8-hydroxyguanine (8-OH-Gua),...

journal_title：BMC cancer

authors： Nyaga SG,Lohani A,Jaruga P,Trzeciak AR,Dizdaroglu M,Evans MK

更新日期：2006-12-27 00:00:00

abstract：BACKGROUND:Perturbing Hsp90 chaperone function targets hypoxia inducible factor (HIF) function in a von Hippel-Lindau (VHL) independent manner, and represents an approach to combat the contribution of HIF to cell renal carcinoma (CCRCC) progression. However, clinical trials with the prototypic Hsp90 inhibitor 17-AAG ha...

journal_title：BMC cancer

authors： Bohonowych JE,Peng S,Gopal U,Hance MW,Wing SB,Argraves KM,Lundgren K,Isaacs JS

更新日期：2011-12-15 00:00:00

abstract：BACKGROUND:Vascular Endothelial Growth Factors (VEGFs) and their receptors (VEGF-Rs) are important regulators for angiogenesis and lymphangiogenesis. VEGFs and VEGF-Rs are not only expressed on endothelial cells but also on various subtypes of solid tumors and leukemias contributing to the growth of the malignant cells...

journal_title：BMC cancer

authors： Quentmeier H,Eberth S,Romani J,Weich HA,Zaborski M,Drexler HG

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:In a phase I study of angiotensin-(1-7) [Ang-(1-7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1-7) induced changes in biomarkers according to cancer type and investigates mechanisms of action engaged in vitro. MET...

journal_title：BMC cancer

authors： Petty WJ,Aklilu M,Varela VA,Lovato J,Savage PD,Miller AA

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expressed in the kidneys, little is known about their influence on human renal cancer. METHODS:To clarify...

journal_title：BMC cancer

authors： Betsunoh H,Fukuda T,Anzai N,Nishihara D,Mizuno T,Yuki H,Masuda A,Yamaguchi Y,Abe H,Yashi M,Fukabori Y,Yoshida K,Kamai T

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:Due to improvements in imaging and radiological techniques as well as the use of chemotherapy, distant metastasis has become the predominant mode of treatment failure in patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Platinum-based systemic chemotherapy has shown survival benefits and is n...

journal_title：BMC cancer

authors： Ke LR,Xia WX,Qiu WZ,Huang XJ,Yang J,Yu YH,Liang H,Liu GY,Ye YF,Xiang YQ,Guo X,Lv X

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:There is limited real-world safety information on palbociclib for treatment of advanced stage HR+/HER2- breast cancer. METHODS:We conducted a cohort study of breast cancer patients initiating palbociclib and fulvestrant from February 2015 to September 2017 using the HealthCore Integrated Research Database (...

journal_title：BMC cancer

authors： Beachler DC,de Luise C,Jamal-Allial A,Yin R,Taylor DH,Suzuki A,Lewis JH,Freston JW,Lanes S

更新日期：2021-01-25 00:00:00

abstract：BACKGROUND:Alterations in the redox balance are involved in the origin, promotion and progression of cancer. Inter-individual differences in the oxidative stress regulation can explain a part of the variability in cancer susceptibility.The aim of this study was to evaluate if polymorphisms in genes codifying for the di...

journal_title：BMC cancer

authors： Rodrigues P,de Marco G,Furriol J,Mansego ML,Pineda-Alonso M,Gonzalez-Neira A,Martin-Escudero JC,Benitez J,Lluch A,Chaves FJ,Eroles P

更新日期：2014-11-21 00:00:00

abstract：BACKGROUND:The majority of patients undergoing hepatectomy for hepatocellular carcinoma (HCC) suffer from underlying liver disease and are exposed to the risk of postoperative ascites, which is favored by an imbalance between portal venous inflow and a diminished hepatic volume. Finding a reversible, non-invasive metho...

journal_title：BMC cancer

authors： Mohkam K,Rayar M,Adam JP,Muscari F,Rode A,Merle P,Pradat P,Bauler S,Delfour I,Chiche L,Ducerf C,Boudjema K,Lesurtel M,Laurent C,Mabrut JY

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma (GB) to anti-angiogenetic treatment with bevacizumab. We hypothesized that circulating VEGF-121 may reduce the amount of bevacizumab available to target ...

journal_title：BMC cancer

authors： Martini M,de Pascalis I,D'Alessandris QG,Fiorentino V,Pierconti F,Marei HE,Ricci-Vitiani L,Pallini R,Larocca LM

更新日期：2018-05-10 00:00:00