Abstract:
BACKGROUND:Although advanced-stage cervical cancer can benefit from current treatments, approximately 30% patients may fail after definitive treatment eventually. Therefore, exploring alternative molecular therapeutic approaches is imperatively needed for this disease. We have recently shown that activation of AMP-activated protein kinase (AMPK), a metabolic sensor, hampers cervical cancer cell growth through blocking the Wnt/β-catenin signaling activity. Here, we report that activated AMPK (p-AMPK) also inhibits cervical cancer cell growth by counteracting FOXM1 function. METHODS:Effect of the activation of AMPK on FOXM1 expression was examined by hypoxia and glucose deprivation, as well as pharmacological AMPK activators such as A23187, AICAR and metformin. RT Q-PCR and Western blot analysis were employed to investigate the activities of AMPK, FOXM1 and AKT/FOXO3a signaling. RESULTS:Consistent with our previous findings, the activation of AMPK by either AMPK activators such as AICAR, A23187, metformin, glucose deprivation or hypoxia significantly inhibited the cervical cancer cell growth. Importantly, we found that activated AMPK activity was concomitantly associated with the reduction of both the mRNA and protein levels of FOXM1. Mechanistically, we showed that activated AMPK was able to reduce AKT mediated phosphorylation of p-FOXO3a (Ser253). Interestingly, activated AMPK could not cause any significant changes in FOXM1 in cervical cancer cells in which endogenous FOXO3a levels were knocked down using siRNAs, suggesting that FOXO3a is involved in the suppression of FOXM1. CONCLUSION:Taken together, our results suggest the activated AMPK impedes cervical cancer cell growth through reducing the expression of FOXM1.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Yung MM,Chan DW,Liu VW,Yao KM,Ngan HYdoi
10.1186/1471-2407-13-327subject
Has Abstractpub_date
2013-07-03 00:00:00pages
327issn
1471-2407pii
1471-2407-13-327journal_volume
13pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Brain-derived neurotrophic factor (BDNF) has been reported to promote tumorigenesis and progression in several human malignancies. The purpose of this study was to explore the function of BDNF in lung squamous cell carcinoma (SCC) and adenocarcinoma (ADC). METHODS:The expression of BDNF was examined in 110 ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2218-0
更新日期:2016-02-29 00:00:00
abstract:BACKGROUND:Although modest improvements in the survival of patients with non-small cell lung cancer (NSCLC) can be achieved with cisplatin-based chemotherapy (CT), its value is disputed in the geriatric setting. In this study, we evaluate the feasibility of vinorelbine/cisplatin CT for elderly NSCLC patients. METHODS:...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-4-69
更新日期:2004-09-29 00:00:00
abstract:BACKGROUND:There are large ethnic differences in cervical cancer survival in New Zealand that are only partly explained by stage at diagnosis. We investigated the association of comorbidity with cervical cancer survival, and whether comorbidity accounted for the previously observed ethnic differences in survival. METH...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-132
更新日期:2011-04-12 00:00:00
abstract:BACKGROUND:No consensus treatment has been reached for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). Hepatic resection (HR) and transarterial chemoembolization (TACE) have been recommended as effective options, but which is better remains unclear. This meta-analysis is to compare the effectiven...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12885-017-3895-z
更新日期:2017-12-28 00:00:00
abstract:BACKGROUND:Breast cancer can impact survivors in many aspects of their life. Scarce information is currently available on the quality of life of cancer survivors in Bahrain. The objective of this study is to describe the quality of life of Bahraini women with breast cancer and its association with their sociodemographi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-212
更新日期:2013-04-28 00:00:00
abstract:BACKGROUND:Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification. METHODS:Three hundred twenty-nine EAC cases were available in Tissue Microarrays (TMA) format. A discovery cohort of 166 EAC cases ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06987-y
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Non-muscle invasive bladder cancer (NMIBC) is usually treated with local therapy including transurethral resection of the bladder tumor and intravesical therapy depending on the stage of the tumor. NMIBC is a rarely a metastatic diseases with lymph node invasion in less of 10%. In the other hand meningeal ca...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3309-2
更新日期:2017-05-11 00:00:00
abstract:BACKGROUND:Methylation of promoter region is the major mechanism affecting gene expression in tumors. Recent methylome studies of brain tumors revealed a list of new epigenetically modified genes. Our aim was to study promoter methylation of newly identified epigenetically silenced genes together with already known epi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-218
更新日期:2012-06-06 00:00:00
abstract:BACKGROUND:Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. However, preclinical experimental data explaining the interaction mechanism(s) are lacking. Our objective is to investig...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-363
更新日期:2013-07-29 00:00:00
abstract:BACKGROUND:As a key gene in the immunosurveillance of cell malignancy, Cytotoxic T-lymphocyte antigen 4 (CTLA-4 is an important negative regulator of T cell activation and proliferation. The CTLA-4 +49G > A polymorphism is one of the most commonly studied polymorphisms in this gene due to its association with cancer ri...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2407-10-522
更新日期:2010-10-04 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC cancer
pub_type: 已发布勘误
doi:10.1186/s12885-020-07245-x
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The application of induction chemotherapy failed to provide a consistent benefit for local control in primary treatment of advanced head and neck (H&N) cancers. The aim of this study was to compare the results of concomitant application of radiochemotherapy for treating locally advanced head-and-neck carcino...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-30
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:The use of computerized systems to support evidence-based practice is commonplace in contemporary medicine. Despite the prolific use of electronic support systems there has been relatively little research on the uptake of web-based systems in the oncology setting. Our objective was to examine the uptake of a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-112
更新日期:2013-03-12 00:00:00
abstract:BACKGROUND:Focal adhesion kinase (FAK) and Src are protein tyrosine kinases that physically and functionally interact to facilitate cancer progression by regulating oncogenic processes such as cell motility, survival, proliferation, invasiveness, and angiogenesis. METHOD:To understand how FAK affects oncogenesis throu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-12
更新日期:2009-01-12 00:00:00
abstract:BACKGROUND:To determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted (DW) MR imaging in patients with breast lesions. METHODS:English and Chinese studies published prior to June 2009 to assess the diagnostic performance of quantitative DWI in patients with breast lesions were revi...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2407-10-693
更新日期:2010-12-29 00:00:00
abstract:BACKGROUND:Metronomic chemotherapy is considered an anti-angiogenic therapy that involves chronic administration of low-dose chemotherapy at regular short intervals. We investigated the optimal metronomic dose of oral vinorelbine when given as monotherapy in patients with metastatic cancer. METHODS:Patients with recur...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-13-263
更新日期:2013-05-29 00:00:00
abstract:BACKGROUND:As inadequate pain communication contributes to difficulties in optimizing outcomes of outpatients, we investigated the effect of reinforced education using WeChat App to the opioid titration treatment of cancer-related pain in the outpatient setting. METHODS:We conducted a prospective study to compare rein...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07270-w
更新日期:2020-09-04 00:00:00
abstract:BACKGROUND:In Australia, associations between geographic remoteness, socioeconomic disadvantage, and colorectal cancer (CRC) survival show that survival rates are lowest among residents of geographically remote regions and those living in disadvantaged areas. At present we know very little about the reasons for these i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-24
更新日期:2010-01-28 00:00:00
abstract:BACKGROUND:The "EMERGE" study, aimed to capture real-life management patterns and outcomes in metastatic breast cancer (MBC) in Greece, also accounting for hormone (HR) and human epidermal growth factor receptor 2 (HER2) status. METHODS:"EMERGE" was a multicenter, retrospective cohort study of adult MBC patients diagn...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-019-5301-5
更新日期:2019-01-18 00:00:00
abstract:BACKGROUND:Worldwide, acute leukemia is the most common type of childhood cancer. It is particularly common in the Hispanic populations residing in the United States, Costa Rica, and Mexico City. The objective of this study was to determine the incidence of acute leukemia in children who were diagnosed and treated in p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-355
更新日期:2011-08-17 00:00:00
abstract:BACKGROUND:Single-cell mRNA profiling of circulating tumour cells may contribute to a better understanding of the biology of these cells and their role in the metastatic process. In addition, such analyses may reveal new knowledge about the mechanisms underlying chemotherapy resistance and tumour progression in patient...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3385-3
更新日期:2017-05-31 00:00:00
abstract:BACKGROUND:Gambogic acid (GA) is a major active ingredient of gamboge, a widely used traditional Chinese medicine that has been reported to be a potent cytotoxic agent against some malignant tumors. Many studies have shown that the NF-kappa B signaling pathway plays an important role in anti-apoptosis and the drug resi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-343
更新日期:2009-09-25 00:00:00
abstract:BACKGROUND:A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, characterization of a key ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07081-z
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:cMyc and p27 are key genes implicated in carcinogenesis. Whether polymorphisms in these genes affect breast cancer risk or prognosis is still unclear. In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and pro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-99
更新日期:2007-06-14 00:00:00
abstract:BACKGROUND:Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigated the BSI in mCRPC and its relationship with prognosis. METHODS:The PubMed, Cochrane, and Embase da...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-020-06739-y
更新日期:2020-03-20 00:00:00
abstract:BACKGROUND:Cyclooxygenases (COX) play a key role in prostaglandin metabolism and are important for tumor development and progression. The aim of this study was to analyze the prognostic impact of COX-2 expression in a cohort of lymph node-negative breast cancer patients not treated in the adjuvant setting. METHODS:COX...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-952
更新日期:2014-12-15 00:00:00
abstract:BACKGROUND:To access the prognostic significance of HER-2 overexpression, the effect of trastuzumab and the cause of death in patients with brain metastases (BM) from breast cancer (BC). METHODS:We analyzed the outcome of 130 patients with BM from BC who received whole-brain radiotherapy (WBRT) (without surgery or rad...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-395
更新日期:2011-09-19 00:00:00
abstract:BACKGROUND:Studies of human polyomavirus (HPyV) infection and lung cancer are limited and those regarding the association of human papillomavirus (HPV) infection and lung cancer have produced inconsistent results. METHODS:We conducted a nested case-control study to assess the association between incident lung cancer o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2381-3
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Despite considerable efforts by scientific research, pancreatic cancer is the fourth leading cause of cancer related mortalities. Sigma-2 receptors, which are overexpressed in several tumors, represent promising targets for triggering selective pancreatic cancer cells death. METHODS:We selected five differe...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-3040-4
更新日期:2017-01-13 00:00:00
abstract:BACKGROUND:We report updated progression-free survival (PFS) and overall survival (OS) data from a trial that compared capecitabine plus oxaliplatin (CapeOX) versus S-1 plus oxaliplatin (SOX) for the first-line treatment of metastatic colorectal cancer. METHODS:This trial was a randomized, two-armed, non-inferiority p...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-14-883
更新日期:2014-11-26 00:00:00