The effect of surgery on the survival status of patients with locally advanced cervical cancer after radiotherapy/chemoradiotherapy: a meta-analysis.

abstract：BACKGROUND:Tumor associated macrophages (TAMs) are alternatively activated macrophages that enhance tumor progression by promoting tumor cell invasion, migration and angiogenesis. TAMs have an anti-inflammatory function resembling M2 macrophages. CD163 is regarded as a highly specific monocyte/macrophage marker for M2 ...

journal_title：BMC cancer

authors： Medrek C,Pontén F,Jirström K,Leandersson K

更新日期：2012-07-23 00:00:00

abstract：BACKGROUND:There are three main therapeutic strategies, namely expectant management (dilation and curettage only), prophylactic chemotherapy and prophylactic total hysterectomy for treating older women with complete hydatidiform mole (CHM). However, the scientific community has so far, not unanimously accepted the abov...

journal_title：BMC cancer

authors： Zhao P,Chen Q,Lu W

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:E2F1 transcription factor plays a vital role in the regulation of diverse cellular processes including cell proliferation, apoptosis, invasion and metastasis. E2F1 overexpression has been demonstrated in small cell lung cancer (SCLC), and extensive metastasis in early phase is the most important feature of S...

journal_title：BMC cancer

authors： Li Z,Guo Y,Jiang H,Zhang T,Jin C,Young CY,Yuan H

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/bevacizumab compared with paclitaxel/bevacizumab. METHODS:This multicenter, randomized phase III trial com...

journal_title：BMC cancer

authors： Rochlitz C,Bigler M,von Moos R,Bernhard J,Matter-Walstra K,Wicki A,Zaman K,Anchisi S,Küng M,Na KJ,Bärtschi D,Borner M,Rordorf T,Rauch D,Müller A,Ruhstaller T,Vetter M,Trojan A,Hasler-Strub U,Cathomas R,Winterhalde

更新日期：2016-10-10 00:00:00

abstract：BACKGROUND:Improving the coordination of cancer care is a priority area for service improvement. However, quality improvement initiatives are hindered by the lack of accurate and reliable measures of this aspect of cancer care. This study was conducted to develop a questionnaire to measures patients' experience of canc...

journal_title：BMC cancer

authors： Young JM,Walsh J,Butow PN,Solomon MJ,Shaw J

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:Brain-derived neurotrophic factor (BDNF) has been reported to promote tumorigenesis and progression in several human malignancies. The purpose of this study was to explore the function of BDNF in lung squamous cell carcinoma (SCC) and adenocarcinoma (ADC). METHODS:The expression of BDNF was examined in 110 ...

journal_title：BMC cancer

authors： Zhang SY,Hui LP,Li CY,Gao J,Cui ZS,Qiu XS

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast cancer-specific mortality in women with breast cancer. Our study will add to the knowledge on whether...

journal_title：BMC cancer

authors： Borch KB,Braaten T,Lund E,Weiderpass E

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve long-term outcome after transplantation. We wanted to prospectively assess feasibility of systemic ant...

journal_title：BMC cancer

authors： Eilard MS,Andersson M,Naredi P,Geronymakis C,Lindnér P,Cahlin C,Bennet W,Rizell M

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:KIAA1199 is a recently identified novel gene that is up-regulated in human cancer with poor survival. Our proteomic study on signaling polarity in chemotactic cells revealed KIAA1199 as a novel protein target that may be involved in cellular chemotaxis and motility. In the present study, we examined the func...

journal_title：BMC cancer

authors： Jami MS,Hou J,Liu M,Varney ML,Hassan H,Dong J,Geng L,Wang J,Yu F,Huang X,Peng H,Fu K,Li Y,Singh RK,Ding SJ

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:Myopericytoma is a rare and usually benign tumor, which is even rarer if it occurs in the liver and stomach space. Previous reports of myopericytoma were mostly related to its pathological manifestations, while imaging reports were rare. Here, we report the computed tomography (CT), computed tomography angio...

journal_title：BMC cancer

authors： Chen Z,Liang W

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:The cost-effectiveness of human papillomavirus (HPV) vaccination in women pre-sexual debut has been demonstrated in many countries. This study aimed to estimate the cost-effectiveness of a 3-dose bivalent HPV vaccination at ages 12 to 55 year in both rural and urban settings in China. METHODS:The Markov coh...

journal_title：BMC cancer

authors： Liu YJ,Zhang Q,Hu SY,Zhao FH

更新日期：2016-02-26 00:00:00

abstract：BACKGROUND:During the last two decades the use of laparoscopic resection and a multimodal approach known as an enhanced recovery programme, have been major changes in colorectal perioperative care. Clinical outcome improves using laparoscopic surgery to resect colorectal cancer but until recently no multicentre trial e...

journal_title：BMC cancer

authors： Kennedy RH,Francis A,Dutton S,Love S,Pearson S,Blazeby JM,Quirke P,Franks PJ,Kerr DJ

更新日期：2012-05-16 00:00:00

abstract：BACKGROUND:Bone mineral density (BMD) and lean mass (LM) may both decrease in breast cancer survivors, thereby increasing risk of falls and fractures. Research is needed to determine whether lean mass (LM) and fat mass (FM) independently relate to BMD in this patient group. METHODS:The Health, Eating, Activity, and Li...

journal_title：BMC cancer

authors： George SM,McTiernan A,Villaseñor A,Alfano CM,Irwin ML,Neuhouser ML,Baumgartner RN,Baumgartner KB,Bernstein L,Smith AW,Ballard-Barbash R

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Chemoresistance is one of the main problems in treatment of cancer. Periostin (PN) is a stromal protein which is mostly secreted from cancer associated fibroblasts in the tumor microenvironment and can promote cancer progression including cell survival, metastasis, and chemoresistance. The main objective of ...

journal_title：BMC cancer

authors： Oo KK,Kamolhan T,Soni A,Thongchot S,Mitrpant C,O-Charoenrat P,Thuwajit C,Thuwajit P

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:Renal cell carcinoma (RCC) is a seventh ranked malignancy with poor prognosis. RCC is lethal at metastatic stage as it does not respond to conventional systemic treatments, and there is an urgent need to find out promising novel biomarkers for effective treatment. The goal of this study was to evaluate the b...

journal_title：BMC cancer

authors： Karim S,Al-Maghrabi JA,Farsi HM,Al-Sayyad AJ,Schulten HJ,Buhmeida A,Mirza Z,Al-Boogmi AA,Ashgan FT,Shabaad MM,NourEldin HF,Al-Ghamdi KB,Abuzenadah A,Chaudhary AG,Al-Qahtani MH

更新日期：2016-09-30 00:00:00

abstract：BACKGROUND:The standard therapy regimen of conventional osteosarcoma includes neoadjuvant chemotherapy followed by surgical resection and postoperative chemotherapy. The percentage of necrotic tissue following induction chemotherapy is assessed by using the Huvos grading system, which classifies patients as "poor respo...

journal_title：BMC cancer

authors： Salas S,Jiguet-Jiglaire C,Campion L,Bartoli C,Frassineti F,Deville JL,Maues De Paula A,Forest F,Jézéquel P,Gentet JC,Bouvier C

更新日期：2014-08-20 00:00:00

abstract：BACKGROUND:C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis. Although information...

journal_title：BMC cancer

authors： Matsushita J,Okamura K,Nakabayashi K,Suzuki T,Horibe Y,Kawai T,Sakurai T,Yamashita S,Higami Y,Ichihara G,Hata K,Nohara K

更新日期：2018-03-22 00:00:00

abstract：INTRODUCTION:A functional polymorphism within MDM2, SNP309 T>G, has been linked to early onset cancer. This study examined clinical associations of breast cancer with SNP309 in a Scottish Caucasian population and investigated additional MDM2 intron 1 polymorphisms. METHODS:Intron 1 of MDM2 was PCR amplified and direct...

journal_title：BMC cancer

authors： Paulin FE,O'Neill M,McGregor G,Cassidy A,Ashfield A,Ali CW,Munro AJ,Baker L,Purdie CA,Lane DP,Thompson AM

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:The etiological factor for intrahepatic cholangiocarcinoma (ICC) is not clear. Although it has been widely accepted that intrahepatic biliary tree stone is associated with increased risk of ICC, the role of extrahepatic biliary tree stone in the incidence of ICC is controversial. In the present study we aim ...

journal_title：BMC cancer

authors： Cai H,Kong WT,Chen CB,Shi GM,Huang C,Shen YH,Sun HC

更新日期：2015-11-02 00:00:00

abstract：BACKGROUND:Mutations activating the α subunit of heterotrimeric Gs protein are associated with a number of highly specific pathological molecular phenotypes. One of the best characterized is the McCune Albright syndrome. The disease presents with an increased incidence of neoplasias in specific tissues. MAIN BODY:A si...

journal_title：BMC cancer

authors： Innamorati G,Wilkie TM,Kantheti HS,Valenti MT,Dalle Carbonare L,Giacomello L,Parenti M,Melisi D,Bassi C

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of any individual gene with traditional predictors of prognosis. METHODS:Patients with T1-T3 primary ...

journal_title：BMC cancer

authors： Mikhitarian K,Martin RH,Ruppel MB,Gillanders WE,Hoda R,Schutte del H,Callahan K,Mitas M,Cole DJ

更新日期：2008-02-20 00:00:00

abstract：BACKGROUND:CST6 promoter is highly methylated in cancer, and its detection can provide important prognostic information in breast cancer patients. The aim of our study was to develop a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation. METHODS:We ...

journal_title：BMC cancer

authors： Dimitrakopoulos L,Vorkas PA,Georgoulias V,Lianidou ES

更新日期：2012-10-22 00:00:00

abstract：BACKGROUND:Signaling pathways that converge on two different transcription factor complexes, NFkappaB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. METHODS:Two cell line models of tamoxifen-resistant ER-positive breast cancer, MCF7/HER2 and B...

journal_title：BMC cancer

authors： Zhou Y,Yau C,Gray JW,Chew K,Dairkee SH,Moore DH,Eppenberger U,Eppenberger-Castori S,Benz CC

更新日期：2007-04-03 00:00:00

abstract：BACKGROUND:Febrile neutropenia (FN) is common in breast cancer patients undergoing chemotherapy. Risk factors for FN have been reported, but risk models that include genetic variability have yet to be described. This study aimed to evaluate the predictive value of patient-related, chemotherapy-related, and genetic risk...

journal_title：BMC cancer

authors： Pfeil AM,Vulsteke C,Paridaens R,Dieudonné AS,Pettengell R,Hatse S,Neven P,Lambrechts D,Szucs TD,Schwenkglenks M,Wildiers H

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Median OS after surgery in curative intent for non-metastasized pancreas cancer ranges under study conditions from 17.9 months to 23.6 months. Tumor recurrence occurs locally, at distant sites (liver, peritoneum, lungs), or both. Observational and autopsy series report local recurrence rates of up to 87% eve...

journal_title：BMC cancer

authors： Tachezy M,Gebauer F,Petersen C,Arnold D,Trepel M,Wegscheider K,Schafhausen P,Bockhorn M,Izbicki JR,Yekebas E

更新日期：2014-06-07 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In order to assess the effectiveness of tailored treatment in regard to the primary tumour the differen...

journal_title：BMC cancer

authors： Mogensen MB,Rossing M,Østrup O,Larsen PN,Heiberg Engel PJ,Jørgensen LN,Hogdall EV,Eriksen J,Ibsen P,Jess P,Grauslund M,Nielsen HJ,Nielsen FC,Vainer B,Osterlind K

更新日期：2018-07-20 00:00:00

abstract：BACKGROUND:Epidemiological studies show that cigarette smoking increase the risk of nasopharyngeal carcinoma (NPC), however, whether other common, potentially adverse household inhalants increase NPC risk remains uncertain. METHODS:We conducted a large case-control study to explore the effects of household inhalants, ...

journal_title：BMC cancer

authors： He YQ,Xue WQ,Shen GP,Tang LL,Zeng YX,Jia WH

更新日期：2015-12-29 00:00:00

abstract：BACKGROUND:Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased cellular proliferation, inhibition of apoptosis, increased invasion and metastasis, and chemoresista...

journal_title：BMC cancer

authors： McEvoy LM,O'Toole SA,Spillane CD,Martin CM,Gallagher MF,Stordal B,Blackshields G,Sheils O,O'Leary JJ

更新日期：2015-07-25 00:00:00

abstract：BACKGROUND:Aprepitant is an FDA-approved medication for chemotherapy-induced nausea and vomiting. It blocks substance P binding to neurokinin-1; substance P has been implicated in itch pathways both as a local and global mediator. CASE PRESENTATIONS:We report a series of four patients, diagnosed with cutaneous T-cell ...

journal_title：BMC cancer

authors： Song JS,Tawa M,Chau NG,Kupper TS,LeBoeuf NR

更新日期：2017-03-16 00:00:00

abstract：BACKGROUND:Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However, the mechanisms involved in lipid modulation of NK cell postoperative anti-tumor function are unkno...

journal_title：BMC cancer

authors： Niavarani SR,Lawson C,Bakos O,Boudaud M,Batenchuk C,Rouleau S,Tai LH

更新日期：2019-08-20 00:00:00