A closed-tube methylation-sensitive high resolution melting assay (MS-HRMA) for the semi-quantitative determination of CST6 promoter methylation in clinical samples.

abstract：BACKGROUND:Pancreas ductal adenocarcinoma (PDAC) has the most dismal prognosis among all human cancers since it is highly resistant to chemotherapy, radiotherapy and immunotherapy. The anticipated consequence of all therapies is induction of tumor apoptosis. The highly resistance nature of PDACs to all therapies sugges...

journal_title：BMC cancer

authors： Lu C,Yang D,Sabbatini ME,Colby AH,Grinstaff MW,Oberlies NH,Pearce C,Liu K

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) are crucially involved in the regulation of multiple stages of cancer progression. Elevated MMP levels have been associated with the development of metastases and poor prognosis in several types of cancer. However, the role of MMPs in osteosarcoma and their prognostic value i...

journal_title：BMC cancer

authors： Kunz P,Sähr H,Lehner B,Fischer C,Seebach E,Fellenberg J

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Metastatic melanoma is an incurable disease with an average survival of less than one year. Talabostat is a novel dipeptidyl peptidase inhibitor with immunostimulatory properties. METHODS:This phase II, open label, single arm study was conducted to evaluate the safety and efficacy of 75-100 mg/m2 cisplatin ...

journal_title：BMC cancer

authors： Eager RM,Cunningham CC,Senzer NN,Stephenson J Jr,Anthony SP,O'Day SJ,Frenette G,Pavlick AC,Jones B,Uprichard M,Nemunaitis J

更新日期：2009-07-30 00:00:00

abstract：BACKGROUND:Sunitinib and pazopanib are extensively used as first-line treatment of metastatic renal cell carcinoma (mRCC). We performed this meta-analysis to assess the anti-tumor effectiveness, toxicity, and total costs of the two drugs among patients with mRCC/advanced RCC (aRCC). MATERIALS AND METHODS:PubMed, Scien...

journal_title：BMC cancer

authors： Deng H,Huang Y,Hong Z,Yuan X,Cao Z,Wei Y,Zhang W

更新日期：2019-05-23 00:00:00

abstract：BACKGROUND:Multidrug resistance (MDR) is a phenomenon that is often associated with decreased intracellular drug accumulation in patient's tumor cells resulting from enhanced drug efflux. It is related to the overexpression of a membrane protein, P-glycoprotein (Pgp-170), thereby reducing drug cytotoxicity. A variety o...

journal_title：BMC cancer

authors： Limtrakul P,Anuchapreeda S,Buddhasukh D

更新日期：2004-04-17 00:00:00

abstract：BACKGROUND:Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior history, who face a life-long risk of reoccurrence. The objective of the current study was to identify ...

journal_title：BMC cancer

authors： Coroiu A,Moran C,Bergeron C,Drapeau M,Wang B,Kezouh A,Ernst J,Batist G,Körner A

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) are currently approved for the treatment of metastatic renal cell carcinoma (mRCC). The cardiotoxic effects of sorafenib and sunitinib may cause hypertension, left ventricular ejection fraction (LVEF) dysfunction and/or congestive heart failure (CHF), and arterial thrombo-em...

journal_title：BMC cancer

authors： Pantaleo MA,Mandrioli A,Saponara M,Nannini M,Erente G,Lolli C,Biasco G

更新日期：2012-06-11 00:00:00

abstract：BACKGROUND:Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine tumours (NETs). Herein, we investigate the use of these treatment combinations in clinical practice. METHO...

journal_title：BMC cancer

authors： Capdevila J,Sevilla I,Alonso V,Antón Aparicio L,Jiménez Fonseca P,Grande E,Reina JJ,Manzano JL,Alonso Lájara JD,Barriuso J,Castellano D,Medina J,López C,Segura Á,Carrera S,Crespo G,Fuster J,Munarriz J,García Alfonso P

更新日期：2015-07-04 00:00:00

abstract：BACKGROUND:Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significanc...

journal_title：BMC cancer

authors： Song Y,Song S,Zhang D,Zhang Y,Chen L,Qian L,Shi M,Zhao H,Jiang Z,Guo N

更新日期：2006-12-28 00:00:00

abstract：BACKGROUND:Pseudomonas fluorescens lectin (PFL) belongs to a recently discovered anti-HIV lectin family and induces anoikis-like cell death of MKN28 gastric cancer cells by causing α2 integrin internalization through recognition of high mannose glycans; however, the detailed anti-cancer mechanism is not fully elucidate...

journal_title：BMC cancer

authors： Sato Y,Kubo T,Morimoto K,Yanagihara K,Seyama T

更新日期：2016-02-06 00:00:00

abstract：BACKGROUND:Mounting evidence demonstrates a causal role for S100 proteins in tumourigenesis and several S100 isoforms have shown utility as biomarkers of several types of cancer. The S100 family is comprised of 21 small isoforms, many of them implicated in important cellular functions such as proliferation, motility an...

journal_title：BMC cancer

authors： Martínez-Aguilar J,Clifton-Bligh R,Molloy MP

更新日期：2015-03-29 00:00:00

abstract：BACKGROUND:In general, human papillomavirus (HPV) vaccines have demonstrated efficacy in young women worldwide, but there is limited evidence on the efficacy of the quadrivalent HPV6/11/16/18 vaccine in adult women and no evidence of its effectiveness in Japanese adult women in particular. This study aims to evaluate t...

journal_title：BMC cancer

authors： Kurokawa T,Yamamoto M,Onuma T,Tsuyoshi H,Shinagawa A,Chino Y,Yoshida Y

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Outpatient autologous stem cell transplantations (ASCTs) in multiple myeloma and lymphoma patients have been shown to reduce the overall costs and improve the quality of life relative to inpatient ASCTs. This systematic review and meta-analysis was performed with the aim of comprehensively comparing the risk...

journal_title：BMC cancer

authors： Owattanapanich W,Suphadirekkul K,Kunacheewa C,Ungprasert P,Prayongratana K

更新日期：2018-11-16 00:00:00

abstract：BACKGROUND:KIAA1199 is a recently identified novel gene that is up-regulated in human cancer with poor survival. Our proteomic study on signaling polarity in chemotactic cells revealed KIAA1199 as a novel protein target that may be involved in cellular chemotaxis and motility. In the present study, we examined the func...

journal_title：BMC cancer

authors： Jami MS,Hou J,Liu M,Varney ML,Hassan H,Dong J,Geng L,Wang J,Yu F,Huang X,Peng H,Fu K,Li Y,Singh RK,Ding SJ

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:Success of cancer prodrugs relying on a foreign gene requires specific delivery of the gene to the cancer, and improvements such as higher level gene transfer and expression. Attaining these objectives will be facilitated in preclinical studies using our newly discovered CNOB-GDEPT, consisting of the produrg...

journal_title：BMC cancer

authors： Wang JH,Endsley AN,Green CE,Matin AC

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Ovarian cancer (OV) is one of the most common malignant tumors of gynecology oncology. The lack of effective early diagnosis methods and treatment strategies result in a low five-year survival rate. Also, immunotherapy plays an important auxiliary role in the treatment of advanced OV patient, so it is of gre...

journal_title：BMC cancer

authors： Yan S,Fang J,Chen Y,Xie Y,Zhang S,Zhu X,Fang F

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Activated pancreatic stellate cells (PaSCs) are the key cellular source of cancer-associated fibroblasts in the pancreatic stroma of patients with pancreatic ductal adenocarcinoma (PDAC), however, the activation mechanism of PaSCs is not yet known. The Notch signaling pathway, components of which are express...

journal_title：BMC cancer

authors： Song H,Zhang Y

更新日期：2018-01-05 00:00:00

abstract：BACKGROUND:The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is mostly based on the personal experience of doctors and lacks specific and clear classification standards. The development of artificial intelligence (AI) provides a new method for BI-RADS categorisation. We analysed the...

journal_title：BMC cancer

authors： Niu S,Huang J,Li J,Liu X,Wang D,Zhang R,Wang Y,Shen H,Qi M,Xiao Y,Guan M,Liu H,Li D,Liu F,Wang X,Xiong Y,Gao S,Wang X,Zhu J

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Bone mineral density (BMD) and lean mass (LM) may both decrease in breast cancer survivors, thereby increasing risk of falls and fractures. Research is needed to determine whether lean mass (LM) and fat mass (FM) independently relate to BMD in this patient group. METHODS:The Health, Eating, Activity, and Li...

journal_title：BMC cancer

authors： George SM,McTiernan A,Villaseñor A,Alfano CM,Irwin ML,Neuhouser ML,Baumgartner RN,Baumgartner KB,Bernstein L,Smith AW,Ballard-Barbash R

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:The role of radiation therapy in addition to chemotherapy has not been well established in non-oligometastatic Stage IV non-small cell lung cancer (NSCLC). We aimed to investigate overall survival (OS) of non-oligometastatic Stage IV NSCLC treated with chemotherapy with concurrent radiation to the primary tu...

journal_title：BMC cancer

authors： Su S,Hu Y,Ouyang W,Ma Z,Li Q,Li H,Wang Y,Wang X,Li T,Li J,Chen M,Lu Y,Bai Y,He Z,Lu B

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Shared decision-making (SDM) is recommended for men facing prostate cancer (PC) screening decisions. We synthesize the evidence on the comparative effectiveness of SDM with usual care. METHODS:We searched academic and grey literature databases, and other sources for primary randomised controlled trials (RCT...

journal_title：BMC cancer

authors： Martínez-González NA,Neuner-Jehle S,Plate A,Rosemann T,Senn O

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary lesion may not match with its...

journal_title：BMC cancer

authors： Zhao J,Hu C,Wang C,Yu W,Guo Y,Shi M,Shui Y,Wei Q

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Radiation-induced parotid damage is one of the most common complications in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy (RT). Intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging has been reported for evaluating irradiated parotid damage. However, the changes of IVIM p...

journal_title：BMC cancer

authors： Zhou N,Chu C,Dou X,Li M,Liu S,Zhu L,Liu B,Guo T,Chen W,He J,Yan J,Zhou Z,Yang X,Liu T

更新日期：2016-11-08 00:00:00

abstract：BACKGROUND:FOXM1 regulates expression of cell cycle related genes that are essential for progression into DNA replication and mitosis. Consistent with its role in proliferation, elevated expression of FOXM1 has been reported in a variety of human tumour entities. FOXM1 is a gene of interest because recently chemical in...

journal_title：BMC cancer

authors： Bektas N,Haaf At,Veeck J,Wild PJ,Lüscher-Firzlaff J,Hartmann A,Knüchel R,Dahl E

更新日期：2008-02-06 00:00:00

abstract：BACKGROUND:According to the very limited cancer registry, incidence and mortality rates for female breast cancer in China are regarded to be increasing especially in the metropolitan areas. Representative data on the breast cancer profile of Chinese women and its time trend over years are relatively rare. The aims of t...

journal_title：BMC cancer

authors： Li J,Zhang BN,Fan JH,Pang Y,Zhang P,Wang SL,Zheng S,Zhang B,Yang HJ,Xie XM,Tang ZH,Li H,Li JY,He JJ,Qiao YL

更新日期：2011-08-22 00:00:00

abstract：BACKGROUND:Less than 20% of Pakistani women with early-onset or familial breast/ovarian cancer harbor germ line mutations in the high-penetrance genes BRCA1, BRCA2 and TP53. Thus, mutations in other genes confer genetic susceptibility to breast cancer, of which CHEK2 is a plausible candidate. CHEK2 encodes a checkpoint...

journal_title：BMC cancer

authors： Rashid MU,Muhammad N,Faisal S,Amin A,Hamann U

更新日期：2013-06-27 00:00:00

abstract：CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...

journal_title：BMC cancer

authors： Wang X,Chen J,Wang J,Yu F,Zhao S,Zhang Y,Tang H,Peng Z

更新日期：2018-01-11 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative morbidity, reduced TME quality or better pathological response. Aim of this study ...

journal_title：BMC cancer

authors： Lichthardt S,Wagner J,Löb S,Matthes N,Kastner C,Anger F,Germer CT,Wiegering A

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...

journal_title：BMC cancer

authors： Lee C,Lee J,Choi SA,Kim SK,Wang KC,Park SH,Kim SH,Lee JY,Phi JH

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:Primary treatment of carcinoma of the oro-/hypopharynx or larynx may consist of combined platinum-containing chemoradiotherapy. In order to improve clinical outcome (i.e. local control/overall survival), combined therapy is intensified by the addition of the EGFR inhibitor cetuximab (Erbitux®). Radiation the...

journal_title：BMC cancer

authors： Habl G,Jensen AD,Potthoff K,Uhl M,Hof H,Hajda J,Simon C,Debus J,Krempien R,Münter MW

更新日期：2010-11-26 00:00:00