Clinical outcomes of HER2-positive metastatic breast cancer patients with brain metastasis treated with lapatinib and capecitabine: an open-label expanded access study in Korea.

abstract：BACKGROUND:There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatocellular carcinoma (HCC). This study aimed to assess the predictive ability of the dNLR-PNI in patien...

journal_title：BMC cancer

authors： Liu C,Li L,Lu WS,Du H,Yan LN,Wen TF,Wei WR,Jiang L,Xu MQ

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:Aprepitant is an FDA-approved medication for chemotherapy-induced nausea and vomiting. It blocks substance P binding to neurokinin-1; substance P has been implicated in itch pathways both as a local and global mediator. CASE PRESENTATIONS:We report a series of four patients, diagnosed with cutaneous T-cell ...

journal_title：BMC cancer

authors： Song JS,Tawa M,Chau NG,Kupper TS,LeBoeuf NR

更新日期：2017-03-16 00:00:00

abstract：BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...

journal_title：BMC cancer

authors： Jameson MB,Gormly K,Espinoza D,Hague W,Asghari G,Jeffery GM,Price TJ,Karapetis CS,Arendse M,Armstrong J,Childs J,Frizelle FA,Ngan S,Stevenson A,Oostendorp M,Ackland SP

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ spe...

journal_title：BMC cancer

authors： Bruin SC,Klijn C,Liefers GJ,Braaf LM,Joosse SA,van Beers EH,Verwaal VJ,Morreau H,Wessels LF,van Velthuysen ML,Tollenaar RA,Van't Veer LJ

更新日期：2010-12-02 00:00:00

abstract：BACKGROUND:SMAD4 is frequently inactivated and associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Abnormal SMAD4 expression also plays an important role in the malignant progression of PDAC. METHODS:We investigated SMAD4 status in PDAC by immunohistochemical methods to explore the relationshi...

journal_title：BMC cancer

authors： Wang Z,Li Y,Zhan S,Zhang L,Zhang S,Tang Q,Li M,Tan Z,Liu S,Xing X

更新日期：2019-11-04 00:00:00

abstract：BACKGROUND:Prostate tumours are commonly poorly oxygenated which is associated with tumour progression and development of resistance to chemotherapeutic drugs and radiotherapy. Fibroblast growth factor 8b (FGF8b) is a mitogenic and angiogenic factor, which is expressed at an increased level in human prostate tumours an...

journal_title：BMC cancer

authors： Tuomela J,Grönroos TJ,Valta MP,Sandholm J,Schrey A,Seppänen J,Marjamäki P,Forsback S,Kinnunen I,Solin O,Minn H,Härkönen PL

更新日期：2010-10-30 00:00:00

abstract：BACKGROUND:Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior of gliomas are still poorly understood. The aim of this study was ...

journal_title：BMC cancer

authors： Lu R,Wu C,Guo L,Liu Y,Mo W,Wang H,Ding J,Wong ET,Yu M

更新日期：2012-12-19 00:00:00

abstract：BACKGROUND:Despite being a mainstay for treating superficial bladder carcinoma and a promising agent for interstitial cystitis, the precise mechanism of Bacillus Calmette-Guerin (BCG) remains poorly understood. It is particularly unclear whether BCG is capable of altering gene expression beyond its well-recognized pro-...

journal_title：BMC cancer

authors： Saban MR,Hellmich HL,Simpson C,Davis CA,Lang ML,Ihnat MA,O'Donnell MA,Wu XR,Saban R

更新日期：2007-11-02 00:00:00

abstract：BACKGROUND:Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer cell resistance to these drugs has not been studied in detail. METHODS:Here, we introduce an analogue...

journal_title：BMC cancer

authors： Olesen UH,Petersen JG,Garten A,Kiess W,Yoshino J,Imai S,Christensen MK,Fristrup P,Thougaard AV,Björkling F,Jensen PB,Nielsen SJ,Sehested M

更新日期：2010-12-12 00:00:00

abstract：BACKGROUND:Currently, clinical studies on the prognosis of prostate cancer (PC) taking aspirin were developing, but the precise mechanism of aspirin on tumor cells was still unclear. In addition, the conclusion that aspirin can improve the prognosis of PC patients continues to be controversial. Therefore, we collected ...

journal_title：BMC cancer

authors： Zhou J,Xia S,Li T,Liu R

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:To investigate the implications of prophylactic intraoperative Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with D2 radical gastrectomy for locally advanced Gastric Cancer (AGC) in a randomized case control study. METHOD:Eighty consecutive patients with locally AGC were randomly separated into 2 groups...

journal_title：BMC cancer

authors： Beeharry MK,Zhu ZL,Liu WT,Yao XX,Yan M,Zhu ZG

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:Despite all benefit provided by established therapies prognosis of gastric cancer remains poor. Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and amplify chemotherapeutic effects. METHODS:This phase I study evaluated dose limiting toxicity (DLT...

journal_title：BMC cancer

authors： Mayr M,Becker K,Schulte N,Belle S,Hofheinz R,Krause A,Schmid RM,Röcken C,Ebert MP

更新日期：2012-12-10 00:00:00

abstract：BACKGROUND:Mutations activating the α subunit of heterotrimeric Gs protein are associated with a number of highly specific pathological molecular phenotypes. One of the best characterized is the McCune Albright syndrome. The disease presents with an increased incidence of neoplasias in specific tissues. MAIN BODY:A si...

journal_title：BMC cancer

authors： Innamorati G,Wilkie TM,Kantheti HS,Valenti MT,Dalle Carbonare L,Giacomello L,Parenti M,Melisi D,Bassi C

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. Several studies have demonstrated discordant HER2 status in the primary and metastatic tumour. However, rates of discordance vary considerably in published report...

journal_title：BMC cancer

authors： Chan A,Morey A,Brown B,Hastrich D,Willsher P,Ingram D

更新日期：2012-11-24 00:00:00

abstract：BACKGROUND:Continued smoking after cancer adversely affects quality of life and survival, but one fifth of cancer survivors still smoke. Despite its demands, cancer presents an opportunity for positive behaviour change. Smoking often occurs in social groups, therefore interventions which target families and individuals...

journal_title：BMC cancer

authors： Wells M,Aitchison P,Harris F,Ozakinci G,Radley A,Bauld L,Entwistle V,Munro A,Haw S,Culbard B,Williams B

更新日期：2017-05-19 00:00:00

abstract：:After publication of the original article [1] the authors found that the article contained an incorrect version of Fig. 4. This does not affect the results and conclusions of the article. ...

journal_title：BMC cancer

authors： Kaveh F,Baumbusch LO,Nebdal D,Børresen-Dale AL,Lingjærde OC,Edvardsen H,Kristensen VN,Solvang HK

更新日期：2018-01-16 00:00:00

abstract：BACKGROUND:The principle of loss of iodine uptake and increased glucose metabolism according to dedifferentiation of thyroid cancer is clinically assessed by imaging. Though these biological properties are widely applied to appropriate iodine therapy, the understanding of the genomic background of this principle is sti...

journal_title：BMC cancer

authors： Suh HY,Choi H,Paeng JC,Cheon GJ,Chung JK,Kang KW

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Few studies compared cancer incidence among migrants both to their host countries and to their population of origin. We aimed to compare cancer incidence of ethnic Germans who migrated from the former Soviet Union to Germany (resettlers) to those living in Russia as well as to the German and the Russian gene...

journal_title：BMC cancer

authors： Jaehn P,Kaucher S,Pikalova LV,Mazeina S,Kajüter H,Becher H,Valkov M,Winkler V

更新日期：2019-09-02 00:00:00

abstract：BACKGROUND:Myopericytoma is a rare and usually benign tumor, which is even rarer if it occurs in the liver and stomach space. Previous reports of myopericytoma were mostly related to its pathological manifestations, while imaging reports were rare. Here, we report the computed tomography (CT), computed tomography angio...

journal_title：BMC cancer

authors： Chen Z,Liang W

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), has been shown to increase the efficacy of endocrine therapies in hormone receptor (HR)-positive metastatic breast cancer. However, because breast cancer is a highly heterogeneous disease, the responses of different patients to everolimus may ...

journal_title：BMC cancer

authors： Yi Z,Ma F,Liu B,Guan X,Li L,Li C,Qian H,Xu B

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Cervical cancer is the most common malignant gynecological cancer, and lymphatic metastasis can occur in the early stage of tumor growth. Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), a marker for lymphatic endothelium, provides powerful tools for studying tumor lymphangiogenesis. The purpose ...

journal_title：BMC cancer

authors： Zhang SQ,Yu H,Zhang LL

更新日期：2009-02-21 00:00:00

abstract：BACKGROUND:Venous thromboembolic events (VTE) are common in cancer patients and associated with higher mortality. In vivo thrombosis and anticoagulation might be involved in tumor growth and progression. We studied the association of warfarin and other anticoagulant use as antithrombotic medication and prostate cancer ...

journal_title：BMC cancer

authors： Kinnunen PTT,Murtola TJ,Talala K,Taari K,Tammela TLJ,Auvinen A

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Fos-related antigen 1 (FRA-1) is an immediate early gene encoding a member of AP-1 family of transcription factors involved in cell proliferation, differentiation, apoptosis, and other biological processes. fra-1 gene overexpression has an important role in the process of cellular transformation, and our pre...

journal_title：BMC cancer

authors： Chiappetta G,Ferraro A,Botti G,Monaco M,Pasquinelli R,Vuttariello E,Arnaldi L,Di Bonito M,D'Aiuto G,Pierantoni GM,Fusco A

更新日期：2007-01-25 00:00:00

abstract：BACKGROUND:Invasion is often found during postoperative pathological examination of cases diagnosed as ductal carcinoma in situ (DCIS) by histological examinations such as core needle biopsy (CNB) or vacuum-assisted biopsy (VAB). A meta-analysis reported that 25.9% of invasive ductal carcinoma (IDC) cases are preoperat...

journal_title：BMC cancer

authors： Takada K,Kashiwagi S,Asano Y,Goto W,Morisaki T,Takahashi K,Fujita H,Takashima T,Tomita S,Hirakawa K,Ohira M

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major ro...

journal_title：BMC cancer

authors： Cegolon L,Salata C,Weiderpass E,Vineis P,Palù G,Mastrangelo G

更新日期：2013-01-03 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) have emerged as promising therapeutic agents in non-small cell lung cancer (NSCLC). However, the duration for which ICIs should be continued remains a clinical problem. METHODS:We examined the efficacy of anti-PD-1/PD-L1 inhibitors after the discontinuation of antibodies ...

journal_title：BMC cancer

authors： Tachihara M,Negoro S,Inoue T,Tamiya M,Akazawa Y,Uenami T,Urata Y,Hattori Y,Hata A,Katakami N,Yokota S

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spectrum of patients with suspected LS in Latin America. METHODS:Eleven LS hereditary cancer registrie...

journal_title：BMC cancer

authors： Rossi BM,Palmero EI,López-Kostner F,Sarroca C,Vaccaro CA,Spirandelli F,Ashton-Prolla P,Rodriguez Y,de Campos Reis Galvão H,Reis RM,Escremim de Paula A,Capochin Romagnolo LG,Alvarez K,Della Valle A,Neffa F,Kalfayan PG,Spir

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Gastric cancer is a considerable burden for worldwide patients. And diffuse gastric cancer is the most insidious subgroup with poor survival. The phenotypic characterization of the diffuse gastric cancer cell line can be useful for gastric cancer researchers. In this article, we aimed to characterize the dif...

journal_title：BMC cancer

authors： Yoon SJ,Park J,Shin Y,Choi Y,Park SW,Kang SG,Son HY,Huh YM

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Plenty of studies have demonstrated the prognostic value of various inflammation-based indexes in cancer. This study was designed to investigate the prognostic value of the C-reactive protein/albumin (CRP/Alb) ratio in esophageal squamous cell carcinoma. METHODS:A retrospective study of 423 cases with newly...

journal_title：BMC cancer

authors： Wei XL,Wang FH,Zhang DS,Qiu MZ,Ren C,Jin Y,Zhou YX,Wang DS,He MM,Bai L,Wang F,Luo HY,Li YH,Xu RH

更新日期：2015-05-02 00:00:00

abstract：BACKGROUND:Male breast cancer (MBC) is rare, accounting for only around 1% of all breast cancers. Most MBCs are hormone-driven. Not only the estrogen receptor (ER), but also other steroid hormone receptors, including the androgen receptor (AR) and progesterone receptor (PgR) are expressed in MBC. AR activation in breas...

journal_title：BMC cancer

authors： Takuwa H,Tsuji W,Shintaku M,Yotsumoto F

更新日期：2018-12-22 00:00:00