Abstract：
BACKGROUND:There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatocellular carcinoma (HCC). This study aimed to assess the predictive ability of the dNLR-PNI in patients with intermediate-to-advanced HCC after transarterial chemoembolization (TACE). METHODS:A total of 761 HCC patients were enrolled in the study. The dNLR-PNI was retrospectively calculated in these patients, as follows: patients with both an elevated dNLR and a decreased PNI, as determined using the cutoffs obtained from receiver operating characteristic curve analysis, were allocated a score of 2, while patients showing one or neither of these alterations were allocated a score of 1 or 0, respectively. RESULTS:During the follow-up period, 562 patients died. Multivariate analysis suggested that elevated total bilirubin, Barcelona Clinic Liver Cancer C stage, repeated TACE, and dNLR-PNI were independently associated with unsatisfactory overall survival. The median survival times of patients with a dNLR-PNI of 0, 1, and 2 were 31.0 (95% confidence interval [CI] 22.5-39.5), 16.0 (95% CI 12.2-19.7) and 6.0 (95% CI 4.8-7.2) months, respectively (P < 0.001). CONCLUSIONS:The dNLR-PNI can predict the survival outcomes of intermediate-to-advanced HCC patients undergoing TACE, and should be further evaluated as a prognostic marker for who are to undergo TACE treatment.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Liu C,Li L,Lu WS,Du H,Yan LN,Wen TF,Wei WR,Jiang L,Xu MQdoi
10.1186/s12885-018-4121-3subject
Has Abstractpub_date
2018-02-21 00:00:00pages
216issue
1issn
1471-2407pii
10.1186/s12885-018-4121-3journal_volume
18pub_type
杂志文章相关文献
BMC CANCER文献大全abstract：BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynaecological cancers as well, since upregulation of SERBP1 was described in ova...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-597
更新日期：2012-12-13 00:00:00
abstract：BACKGROUND:Biannual ultrasound (US)-with or without alpha-fetoprotein (AFP)-is recommended by current guidelines for the surveillance of hepatocellular carcinoma (HCC). However, the inadequate sensitivity of US has been a concern. Magnetic resonance imaging (MRI) is known to have high sensitivity in detecting hepatic m...
journal_title：BMC cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1186/s12885-018-4827-2
更新日期：2018-09-24 00:00:00
abstract：BACKGROUND:Following resection of liver metastases from colorectal cancer, 5-year survivals are reportedly 30 - 39%. It can be assumed that this clinical situation represents systemic disease. Therefore, it is postulated that systemic chemotherapy would improve outcomes, particularly in those whose disease is sensitive...
journal_title：BMC cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1186/1471-2407-4-32
更新日期：2004-07-10 00:00:00
abstract：BACKGROUND:Treatment with recombinant human granulocyte-colony stimulating factor (G-CSF) is accepted standard for prevention of chemotherapy-induced neutropenia. RGB-02 (Gedeon Richter) is a proposed biosimilar to pegylated G-CSF (Neulasta®, Amgen) with sustained release properties. This is a randomized, comparative, ...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12885-019-5329-6
更新日期：2019-02-06 00:00:00
abstract：BACKGROUND:Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immunoproteomics approach, for the detection of 'tumor-associated antigens (TAAs) that elicit humoral resp...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07676-6
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Most currently known breast cancer predisposition genes play a role in DNA repair by homologous recombination. Recent studies conducted on RAD51 paralogs, involved in the same DNA repair pathway, have identified rare germline mutations conferring breast and/or ovarian cancer predisposition in the RAD51C, RAD...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-484
更新日期：2013-10-19 00:00:00
abstract：BACKGROUND:Recent randomized controlled trials comparing neoadjuvant chemoradiation plus surgery or perioperative chemotherapy plus surgery with surgery alone showed significant survival benefits for combined modality treatment of patients with localized esophageal adenocarcinoma. However, head-to-head comparisons of n...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12885-016-2564-y
更新日期：2016-07-19 00:00:00
abstract：BACKGROUND:Chemoresistance is one of the main problems in treatment of cancer. Periostin (PN) is a stromal protein which is mostly secreted from cancer associated fibroblasts in the tumor microenvironment and can promote cancer progression including cell survival, metastasis, and chemoresistance. The main objective of ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07761-w
更新日期：2021-01-14 00:00:00
abstract：BACKGROUND:To compare the survival outcomes and acute toxicities of concurrent chemoradiotherapy (CCRT), induction chemotherapy (IC) plus radiotherapy (RT), and IC plus CCRT in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated using intensity-modulated radiotherapy (IMRT). METHODS:Patients w...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1768-x
更新日期：2015-10-27 00:00:00
abstract：BACKGROUND:Patients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonary complications. This is partly due to one-lung ventilation during thoracotomy. This often accounts for prolonged stay on intensive care units, delayed postoperative reconvalescence...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12885-017-3400-8
更新日期：2017-06-14 00:00:00
abstract：BACKGROUND:Cell migration and invasion are essential processes for metastatic dissemination of cancer cells. Significant progress has been made in developing new therapies against oncogenic signaling to eliminate cancer cells and shrink tumors. However, inherent heterogeneity and treatment-induced adaptation to drugs c...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-6479-2
更新日期：2020-01-02 00:00:00
abstract：BACKGROUND:The enhancer of zeste homolog 2 (EZH2) gene exerts oncogene-like activities and its (over)expression has been linked to several human malignancies. Here, we studied a possible association between EZH2 expression and prognosis in patients with renal cell carcinoma (RCC). METHODS:EZH2 protein expression in RC...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-524
更新日期：2010-10-04 00:00:00
abstract：BACKGROUND:Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and par...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2407-7-136
更新日期：2007-07-25 00:00:00
abstract：BACKGROUND:High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogran...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-6498-z
更新日期：2020-01-10 00:00:00
abstract：BACKGROUND:Clinical studies implying the sunitinib multi-kinase inhibitor have led to disappointing results for breast cancer care but mostly focused on HER2-negative subtypes. Preclinical researches involving this drug mostly concern Triple Negative Breast Cancer (TNBC) murine models. Here, we explored the therapeutic...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1540-2
更新日期：2015-07-22 00:00:00
abstract：BACKGROUND:When individuals stop working due to cancer this represents a loss to society - the loss of productivity. The aim of this analysis was to estimate productivity losses associated with premature mortality from all adult cancers and from the 20 highest mortality adult cancers in Ireland in 2011, and project the...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2854-4
更新日期：2016-10-18 00:00:00
abstract：BACKGROUND:The association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenomatous polyposis coli (APC) gene has been reported to have a "gatekeeper" function in the colonic muc...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-6-71
更新日期：2006-03-17 00:00:00
abstract：BACKGROUND:Sorafenib is an orally active multikinase tyrosine kinase inhibitor (TKI) that targets B-type Raf kinase (BRAF), vascular endothelial growth factor receptors (VEGFR) 1 and 2, and rearranged during transfection (RET), inducing anti-angiogenic and pro-apoptotic actions in a wide range of solid tumors. A side e...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2060-4
更新日期：2016-01-19 00:00:00
abstract：BACKGROUND:To investigate the diagnostic reliability of selective microdochectomy after direct ductoscopic wire marking of suspect lesions in patients with pathological nipple discharge. METHODS:Selective microdochectomy due to pathological discharge was performed in 33 patients with mean age of 51.7 years. Ductoscope...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-9-151
更新日期：2009-05-17 00:00:00
abstract：BACKGROUND:Cervical cancer is the fourth most common cancer among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage and underutilization of screening facilities. This study aims to assess knowledge and attitude towards cervical cancer and its prevention, as well as prac...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07060-4
更新日期：2020-06-17 00:00:00
abstract：BACKGROUND:Recent reports indicate the existence of breast cancer cells expressing very high levels of the Arylhydrocarbon receptor (AhR), a ubiquitous intracellular receptor best known for mediating toxic action of dioxin and related pollutants. Positive correlation between the degree of AhR overexpression and states ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-9-234
更新日期：2009-07-15 00:00:00
abstract：BACKGROUND:Immunotherapies have advanced the treatment of metastatic melanoma; however, they are associated with immune-related toxicities. Patients with pre-existing autoimmune comorbidities are commonly excluded from clinical trials investigating immunotherapies in metastatic melanoma. Since information on pre-existi...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4051-0
更新日期：2018-02-06 00:00:00
abstract：BACKGROUND:Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), has been shown to increase the efficacy of endocrine therapies in hormone receptor (HR)-positive metastatic breast cancer. However, because breast cancer is a highly heterogeneous disease, the responses of different patients to everolimus may ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-5668-3
更新日期：2019-05-14 00:00:00
abstract：BACKGROUND:High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4475-6
更新日期：2018-05-11 00:00:00
abstract：BACKGROUND:Disorders of cell adhesion are critical steps in cancer progression in which varieties of markers including cadherins are involved in.Btbd7 was found to inhibit E-cadherin expression in MDCK cells and play important roles during branching morphogenesis of embryonic salivary glands and lungs. However its func...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-704
更新日期：2014-09-24 00:00:00
abstract：BACKGROUND:Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12885-017-3803-6
更新日期：2017-12-14 00:00:00
abstract：BACKGROUND:An emerging immunotherapy is infusion of tumor infiltrating Lymphocytes (TIL), with objective response rates of around 50% versus 19% for ipilimumab. As an Advanced Therapeutic Medicinal Products (ATMP), TIL is highly personalized and complex therapy. It requests substantial upfront investments from the hosp...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4788-5
更新日期：2018-09-15 00:00:00
abstract：BACKGROUND:Advanced biliary tract carcinomas (BTCs) have poor prognosis and limited therapeutic options. Therefore, it is crucial to combine standard therapies with molecular targeting. In this study EGFR, HER2, and their molecular transducers were analysed in terms of mutations, amplifications and over-expression in a...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-631
更新日期：2010-11-18 00:00:00
abstract：BACKGROUND:Gastric cancer is a considerable burden for worldwide patients. And diffuse gastric cancer is the most insidious subgroup with poor survival. The phenotypic characterization of the diffuse gastric cancer cell line can be useful for gastric cancer researchers. In this article, we aimed to characterize the dif...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-06814-4
更新日期：2020-04-15 00:00:00
abstract：BACKGROUND:The aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing surgical treatment. METHODS:Between January 1996 and December 2006, a total of 1367 CRC patients who ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-9-288
更新日期：2009-08-20 00:00:00
