Projecting productivity losses for cancer-related mortality 2011 - 2030.

abstract：:It has been highlighted that in the original manuscript [1] Table S3 'An example of the predictive computational modeling process. Specific details on an annexure section of the PD-L1 pathway show the step-by-step reactions, mechanisms, and reaction equations that occur. Such reactions also occurred in all of the othe...

journal_title：BMC cancer

authors： Brogden KA,Parashar D,Hallier AR,Braun T,Qian F,Rizvi NA,Bossler AD,Milhem MM,Chan TA,Abbasi T,Vali S

更新日期：2018-04-12 00:00:00

abstract：BACKGROUND:Malignant pleural mesothelioma (MPM) is a tumor known to be resistant to conventional therapies. Thus, an in vivo model can represent an important tool for assessing the efficacy of novel approaches in the treatment of MPM.Presently, human MPM cells have been grown orthotopically in mice upon transplantation...

journal_title：BMC cancer

authors： Martarelli D,Catalano A,Procopio A,Orecchia S,Libener R,Santoni G

更新日期：2006-05-17 00:00:00

abstract：BACKGROUND:Advances in the knowledge of renal neoplasms have demonstrated the implication of several proteases in their genesis, growth and dissemination. Glutamyl-aminopeptidase (GAP) (EC. 3.4.11.7) is a zinc metallopeptidase with angiotensinase activity highly expressed in kidney tissues and its expression and activi...

journal_title：BMC cancer

authors： Blanco L,Sanz B,Perez I,Sánchez CE,Cándenas ML,Pinto FM,Gil J,Casis L,López JI,Larrinaga G

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:NF1(Neurofibromatosis type 1) is an autosomal dominant genetic disorder. Patients with NF1 have an increased risk of developing benign or malignant tumours, such as gastrointestinal stromal tumours (GISTs). However, the coexistence of NF1, GIST and colon cancer is very rare, and few cases have been reported ...

journal_title：BMC cancer

authors： Shang L,Fang Z,Liu J,Du F,Jing H,Xu Y,Dong K,Zhang X,Wu H,Jing C,Li L

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:We studied the cases of single and multiple HPV infection and analyzed the correlation with negative cases, and preneoplastic and neoplastic lesions of the uterine cervix with the aim of making a contribution to the prognostic factor under discussion. METHODS:Nine hundred nine women undergoing second level ...

journal_title：BMC cancer

authors： Bruno MT,Scalia G,Cassaro N,Boemi S

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Abundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors. Therefore, it is very important that finding the agents that increase the death receptors of cancer cells. In this study, we demonstrated that the snake venom toxin...

journal_title：BMC cancer

authors： Park MH,Jo M,Won D,Song HS,Han SB,Song MJ,Hong JT

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...

journal_title：BMC cancer

authors： Knoll S,Zimmer S,Hinney A,Scherag A,Neubauer A,Hebebrand J

更新日期：2008-03-31 00:00:00

abstract：BACKGROUND:Axillary lymph node (ALN) status is an important prognostic factor for breast cancer. We retrospectively used contrast-enhanced computed tomography (CE-CT) to evaluate the presence of ALN, metastasis based on size, shape, and contrasting effects. METHODS:Of 131 consecutive patients who underwent CE-CT follo...

journal_title：BMC cancer

authors： Urata M,Kijima Y,Hirata M,Shinden Y,Arima H,Nakajo A,Koriyama C,Arigami T,Uenosono Y,Okumura H,Maemura K,Ishigami S,Yoshinaka H,Natsugoe S

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:To evaluate the safety and efficacy of intra-arterial chemotherapy (IAC) for the primary or secondary treatment of infants diagnosed with advanced retinoblastoma before 3 months of age. METHODS:This single-center retrospective study included 39 infants (42 eyes) aged ≤3 months who were diagnosed with unilat...

journal_title：BMC cancer

authors： Chen Q,Zhang B,Dong Y,Mo X,Zhang L,Xia J,Zhang J,Zhang S

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:The majority of patients undergoing hepatectomy for hepatocellular carcinoma (HCC) suffer from underlying liver disease and are exposed to the risk of postoperative ascites, which is favored by an imbalance between portal venous inflow and a diminished hepatic volume. Finding a reversible, non-invasive metho...

journal_title：BMC cancer

authors： Mohkam K,Rayar M,Adam JP,Muscari F,Rode A,Merle P,Pradat P,Bauler S,Delfour I,Chiche L,Ducerf C,Boudjema K,Lesurtel M,Laurent C,Mabrut JY

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:We examined 15 years of key performance indicators (KPIs) of the population-based mammography screening programme (PMSP) in Flanders, Belgium. METHODS:Individual screening data were linked to the national cancer registry to obtain oncological follow-up. We benchmarked crude KPI results against KPI-targets s...

journal_title：BMC cancer

authors： Goossens M,De Brabander I,De Grève J,Van Ongeval C,Martens P,Van Limbergen E,Kellen E

更新日期：2019-10-28 00:00:00

abstract：BACKGROUND:Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigated the BSI in mCRPC and its relationship with prognosis. METHODS:The PubMed, Cochrane, and Embase da...

journal_title：BMC cancer

authors： Song H,Jin S,Xiang P,Hu S,Jin J

更新日期：2020-03-20 00:00:00

abstract：BACKGROUND:To investigate whether genetic variants of the HBV receptor gene NTCP are associated with HBV infection in the Han Chinese population. METHODS:We sequenced the entire 23 kb NTCP gene from 111 HBeAg-positive HBsAg carriers (PSE group), 110 HBeAg-negative HBsAg carriers (PS group), and 110 control subjects. T...

journal_title：BMC cancer

authors： Yang J,Yang Y,Xia M,Wang L,Zhou W,Yang Y,Jiang Y,Wang H,Qian J,Jin L,Wang X

更新日期：2016-03-12 00:00:00

abstract：BACKGROUND:Patient-derived xenograft (PDX) models are important tools in precision medicine and for the development of targeted therapies to treat cancer patients. This study aimed to evaluate our precision medicine strategy that integrates genomic profiling and preclinical drug-screening platforms, in order to persona...

journal_title：BMC cancer

authors： Oh DY,Jung K,Song JY,Kim S,Shin S,Kwon YJ,Oh E,Park WY,Song SY,Choi YL

更新日期：2017-08-10 00:00:00

abstract：BACKGROUND:The associations between microRNAs and lung cancer have received increasing attention. This study assess the association between polymorphisms in miR-135a-2, miR-219-2 and miR-211 genes and the risk of lung cancer, as well as the gene-environment interaction between these polymorphisms and cooking oil fume e...

journal_title：BMC cancer

authors： Yin Z,Cui Z,Li H,Ren Y,Qian B,Rothman N,Lan Q,Zhou B

更新日期：2016-09-23 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the safety and feasibility of self-expanding metallic stent (SEMS) followed by neoadjuvant chemotherapy prior to elective surgery for obstructing left-sided colon cancer. METHODS:Eleven consecutive patients with obstructing left-sided colon cancer between May 2014 and November 2...

journal_title：BMC cancer

authors： Han JG,Wang ZJ,Zeng WG,Wang YB,Wei GH,Zhai ZW,Zhao BC,Yi BQ

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:Improved insight into the molecular characteristics of the different ovarian cancer subgroups is needed for developing a more individualized and optimized treatment regimen. The aim of this study was to a) identify differentially expressed miRNAs in high-grade serous ovarian carcinoma (HGSC), clear cell ovar...

journal_title：BMC cancer

authors： Vilming Elgaaen B,Olstad OK,Haug KB,Brusletto B,Sandvik L,Staff AC,Gautvik KM,Davidson B

更新日期：2014-02-11 00:00:00

abstract：BACKGROUND:To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT). METHODS:A total of 97 locally advanced ESCC patients were enrolled. All the patients had their ...

journal_title：BMC cancer

authors： Chen YH,Lu HI,Lo CM,Wang YM,Chou SY,Hsiao CC,Huang CC,Shih LH,Chen SW,Li SH

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFAs) were proposed to have potential effects against inflammation and cancer. However, results from epidemiology studies remain inconsistent. We aimed to explore the associations of plasma PUFAs with EC recurrence and all-cause mortality. METHOD:Women diagnosed with en...

journal_title：BMC cancer

authors： Li P,Shan B,Jia K,Hu F,Xiao Y,Zheng J,Gao YT,Wang H,Gao Y

更新日期：2020-06-20 00:00:00

abstract：BACKGROUND:During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening with mammography played a role in the decline in mortality. Evaluating the contribution of these int...

journal_title：BMC cancer

authors： Vilaprinyo E,Rué M,Marcos-Gragera R,Martínez-Alonso M

更新日期：2009-03-30 00:00:00

abstract：BACKGROUND:High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination...

journal_title：BMC cancer

authors： De-Masi A,Davis E,Cuming T,Chindawi N,Pesola F,Cappello C,Chambers S,Bowring J,Rosenthal AN,Sasieni P,Nathan M

更新日期：2018-05-11 00:00:00

abstract：BACKGROUND:We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth. METHODS:Pancreatic carcinomas were assessed in a syngenei...

journal_title：BMC cancer

authors： Zechner D,Radecke T,Amme J,Bürtin F,Albert AC,Partecke LI,Vollmar B

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:Ethyl carbamate (EC) is a multi-site carcinogen in experimental animals and probably carcinogenic to humans (IARC group 2A). Traces of EC below health-relevant ranges naturally occur in several fermented foods and beverages, while higher concentrations above 1 mg/l are regularly detected in only certain spir...

journal_title：BMC cancer

authors： Lachenmeier DW,Lima MC,Nóbrega IC,Pereira JA,Kerr-Corrêa F,Kanteres F,Rehm J

更新日期：2010-06-08 00:00:00

abstract：BACKGROUND:In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behaviour of CAFs and bone invasion in OSCC. METHODS:The clinicopatholo...

journal_title：BMC cancer

authors： An YZ,Cho E,Ling J,Zhang X

更新日期：2020-10-12 00:00:00

abstract：BACKGROUND:Increased level of serum S100B can serve as a marker of metastatic spread in patients with cutaneous melanoma (CM). In patients with elevated S100 B and/or clinical signs of disease progression PET-CT scan is a valuable tool for discovering metastases and planning treatment.The aims of this study were to det...

journal_title：BMC cancer

authors： Peric B,Zagar I,Novakovic S,Zgajnar J,Hocevar M

更新日期：2011-08-02 00:00:00

abstract：BACKGROUND:MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. To investigate the progn...

journal_title：BMC cancer

authors： Gomez-Millan J,Pajares B,Perez-Villa L,Carnero A,Alvarez M,De Luque V,Rivas F,Trigo JM,Toledo MD,Alba E,Medina JA

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:Human Papillomavirus (HPV) genotyping has an increasingly important role in cervical cancer screening and vaccination monitoring, however, without an internationally agreed standard reference assay. The test results from the most widely used genotyping assays are read manually and hence prone to inter-observ...

journal_title：BMC cancer

authors： Ejegod DM,Rebolj M,Bonde J

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectomy (RAE). Previous studies had demonstrated the better short-term outcomes in MIE or RAE when compare...

journal_title：BMC cancer

authors： Yang Y,Zhang X,Li B,Li Z,Sun Y,Mao T,Hua R,Yang Y,Guo X,He Y,Li H,Chen H,Tan L

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Male breast cancer (MBC) is rare, accounting for only around 1% of all breast cancers. Most MBCs are hormone-driven. Not only the estrogen receptor (ER), but also other steroid hormone receptors, including the androgen receptor (AR) and progesterone receptor (PgR) are expressed in MBC. AR activation in breas...

journal_title：BMC cancer

authors： Takuwa H,Tsuji W,Shintaku M,Yotsumoto F

更新日期：2018-12-22 00:00:00

abstract：BACKGROUND:Metastatic breast cancer (MBC) rest an incurably disease associated with bad prognosis and a median overall survival of 23-31 months. There are several treatment options including chemotherapy and sometimes endocrine therapy. Currently, there is no standard treatment for patients with MBC who have already be...

journal_title：BMC cancer

authors： Fumet JD,Wickre M,Jacquot JP,Bizollon MH,Melis A,Vanoli A,Viel E

更新日期：2018-08-20 00:00:00