Early cost-effectiveness of tumor infiltrating lymphocytes (TIL) for second line treatment in advanced melanoma: a model-based economic evaluation.

abstract：BACKGROUND:Despite all benefit provided by established therapies prognosis of gastric cancer remains poor. Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and amplify chemotherapeutic effects. METHODS:This phase I study evaluated dose limiting toxicity (DLT...

journal_title：BMC cancer

authors： Mayr M,Becker K,Schulte N,Belle S,Hofheinz R,Krause A,Schmid RM,Röcken C,Ebert MP

更新日期：2012-12-10 00:00:00

abstract：BACKGROUND:In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer development in Tunisia. We have also tried to evaluate whether these variants affect the bladder tumor...

journal_title：BMC cancer

authors： Rouissi K,Bahria IB,Bougatef K,Marrakchi R,Stambouli N,Hamdi K,Cherif M,Ben Slama MR,Sfaxi M,Othman FB,Chebil M,Elgaaied AB,Ouerhani S

更新日期：2011-03-22 00:00:00

abstract：BACKGROUND:Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small (<5mm) to large (≥ 5mm) papillary thy...

journal_title：BMC cancer

authors： Bradley NL,Wiseman SM

更新日期：2017-02-16 00:00:00

abstract：BACKGROUND:We conducted a case-control study in the greater Toronto area to evaluate potential lung cancer risk factors including environmental tobacco smoke (ETS) exposure, family history of cancer, indoor air pollution, workplace exposures and history of previous respiratory diseases with special consideration given ...

journal_title：BMC cancer

authors： Brenner DR,Hung RJ,Tsao MS,Shepherd FA,Johnston MR,Narod S,Rubenstein W,McLaughlin JR

更新日期：2010-06-14 00:00:00

abstract：BACKGROUND:c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good candidate for targeted therapy in gastric cancer. Herein, we report our newly synthesized c-Met ...

journal_title：BMC cancer

authors： Park CH,Cho SY,Ha JD,Jung H,Kim HR,Lee CO,Jang IY,Chae CH,Lee HK,Choi SU

更新日期：2016-01-22 00:00:00

abstract：BACKGROUND:TGFβ signaling has typically been associated with suppression of tumor initiation while the role it plays in metastasis is generally associated with progression of malignancy. However, we present evidence here for an anti-metastatic role of TGFβ signaling. METHODS:To test the importance of TGFβ signaling to...

journal_title：BMC cancer

authors： Simms NA,Rajput A,Sharratt EA,Ongchin M,Teggart CA,Wang J,Brattain MG

更新日期：2012-06-06 00:00:00

abstract：BACKGROUND:Oesophageal squamous cell carcinoma (OSCC) is a major health burden in Sub-Saharan Africa, and novel chemotherapies are urgently required to combat this disease. The heat shock protein 90 (HSP90) inhibitor 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) has previously been proposed as a possible candidate ...

journal_title：BMC cancer

authors： Hadley KE,Hendricks DT

更新日期：2014-05-15 00:00:00

abstract：BACKGROUND:We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of any individual gene with traditional predictors of prognosis. METHODS:Patients with T1-T3 primary ...

journal_title：BMC cancer

authors： Mikhitarian K,Martin RH,Ruppel MB,Gillanders WE,Hoda R,Schutte del H,Callahan K,Mitas M,Cole DJ

更新日期：2008-02-20 00:00:00

abstract：BACKGROUND:Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve long-term outcome after transplantation. We wanted to prospectively assess feasibility of systemic ant...

journal_title：BMC cancer

authors： Eilard MS,Andersson M,Naredi P,Geronymakis C,Lindnér P,Cahlin C,Bennet W,Rizell M

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:Cytochrome P450 1B1 (CYP1B1) has been shown to be up-regulated in many types of cancer including renal cell carcinoma (RCC). Several reports have shown that CYP1B1 can influence the regulation of tumor development; however, its role in RCC has not been well investigated. The aim of the present study was to d...

journal_title：BMC cancer

authors： Mitsui Y,Chang I,Fukuhara S,Hiraki M,Arichi N,Yasumoto H,Hirata H,Yamamura S,Shahryari V,Deng G,Wong DK,Majid S,Shiina H,Dahiya R,Tanaka Y

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Recurrence of colorectal cancer (CRC) may arise due to the persistence of drug-resistant and cancer-initiating cells that survive exposure to chemotherapy. Proteins responsible for this recurrence include the chemokine receptor CXCR4, which is known to enable CRC metastasis, as well as the cancer-initiating ...

journal_title：BMC cancer

authors： Cutler MJ,Lowthers EL,Richard CL,Hajducek DM,Spagnuolo PA,Blay J

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...

journal_title：BMC cancer

authors： Knoll S,Zimmer S,Hinney A,Scherag A,Neubauer A,Hebebrand J

更新日期：2008-03-31 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that alterations in mitochondrial DNA (mtDNA) content may be implicated in the tumorigenesis of several malignancies. However, the association between mtDNA content in peripheral blood lymphocytes (PBLs) and glioma risk has not been investigated. METHODS:Real-time PCR was used t...

journal_title：BMC cancer

authors： Zhang J,Li D,Qu F,Chen Y,Li G,Jiang H,Huang X,Yang H,Xing J

更新日期：2014-09-19 00:00:00

abstract：BACKGROUND:When individuals stop working due to cancer this represents a loss to society - the loss of productivity. The aim of this analysis was to estimate productivity losses associated with premature mortality from all adult cancers and from the 20 highest mortality adult cancers in Ireland in 2011, and project the...

journal_title：BMC cancer

authors： Pearce A,Bradley C,Hanly P,O'Neill C,Thomas AA,Molcho M,Sharp L

更新日期：2016-10-18 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In order to assess the effectiveness of tailored treatment in regard to the primary tumour the differen...

journal_title：BMC cancer

authors： Mogensen MB,Rossing M,Østrup O,Larsen PN,Heiberg Engel PJ,Jørgensen LN,Hogdall EV,Eriksen J,Ibsen P,Jess P,Grauslund M,Nielsen HJ,Nielsen FC,Vainer B,Osterlind K

更新日期：2018-07-20 00:00:00

abstract：BACKGROUND:BRAF-activated noncoding RNA (BANCR) is aberrantly expressed in various tumor tissues and has been confirmed to function as a tumor suppressor or oncogene in many types of cancers. Considering the conflicting results and insufficient sampling, a meta-analysis was performed to explore the prognostic value of ...

journal_title：BMC cancer

authors： Fang S,Liu Z,Guo Q,Chen C,Ke X,Xu G

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting an important role for somatic mutations. This study investigated genomic differences betwee...

journal_title：BMC cancer

authors： Mealey NE,O'Sullivan DE,Pader J,Ruan Y,Wang E,Quan ML,Brenner DR

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:In Australia, associations between geographic remoteness, socioeconomic disadvantage, and colorectal cancer (CRC) survival show that survival rates are lowest among residents of geographically remote regions and those living in disadvantaged areas. At present we know very little about the reasons for these i...

journal_title：BMC cancer

authors： Baade PD,Turrell G,Aitken JF

更新日期：2010-01-28 00:00:00

abstract：BACKGROUND:The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclea...

journal_title：BMC cancer

authors： Xia B,Hou L,Kang H,Chang W,Liu Y,Zhang Y,Ding Y

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA genes, BRCA1 or BRCA2, the risk of developing breast or ovarian cancer is significantly increase...

journal_title：BMC cancer

authors： Guinan EM,Hussey J,McGarrigle SA,Healy LA,O'Sullivan JN,Bennett K,Connolly EM

更新日期：2013-03-21 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4-12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibitors (TKIs). Development of effective therapies for patients with EGFRex20ins mutant non-small-cell ...

journal_title：BMC cancer

authors： Fang W,Huang Y,Hong S,Zhang Z,Wang M,Gan J,Wang W,Guo H,Wang K,Zhang L

更新日期：2019-06-17 00:00:00

abstract：OBJECTIVE:C-reactive protein (CRP) is considered a useful serum marker for patients with RCC. However, its clinical utility in advanced metastatic renal cell carcinoma (AM-RCC), particularly in deciding whether to perform nephrectomy at the onset, is not well studied. PATIENTS AND METHODS:We retrospectively evaluated ...

journal_title：BMC cancer

authors： Ito H,Shioi K,Murakami T,Takizawa A,Sano F,Kawahara T,Mizuno N,Makiyama K,Nakaigawa N,Kishida T,Miura T,Kubota Y,Yao M

更新日期：2012-08-02 00:00:00

abstract：BACKGROUND:The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The diminished capability of the immune system to control and resolve HPV infection is one of several hyp...

journal_title：BMC cancer

authors： Gillio-Tos A,Bicalho Mda G,Fiano V,Grasso C,Tarallo V,De Marco L,Trevisan M,Xavier M,Slowik R,Carvalho NS,Maestri CA,Lacerda HM,Zugna D,Richiardi L,Merletti F

更新日期：2012-12-24 00:00:00

abstract：BACKGROUND:Increasing the biological effective dose (BED) of radiotherapy for non-small cell lung cancer (NSCLC) can increase local control rates and improve overall survival. Compared with conventional fractionated radiotherapy, accelerated hypofractionated radiotherapy can yield higher BED, shorten the total treatmen...

journal_title：BMC cancer

authors： Ren XC,Wang QY,Zhang R,Chen XJ,Wang N,Liu YE,Zong J,Guo ZJ,Wang DY,Lin Q

更新日期：2016-04-23 00:00:00

abstract：BACKGROUND:Treatment of locally advanced non-small-cell lung cancer is based on a combined approach. To study the impact of trimodal therapy for stage III-N2 NSCLC a single centre retrospective evaluation focusing on survival and therapy-related toxicity was performed. METHODS:71 patients diagnosed between March 2001 ...

journal_title：BMC cancer

authors： Askoxylakis V,Tanner J,Kappes J,Hoffmann H,Nicolay NH,Rief H,Debus J,Thomas M,Bischof M

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:In the presence of both HIV infection and cervical intraepithelial neoplasia (CIN), the risk of cancer development despite treatment may be greater. We investigated clinical predictors of persistent cytological abnormalities in women who had had a large loop excision of the transformation zone (LLETZ). METH...

journal_title：BMC cancer

authors： Adam Y,van Gelderen CJ,de Bruyn G,McIntyre JA,Turton DA,Martinson NA

更新日期：2008-07-25 00:00:00

abstract：BACKGROUND:The cost-effectiveness of human papillomavirus (HPV) vaccination in women pre-sexual debut has been demonstrated in many countries. This study aimed to estimate the cost-effectiveness of a 3-dose bivalent HPV vaccination at ages 12 to 55 year in both rural and urban settings in China. METHODS:The Markov coh...

journal_title：BMC cancer

authors： Liu YJ,Zhang Q,Hu SY,Zhao FH

更新日期：2016-02-26 00:00:00

abstract：BACKGROUND:Sorafenib is an orally active multikinase tyrosine kinase inhibitor (TKI) that targets B-type Raf kinase (BRAF), vascular endothelial growth factor receptors (VEGFR) 1 and 2, and rearranged during transfection (RET), inducing anti-angiogenic and pro-apoptotic actions in a wide range of solid tumors. A side e...

journal_title：BMC cancer

authors： Schneider TC,Kapiteijn E,van Wezel T,Smit JWA,van der Hoeven JJM,Morreau H

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:Treatment of solid malignancies has been revolutionized with the introduction of immune checkpoint inhibitors (ICIs) and their use is being expanded in therapy of different cancers. However, immune related adverse events (IRAEs) can occur during treatment. These side effects occur due to stimulation of the i...

journal_title：BMC cancer

authors： Khaddour K,Singh V,Shayuk M

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS:The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were...

journal_title：BMC cancer

authors： Stücker I,Loriot MA,N'koutchou G,Cénée S,Bodin L,Mulot C,Gelu-Simeon M,Pelletier L,Bronowicki JP,Degos F,Beaune P,Laurent-Puig P,Hémon D,Trinchet JC,Pelletier G

更新日期：2007-11-19 00:00:00