Abstract:
BACKGROUND:Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function via increased expression of arginase I and production of reactive oxygen species (ROS) and nitric oxide (NO). Immune suppression by MDSC was found to be one of the main factors for immunotherapy insufficiency. Here we investigate if the in vivo immunoregulatory function of MDSC can be reversed by inhibiting prostaglandin synthesis by specific COX-2 inhibition focussing on ROS production by MDSC subtypes. In addition, we determined if dietary celecoxib treatment leads to refinement of immunotherapeutic strategies. METHODS:MDSC numbers and function were analysed during tumour progression in a murine model for mesothelioma. Mice were inoculated with mesothelioma tumour cells and treated with cyclooxygenase-2 (COX-2) inhibitor celecoxib, either as single agent or in combination with dendritic cell-based immunotherapy. RESULTS:We found that large numbers of infiltrating MDSC co-localise with COX-2 expression in those areas where tumour growth takes place. Celecoxib reduced prostaglandin E2 levels in vitro and in vivo. Treatment of tumour-bearing mice with dietary celecoxib prevented the local and systemic expansion of all MDSC subtypes. The function of MDSC was impaired as was noticed by reduced levels of ROS and NO and reversal of T cell tolerance; resulting in refinement of immunotherapy. CONCLUSIONS:We conclude that celecoxib is a powerful tool to improve dendritic cell-based immunotherapy and is associated with a reduction in the numbers and suppressive function of MDSC. These data suggest that immunotherapy approaches benefit from simultaneously blocking cyclooxygenase-2 activity.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Veltman JD,Lambers ME,van Nimwegen M,Hendriks RW,Hoogsteden HC,Aerts JG,Hegmans JPdoi
10.1186/1471-2407-10-464subject
Has Abstractpub_date
2010-08-30 00:00:00pages
464issn
1471-2407pii
1471-2407-10-464journal_volume
10pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification. METHODS:Three hundred twenty-nine EAC cases were available in Tissue Microarrays (TMA) format. A discovery cohort of 166 EAC cases ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06987-y
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Identifying cellular signaling pathways that become corrupted in the presence of androgens that increase the metastatic potential of organ-confined tumor cells is critical to devising strategies capable of attenuating the metastatic progression of hormone-naïve, organ-confined tumors. In localized prostate c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1201-5
更新日期:2015-03-31 00:00:00
abstract:BACKGROUND:Despite being a mainstay for treating superficial bladder carcinoma and a promising agent for interstitial cystitis, the precise mechanism of Bacillus Calmette-Guerin (BCG) remains poorly understood. It is particularly unclear whether BCG is capable of altering gene expression beyond its well-recognized pro-...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-204
更新日期:2007-11-02 00:00:00
abstract:BACKGROUND:Alterations in the redox balance are involved in the origin, promotion and progression of cancer. Inter-individual differences in the oxidative stress regulation can explain a part of the variability in cancer susceptibility.The aim of this study was to evaluate if polymorphisms in genes codifying for the di...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-861
更新日期:2014-11-21 00:00:00
abstract:BACKGROUND:Locally advanced or metastatic adenocarcinoma of the pancreas remains - despite the implementation of new chemotherapy protocols - a disease with short overall survival (OS). METHODS:Eighty-three patients were treated with locally advanced or metastatic adenocarcinoma of the pancreas with either FOLFIRINOX ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5240-6
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:Median OS after surgery in curative intent for non-metastasized pancreas cancer ranges under study conditions from 17.9 months to 23.6 months. Tumor recurrence occurs locally, at distant sites (liver, peritoneum, lungs), or both. Observational and autopsy series report local recurrence rates of up to 87% eve...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-14-411
更新日期:2014-06-07 00:00:00
abstract:BACKGROUND:There are limited effective drugs that can reach the brain to target brain tumors, in particular glioblastoma, which is one of the most difficult cancers to be cured from. Because the overexpression of the sigma-2 receptor is frequently reported in glioma clinical samples and associated with poor prognosis a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5700-7
更新日期:2019-05-20 00:00:00
abstract:BACKGROUND:Women with ovarian cancer can present with a variety of symptoms and signs, and an increasing range of tests are available for their investigation. A number of international guidelines provide advice for the initial assessment of possible ovarian cancer in symptomatic women. We systematically identified and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6211-2
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFAs) were proposed to have potential effects against inflammation and cancer. However, results from epidemiology studies remain inconsistent. We aimed to explore the associations of plasma PUFAs with EC recurrence and all-cause mortality. METHOD:Women diagnosed with en...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07035-5
更新日期:2020-06-20 00:00:00
abstract:BACKGROUND:Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune contexture within the tumor microenvironment. Such models are urgently needed. Mutations of the tumor p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07212-6
更新日期:2020-08-08 00:00:00
abstract:BACKGROUND:Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a majority of solid tumors. Basement membrane breakdown is one of the hallmarks of invasion; therefore...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3660-3
更新日期:2017-10-04 00:00:00
abstract:BACKGROUND:Studies of human polyomavirus (HPyV) infection and lung cancer are limited and those regarding the association of human papillomavirus (HPV) infection and lung cancer have produced inconsistent results. METHODS:We conducted a nested case-control study to assess the association between incident lung cancer o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2381-3
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Over-expression of HER2 in a subset of breast cancers (HER2+) is associated with high histological grade and aggressive clinical course. Despite these distinctive features, the differences in response of HER2+ patients to both adjuvant cytotoxic chemotherapy and targeted therapy (e.g. trastuzumab) suggests t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-108
更新日期:2010-03-22 00:00:00
abstract:BACKGROUND:The biological relevance of nuclear ErbB-2/HER2 (NuclErbB-2) presence in breast tumors remains unexplored. In this study we assessed the clinical significance of ErbB-2 nuclear localization in primary invasive breast cancer. The reporting recommendations for tumor marker prognostic studies (REMARK) guideline...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-74
更新日期:2012-02-22 00:00:00
abstract:BACKGROUND:Thymidylate synthase (TS) and Topoisomerase I (Topo I) are significant biomarkers in colorectal cancer (CRC). We aimed to study the expression of TS and Topo I in patients with resected CRC who received adjuvant chemotherapy and correlated it with clinical outcome. METHODS:All patients diagnosed with CRC be...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-339
更新日期:2009-09-24 00:00:00
abstract:BACKGROUND:Characterization of the linkage disequilibrium (LD) structure of candidate genes is the basis for an effective association study of complex diseases such as cancer. In this study, we report the LD and haplotype architecture and tagging-single nucleotide polymorphisms (tSNPs) for five DNA repair genes: ATM, M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-99
更新日期:2005-08-09 00:00:00
abstract:BACKGROUND:Colorectal cancer screening is key to early detection and thus to early treatment, but uptake is often sub-optimal, particularly amongst lower income groups. It is proposed that the imminent introduction of the single-sample Faecal Immunochemical Test (FIT) in Scotland may lead to increased uptake as compare...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2133-4
更新日期:2016-02-13 00:00:00
abstract:BACKGROUND:Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4637-6
更新日期:2018-07-09 00:00:00
abstract:BACKGROUND:The effects of exposure to ultraviolet radiation are a significant concern in Australia which has one of the highest incidences of skin cancer in the world. Despite most skin cancers being preventable by encouraging consistent adoption of sun-protective behaviours, incidence rates are not decreasing. There i...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1471-2407-14-162
更新日期:2014-03-07 00:00:00
abstract:BACKGROUND:Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a role in cancer development. We recently reported that downregulation of TFPI inhibited apoptosis in a b...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-357
更新日期:2011-08-17 00:00:00
abstract:BACKGROUND:Amyloid-β precursor protein (APP) is a highly conserved single transmembrane protein that has been linked to Alzheimer disease. Recently, the increased expression of APP in multiple types of cancers has been reported where it has significant correlation with the cancer cell proliferation. However, the functi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-928
更新日期:2014-12-10 00:00:00
abstract:BACKGROUND:Renal cell carcinoma (RCC) is a seventh ranked malignancy with poor prognosis. RCC is lethal at metastatic stage as it does not respond to conventional systemic treatments, and there is an urgent need to find out promising novel biomarkers for effective treatment. The goal of this study was to evaluate the b...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2775-2
更新日期:2016-09-30 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract and liver and peritoneum are the main sites of recurrence. Ovarian metastases from GIST are very rare. CASE PRESENTATION:A 50 years-old woman was found to have a pelvic mass on transvaginal ultrasound...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4204-1
更新日期:2018-03-16 00:00:00
abstract:BACKGROUND:High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate the molecular mechanism by which hypoxia prom...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-108
更新日期:2013-03-09 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of decitabine (DAC) in the European Union (EU) in 2012 for the treatment of patients with AML ≥65 years marks the potential for hypomethylating agents in elderly AML. Nevertheless the situation ...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-015-1432-5
更新日期:2015-05-26 00:00:00
abstract:BACKGROUND:Continued smoking after cancer adversely affects quality of life and survival, but one fifth of cancer survivors still smoke. Despite its demands, cancer presents an opportunity for positive behaviour change. Smoking often occurs in social groups, therefore interventions which target families and individuals...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3344-z
更新日期:2017-05-19 00:00:00
abstract:BACKGROUND:Ovarian carcinoma is a common, and often deadly, gynecological cancer. Mutations in BRCA1 and BRCA2 genes are present in at least a fifth of patients. Uncovering other genes that become mutated subsequent to BRCA1/BRCA2 inactivation during cancer development will be helpful for more effective treatments. ME...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-146
更新日期:2013-03-22 00:00:00
abstract:BACKGROUND:Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In this study, we examined the possibility of HemoHIM both to enhance anticancer effect with cisplatin an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-85
更新日期:2009-03-17 00:00:00
abstract:BACKGROUND:Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune system is not fully understood although a number of case reports indicate autoimmune side effects rel...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6661-6
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:Breast metastasis from extramammary malignancy is uncommon and often presents diagnostic challenges. Herein, we report a case of a patient with metachronous isolated breast metastasis from pulmonary adenocarcinoma with micropapillary component. CASE PRESENTATION:A 47-year-old woman presented with left breas...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-736
更新日期:2014-10-01 00:00:00