Gefitinib provides similar effectiveness and improved safety than erlotinib for east Asian populations with advanced non-small cell lung cancer: a meta-analysis.

abstract：BACKGROUND:MicroRNAs (miRs) represent a distinct class of posttranscriptional modulators of gene expression with remarkable stability in sera. Several miRs are oncogenic (oncomiRs) and are deregulated in the pathogenesis of breast cancer and function to inhibit tumor suppressors. Routine blood monitoring of these circu...

journal_title：BMC cancer

authors： Sochor M,Basova P,Pesta M,Dusilkova N,Bartos J,Burda P,Pospisil V,Stopka T

更新日期：2014-06-18 00:00:00

abstract：BACKGROUND:MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung cancer (NSCLC) specimens and cell lines. However, the underlying mechanisms of miR-148b in regulatin...

journal_title：BMC cancer

authors： Lu L,Liu Q,Wang P,Wu Y,Liu X,Weng C,Fang X,Li B,Cao X,Mao H,Wang L,Guan M,Wang W,Liu G

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:Along with the marked increase in early gastric cancer (EGC) in the Eastern countries, there has been an effort to adopt the sentinel node concept in EGC to preserve gastric function and reduce the occurrence of postoperative complications. Based on promising results from a previous quality control study, th...

journal_title：BMC cancer

authors： Park JY,Kim YW,Ryu KW,Nam BH,Lee YJ,Jeong SH,Park JH,Hur H,Han SU,Min JS,An JY,Hyung WJ,Cho GS,Jeong GA,Jeong O,Park YK,Jung MR,Yoon HM,Eom BW

更新日期：2016-05-31 00:00:00

abstract：BACKGROUND:There are racial/ethnic disparities in breast cancer mortality may be attributed to differences in receipt of adjuvant cancer treatment. Our purpose was to determine whether the mortality disparities could be explained by racial/ethnic differences in long-term adherence to adjuvant endocrine therapy (AET). ...

journal_title：BMC cancer

authors： Farias AJ,Wu WH,Du XL

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:To assess the relationship between responses within 1 year and health-related quality of life (HRQoL) outcomes by exploring profiles of patients with CML-CP who were treated with front-line imatinib or nilotinib. METHODS:A prospective, longitudinal, single-center study was conducted to assess the response t...

journal_title：BMC cancer

authors： Yu L,Wang H,Milijkovic D,Huang X,Jiang Q

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Some breast cancer patients receiving anti-angiogenic treatment show increased metastases, possibly as a result of induced hypoxia. The effect of hypoxia on tumor cell migration was assessed in selected luminal, post-EMT and basal-like breast carcinoma cell lines. METHODS:Migration was assessed in luminal (...

journal_title：BMC cancer

authors： Voss MJ,Möller MF,Powe DG,Niggemann B,Zänker KS,Entschladen F

更新日期：2011-05-02 00:00:00

abstract：BACKGROUND:Activation of caspase-9 in response to treatment with cytotoxic drugs is inhibited in NSCLC cells, which may contribute to the clinical resistance to chemotherapy shown in this type of tumor. The aim of the present study was to investigate the mechanism of caspase-9 inhibition, with a focus on a possible rol...

journal_title：BMC cancer

authors： Checinska A,Giaccone G,Hoogeland BS,Ferreira CG,Rodriguez JA,Kruyt FA

更新日期：2006-06-23 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...

journal_title：BMC cancer

authors： Miwa K,Oki E,Enomoto M,Ihara K,Ando K,Fujita F,Tominaga M,Mori S,Nakayama G,Shimokawa M,Saeki H,Baba H,Mori M,Akagi Y

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:The combination of virotherapy and chemotherapy may enable efficient tumor regression that would be unachievable using either therapy alone. In this study, we investigated the efficiency of transgene delivery and the cytotoxic effects of alphaviral vector in combination with 5-fluorouracil (5-FU) in a mouse ...

journal_title：BMC cancer

authors： Zajakina A,Vasilevska J,Zhulenkovs D,Skrastina D,Spaks A,Plotniece A,Kozlovska T

更新日期：2014-06-20 00:00:00

abstract：BACKGROUND:Thymidylate synthase (TS) and Topoisomerase I (Topo I) are significant biomarkers in colorectal cancer (CRC). We aimed to study the expression of TS and Topo I in patients with resected CRC who received adjuvant chemotherapy and correlated it with clinical outcome. METHODS:All patients diagnosed with CRC be...

journal_title：BMC cancer

authors： Kostopoulos I,Karavasilis V,Karina M,Bobos M,Xiros N,Pentheroudakis G,Kafiri G,Papakostas P,Vrettou E,Fountzilas G

更新日期：2009-09-24 00:00:00

abstract：BACKGROUND:Our aim was to investigate the value of serum squamous cell carcinoma (SCC) antigen levels in predicting chemosensitivity, lymph node metastasis, as well as prognosis in patients with cervical squamous cell carcinoma who received neoadjuvant chemotherapy (NACT). METHODS:This retrospective study enrolled 103...

journal_title：BMC cancer

authors： Chen P,Jiao L,Ren F,Wang DB

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate cancer carcinogenesis is increasingly evident. In this study, the focus will be on histone modifica...

journal_title：BMC cancer

authors： Ngollo M,Lebert A,Dagdemir A,Judes G,Karsli-Ceppioglu S,Daures M,Kemeny JL,Penault-Llorca F,Boiteux JP,Bignon YJ,Guy L,Bernard-Gallon D

更新日期：2014-12-23 00:00:00

abstract：BACKGROUND:Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such approach. Here we investigated the concordance between mutations found in the primary tumor and pancre...

journal_title：BMC cancer

authors： Choi MH,Mejlænder-Andersen E,Manueldas S,El Jellas K,Steine SJ,Tjensvoll K,Sætran HA,Knappskog S,Hoem D,Nordgård O,Hovland R,Molven A

更新日期：2019-01-05 00:00:00

abstract：BACKGROUND:The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and 4-hydroxy-N-demethyltamoxifen (4OHNDtam, endoxifen). Inter-individual variations of the activity of these ...

journal_title：BMC cancer

authors： Gjerde J,Geisler J,Lundgren S,Ekse D,Varhaug JE,Mellgren G,Steen VM,Lien EA

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:The Cancer/Testis Antigens (CTAs) are a heterogeneous group of proteins whose expression is typically restricted to the testis. However, they are aberrantly expressed in most cancers that have been examined to date. Broadly speaking, the CTAs can be divided into two groups: the CTX antigens that are encoded ...

journal_title：BMC cancer

authors： Kim R,Kulkarni P,Hannenhalli S

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:The receptor tyrosine kinases (RTKs) play critical roles in the development of cancers. Clear cell renal cell carcinoma (ccRCC) accounts for 75% of the RCC. The previous studies on the RTKs in ccRCCs mainly focused on their gene expressions. The activation and function of the RTKs in ccRCC have not been full...

journal_title：BMC cancer

authors： Zhang Q,Liu JH,Liu JL,Qi CT,Yan L,Chen Y,Yu Q

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:The main objective of this study was to evaluate the safety of second-line pemetrexed in Stage IIIB or IV NSCLC. METHODS:Overall, 95 patients received pemetrexed 500 mg/m2 i.v. over Day 1 of a 21-day cycle. Patients also received oral dexamethasone, oral folic acid and i.m. vitamin B12 supplementation to re...

journal_title：BMC cancer

authors： Russo F,Bearz A,Pampaloni G,Investigators of Italian Pemetrexed Monotherapy of NSCLC Group.

更新日期：2008-07-31 00:00:00

abstract：BACKGROUND:Improved insight into the molecular characteristics of the different ovarian cancer subgroups is needed for developing a more individualized and optimized treatment regimen. The aim of this study was to a) identify differentially expressed miRNAs in high-grade serous ovarian carcinoma (HGSC), clear cell ovar...

journal_title：BMC cancer

authors： Vilming Elgaaen B,Olstad OK,Haug KB,Brusletto B,Sandvik L,Staff AC,Gautvik KM,Davidson B

更新日期：2014-02-11 00:00:00

abstract：BACKGROUND:EndoPredict (EP) is a clinically validated multianalyte gene expression test to predict distant metastasis in ER-positive, HER2-negative breast cancer treated with endocrine therapy alone. The test is based on the combined analysis of 12 genes in formalin-fixed, paraffin-embedded (FFPE) tissue by reverse tra...

journal_title：BMC cancer

authors： Kronenwett R,Bohmann K,Prinzler J,Sinn BV,Haufe F,Roth C,Averdick M,Ropers T,Windbergs C,Brase JC,Weber KE,Fisch K,Müller BM,Schmidt M,Filipits M,Dubsky P,Petry C,Dietel M,Denkert C

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:Extramammary Paget's disease (EMPD) remains a rare condition with only a limited number of cases reported in the literature. EMPD is mainly composed of intraepidermal Paget cells, and possesses variable clinical behaviors and histological appearances, leading to difficulty in the diagnosis of this disease. ...

journal_title：BMC cancer

authors： Wang X,Yang W,Yang J

更新日期：2010-08-04 00:00:00

abstract：BACKGROUND:ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in triple-negative breast cancer (TNBC) and their predictive role in determining the patient's outcome are u...

journal_title：BMC cancer

authors： Ouyang M,Wang H,Ma J,Lü W,Li J,Yao C,Chang G,Bi J,Wang S,Wang W

更新日期：2015-03-15 00:00:00

abstract：BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...

journal_title：BMC cancer

authors： Dillon MF,Mohd Nazri SR,Nasir S,McDermott EW,Evoy D,Crotty TB,O'Higgins N,Hill AD

更新日期：2006-06-23 00:00:00

abstract：BACKGROUND:Analysis of the clinical response of extramedullary lesions in leukemic patients treated with radiation therapy (RT) and defining the optimal dose of radiation. METHODS:Forty-two extramedullary lesions found in 24 leukemic patients treated with RT were reviewed. The radiation was delivered usually 2 Gy/day,...

journal_title：BMC cancer

authors： Song JH,Son SH,Lee JH,Chung SM,Jang HS,Choi BO

更新日期：2011-10-06 00:00:00

abstract：BACKGROUND:The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are important for understanding the molecular biology and progression of cancer. HOTAIR (HOX transcript antisense intergenic RNA) has been implicated in several cancers; however, its...

journal_title：BMC cancer

authors： Liu XH,Liu ZL,Sun M,Liu J,Wang ZX,De W

更新日期：2013-10-08 00:00:00

abstract：BACKGROUND:P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour suppressor, and it may represent a novel target for breast cancer treatment. The aim of this study is t...

journal_title：BMC cancer

authors： Johnston SJ,Ahmad D,Aleskandarany MA,Kurozumi S,Nolan CC,Diez-Rodriguez M,Green AR,Rakha EA

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynaecological cancers as well, since upregulation of SERBP1 was described in ova...

journal_title：BMC cancer

authors： Serce NB,Boesl A,Klaman I,von Serényi S,Noetzel E,Press MF,Dimmler A,Hartmann A,Sehouli J,Knuechel R,Beckmann MW,Fasching PA,Dahl E

更新日期：2012-12-13 00:00:00

abstract：BACKGROUND:Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging can be biased due to the anatomic complexity of this region. Recently, several markers related to canc...

journal_title：BMC cancer

authors： Chong Y,Thakur N,Paik KY,Lee EJ,Kang CS

更新日期：2020-03-14 00:00:00

abstract：BACKGROUND:Vascular Endothelial Growth Factors (VEGFs) and their receptors (VEGF-Rs) are important regulators for angiogenesis and lymphangiogenesis. VEGFs and VEGF-Rs are not only expressed on endothelial cells but also on various subtypes of solid tumors and leukemias contributing to the growth of the malignant cells...

journal_title：BMC cancer

authors： Quentmeier H,Eberth S,Romani J,Weich HA,Zaborski M,Drexler HG

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is a type of breast cancer with a high degree of malignancy. Because of the remarkable biological characteristics of high invasion, metastasis and recurrence, TNBC is often accompanied by a poor prognosis. As a molecular characteristic of TNBC, high expression of CD147 ha...

journal_title：BMC cancer

authors： Wang C,Xu C,Niu R,Hu G,Gu Z,Zhuang Z

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Metformin and the thiazolidinediones (TZDs) may have a protective effect against the development of lung cancer. METHODS:Patients with diabetes mellitus (DM) were identified from the electronic medical records of the Cleveland Clinic. Diabetics with lung cancer were identified then verified by direct review...

journal_title：BMC cancer

authors： Mazzone PJ,Rai H,Beukemann M,Xu M,Jain A,Sasidhar M

更新日期：2012-09-14 00:00:00