Abstract:
BACKGROUND:Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk. METHODS:A case-control study design was used to test the association between prostate cancer risk and the polymorphisms TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587) and MCP-1 2518 G/A (rs 1024611) in 296 patients diagnosed with prostate cancer and in 311 healthy controls from the same area. RESULTS:Diagnosis of prostate cancer was significantly associated with TNF-A GA + AA genotype (OR, 1.61; 95% CI, 1.09-2.64) and RANTES GA + AA genotype (OR, 1.44; 95% CI, 1.09-2.38). A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects. No epistatic effect was found for the combination of different polymorphisms studied. Finally, no overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms. CONCLUSION:Our results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Sáenz-López P,Carretero R,Cózar JM,Romero JM,Canton J,Vilchez JR,Tallada M,Garrido F,Ruiz-Cabello Fdoi
10.1186/1471-2407-8-382subject
Has Abstractpub_date
2008-12-19 00:00:00pages
382issn
1471-2407pii
1471-2407-8-382journal_volume
8pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such approach. Here we investigated the concordance between mutations found in the primary tumor and pancre...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5195-7
更新日期:2019-01-05 00:00:00
abstract:BACKGROUND:Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population studies. Consequently, very limited information on the disorder is available, making it difficult to ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-3015-5
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set up and assay. In this report, we introduce a microfluidic OrganoPlate® platform for extracellular m...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3709-3
更新日期:2017-11-02 00:00:00
abstract:BACKGROUND:We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of any individual gene with traditional predictors of prognosis. METHODS:Patients with T1-T3 primary ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-55
更新日期:2008-02-20 00:00:00
abstract:BACKGROUND:Uridine 5'-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT2B15, UGT2B17, and UGT2B28 enzymes has not been evaluated in prostate...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3463-6
更新日期:2017-07-03 00:00:00
abstract:BACKGROUND:Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the role of mesothelioma stem cells (MSC) in treatment failure and eventually to design specific target...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4354-1
更新日期:2018-04-27 00:00:00
abstract:BACKGROUND:To provide estimations of partial and total prevalence of 24 cancer sites in France in 2008. The estimations of partial prevalence were compared with the previous estimations for 2002. METHODS:Nationwide estimations of incidence and survival data from cancer registries were used for partial prevalence. Nati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1168-2
更新日期:2015-03-19 00:00:00
abstract:BACKGROUND:NF1(Neurofibromatosis type 1) is an autosomal dominant genetic disorder. Patients with NF1 have an increased risk of developing benign or malignant tumours, such as gastrointestinal stromal tumours (GISTs). However, the coexistence of NF1, GIST and colon cancer is very rare, and few cases have been reported ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6375-9
更新日期:2019-12-05 00:00:00
abstract:BACKGROUND:There is limited real-world safety information on palbociclib for treatment of advanced stage HR+/HER2- breast cancer. METHODS:We conducted a cohort study of breast cancer patients initiating palbociclib and fulvestrant from February 2015 to September 2017 using the HealthCore Integrated Research Database (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-021-07790-z
更新日期:2021-01-25 00:00:00
abstract::Autologous stem cell transplantation (ASCT) is a well-established approach to treatment of patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) recommended by both the European Society for Medical Oncology and the National Comprehensive Cancer Network based on the results from randomized controlled studies. H...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-020-07561-2
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation. Recently, a study has demonstrated that the presence or absence of all isomiRs could efficiently discriminate amongst 32 TCGA cancer t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5340-y
更新日期:2019-02-07 00:00:00
abstract:BACKGROUND:Higher sunlight exposure is correlated with lower incidence of breast cancer in ecological studies, but findings from prospective studies regarding the association of circulating levels of vitamin D with the risk of breast cancer have been null. The objective of this study was to examine the relation between...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-29
更新日期:2014-01-17 00:00:00
abstract:BACKGROUND:Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ spe...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-662
更新日期:2010-12-02 00:00:00
abstract:BACKGROUND:Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensification of treatment schedules through introduction of novel induction and combination chemotherapy regime...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-182
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to endothelial cells. It requires interactions between adhesion receptors on endothelial cells and their counter-receptors on cancer cells. Notably, E-selectin, a major endot...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-285
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Splenic marginal zone lymphoma (SMZL) is a rare lymphoid B-cell malignant neoplasm with primary involvement of the spleen. It is a chronic disease, of indolent behavior and prolonged survival. However, 25% of cases have higher biological aggressiveness, propensity for histological transformation to high grad...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07204-6
更新日期:2020-08-03 00:00:00
abstract:BACKGROUND:The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these b...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-333
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Breast cancer is the most common cancer type in female. As microRNAs play vital role in breast cancer, this study aimed to explore the molecular mechanism and clinical value of miR-21 in breast cancer. METHODS:qRT-PCR was performed to detect miR-21 levels in plasma of 127 healthy controls, 82 benign breast ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5951-3
更新日期:2019-07-27 00:00:00
abstract:BACKGROUND:Cancers of unknown primary origin (CUPs) are reported to be the 3-4th most common causes of cancer death. Recent years have seen advances in mutational analysis and genomics profiling. These advances could improve accuracy of diagnosis of CUPs and might improve the prognosis of patients with CUPs. CASE PRES...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-019-5277-1
更新日期:2019-01-11 00:00:00
abstract:BACKGROUND:The main objective of this study was to evaluate the safety of second-line pemetrexed in Stage IIIB or IV NSCLC. METHODS:Overall, 95 patients received pemetrexed 500 mg/m2 i.v. over Day 1 of a 21-day cycle. Patients also received oral dexamethasone, oral folic acid and i.m. vitamin B12 supplementation to re...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-216
更新日期:2008-07-31 00:00:00
abstract:BACKGROUND:EndoPredict (EP) is a clinically validated multianalyte gene expression test to predict distant metastasis in ER-positive, HER2-negative breast cancer treated with endocrine therapy alone. The test is based on the combined analysis of 12 genes in formalin-fixed, paraffin-embedded (FFPE) tissue by reverse tra...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-456
更新日期:2012-10-05 00:00:00
abstract:BACKGROUND:UroVysion fluorescence in situ hybridization (uFISH) was reported to have superior sensitivity to urine cytology. However uFISH studies are limited by varying definitions of what is considered a positive result, absence of histopathology and small sample size. The aim of our study was to better determine the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3227-3
更新日期:2017-04-07 00:00:00
abstract:BACKGROUND:To evaluate the effect of Recurrence Score® results (RS; Oncotype DX® multigene assay ODX) on treatment recommendations by Swiss multidisciplinary tumor boards (TB). METHODS:SAKK 26/10 is a multicenter, prospective cohort study of early breast cancer patients: Eligibility: R0-resection, ≥10% ER+ malignant c...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-017-3261-1
更新日期:2017-04-13 00:00:00
abstract:BACKGROUND:Obesity is linked to poor disease outcomes in breast cancer patients. However, this link was mostly based on body weight or BMI rather than body-fat. The purpose of this study was to evaluate the relationship between body-fat gain and disease progression in Taiwanese women after breast cancer surgery and how...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3869-1
更新日期:2017-12-18 00:00:00
abstract:BACKGROUND:This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC). METHODS:A total of 303 TNBC patients who underwent weekly paclitaxel plus carboplatin treatments followed by surgical resection were ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4822-7
更新日期:2018-09-21 00:00:00
abstract:BACKGROUND:Modeling the relationship between age and mortality for breast cancer patients may have important prognostic and therapeutic implications. METHODS:Data from 9 registries of the Surveillance, Epidemiology, and End Results Program (SEER) of the United States were used. This study employed proportional hazards...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-130
更新日期:2005-10-08 00:00:00
abstract:BACKGROUND:Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involvement in ovarian tumorigenesis. Herein, we focused on the functional roles of Nodal in ovarian endome...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5539-y
更新日期:2019-04-03 00:00:00
abstract:BACKGROUND:Matrix metalloproteinases (MMPs) are crucially involved in the regulation of multiple stages of cancer progression. Elevated MMP levels have been associated with the development of metastases and poor prognosis in several types of cancer. However, the role of MMPs in osteosarcoma and their prognostic value i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2266-5
更新日期:2016-03-15 00:00:00
abstract:BACKGROUND:Pancreatic cancer is the fourth-leading cause of cancer deaths in the United States. The silent nature of the disease and its poor prognosis, the need for further research, along with the need to assess the outcomes of current approaches necessitate an ongoing evaluation of the epidemiology and mortality-tre...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4610-4
更新日期:2018-06-25 00:00:00
abstract:BACKGROUND:Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However, genetically engineered T cells have been associated with serious side-effects due to off-target tox...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3539-3
更新日期:2017-08-17 00:00:00