当前位置： SCI文献检索 > BMC CANCER期刊下所有文献 > Expression profile and prognostic role of sex hormone receptors in gastric cancer.

Expression profile and prognostic role of sex hormone receptors in gastric cancer.

Abstract：

BACKGROUND:Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile of sex hormone receptors in gastric cancer and their clinicopathological and prognostic value were determined in a large Chinese cohort. METHODS:The mRNA and protein expression of estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), progesterone receptor (PR), and androgen receptor (AR) in primary gastric tumors and corresponding adjacent normal tissues from 60 and 866 Chinese gastric cancer patients was detected by real-time quantitative PCR and immunohistochemistry method, respectively. The expression profile of the four receptors was compared and their associations with clinicopathological characteristics were assessed by using Chi-square test. The prognostic value of the four receptors in gastric cancer was evaluated by using univariate and multivariate Cox regression analysis. RESULTS:The presence of ERα, ERβ, PR, and AR in both gastric tumors and normal tissues was confirmed but their expression levels were extremely low except for the predominance of ERβ. The four receptors were expressed independently and showed a decreased expression pattern in gastric tumors compared to adjacent normal tissues. The positive expression of the four receptors all correlated with high tumor grade and intestinal type, and ERα and AR were also associated with early TNM stage and thereby a favorable outcome. However, ERα and AR were not independent prognostic factors for gastric cancer when multivariate survival analysis was performed. CONCLUSIONS:Our findings indicate that the sex hormone receptors may be partly involved in gastric carcinogenesis but their clinicopathological and prognostic significance in gastric cancer appears to be limited.

journal_name

BMC Cancer

journal_title

BMC cancer

authors

Gan L,He J,Zhang X,Zhang YJ,Yu GZ,Chen Y,Pan J,Wang JJ,Wang X

doi

10.1186/1471-2407-12-566

subject

Has Abstract

pub_date

2012-12-02 00:00:00

pages

566

issn

1471-2407

pii

1471-2407-12-566

journal_volume

12

pub_type

杂志文章

相关文献

BMC CANCER文献大全
  • Increased expression of system large amino acid transporter (LAT)-1 mRNA is associated with invasive potential and unfavorable prognosis of human clear cell renal cell carcinoma.

    abstract：BACKGROUND:The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expressed in the kidneys, little is known about their influence on human renal cancer. METHODS:To clarify...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-13-509

    authors： Betsunoh H,Fukuda T,Anzai N,Nishihara D,Mizuno T,Yuki H,Masuda A,Yamaguchi Y,Abe H,Yashi M,Fukabori Y,Yoshida K,Kamai T

    更新日期：2013-10-30 00:00:00

  • Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma.

    abstract：BACKGROUND:High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate the molecular mechanism by which hypoxia prom...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-13-108

    authors： Zhang L,Huang G,Li X,Zhang Y,Jiang Y,Shen J,Liu J,Wang Q,Zhu J,Feng X,Dong J,Qian C

    更新日期：2013-03-09 00:00:00

  • Acral vascular necrosis associated with immune-check point inhibitors: case report with literature review.

    abstract：BACKGROUND:Treatment of solid malignancies has been revolutionized with the introduction of immune checkpoint inhibitors (ICIs) and their use is being expanded in therapy of different cancers. However, immune related adverse events (IRAEs) can occur during treatment. These side effects occur due to stimulation of the i...

    journal_title：BMC cancer

    pub_type： 杂志文章,评审

    doi：10.1186/s12885-019-5661-x

    authors： Khaddour K,Singh V,Shayuk M

    更新日期：2019-05-14 00:00:00

  • UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?

    abstract：BACKGROUND:We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS:The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-7-214

    authors： Stücker I,Loriot MA,N'koutchou G,Cénée S,Bodin L,Mulot C,Gelu-Simeon M,Pelletier L,Bronowicki JP,Degos F,Beaune P,Laurent-Puig P,Hémon D,Trinchet JC,Pelletier G

    更新日期：2007-11-19 00:00:00

  • Primary neuroendocrine breast carcinomas are associated with poor local control despite favourable biological profile: a retrospective clinical study.

    abstract：BACKGROUND:Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC. METHODS:We collected retrospectively patients with NEBC ...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-017-3056-4

    authors： Roininen N,Takala S,Haapasaari KM,Jukkola-Vuorinen A,Mattson J,Heikkilä P,Karihtala P

    更新日期：2017-01-24 00:00:00

  • Metabolic complete response with vinflunine as second-line therapy in a kidney-transplanted patient with advanced urothelial carcinoma: a case report.

    abstract：BACKGROUND:Patients undergone kidney transplantation present higher risk of Urothelial Carcinoma (UC) development and represent a subgroup of special interest. To date, vinflunine is the only drug approved in Europe for the treatment of advanced UC after failure of platinum-based chemotherapy. However, to our knowledge...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-016-2666-6

    authors： Bordi P,Tiseo M,Baldari G,Buti S

    更新日期：2016-08-12 00:00:00

  • Enhancing adherence in trials promoting change in diet and physical activity in individuals with a diagnosis of colorectal adenoma; a systematic review of behavioural intervention approaches.

    abstract：BACKGROUND:Little is known about colorectal adenoma patients' ability to adhere to behavioural interventions promoting a change in diet and physical activity. This review aimed to examine health behaviour intervention programmes promoting change in diet and/or physical activity in adenoma patients and characterise inte...

    journal_title：BMC cancer

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/s12885-015-1502-8

    authors： McCahon D,Daley AJ,Jones J,Haslop R,Shajpal A,Taylor A,Wilson S,Dowswell G

    更新日期：2015-07-07 00:00:00

  • A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma.

    abstract：BACKGROUND:5-fluorouracil, leucovorin, irinotecan and oxaliplatin (FOLFIRINOX) is superior to gemcitabine in patients with metastatic pancreatic cancer who have a good performance status. We investigated this combination as neoadjuvant therapy for locally advanced pancreatic cancer (LAPC). METHODS:In this retrospectiv...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-12-199

    authors： Hosein PJ,Macintyre J,Kawamura C,Maldonado JC,Ernani V,Loaiza-Bonilla A,Narayanan G,Ribeiro A,Portelance L,Merchan JR,Levi JU,Rocha-Lima CM

    更新日期：2012-05-29 00:00:00

  • Concurrent chemoradiotherapy with or without cetuximab for stage II to IVb nasopharyngeal carcinoma: a case-control study.

    abstract：BACKGROUND:This study aimed to evaluate the long-term outcome and toxicities in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated by concurrent chemoradiotherapy (CCRT) with/without adding cetuximab. METHODS:A total of 62 patients treated with CCRT plus cetuximab were matched with 124 patien...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-017-3552-6

    authors： Li Y,Chen QY,Tang LQ,Liu LT,Guo SS,Guo L,Mo HY,Chen MY,Guo X,Cao KJ,Qian CN,Zeng MS,Bei JX,Shao JY,Sun Y,Tan J,Chen S,Ma J,Zhao C,Mai HQ

    更新日期：2017-08-24 00:00:00

  • Synergistic inhibition of tumor growth by combination treatment with drugs against different subpopulations of glioblastoma cells.

    abstract：BACKGROUND:Glioma stem cells (GSCs) contribute to tumor recurrence and drug resistance. This study characterizes the tumorigenesis of CD133+ cells and their sensitivity to pharmacological inhibition. METHODS:GSCs from human U87 and rat C6 glioblastoma cell lines were isolated via magnetic cell sorting using CD133 as a...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-017-3924-y

    authors： Chang CH,Liu WT,Hung HC,Gean CY,Tsai HM,Su CL,Gean PW

    更新日期：2017-12-29 00:00:00

  • MAGENTA (Making Genetic testing accessible): a prospective randomized controlled trial comparing online genetic education and telephone genetic counseling for hereditary cancer genetic testing.

    abstract：BACKGROUND:Studies have consistently indicated that the majority of individuals meeting the US Prevention Services Task Force guidelines for genetic testing have not had genetic counseling or testing. Despite increased availability and lower costs of multiplex cancer gene panels, there remains a gap in genetics service...

    journal_title：BMC cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s12885-019-5868-x

    authors： Rayes N,Bowen DJ,Coffin T,Nebgen D,Peterson C,Munsell MF,Gavin K,Lechner R,Crase J,Polinsky D,Romero I,Blank SV,Levine DA,Norquist BM,Swisher EM,Lu KH

    更新日期：2019-07-02 00:00:00

  • Correction to: A systematic comparison of copy number alterations in four types of female cancer.

    abstract：:After publication of the original article [1] the authors found that the article contained an incorrect version of Fig. 4. This does not affect the results and conclusions of the article. ...

    journal_title：BMC cancer

    pub_type： 杂志文章,已发布勘误

    doi：10.1186/s12885-017-3766-7

    authors： Kaveh F,Baumbusch LO,Nebdal D,Børresen-Dale AL,Lingjærde OC,Edvardsen H,Kristensen VN,Solvang HK

    更新日期：2018-01-16 00:00:00

  • Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study.

    abstract：BACKGROUND:Cervical cancer is the 4th highest cause of female reproductive tract malignancies. Multiple loci have been identified as important determinant factors for tumor susceptibility. In this report, we aimed to explore the roles of gene polymorphisms affecting x-ray repair cross complementing 1 (XRCC1), the tumor...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-018-5149-0

    authors： Liu GC,Zhou YF,Su XC,Zhang J

    更新日期：2019-01-07 00:00:00

  • Putative cancer stem cells may be the key target to inhibit cancer cell repopulation between the intervals of chemoradiation in murine mesothelioma.

    abstract：BACKGROUND:Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the role of mesothelioma stem cells (MSC) in treatment failure and eventually to design specific target...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-018-4354-1

    authors： Wu L,Blum W,Zhu CQ,Yun Z,Pecze L,Kohno M,Chan ML,Zhao Y,Felley-Bosco E,Schwaller B,de Perrot M

    更新日期：2018-04-27 00:00:00

  • Platelet to lymphocyte ratio as an independent prognostic indicator for prostate cancer patients receiving androgen deprivation therapy.

    abstract：BACKGROUND:Platelet to Lymphocyte ratio (PLR) is thought to be associated with a worse outcome in multiple types of cancer. However, the prognostic significance of PLR has not been investigated in the prostate cancer (PCa) patients receiving hormonal therapy. The objective of this study was to determine the prognostic ...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-016-2363-5

    authors： Wang Y,Xu F,Pan J,Zhu Y,Shao X,Sha J,Wang Z,Cai Y,Liu Q,Dong B,Xue W,Huang Y

    更新日期：2016-05-24 00:00:00

  • Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice.

    abstract：BACKGROUND:Serine-threonine kinases of the Raf family (A-Raf, B-Raf, C-Raf) are central players in cellular signal transduction, and thus often causally involved in the development of cancer when mutated or over-expressed. Therefore these proteins are potential targets for immunotherapy and a possible basis for vaccine...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-5-15

    authors： Gentschev I,Fensterle J,Schmidt A,Potapenko T,Troppmair J,Goebel W,Rapp UR

    更新日期：2005-02-09 00:00:00

  • A high-throughput and sensitive method to measure global DNA methylation: application in lung cancer.

    abstract：BACKGROUND:Genome-wide changes in DNA methylation are an epigenetic phenomenon that can lead to the development of disease. The study of global DNA methylation utilizes technology that requires both expensive equipment and highly specialized skill sets. METHODS:We have designed and developed an assay, CpGlobal, which ...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-8-222

    authors： Anisowicz A,Huang H,Braunschweiger KI,Liu Z,Giese H,Wang H,Mamaev S,Olejnik J,Massion PP,Del Mastro RG

    更新日期：2008-08-03 00:00:00

  • APC/β-catenin-rich complexes at membrane protrusions regulate mammary tumor cell migration and mesenchymal morphology.

    abstract：BACKGROUND:The APC tumor suppressor is mutated or downregulated in many tumor types, and is prominently localized to punctate clusters at protrusion tips in migratory cells, such as in astrocytes where it has been implicated in directed cell motility. Although APC loss is considered an initiating event in colorectal ca...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-13-12

    authors： Odenwald MA,Prosperi JR,Goss KH

    更新日期：2013-01-09 00:00:00

  • Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids.

    abstract：BACKGROUND:Multidrug resistance (MDR) is a phenomenon that is often associated with decreased intracellular drug accumulation in patient's tumor cells resulting from enhanced drug efflux. It is related to the overexpression of a membrane protein, P-glycoprotein (Pgp-170), thereby reducing drug cytotoxicity. A variety o...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-4-13

    authors： Limtrakul P,Anuchapreeda S,Buddhasukh D

    更新日期：2004-04-17 00:00:00

  • Smokers' interest in a lung cancer screening programme: a national survey in England.

    abstract：BACKGROUND:Following the recommendation of lung cancer screening in the US, screening committees in several European countries are reviewing the evidence for implementing national programmes. However, inadequate participation from high-risk groups poses a potential barrier to its effectiveness. The present study examin...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-018-4430-6

    authors： Quaife SL,Vrinten C,Ruparel M,Janes SM,Beeken RJ,Waller J,McEwen A

    更新日期：2018-05-02 00:00:00

  • Comparative benefit from small tumour size and adjuvant chemotherapy: clues for explaining breast cancer mortality decline.

    abstract：BACKGROUND:Breast cancer mortality steadily declined from the 1990s and this has been attributed to early detection and/or to improvements in therapy. Which of those two has had the greater impact is a subject of contention. METHODS:A database of 386 patients, enrolled in a randomized clinical trial on the effect of a...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-14-702

    authors： Demicheli R,Ambrogi F

    更新日期：2014-09-24 00:00:00

  • p300 promotes proliferation, migration, and invasion via inducing epithelial-mesenchymal transition in non-small cell lung cancer cells.

    abstract：BACKGROUND:Histone acetyltransferase p300 is a crucial transcriptional coactivator and has been implicated as a poor prognostic factor in human cancers. However, little is known about the substantial functions and mechanisms of p300 in NSCLC proliferation and distant metastasis. METHODS:We constructed p300 down-regula...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-018-4559-3

    authors： Hou X,Gong R,Zhan J,Zhou T,Ma Y,Zhao Y,Zhang Y,Chen G,Zhang Z,Ma S,Chen X,Gao F,Hong S,Luo F,Fang W,Yang Y,Huang Y,Chen L,Yang H,Zhang L

    更新日期：2018-06-07 00:00:00

  • GRcalculator: an online tool for calculating and mining dose-response data.

    abstract：BACKGROUND:Quantifying the response of cell lines to drugs or other perturbagens is the cornerstone of pre-clinical drug development and pharmacogenomics as well as a means to study factors that contribute to sensitivity and resistance. In dividing cells, traditional metrics derived from dose-response curves such as IC...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-017-3689-3

    authors： Clark NA,Hafner M,Kouril M,Williams EH,Muhlich JL,Pilarczyk M,Niepel M,Sorger PK,Medvedovic M

    更新日期：2017-10-24 00:00:00

  • Correction to: Exploring the efficacy of an electronic symptom assessment and self-care intervention to preserve physical function in individuals receiving neurotoxic chemotherapy.

    abstract：:... ...

    journal_title：BMC cancer

    pub_type： 杂志文章,已发布勘误

    doi：10.1186/s12885-019-5669-2

    authors： Knoerl R,Weller E,Halpenny B,Berry D

    更新日期：2019-05-13 00:00:00

  • From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes.

    abstract：BACKGROUND:Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutational signature. METHODS:We systematically analyzed the smoking-related DNA methylation sites reported ...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-020-07368-1

    authors： Chen Z,Wen W,Cai Q,Long J,Wang Y,Lin W,Shu XO,Zheng W,Guo X

    更新日期：2020-09-14 00:00:00

  • Promotion of the occurrence of endometrioid carcinoma by S100 calcium binding protein P.

    abstract：BACKGROUND:Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. The present study aimed to investigate the e...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-020-07350-x

    authors： Zhang D,Chen X,Xia H,Wang L,Zhao H,Xu B,Zhang A,Zhang W

    更新日期：2020-09-03 00:00:00

  • Prognostic significance of p53 expression in patients with esophageal cancer: a meta-analysis.

    abstract：BACKGROUND:The prognostic value of p53 protein expression in esophageal cancer has been evaluated, but the results remain inconclusive and no consensus has yet been achieved. This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in esophageal cancer. METHODS:Publicatio...

    journal_title：BMC cancer

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12885-016-2427-6

    authors： Wang L,Yu X,Li J,Zhang Z,Hou J,Li F

    更新日期：2016-07-01 00:00:00

  • Adherence to quality breast cancer survivorship care in four Canadian provinces: a CanIMPACT retrospective cohort study.

    abstract：BACKGROUND:In order to maximize later health, there are established components and guidelines for quality follow-up care of breast cancer survivors. However, adherence to quality follow-up in Canada may not be optimal, and may vary by province. We determined and compared the proportion of patients in each province who ...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-019-5882-z

    authors： McBride ML,Groome PA,Decker K,Kendell C,Jiang L,Whitehead M,Li D,Grunfeld E,CanIMPACT Team.

    更新日期：2019-07-04 00:00:00

  • Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients.

    abstract：BACKGROUND:The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5F...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/s12885-019-5327-8

    authors： Rot S,Kaune T,Taubert H,Greither T,Kotrba J,Güttler A,Wichmann H,Bilkenroth U,Wienke A,Al-Nawas B,Bache M,Vordermark D,Wickenhauser C,Bethmann D,Eckert AW,Kappler M

    更新日期：2019-02-15 00:00:00

  • Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer.

    abstract：BACKGROUND:p53 (encoded by TP53) is involved in DNA damage repair, cell cycle regulation, apoptosis, aging and cellular senescence. TP53 is mutated in around 50% of human cancers. Nevertheless, the consequences of p53 inactivation in colon cancer outcome remain unclear. Recently, a new role of p53 together with CSNK1A1...

    journal_title：BMC cancer

    pub_type： 杂志文章

    doi：10.1186/1471-2407-13-277

    authors： Sarasqueta AF,Forte G,Corver WE,de Miranda NF,Ruano D,van Eijk R,Oosting J,Tollenaar RA,van Wezel T,Morreau H

    更新日期：2013-06-05 00:00:00