TROG 15.03 phase II clinical trial of Focal Ablative STereotactic Radiosurgery for Cancers of the Kidney - FASTRACK II.

abstract：BACKGROUND:The effects of exposure to ultraviolet radiation are a significant concern in Australia which has one of the highest incidences of skin cancer in the world. Despite most skin cancers being preventable by encouraging consistent adoption of sun-protective behaviours, incidence rates are not decreasing. There i...

journal_title：BMC cancer

authors： Cleary CM,White KM,Young RM,Hawkes AL,Leske S,Starfelt LC,Wihardjo K

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) patients with hepatic vein tumor thrombosis (HVTT) extending to the inferior vena cava (IVC) have an extremely poor prognosis. Here we report a case of HCC with HVTT and renal dysfunction after hepatic arterial infusion chemotherapy (HAIC) successfully treated by liver resectio...

journal_title：BMC cancer

authors： Itoh A,Sadamori H,Yabushita K,Monden K,Tatsukawa M,Hioki M,Hyodo T,Omonishi K,Ueki T,Ohno S,Sakaguchi K,Takakura N

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Primary angiosarcomas of the right atrium are extremely rare, often resulted in missed diagnosis or misdiagnosis with routine examination tools. These malignant cardiac tumors are highly aggressive with generally poor prognosis. Surgical excision is the mainstay of treatment as it is essentially not responsi...

journal_title：BMC cancer

authors： Yu Y,Wang Q,Sun J,Zhao J,Chen S,Li Y

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Treatment options for advanced head and neck adenoid cystic carcinoma (AdCC) are limited. Prostate-Specific Membrane Antigen (PSMA), a transmembrane protein that is known for its use in diagnostics and targeted therapy in prostate cancer, is also expressed by AdCC. This study aimed to analyse PSMA expression...

journal_title：BMC cancer

authors： Klein Nulent TJW,Valstar MH,Smit LA,Smeele LE,Zuithoff NPA,de Keizer B,de Bree R,van Es RJJ,Willems SM

更新日期：2020-06-05 00:00:00

abstract：BACKGROUND:Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatment of hypercholesterolemia and have been shown to trigger apoptosis in a tumor-specific manner. Rec...

journal_title：BMC cancer

authors： Martirosyan A,Clendening JW,Goard CA,Penn LZ

更新日期：2010-03-18 00:00:00

abstract：BACKGROUND:Treatment of locally advanced non-small-cell lung cancer is based on a combined approach. To study the impact of trimodal therapy for stage III-N2 NSCLC a single centre retrospective evaluation focusing on survival and therapy-related toxicity was performed. METHODS:71 patients diagnosed between March 2001 ...

journal_title：BMC cancer

authors： Askoxylakis V,Tanner J,Kappes J,Hoffmann H,Nicolay NH,Rief H,Debus J,Thomas M,Bischof M

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Cationic antimicrobial peptides (CAPs) with antitumor activity constitute a promising group of novel anticancer agents. These peptides induce lysis of cancer cells through interactions with the plasma membrane. It is not known which cancer cell membrane components influence their susceptibility to CAPs. We h...

journal_title：BMC cancer

authors： Fadnes B,Rekdal O,Uhlin-Hansen L

更新日期：2009-06-15 00:00:00

abstract：:Recently, Shu-Yu Tai et al. reported that personal hair dye use increased risk of prostate cancer with a dose-response effect. Although hair dyes were identified as carcinogenic in animals and increased risk of some cancers among hairdressers, the existing epidemiological data did not support that personal hair dye us...

journal_title：BMC cancer

authors： Jiann BP

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Malignant pleural mesothelioma (MPM) is a tumor known to be resistant to conventional therapies. Thus, an in vivo model can represent an important tool for assessing the efficacy of novel approaches in the treatment of MPM.Presently, human MPM cells have been grown orthotopically in mice upon transplantation...

journal_title：BMC cancer

authors： Martarelli D,Catalano A,Procopio A,Orecchia S,Libener R,Santoni G

更新日期：2006-05-17 00:00:00

abstract：BACKGROUND:Osteopontin (OPN) and thrombospondin-1 (TSP-1) are extracellular matrix proteins secreted by stromal and tumor cells. These proteins appear to have a key role in the tumor microenvironment for cancer development and metastasis. There is little information regarding the prognostic value of the combination of ...

journal_title：BMC cancer

authors： Rouanne M,Adam J,Goubar A,Robin A,Ohana C,Louvet E,Cormier J,Mercier O,Dorfmüller P,Fattal S,de Montpreville VT,Lebret T,Dartevelle P,Fadel E,Besse B,Olaussen KA,Auclair C,Soria JC

更新日期：2016-07-15 00:00:00

abstract：BACKGROUND:For metastatic spinal cord compression (MSCC), conventional radiotherapy with 10 × 3 Gy in 2 weeks results in better local progression-free survival (LPFS) than 5 × 4 Gy in 1 week. Since patients with MSCC are often significantly impaired, an overall treatment time of 1 week would be preferable if resulting ...

journal_title：BMC cancer

authors： Rades D,Cacicedo J,Conde-Moreno AJ,Doemer C,Dunst J,Lomidze D,Segedin B,Olbrich D,Holländer NH

更新日期：2017-12-04 00:00:00

abstract：BACKGROUND:"Biomarker-driven targeted therapy," the practice of tailoring patients' treatment to the expression/activity levels of disease-specific genes/proteins, remains challenging. For example, while the anti-ERBB2 monoclonal antibody, trastuzumab, was first developed using well-characterized, diverse in vitro brea...

journal_title：BMC cancer

authors： Chang HR,Park HS,Ahn YZ,Nam S,Jung HR,Park S,Lee SJ,Balch C,Powis G,Ku JL,Kim YH

更新日期：2016-03-09 00:00:00

abstract：BACKGROUND:At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene (MC4R) in the development of cancer cachexia. In humans, MC4R mutations that lead to an impaired receptor function are associated with obesity; in contrast...

journal_title：BMC cancer

authors： Knoll S,Zimmer S,Hinney A,Scherag A,Neubauer A,Hebebrand J

更新日期：2008-03-31 00:00:00

abstract：BACKGROUND:Solid tumours are less oxygenated than normal tissues. This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. The molecular mechanisms underlying such resistance have been investigated in a range of tumour types, including the adult brain tumours glioblastoma, yet little is k...

journal_title：BMC cancer

authors： Cowman S,Fan YN,Pizer B,Sée V

更新日期：2019-04-03 00:00:00

abstract：BACKGROUND:It is often difficult to diagnose inflammatory bowel disease (IBD)-associated neoplasia endoscopically due to background inflammation. In addition, due to the absence of sensitive tumor biomarkers, countermeasures against IBD-associated neoplasia are crucial. The purpose of this study is to develop a new dia...

journal_title：BMC cancer

authors： Kinugasa H,Hiraoka S,Nouso K,Yamamoto S,Hirai M,Terasawa H,Yasutomi E,Oka S,Ohmori M,Yamasaki Y,Inokuchi T,Takahara M,Harada K,Tanaka T,Okada H

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 mutations, and are characterized by the development of central nervous system tumors, sarcomas, adrenocortical carcinomas, and other early-onset tumors. Due to the high frequency of breast cancer in LFS/LFL families, these...

journal_title：BMC cancer

authors： Silva AG,Ewald IP,Sapienza M,Pinheiro M,Peixoto A,de Nóbrega AF,Carraro DM,Teixeira MR,Ashton-Prolla P,Achatz MI,Rosenberg C,Krepischi AC

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth. METHODS:Pancreatic carcinomas were assessed in a syngenei...

journal_title：BMC cancer

authors： Zechner D,Radecke T,Amme J,Bürtin F,Albert AC,Partecke LI,Vollmar B

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which were found to have the highest frequency of aberration for use as probes in fluorescent in-situ hyb...

journal_title：BMC cancer

authors： Policht FA,Song M,Sitailo S,O'Hare A,Ashfaq R,Muller CY,Morrison LE,King W,Sokolova IA

更新日期：2010-08-16 00:00:00

abstract：BACKGROUND:Malignant Pleural Mesothelioma (MPM) is an aggressive tumor arising from mesothelial cells lining the pleural cavities characterized by resistance to standard therapies. Most of the molecular steps responsible for pleural transformation remain unclear; however, several growth factor signaling cascades are kn...

journal_title：BMC cancer

authors： Pignochino Y,Dell'Aglio C,Inghilleri S,Zorzetto M,Basiricò M,Capozzi F,Canta M,Piloni D,Cemmi F,Sangiolo D,Gammaitoni L,Soster M,Marchiò S,Pozzi E,Morbini P,Luisetti M,Aglietta M,Grignani G,Stella GM

更新日期：2015-05-08 00:00:00

abstract：BACKGROUND:Selection of patients with local failure of nasopharyngeal carcinoma (NPC) for appropriate type of salvage treatment can be difficult due to the lack of data on comparative efficacy of different salvage treatments. The purpose of the present study was to validate a previously published prognostic scoring sys...

journal_title：BMC cancer

authors： Chua DT,Hung KN,Lee V,Ng SC,Tsang J

更新日期：2009-04-29 00:00:00

abstract：BACKGROUND:The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic disease who might benefit from adjuvant therapies. The aim was to examine if cellular immune markers...

journal_title：BMC cancer

authors： Falkenius J,Johansson H,Tuominen R,Frostvik Stolt M,Hansson J,Egyhazi Brage S

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT). METHODS:A total of 97 locally advanced ESCC patients were enrolled. All the patients had their ...

journal_title：BMC cancer

authors： Chen YH,Lu HI,Lo CM,Wang YM,Chou SY,Hsiao CC,Huang CC,Shih LH,Chen SW,Li SH

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:Our previous study showed that GATA6 plays important roles in cholangiocarcinoma (CCA) cell invasion and metastasis. However, the regulation mechanism of GATA6 in CCA is not clear. In this study, we studied the potential function of miR-124 in CCA and the mechanism of GATA6 regulation. METHODS:The expressio...

journal_title：BMC cancer

authors： Tian F,Chen J,Zheng S,Li D,Zhao X,Jiang P,Li J,Wang S

更新日期：2017-03-07 00:00:00

abstract：BACKGROUND:In vitro and in vivo studies have suggested that osteopontin (OPN) is associated with many types of cancers. However, no studies have reported the incidence of OPN polymorphisms and the risk of gastric cancer. The aim of this study was to investigate the association between OPN polymorphisms and gastric canc...

journal_title：BMC cancer

authors： Zhao F,Chen X,Meng T,Hao B,Zhang Z,Zhang G

更新日期：2012-10-16 00:00:00

abstract：BACKGROUND:We report an extremely rare case of vaginal clear cell carcinoma, which originated from the malignant transformation of vaginal adenosis without prenatal diethylstilbestrol (DES) exposure. CASE PRESENTATION:In this case, the patient was a Chinese woman with a history of two decades of intermittent vaginal p...

journal_title：BMC cancer

authors： Pang L,Li L,Zhu L,Lang J,Bi Y

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:Colon cancer patients with the same stage show diverse clinical behavior due to tumor heterogeneity. We aimed to discover distinct classes of tumors based on microarray expression patterns, to analyze whether the molecular classification correlated with the histopathological stages or other clinical paramete...

journal_title：BMC cancer

authors： Perez-Villamil B,Romera-Lopez A,Hernandez-Prieto S,Lopez-Campos G,Calles A,Lopez-Asenjo JA,Sanz-Ortega J,Fernandez-Perez C,Sastre J,Alfonso R,Caldes T,Martin-Sanchez F,Diaz-Rubio E

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:Development of escape pathways from antiangiogenic treatments was reported to be associated with enhanced tumor aggressiveness and rebound effect was suggested after treatment stop. Aim of the study was to evaluate tumor response simulating different conditions of administration of antiangiogenic treatment (...

journal_title：BMC cancer

authors： Marinelli S,Salvatore V,Baron Toaldo M,Milazzo M,Croci L,Venerandi L,Pecorelli A,Palamà C,Diana A,Bolondi L,Piscaglia F

更新日期：2014-06-04 00:00:00

abstract：BACKGROUND:Continued smoking after cancer adversely affects quality of life and survival, but one fifth of cancer survivors still smoke. Despite its demands, cancer presents an opportunity for positive behaviour change. Smoking often occurs in social groups, therefore interventions which target families and individuals...

journal_title：BMC cancer

authors： Wells M,Aitchison P,Harris F,Ozakinci G,Radley A,Bauld L,Entwistle V,Munro A,Haw S,Culbard B,Williams B

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis model of gastric cancer using VX2 tumor, and analyze the clinico-pathological features. METHODS:VX...

journal_title：BMC cancer

authors： Mei LJ,Yang XJ,Tang L,Hassan AH,Yonemura Y,Li Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multiple tyrosine kinase o...

journal_title：BMC cancer

authors： Zhao H,Agazie YM

更新日期：2015-03-08 00:00:00