Abstract:
BACKGROUND:Risk estimation of gastrointestinal stromal tumours (GIST) is based on tumour size and mitotic rate according to the National Institutes of Health consensus classification. The indication for adjuvant treatment of patients with high risk GIST after R0 resection with small molecule inhibitors is still a controversial issue, since these patients represent a highly heterogeneous population. Therefore, additional prognostic indicators are needed. Here, we evaluated the prognostic value of cyclin H expression in GIST. METHODS:In order to identify prognostic factors of GIST we evaluated a single centre cohort of ninety-five GIST patients. First, GISTs were classified with regard to tumour size, mitotic rate and localisation according to the NIH consensus and to three additional suggested risk classifications. Second, Cyclin H expression was analysed. RESULTS:Of ninety-five patients with GIST (53 female/42 male; median age: 66.78a; range 17-94a) risk classification revealed: 42% high risk, 20% intermediate risk, 23% low risk and 15% very low risk GIST. In patients with high risk GIST, the expression of cyclin H was highly predictive for reduced disease-specific survival (p = 0.038). A combination of cyclin H expression level and high risk classification yielded the strongest prognostic indicator for disease-specific and disease-free survival (p < or = 0.001). Moreover, in patients with tumour recurrence and/or metastases, cyclin H positivity was significantly associated with reduced disease-specific survival (p = 0.016) regardless of risk-classification. CONCLUSION:Our data suggest that, in addition to high risk classification, cyclin H expression might be an indicator for "very-high risk" GIST.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Dorn J,Spatz H,Schmieder M,Barth TF,Blatz A,Henne-Bruns D,Knippschild U,Kramer Kdoi
10.1186/1471-2407-10-350subject
Has Abstractpub_date
2010-07-02 00:00:00pages
350issn
1471-2407pii
1471-2407-10-350journal_volume
10pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Hemostatic alterations occur during the development of cancer. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker that is increased in patients with various solid tumours. The aim of this study was to evaluate the hemostatic status of nasopharyngeal carcinoma (NPC) patients by assessing pl...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-583
更新日期:2014-08-10 00:00:00
abstract:BACKGROUND:Alcohol consumption is associated with increased risk of breast cancer (BC), and the underlying mechanism is thought to be sex-hormone driven. In vitro and observational studies suggest a mechanism involving peroxisome proliferator-activated receptor gamma (PPARγ) in a complex with peroxisome proliferator-ac...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-016-2317-y
更新日期:2016-04-21 00:00:00
abstract:BACKGROUND:Spontaneous regression/complete resistance (SR/CR) mice are a unique colony of mice that possess an inheritable, natural cancer resistance mediated primarily by innate cellular immunity. This resistance is effective against sarcoma 180 (S180) at exceptionally high doses and these mice remain healthy. METHOD...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-179
更新日期:2010-05-03 00:00:00
abstract:BACKGROUND:Amphiregulin (AREG) and Epiregulin (EREG), ligands of EGFR, are reported to be predictive biomarkers of colorectal cancer patients treated with Cetuximab, an anti-EGFR antibody. The purpose of this study is to determine the correlation of AREG and EREG expression between primary colorectal cancer and corresp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-88
更新日期:2012-03-13 00:00:00
abstract:BACKGROUND:Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine (HCY), marker of folate metabolism was also investigated. METHODS:The SHMT1 and MTHFR genotypes w...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-525
更新日期:2010-10-04 00:00:00
abstract:BACKGROUND:The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5F...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5327-8
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms. METHODS:The response of breast cancer cell lines (MCF-7 and MDA-MB-231) to doxorubicin was ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3953-6
更新日期:2018-01-06 00:00:00
abstract:BACKGROUND:Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study were to see if the national target of 70% of all cancer patients being included in a CPP was met, and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06979-y
更新日期:2020-05-30 00:00:00
abstract:BACKGROUND:In developed countries, the lifetime risk of developing colorectal cancer (CRC) is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherite...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-424
更新日期:2011-10-04 00:00:00
abstract:BACKGROUND:Lactic acid bacteria (LAB) are beneficial probiotic organisms that contribute to improved nutrition, microbial balance, and immuno-enhancement of the intestinal tract, as well as anti-tumor activity. The aim of the present work was to study the growth inhibition of tumor cells by butanol extract of Bifidobac...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-310
更新日期:2008-10-27 00:00:00
abstract:BACKGROUND:Breast cancer is the most common cancer type in female. As microRNAs play vital role in breast cancer, this study aimed to explore the molecular mechanism and clinical value of miR-21 in breast cancer. METHODS:qRT-PCR was performed to detect miR-21 levels in plasma of 127 healthy controls, 82 benign breast ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5951-3
更新日期:2019-07-27 00:00:00
abstract:BACKGROUND:The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast cancer-specific mortality in women with breast cancer. Our study will add to the knowledge on whether...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1971-9
更新日期:2015-12-16 00:00:00
abstract:BACKGROUND:Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-382
更新日期:2008-12-19 00:00:00
abstract:BACKGROUND:Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizer-replete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and induction of an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1994-2
更新日期:2015-12-26 00:00:00
abstract:BACKGROUND:Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal ch...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-402
更新日期:2010-08-02 00:00:00
abstract:BACKGROUND:The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic disease who might benefit from adjuvant therapies. The aim was to examine if cellular immune markers...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3577-x
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. Aberrant expression of SLIT-ROBO genes was repeatedly shown in a wide variety of cancers, yet data about their collective behavior in hepatocellular carcinoma (HCC) is missing. Hence, we qua...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-392
更新日期:2008-12-29 00:00:00
abstract:BACKGROUND:Squamous cell carcinoma of the head and neck (SCCHN) often contain highly radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality for these tumours. Reoxygenation during fractionated radiotherapy is desired to render these hypoxic tumour regions more radiosensitive. Hypoxia a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-143
更新日期:2007-07-30 00:00:00
abstract:BACKGROUND:This study aims to evaluate the impact of colony stimulating factor-1 (CSF-1) expression on recurrence and survival of patients with clear-cell renal cell carcinoma (ccRCC) following surgery. METHODS:We retrospectively enrolled 267 patients (195 in the training cohort and 72 in the validation cohort) with c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1076-5
更新日期:2015-02-18 00:00:00
abstract:BACKGROUND:Increased mammographic breast density is a moderate risk factor for breast cancer. Different scales have been proposed for classifying mammographic density. This study sought to assess intra-rater agreement for the most widely used scales (Wolfe, Tabár, BI-RADS and Boyd) and compare them in terms of classify...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-485
更新日期:2010-09-13 00:00:00
abstract:BACKGROUND:Although adjuvant chemotherapy with S-1 after curative gastrectomy has been performed as a standard treatment for Stage II and III gastric cancer (GC) in Japan, patients with Stage III GC still have a high incidence of recurrence and a poor prognostic outcome. The aim of this study was to investigate risk fa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4052-z
更新日期:2018-01-30 00:00:00
abstract:BACKGROUND:The management of unresectable or metastatic gastrointestinal stromal tumors (GISTs) has previously been difficult as they are resistant to conventional chemotherapy and radiation. The development of imatinib mesylate has made a major impact on the management of advanced GISTs. It is apparent that there are ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-4-74
更新日期:2004-10-09 00:00:00
abstract:BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-164
更新日期:2006-06-23 00:00:00
abstract:BACKGROUND:Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such approach. Here we investigated the concordance between mutations found in the primary tumor and pancre...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5195-7
更新日期:2019-01-05 00:00:00
abstract:BACKGROUND:To assess the clinical value of peritoneal washing cytology (PWC) in women with BRCA1 or BRCA2 mutations and women from a family with hereditary breast and/or ovarian cancer (HBOC) undergoing risk-reducing salpingo-oophorectomy (RRSO) in detecting primary peritoneal cancer (PPC) or occult ovarian/fallopian t...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12885-015-2011-5
更新日期:2016-01-14 00:00:00
abstract:BACKGROUND:It has been previously demonstrated in several cancer models, that Dronabinol (THC) may have anti-tumor activity--however, controversial data exists for acute leukemia. We have anecdotal evidence that THC may have contributed to disease control in a patient with acute undifferentiated leukemia. METHODS:To t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-2029-8
更新日期:2016-01-16 00:00:00
abstract::Following publication of the original article [1], the authors reported an error in Figure 2, where the color code of the text boxes is reversed. Figure 2-amended shows the correct color association between the text boxes and the different areas in the map: Navarra, neighbouring communities and other Spanish communiti...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-019-6458-7
更新日期:2019-12-17 00:00:00
abstract:BACKGROUND:Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine tumours (NETs). Herein, we investigate the use of these treatment combinations in clinical practice. METHO...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1512-6
更新日期:2015-07-04 00:00:00
abstract:BACKGROUND:Recent large trials have shown the survival benefits of 10-year use of tamoxifen by reducing late recurrence compared with 5-year therapy in estrogen receptor(ER)-positive breast cancer. We tried to identify clinical factors associated with the late recurrence. METHODS:We reviewed our database of ER-positiv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2423-x
更新日期:2016-07-07 00:00:00
abstract:BACKGROUND:Aboriginal status has been unreliably and incompletely recorded in health and vital registration data collections for the most populous areas of Australia, including NSW where 29% of Australian Aboriginal people reside. This paper reports an assessment of Aboriginal status recording in NSW cancer registratio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-168
更新日期:2012-05-06 00:00:00