Long-term survival of women with basal-like ductal carcinoma in situ of the breast: a population-based cohort study.


BACKGROUND:Microarray gene-profiling of invasive breast cancer has identified different subtypes including luminal A, luminal B, HER2-overexpressing and basal-like groups. Basal-like invasive breast cancer is associated with a worse prognosis. However, the prognosis of basal-like ductal carcinoma in situ (DCIS) is still unknown. Our aim was to study the prognosis of basal-like DCIS in a large population-based cohort. METHODS:All 458 women with a primary DCIS diagnosed between 1986 and 2004, in Uppland and Västmanland, Sweden were included. TMA blocks were constructed. To classify the DCIS tumors, we used immunohistochemical (IHC) markers (estrogen-, progesterone-, HER2, cytokeratin 5/6 and epidermal growth factor receptor) as a surrogate for the gene expression profiling. The association with prognosis was examined for basal-like DCIS and other subtypes using Kaplan-Meier survival analyses and Cox proportional hazards regression models. RESULTS:IHC data were complete for 392 women. Thirty-two were basal-like (8.2%), 351 were luminal or HER2-positive (89.5%) and 9 unclassified (2.3%). Seventy-six women had a local recurrence of which 34 were invasive. Another 3 women had general metastases as first event. Basal-like DCIS showed a higher risk of local recurrence and invasive recurrence 1.8 (Confidence interval (CI) 95%, 0.8-4.2) and 1.9 (0.7-5.1), respectively. However, the difference was not statistically significant. Also, no statistically significant increased risk was seen for triple-negative or high grade DCIS. CONCLUSIONS:Basal-like DCIS showed about a doubled, however not statistically significant risk for local recurrence and developing invasive cancer compared with the other molecular subtypes. Molecular subtyping was a better prognostic parameter than histopathological grade.


BMC Cancer


BMC cancer


Zhou W,Jirström K,Johansson C,Amini RM,Blomqvist C,Agbaje O,Wärnberg F




Has Abstract


2010-11-30 00:00:00










  • Reduced mRNA expression levels of NFE2L2 are associated with poor outcome in breast cancer patients.

    abstract:BACKGROUND:The transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2; previously known as NRF2) is a crucial regulator of the intracellular antioxidant response. It controls the expression of genes involved in the detoxification and elimination of reactive oxidants and electrophilic agents. The role ...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Wolf B,Goebel G,Hackl H,Fiegl H

    更新日期:2016-10-22 00:00:00

  • Cancer stem-like sphere cells induced from de-differentiated hepatocellular carcinoma-derived cell lines possess the resistance to anti-cancer drugs.

    abstract:BACKGROUND:Cancer stem cells (CSCs) are thought to play important roles in therapy-resistance. In this study, we induced cancer stem-like cells from hepatocellular carcinoma (HCC) cell lines using a unique medium, and examined their potential for resistance to anti-cancer drugs. METHODS:The human HCC cell lines SK-HEP...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Hashimoto N,Tsunedomi R,Yoshimura K,Watanabe Y,Hazama S,Oka M

    更新日期:2014-09-27 00:00:00

  • A novel combined systemic inflammation-based score can predict survival of intermediate-to-advanced hepatocellular carcinoma patients undergoing transarterial chemoembolization.

    abstract:BACKGROUND:There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatocellular carcinoma (HCC). This study aimed to assess the predictive ability of the dNLR-PNI in patien...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Liu C,Li L,Lu WS,Du H,Yan LN,Wen TF,Wei WR,Jiang L,Xu MQ

    更新日期:2018-02-21 00:00:00

  • A novel circular invasion assay mimics in vivo invasive behavior of cancer cell lines and distinguishes single-cell motility in vitro.

    abstract:BACKGROUND:Classical in vitro wound-healing assays and other techniques designed to study cell migration and invasion have been used for many years to elucidate the various mechanisms associated with metastasis. However, many of these methods are limited in their ability to achieve reproducible, quantitative results th...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Kam Y,Guess C,Estrada L,Weidow B,Quaranta V

    更新日期:2008-07-14 00:00:00

  • MicroRNA-148b regulates tumor growth of non-small cell lung cancer through targeting MAPK/JNK pathway.

    abstract:BACKGROUND:MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung cancer (NSCLC) specimens and cell lines. However, the underlying mechanisms of miR-148b in regulatin...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Lu L,Liu Q,Wang P,Wu Y,Liu X,Weng C,Fang X,Li B,Cao X,Mao H,Wang L,Guan M,Wang W,Liu G

    更新日期:2019-03-08 00:00:00

  • Prediction of advanced colonic neoplasm in symptomatic patients: a scoring system to prioritize colonoscopy (COLONOFIT study).

    abstract:BACKGROUND:Fast-track colonoscopy to detect patients with colorectal cancer based on high-risk symptoms is associated with low sensitivity and specificity. The aim was to derive a predictive score of advanced colonic neoplasia in symptomatic patients in fast-track programs. METHODS:All patients referred for fast-track...

    journal_title:BMC cancer

    pub_type: 杂志文章,多中心研究


    authors: Fernández-Bañares F,Clèries R,Boadas J,Ribes J,Oliva JC,Alsius A,Sanz X,Martínez-Bauer E,Galter S,Pujals M,Pujol M,Del Pozo P,Campo R

    更新日期:2019-07-25 00:00:00

  • Protocol for the "Chemobrain in Motion - study" (CIM - study): a randomized placebo-controlled trial of the impact of a high-intensity interval endurance training on cancer related cognitive impairments in women with breast cancer receiving first-line che

    abstract:BACKGROUND:Up to 80% of breast cancer patients suffer from Cancer Related Cognitive Impairments (CRCI). Exercise is suggested as a potential supportive care option to reduce cognitive decline in cancer patients. This study will investigate the effects of a high-intensity interval endurance training (HIIT) on CRCI in br...

    journal_title:BMC cancer

    pub_type: 杂志文章,随机对照试验


    authors: Oberste M,Schaffrath N,Schmidt K,Bloch W,Jäger E,Steindorf K,Hartig P,Joisten N,Zimmer P

    更新日期:2018-11-06 00:00:00

  • Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors.

    abstract:BACKGROUND:Several stromal cell subtypes including macrophages contribute to tumor progression by inducing epithelial-mesenchymal transition (EMT) at the invasive front, a mechanism also linked to metastasis. Tumor associated macrophages (TAM) reside mainly at the invasive front but they also infiltrate tumors and in t...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Bonde AK,Tischler V,Kumar S,Soltermann A,Schwendener RA

    更新日期:2012-01-24 00:00:00

  • Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer.

    abstract:BACKGROUND:Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTOR inhibitors in small cell lung cancer (SCLC) cells and sought to clarify the mechanism of resistanc...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Matsumoto M,Seike M,Noro R,Soeno C,Sugano T,Takeuchi S,Miyanaga A,Kitamura K,Kubota K,Gemma A

    更新日期:2015-04-09 00:00:00

  • Selective microdochectomy after ductoscopic wire marking in women with pathological nipple discharge.

    abstract:BACKGROUND:To investigate the diagnostic reliability of selective microdochectomy after direct ductoscopic wire marking of suspect lesions in patients with pathological nipple discharge. METHODS:Selective microdochectomy due to pathological discharge was performed in 33 patients with mean age of 51.7 years. Ductoscope...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Hahn M,Fehm T,Solomayer EF,Siegmann KC,Hengstmann AS,Wallwiener D,Ohlinger R

    更新日期:2009-05-17 00:00:00

  • The role of major duct excision and microdochectomy in the detection of breast carcinoma.

    abstract:BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Dillon MF,Mohd Nazri SR,Nasir S,McDermott EW,Evoy D,Crotty TB,O'Higgins N,Hill AD

    更新日期:2006-06-23 00:00:00

  • Pharmacodynamic modeling of synergistic birinapant/paclitaxel interactions in pancreatic cancer cells.

    abstract:BACKGROUND:For most patients, pancreatic adenocarcinoma responds poorly to treatment, and novel therapeutic approaches are needed. Standard-of-care paclitaxel (PTX), combined with birinapant (BRP), a bivalent mimetic of the apoptosis antagonist SMAC (second mitochondria-derived activator of caspases), exerts synergisti...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Niu J,Wang X,Qu J,Mager DE,Straubinger RM

    更新日期:2020-10-23 00:00:00

  • Classifying breast cancer surgery: a novel, complexity-based system for oncological, oncoplastic and reconstructive procedures, and proof of principle by analysis of 1225 operations in 1166 patients.

    abstract:BACKGROUND:One of the basic prerequisites for generating evidence-based data is the availability of classification systems. Attempts to date to classify breast cancer operations have focussed on specific problems, e.g. the avoidance of secondary corrective surgery for surgical defects, rather than taking a generic appr...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Hoffmann J,Wallwiener D

    更新日期:2009-04-08 00:00:00

  • Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells.

    abstract:BACKGROUND:The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements character...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Schmidt JW,Wehde BL,Sakamoto K,Triplett AA,West WW,Wagner KU

    更新日期:2014-03-15 00:00:00

  • Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.

    abstract:BACKGROUND:Although advanced-stage cervical cancer can benefit from current treatments, approximately 30% patients may fail after definitive treatment eventually. Therefore, exploring alternative molecular therapeutic approaches is imperatively needed for this disease. We have recently shown that activation of AMP-acti...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Yung MM,Chan DW,Liu VW,Yao KM,Ngan HY

    更新日期:2013-07-03 00:00:00

  • Cytology material is equivalent to tumor tissue in determining mutations of BRCA 1/2 genes in patients with tubo-ovarian high grade serous carcinoma.

    abstract:BACKGROUND:High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible for treatment with poly(ADP-ribose) polymerase inhibitors (PARPi). The aim of this study was to ...

    journal_title:BMC cancer

    pub_type: 临床试验,杂志文章


    authors: Gornjec A,Novakovic S,Stegel V,Hocevar M,Pohar Marinsek Z,Gazic B,Krajc M,Skof E

    更新日期:2019-04-02 00:00:00

  • ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286).

    abstract:BACKGROUND:Recent randomized controlled trials comparing neoadjuvant chemoradiation plus surgery or perioperative chemotherapy plus surgery with surgery alone showed significant survival benefits for combined modality treatment of patients with localized esophageal adenocarcinoma. However, head-to-head comparisons of n...

    journal_title:BMC cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Hoeppner J,Lordick F,Brunner T,Glatz T,Bronsert P,Röthling N,Schmoor C,Lorenz D,Ell C,Hopt UT,Siewert JR

    更新日期:2016-07-19 00:00:00

  • Cardiopulmonary bypass has a modest association with cancer progression: a retrospective cohort study.

    abstract:BACKGROUND:Given their frequency of occurrence in the United States, cancer and heart disease often coexist. For patients requiring open-heart surgery, this raises concern that the use of cardiopulmonary bypass (CPB) may cause a transient immunosuppression with the potential to promote the spread and growth of coexisti...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Pinto CA,Marcella S,August DA,Holland B,Kostis JB,Demissie K

    更新日期:2013-11-03 00:00:00

  • Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry.

    abstract:BACKGROUND:Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or l...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Call J,Walentas CD,Eickhoff JC,Scherzer N

    更新日期:2012-03-19 00:00:00

  • Attention to the principles of exercise training in exercise studies on prostate cancer survivors: a systematic review.

    abstract:BACKGROUND:The purpose of this review is to update previously published reviews on exercise programming in exercise trials in prostate cancer survivors. We evaluated: 1) the application of the principles of exercise training in prescribed programs; 2) the reporting of the components of the exercise prescription; and 3)...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Neil-Sztramko SE,Medysky ME,Campbell KL,Bland KA,Winters-Stone KM

    更新日期:2019-04-05 00:00:00

  • Cancer incidence and mortality in Serbia 1999-2009.

    abstract:BACKGROUND:Despite the increase in cancer incidence in the last years in Serbia, no nation-wide, population-based cancer epidemiology data have been reported. In this study cancer incidence and mortality rates for Serbia are presented using nation-wide data from two population-based cancer registries. These rates are a...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Mihajlović J,Pechlivanoglou P,Miladinov-Mikov M,Zivković S,Postma MJ

    更新日期:2013-01-15 00:00:00

  • The acceptability of high resolution anoscopy examination in patients attending a tertiary referral centre.

    abstract:BACKGROUND:High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: De-Masi A,Davis E,Cuming T,Chindawi N,Pesola F,Cappello C,Chambers S,Bowring J,Rosenthal AN,Sasieni P,Nathan M

    更新日期:2018-05-11 00:00:00

  • Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis.

    abstract:BACKGROUND:Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the prognostic value of MDSCs ...

    journal_title:BMC cancer

    pub_type: 杂志文章,meta分析


    authors: Ai L,Mu S,Wang Y,Wang H,Cai L,Li W,Hu Y

    更新日期:2018-12-05 00:00:00

  • Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.

    abstract:BACKGROUND:Clinical trials where cancer patients were treated with protease inhibitors have suggested that the serine protease, prostasin, may act as a tumour suppressor. Prostasin is proteolytically activated by the serine protease, matriptase, which has a very high oncogenic potential. Prostasin is inhibited by prote...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Selzer-Plon J,Bornholdt J,Friis S,Bisgaard HC,Lothe IM,Tveit KM,Kure EH,Vogel U,Vogel LK

    更新日期:2009-06-25 00:00:00

  • Retinal and vitreous metastases from hepatocholangiocarcinoma.

    abstract:BACKGROUND:To report a case of metastatic hepatocholangiocarcinoma to the vitreous and retina. CASE PRESENTATION:A 70-year-old male, who was recently diagnosed with hepatocholangiocarcinoma, was complaining of floaters in his right eye over the past 5 months and was referred to the Liverpool Ocular Oncology Centre. On...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Praidou A,Jacob S,Irion L,Sivaraj R,Groenewald C,Coupland SE,Heimann H

    更新日期:2017-06-19 00:00:00

  • Identification of novel signaling components in N,N'-dinitrosopiperazine-mediated metastasis of nasopharyngeal carcinoma by quantitative phosphoproteomics.

    abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer. N,N'-dinitrosopiperazine (DNP), a carcinogen with specificity for nasopharyngeal epithelium, facilitates NPC metastasis. However, the underlying mechanism is not known. METHODS:Quantitative phosphoproteomics, using stable isotope lab...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Huang D,Li Y,Liu N,Zhang Z,Peng Z,Duan C,Tang X,Tan G,Yan G,Tang F

    更新日期:2014-04-05 00:00:00

  • Elevated levels of plasma D-dimer predict a worse outcome in patients with nasopharyngeal carcinoma.

    abstract:BACKGROUND:Hemostatic alterations occur during the development of cancer. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker that is increased in patients with various solid tumours. The aim of this study was to evaluate the hemostatic status of nasopharyngeal carcinoma (NPC) patients by assessing pl...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Chen WH,Tang LQ,Wang FW,Li CP,Tian XP,Huang XX,Mai SJ,Liao YJ,Deng HX,Chen QY,Liu H,Zhang L,Guo SS,Liu LT,Yan SM,Li CF,Zhang JP,Liu Q,Liu XW,Liu LZ,Mai HQ,Zeng MS,Xie D

    更新日期:2014-08-10 00:00:00

  • miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms' tumor.

    abstract:BACKGROUND:Wilms' tumor is also called nephroblastoma and is the most common pediatric renal cancer. Several genetic and epigenetic factors have been found to account for the development of Wilms' tumor. MiRNAs play important roles in this tumorigenic process. In the present study, we aimed to investigate the role of m...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Liu Z,He F,OuYang S,Li Y,Ma F,Chang H,Cao D,Wu J

    更新日期:2019-04-29 00:00:00

  • TROG 15.03 phase II clinical trial of Focal Ablative STereotactic Radiosurgery for Cancers of the Kidney - FASTRACK II.

    abstract:BACKGROUND:Stereotactic ablative body radiotherapy (SABR) is a non-invasive alternative to surgery to control primary renal cell cancer (RCC) in patients that are medically inoperable or at high-risk of post-surgical dialysis. The objective of the FASTRACK II clinical trial is to investigate the efficacy of SABR for pr...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Siva S,Chesson B,Bressel M,Pryor D,Higgs B,Reynolds HM,Hardcastle N,Montgomery R,Vanneste B,Khoo V,Ruben J,Lau E,Hofman MS,De Abreu Lourenco R,Sridharan S,Brook NR,Martin J,Lawrentschuk N,Kron T,Foroudi F

    更新日期:2018-10-23 00:00:00

  • MGMT, GATA6, CD81, DR4, and CASP8 gene promoter methylation in glioblastoma.

    abstract:BACKGROUND:Methylation of promoter region is the major mechanism affecting gene expression in tumors. Recent methylome studies of brain tumors revealed a list of new epigenetically modified genes. Our aim was to study promoter methylation of newly identified epigenetically silenced genes together with already known epi...

    journal_title:BMC cancer

    pub_type: 杂志文章


    authors: Skiriute D,Vaitkiene P,Saferis V,Asmoniene V,Skauminas K,Deltuva VP,Tamasauskas A

    更新日期:2012-06-06 00:00:00