Abstract:
BACKGROUND:Allelic counterparts of biallelically expressed genes display an epigenetic symmetry normally manifested by synchronous replication, different from genes subjected to monoallelic expression, which normally are characterized by an asynchronous mode of replication (well exemplified by the SNRPN imprinted locus). Malignancy was documented to be associated with gross modifications in the inherent replication-timing coordination between allelic counterparts of imprinted genes as well as of biallelically expressed loci. The cancer-related allelic replication timing aberrations are non-disease specific and appear in peripheral blood cells of cancer patients, including those with solid tumors. As such they offer potential blood markers for non-invasive cancer test. The present study was aimed to gain some insight into the mechanism leading to the replication timing alterations of genes in blood lymphocytes of cancer patients. METHODS:Peripheral blood samples derived from patients with prostate cancer were chosen to represent the cancerous status, and samples taken from patients with no cancer but with benign prostate hyperplasia were used to portray the normal status. Fluorescence In Situ Hybridization (FISH) replication assay, applied to phytohemagglutinin (PHA)-stimulated blood lymphocytes, was used to evaluate the temporal order (either synchronous or asynchronous) of genes in the patients' cells. RESULTS:We demonstrated that: (i) the aberrant epigenetic profile, as delineated by the cancer status, is a reversible modification, evidenced by our ability to restore the normal patterns of replication in three unrelated loci (CEN15, SNRPN and RB1) by introducing an archetypical demethylating agent, 5-azacytidine; (ii) following the rehabilitating effect of demethylation, an imprinted gene (SNRPN) retains its original parental imprint; and (iii) the choice of an allele between early or late replication in the aberrant asynchronous replication, delineated by the cancer status, is not random but is independent of the parental origin. CONCLUSION:The non-disease specific aberrant epigenetic profile displayed in peripheral blood cells of patients with a solid tumour (unlike genetic aberrations) can be reversed, by an epigenetic drug applied in vitro, to the normal. It appears that the cancerous status differentiates between two allelic counterparts in a non-random manner, but independent of the parental origin.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Dotan ZA,Dotan A,Ramon J,Avivi Ldoi
10.1186/1471-2407-8-390subject
Has Abstractpub_date
2008-12-25 00:00:00pages
390issn
1471-2407pii
1471-2407-8-390journal_volume
8pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements character...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-195
更新日期:2014-03-15 00:00:00
abstract:BACKGROUND:Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However, the mechanisms involved in lipid modulation of NK cell postoperative anti-tumor function are unkno...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6045-y
更新日期:2019-08-20 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators ("writer," "eraser," and "reader" proteins), which are associated with cancer occurrence and development. Th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6638-5
更新日期:2020-02-28 00:00:00
abstract:BACKGROUND:The objective of this study is to investigate the role and experience of early stage non-small cell lung cancer (NSCLC) patient in decision making process concerning treatment selection in the current clinical practice. METHODS:Stage I-II NSCLC patients (surgery 55 patients, SBRT 29 patients, median age 68)...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-3986-5
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:Patients suffering from squamous cell carcinoma of the larynx (LSCC) with lymphatic metastasis have a relatively poor prognosis and often require radical therapeutic management. The mechanisms which drive metastasis to the lymph nodes are largely unknown but may be promoted by a pro-angiogenic tumor microenv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4180-5
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:Several stromal cell subtypes including macrophages contribute to tumor progression by inducing epithelial-mesenchymal transition (EMT) at the invasive front, a mechanism also linked to metastasis. Tumor associated macrophages (TAM) reside mainly at the invasive front but they also infiltrate tumors and in t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-35
更新日期:2012-01-24 00:00:00
abstract:BACKGROUND:Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by its combination with other microtubule-binding agents. METHODS:The interactions between ABZ and micro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-86
更新日期:2013-02-23 00:00:00
abstract:BACKGROUND:Chromosomal and genomic aberrations are common features of human cancers. However, chromosomal numerical and structural aberrations, breakpoints and disrupted genes have yet to be identified in esophageal squamous cell carcinoma (ESCC). METHODS:Using multiplex-fluorescence in situ hybridization (M-FISH) and...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-367
更新日期:2012-08-24 00:00:00
abstract:BACKGROUND:In Egypt, where bilharziasis is endemic, bladder cancer is the commonest cancer in males and the 2nd in females; squamous cell carcinoma (SCC) is the commonest type found, with a peculiar mode of presentation. The aim of this study is to identify and rank the risk factors of muscle invasive bladder cancer (M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-250
更新日期:2008-08-29 00:00:00
abstract:BACKGROUND:Our previous study showed that GATA6 plays important roles in cholangiocarcinoma (CCA) cell invasion and metastasis. However, the regulation mechanism of GATA6 in CCA is not clear. In this study, we studied the potential function of miR-124 in CCA and the mechanism of GATA6 regulation. METHODS:The expressio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3166-z
更新日期:2017-03-07 00:00:00
abstract:BACKGROUND:KAI1 was initially identified as a metastasis-suppressor gene in prostate cancer. It is a member of the tetraspan transmembrane superfamily (TM4SF) of membrane glycoproteins. As part of a tetraspanin-enriched microdomain (TEM), KAI1 inhibits tumor metastasis by negative regulation of Src. However, the underl...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-81
更新日期:2012-03-06 00:00:00
abstract:BACKGROUND:Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4-12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibitors (TKIs). Development of effective therapies for patients with EGFRex20ins mutant non-small-cell ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5820-0
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:FOXM1 regulates expression of cell cycle related genes that are essential for progression into DNA replication and mitosis. Consistent with its role in proliferation, elevated expression of FOXM1 has been reported in a variety of human tumour entities. FOXM1 is a gene of interest because recently chemical in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-42
更新日期:2008-02-06 00:00:00
abstract:BACKGOUND:Oropharyngeal cancer (OPC) associated with human papilloma virus (HPV OPC) shows better treatment outcomes than non-HPV OPC. We investigated the expression of p53, β-tubulin, bcl-2 and ERCC 1, which are well-known biomarkers to predict the chemotherapy response, according to HPV status in OPC patients. METHO...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-824
更新日期:2014-11-07 00:00:00
abstract:BACKGROUND:We analyzed the influence of 8 germinal polymorphisms of candidate genes potentially related to EGFR signalling (EGFR, EGF, CCND1) or antibody-directed cell cytotoxicity (FCGR2A and FCGR3A) on outcome of colorectal cancer (CRC) patients receiving cetuximab-based therapy. METHODS:Fifty-eight advanced CRC pat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-496
更新日期:2011-11-25 00:00:00
abstract:BACKGROUND:Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve long-term outcome after transplantation. We wanted to prospectively assess feasibility of systemic ant...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-019-5760-8
更新日期:2019-06-11 00:00:00
abstract:BACKGROUND:While mathematical models are often used to predict progression of cancer and treatment outcomes, there is still uncertainty over how to best model tumor growth. Seven ordinary differential equation (ODE) models of tumor growth (exponential, Mendelsohn, logistic, linear, surface, Gompertz, and Bertalanffy) h...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2164-x
更新日期:2016-02-26 00:00:00
abstract:BACKGROUND:Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors for which no effective therapies are currently available. Oncolytic Newcastle disease virus (NDV) has shown the potential to induce oncolytic cell death in a variety of cancer cells of diverse origins. However, whether oncolyti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4522-3
更新日期:2018-07-18 00:00:00
abstract:BACKGROUND:The impact of local tumor ablative therapy in oligometastasized prostate cancer (PC) is still under debate. To gain data for this approach, we evaluated oligometastasized PC patients receiving stereotactic body radiotherapy (SBRT) to bone metastases. METHODS:In this retrospective study, 15 oligometastasized...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3341-2
更新日期:2017-05-22 00:00:00
abstract:BACKGROUND:We aimed to evaluate the prognostic value of quality of life (QOL) for predicting survival among disease-free survivors of surgically-treated lung cancer after the completion of cancer treatment. METHODS:We administered the European Organization for Research and Treatment of Cancer Quality of Life Questionn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2504-x
更新日期:2016-07-20 00:00:00
abstract:BACKGROUND:The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and 4-hydroxy-N-demethyltamoxifen (4OHNDtam, endoxifen). Inter-individual variations of the activity of these ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-313
更新日期:2010-06-21 00:00:00
abstract:BACKGROUND:Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer cell resistance to these drugs has not been studied in detail. METHODS:Here, we introduce an analogue...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-677
更新日期:2010-12-12 00:00:00
abstract::Following definitive chemoradiation for anal squamous cell carcinoma (ASCC), patients face a variety of chronic issues including: bowel dysfunction, accelerated bone loss, sexual dysfunction, and psychosocial distress. The increasing incidence of this disease, high cure rates, and significant long-term sequelae warran...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-019-6053-y
更新日期:2019-09-11 00:00:00
abstract:BACKGROUND:Whether perioperative blood transfusions (PBTs) adversely influence oncological outcomes for intrahepatic cholangiocarcinoma (ICC) patients after curative resection remains undetermined. METHODS:Of the 605 patients who underwent curative liver resection for ICC between 2000 and 2012, 93 received PBT. We con...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3745-z
更新日期:2017-11-14 00:00:00
abstract:BACKGROUND:SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes. Therefore, it could be implicated in the process of carcinogenesis. Furthermore, this gene is ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-290
更新日期:2009-08-21 00:00:00
abstract:BACKGROUND:Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumour settings. The Grey phenotype in horses, caused by a 4.6 kb duplication in intron 6 of Syntaxin 17 ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-857
更新日期:2014-11-21 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In order to assess the effectiveness of tailored treatment in regard to the primary tumour the differen...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4639-4
更新日期:2018-07-20 00:00:00
abstract:BACKGROUND:The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle. We have previously demonstrated using RNA interference that cells lacking VHR arrest in the G1 and G2 phases...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-147
更新日期:2008-05-27 00:00:00
abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer. N,N'-dinitrosopiperazine (DNP), a carcinogen with specificity for nasopharyngeal epithelium, facilitates NPC metastasis. However, the underlying mechanism is not known. METHODS:Quantitative phosphoproteomics, using stable isotope lab...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-243
更新日期:2014-04-05 00:00:00
abstract::Following publication of the original article [1], the authors reported an error in Figure 2, where the color code of the text boxes is reversed. Figure 2-amended shows the correct color association between the text boxes and the different areas in the map: Navarra, neighbouring communities and other Spanish communiti...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-019-6458-7
更新日期:2019-12-17 00:00:00