Investigating young women's motivations to engage in early mammography screening in Switzerland: results of a cross-sectional study.

abstract：BACKGROUND:The management of unresectable or metastatic gastrointestinal stromal tumors (GISTs) has previously been difficult as they are resistant to conventional chemotherapy and radiation. The development of imatinib mesylate has made a major impact on the management of advanced GISTs. It is apparent that there are ...

journal_title：BMC cancer

authors： Hughes B,Yip D,Goldstein D,Waring P,Beshay V,Chong G

更新日期：2004-10-09 00:00:00

abstract：BACKGROUND:Patients with advanced or metastatic non-small cell lung cancer (NSCLC) can develop acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib. Here, we report the successful treatment with alternating chemotherapy and TKIs of two cases of advanced NSCLC...

journal_title：BMC cancer

authors： Guo R,Chen X,Wang T,Zhang Z,Sun J,Shu Y

更新日期：2011-03-02 00:00:00

abstract：BACKGROUND:Development of escape pathways from antiangiogenic treatments was reported to be associated with enhanced tumor aggressiveness and rebound effect was suggested after treatment stop. Aim of the study was to evaluate tumor response simulating different conditions of administration of antiangiogenic treatment (...

journal_title：BMC cancer

authors： Marinelli S,Salvatore V,Baron Toaldo M,Milazzo M,Croci L,Venerandi L,Pecorelli A,Palamà C,Diana A,Bolondi L,Piscaglia F

更新日期：2014-06-04 00:00:00

abstract：BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...

journal_title：BMC cancer

authors： Isakova J,Talaibekova E,Aldasheva N,Vinnikov D,Aldashev A

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:This planning study compares different radiotherapy techniques for patients with pituitary adenoma, including flatness filter free mode (FFF), concerning plan quality and secondary malignancies for potentially young patients. The flatness filter has been described as main source of photon scatter. MATERIAL ...

journal_title：BMC cancer

authors： Treutwein M,Steger F,Loeschel R,Koelbl O,Dobler B

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Metastatic breast cancer (MBC) rest an incurably disease associated with bad prognosis and a median overall survival of 23-31 months. There are several treatment options including chemotherapy and sometimes endocrine therapy. Currently, there is no standard treatment for patients with MBC who have already be...

journal_title：BMC cancer

authors： Fumet JD,Wickre M,Jacquot JP,Bizollon MH,Melis A,Vanoli A,Viel E

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:Cell-free DNA's (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning guided panel design strategy for improving the detection of tumor variants in cfDNA. Using this app...

journal_title：BMC cancer

authors： Cario CL,Chen E,Leong L,Emami NC,Lopez K,Tenggara I,Simko JP,Friedlander TW,Li PS,Paris PL,Carroll PR,Witte JS

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:Reports on childhood cancer survivors estimated cumulative probability of developing secondary neoplasms vary from 3.3% to 25% at 25 years from diagnosis, and the risk of developing another cancer to several times greater than in the general population. METHODS:In our retrospective study, we have used the c...

journal_title：BMC cancer

authors： Jazbec J,Todorovski L,Jereb B

更新日期：2007-02-02 00:00:00

abstract：BACKGROUND:Studies of human polyomavirus (HPyV) infection and lung cancer are limited and those regarding the association of human papillomavirus (HPV) infection and lung cancer have produced inconsistent results. METHODS:We conducted a nested case-control study to assess the association between incident lung cancer o...

journal_title：BMC cancer

authors： Colombara DV,Manhart LE,Carter JJ,Hawes SE,Weiss NS,Hughes JP,Qiao YL,Taylor PR,Smith JS,Galloway DA

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an important role in tumor-associated angiogenesis. However, the effects of simultaneously targeting on VE...

journal_title：BMC cancer

authors： Ding C,Li L,Yang T,Fan X,Wu G

更新日期：2016-10-12 00:00:00

abstract：BACKGROUND:The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5F...

journal_title：BMC cancer

authors： Rot S,Kaune T,Taubert H,Greither T,Kotrba J,Güttler A,Wichmann H,Bilkenroth U,Wienke A,Al-Nawas B,Bache M,Vordermark D,Wickenhauser C,Bethmann D,Eckert AW,Kappler M

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The diminished capability of the immune system to control and resolve HPV infection is one of several hyp...

journal_title：BMC cancer

authors： Gillio-Tos A,Bicalho Mda G,Fiano V,Grasso C,Tarallo V,De Marco L,Trevisan M,Xavier M,Slowik R,Carvalho NS,Maestri CA,Lacerda HM,Zugna D,Richiardi L,Merletti F

更新日期：2012-12-24 00:00:00

abstract：BACKGROUND:Nasopharyngeal carcinoma (NPC) is a type of head-neck cancer with a distinguishable geographic and racial distribution worldwide. Increasing evidence supports that the accumulation of additional genetic and epigenetic abnormalities is important in driving the NPC tumorigenic process. In this study, we aim to...

journal_title：BMC cancer

authors： Huang PY,Zeng TT,Ban X,Li MQ,Zhang BZ,Zhu YH,Hua WF,Mai HQ,Zhang L,Guan XY,Li Y

更新日期：2016-08-22 00:00:00

abstract：BACKGROUND:Extrahepatic biliary duct cancers (EBDC) are uncommon malignancies characterized by a poor prognosis with high rate of loco-regional recurrence. The purpose of the present study is to assess the feasibility and the potential impact of adjuvant radiotherapy (RT) in a series of patients treated in one institut...

journal_title：BMC cancer

authors： Bonet Beltrán M,Roth AD,Mentha G,Allal AS

更新日期：2011-06-24 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma (GB) to anti-angiogenetic treatment with bevacizumab. We hypothesized that circulating VEGF-121 may reduce the amount of bevacizumab available to target ...

journal_title：BMC cancer

authors： Martini M,de Pascalis I,D'Alessandris QG,Fiorentino V,Pierconti F,Marei HE,Ricci-Vitiani L,Pallini R,Larocca LM

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:Circulating tumor cells (CTCs) are detectable in peripheral blood of metastatic breast cancer patients (MBC). In this paper we evaluate a new CTC separation method based on a combination of anti-EpCAM- and anti-cytokeratin magnetic cell separation with the aim to improve CTC detection with low target antigen...

journal_title：BMC cancer

authors： Weissenstein U,Schumann A,Reif M,Link S,Toffol-Schmidt UD,Heusser P

更新日期：2012-05-30 00:00:00

abstract：BACKGROUND:Comorbidity has a well documented detrimental effect on cancer survival. However it is difficult to disentangle the direct effects of comorbidity on survival from indirect effects via the influence of comorbidity on treatment choice. This study aimed to assess the impact of comorbidity on colon cancer patien...

journal_title：BMC cancer

authors： Sarfati D,Hill S,Blakely T,Robson B,Purdie G,Dennett E,Cormack D,Dew K

更新日期：2009-04-20 00:00:00

abstract：BACKGROUND:Elucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for the treatment of Her2-overexpressed metastatic breast cancer. METHODS:To further understand Herceptin resistance mechanisms at the molecular level, we used comparative proteome approaches to analyze two human ...

journal_title：BMC cancer

authors： Kang SH,Kang KW,Kim KH,Kwon B,Kim SK,Lee HY,Kong SY,Lee ES,Jang SG,Yoo BC

更新日期：2008-10-04 00:00:00

abstract：BACKGROUND:Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts (CAFs) are the predominant type of stromal cell, in which TGF-β signaling is activated. Among the s...

journal_title：BMC cancer

authors： Horie M,Saito A,Noguchi S,Yamaguchi Y,Ohshima M,Morishita Y,Suzuki HI,Kohyama T,Nagase T

更新日期：2014-08-09 00:00:00

abstract：BACKGROUND:Lung cancer patients with an activating mutation in the EGFR (epidermal growth factor receptor) can develop resistance to erlotinib treatment, which is often mediated by the T790M resistance mutation in EGFR. The difficulties in obtaining biopsies at progression make it challenging to investigate the appeara...

journal_title：BMC cancer

authors： Demuth C,Madsen AT,Weber B,Wu L,Meldgaard P,Sorensen BS

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC). METHODS:A total of 303 TNBC patients who underwent weekly paclitaxel plus carboplatin treatments followed by surgical resection were ...

journal_title：BMC cancer

authors： Wang RX,Chen S,Huang L,Shao ZM

更新日期：2018-09-21 00:00:00

abstract：BACKGROUND:A life threatening illness such as breast cancer can lead to a secondary diagnosis of PTSD (post traumatic stress disorder) with intrusive thoughts and avoidance as major symptoms. In a former study by the research group, 80% of the patients with breast cancer reported a high level of stress symptoms close t...

journal_title：BMC cancer

authors： Nordin K,Rissanen R,Ahlgren J,Burell G,Fjällskog ML,Börjesson S,Arving C

更新日期：2012-05-04 00:00:00

abstract：BACKGROUND:Translationally controlled tumor protein (TCTP), alternatively called fortilin, is believed to be involved in the development of the chemoresistance of tumor cells against anticancer drugs such as etoposide, taxol, and oxaliplatin, the underlying mechanisms of which still remain elusive. METHODS:Cell death ...

journal_title：BMC cancer

authors： Jung J,Kim HY,Maeng J,Kim M,Shin DH,Lee K

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:Hypoxia is an important factor that contributes to tumour aggressiveness and correlates with poor prognosis and resistance to conventional therapy. Therefore, identifying hypoxic environments within tumours is extremely useful for understanding cancer biology and developing novel therapeutic strategies. Seve...

journal_title：BMC cancer

authors： Takei N,Yoneda A,Kosaka M,Sakai-Sawada K,Tamura Y

更新日期：2019-05-29 00:00:00

abstract：BACKGROUND:It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas ...

journal_title：BMC cancer

authors： Pelizzo G,Veschi V,Mantelli M,Croce S,Di Benedetto V,D'Angelo P,Maltese A,Catenacci L,Apuzzo T,Scavo E,Moretta A,Todaro M,Stassi G,Avanzini MA,Calcaterra V

更新日期：2018-11-27 00:00:00

abstract：BACKGROUND:Activating transcription factor-3 (ATF3) is involved in the complex process of cellular stress response. However, its exact role in cancer is discussed controversially because both tumor suppressive and oncogenic effects have been described. Here we followed-up on our previous observation that inhibition of ...

journal_title：BMC cancer

authors： Hackl C,Lang SA,Moser C,Mori A,Fichtner-Feigl S,Hellerbrand C,Dietmeier W,Schlitt HJ,Geissler EK,Stoeltzing O

更新日期：2010-12-03 00:00:00

abstract：BACKGROUND:Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensification of treatment schedules through introduction of novel induction and combination chemotherapy regime...

journal_title：BMC cancer

authors： Jensen AD,Krauss J,Potthoff K,Desta A,Habl G,Mavtratzas A,Windemuth-Kiesselbach C,Debus J,Münter MW

更新日期：2011-05-19 00:00:00

abstract：BACKGROUND:The efficacy of immunotherapy targeting the PD-1/PD-L1 pathway has previously been demonstrated in metastatic head and neck squamous cell carcinoma (HNSCC). Stereotactic Body Radiotherapy (SBRT) aims at ablating metastatic lesions and may play a synergistic role with immunotherapy. The purpose of this study ...

journal_title：BMC cancer

authors： Bahig H,Aubin F,Stagg J,Gologan O,Ballivy O,Bissada E,Nguyen-Tan FP,Soulières D,Guertin L,Filion E,Christopoulos A,Lambert L,Tehfe M,Ayad T,Charpentier D,Jamal R,Wong P

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:Racial disparities are well-documented in preventive cancer care, but they have not been fully explored in the context of lung cancer screening. We sought to explore racial differences in lung cancer screening outcomes within a lung cancer screening program (LCSP) at our urban academic medical center includi...

journal_title：BMC cancer

authors： Lake M,Shusted CS,Juon HS,McIntire RK,Zeigler-Johnson C,Evans NR,Kane GC,Barta JA

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the prognostic and predictive significance of tumor length in patients with esophageal squamous cell carcinoma undergoing radical resection. METHODS:Tumor length and other clinicopathological variables were retrospectively evaluated in 1435 patients with squamo...

journal_title：BMC cancer

authors： Wu J,Chen QX

更新日期：2016-07-07 00:00:00