Abstract:
BACKGROUND:In metastatic breast cancer (MBC), antigen profiles of metastatic tissue and primary tumor differ in up to 20 % of patients. Reassessment of predictive markers, including human epidermal growth factor receptor 2 (HER2) expression, might help to optimize MBC treatment. While tissue sampling is invasive and often difficult to repeat, circulating tumor cell (CTC) analysis requires only a blood sample and might provide an easy-to-repeat, real-time "liquid biopsy" approach. The present retrospective study was conducted to compare HER2 expression in primary tumors, metastatic tissue, and circulating tumor cells (CTCs) from MBC patients and to analyze the potential impact of HER2 overexpression by CTCs on progression-free (PFS) and overall survival (OS) in MBC. METHODS:CTC-positive (five or more CTCs/7.5 mL blood; CellSearch®, Janssen Diagnostics) MBC patients starting a new line of systemic treatment were eligible for the study. HER2 status of CTCs was determined by immunofluorescence (CellSearch®). HER2 status of primary (PRIM) and metastatic (MET) tumor tissue was determined by immunohistochemistry. Data were analyzed using descriptive statistics and Kaplan-Meier plots. RESULTS:One hundred seven patients (median age (range) 57 (33-81) years) were included. 100/107 (93%) patients were followed-up for a median [95% confidence interval (CI)] of 28.5 [25.1-40.1] months. Of 37/107 (35%) CTC-HER2-positive patients only 10 (27%) were PRIM-HER2-positive. 6/46 (13%) patients were MET-HER2-positive; only 2/10 (20%) CTC-HER2-positive patients were MET-HER2-positive. Overall accuracy between CTC-HER2 expression and PRIM-HER2 and MET-HER2 status was 69% and 74%, respectively. Kaplan-Meier plots of PFS and OS by CTC-HER2 status revealed significantly longer median [95% CI] PFS of CTC-HER2-positive versus CTC-HER2-negative patients (7.4 [4.7-13.7] versus 4.34 [3.5-5.9] months; p = 0.035). CTC-HER2-positive status showed no significant difference for OS (13.7 [7.7-30.0] versus 8.7 [5.9-15.3] months; p = 0.287). CONCLUSIONS:HER2 status can change during the course of breast cancer. CTC phenotyping may serve as an easy-to-perform "liquid biopsy" to reevaluate HER2 status and potentially guide treatment decisions. Further, prospective studies are needed.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Wallwiener M,Hartkopf AD,Riethdorf S,Nees J,Sprick MR,Schönfisch B,Taran FA,Heil J,Sohn C,Pantel K,Trumpp A,Schneeweiss Adoi
10.1186/s12885-015-1423-6subject
Has Abstractpub_date
2015-05-14 00:00:00pages
403issn
1471-2407pii
10.1186/s12885-015-1423-6journal_volume
15pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative role of this cytokine in prostate tumor progression. METHODS:FAM3B expression was analyzed by quantita...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3950-9
更新日期:2018-01-22 00:00:00
abstract:BACKGROUND:Oncolytic viruses, including vaccinia virus (VACV), are a promising alternative to classical mono-cancer treatment methods such as surgery, chemo- or radiotherapy. However, combined therapeutic modalities may be more effective than mono-therapies. In this study, we enhanced the effectiveness of oncolytic vir...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-366
更新日期:2012-08-23 00:00:00
abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer deaths. Radiation therapy (RT), alone or in combination with chemotherapy, is the standard of care for curative intent treatment of patients with locally advanced or inoperable NSCLC. The ability to intens...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-14-740
更新日期:2014-10-02 00:00:00
abstract:BACKGROUND:The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting an important role for somatic mutations. This study investigated genomic differences betwee...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6684-z
更新日期:2020-03-12 00:00:00
abstract::Following definitive chemoradiation for anal squamous cell carcinoma (ASCC), patients face a variety of chronic issues including: bowel dysfunction, accelerated bone loss, sexual dysfunction, and psychosocial distress. The increasing incidence of this disease, high cure rates, and significant long-term sequelae warran...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-019-6053-y
更新日期:2019-09-11 00:00:00
abstract:BACKGROUND:Tumor recurrence and metastasis are the most common reason for treatment failure. Metastasis-associate in colon cancer-1 (MACC1) has been identified as a metastatic and prognostic biomarker for colorectal cancer and other solid tumors. Aldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, is also ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2903-z
更新日期:2016-11-10 00:00:00
abstract:BACKGROUND:MicroRNAs in solid malignancies can behave as predictors of either good or poor outcome. This is the case with members of the miR-200 family, which are the primary regulators of the epithelial to mesenchymal transition and have been reported to act as both oncogenes and tumor suppressors. This study assessed...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-72
更新日期:2013-02-08 00:00:00
abstract:BACKGROUND:Less than 1% of all breast cancer cases are found in men, who reportedly have inferior outcomes compared with matched women patients. Ethnic differences may also affect their prognosis. Here, we investigated overall survival (OS) and major prognostic factors for male breast cancer (MBC) in a cohort of Egypti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-227
更新日期:2014-03-28 00:00:00
abstract:BACKGROUND:Gynecologic cancer is one of the most common malignant diseases in working-age women. This study investigated whether several characteristics influence return to work after treatment of gynecologic cancer. METHODS:We investigated the correlations between return to work and several other characteristics in 1...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2627-0
更新日期:2016-07-29 00:00:00
abstract:BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-807
更新日期:2014-11-04 00:00:00
abstract:BACKGROUND:Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artificial intelligence models for 5-year overall survival prediction in patients with cervical cancer tre...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3806-3
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:Carcinoma in situ (CIS) is believed to be a precursor of invasive bladder cancer. Identification of CIS is a valuable prognostic factor since radical treatment strategies can be offered these patients before the disease becomes invasive. METHODS:We developed a pathway based classifier approach to predict pr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-37
更新日期:2008-01-31 00:00:00
abstract:BACKGROUND:The purpose of the present study was to obtain information on the use of PD-1/PD-L1 inhibitors by oncologists in China through a national questionnaire survey. METHODS:Between the 7th and 25th of July in 2019, a questionnaire designed by the Chinese Society of Clinical Oncology Immuno-Oncology (CSCO IO) Com...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6583-3
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:In high-income countries (HICs), increased rates of survival among pediatric cancer patients are achieved through the use of protocol-driven treatment. Compared to HICs, differences in infrastructure, supportive care, and human resources, make compliance with protocol-driven treatment challenging in low- and...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6611-3
更新日期:2020-03-29 00:00:00
abstract:BACKGROUND:High-risk Human Papillomavirus (HPV) testing is replacing cytology in cervical cancer screening as it is more sensitive for preinvasive cervical lesions. However, the bottleneck of HPV testing is the many false positive test results (positive tests without cervical lesions). Here, we evaluated to what extent...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2518-4
更新日期:2016-07-20 00:00:00
abstract:BACKGROUND:It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate cancer carcinogenesis is increasingly evident. In this study, the focus will be on histone modifica...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-994
更新日期:2014-12-23 00:00:00
abstract:BACKGROUND:To the best of our knowledge, no study has reported mediastinal shift accompanied with obstructive atelectasis due to bulky primary esophageal tumor components treated with adaptive radiotherapy and concurrent chemotherapy. CASE PRESENTATION:Here we report the case of a 65-year-old male patient diagnosed wi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6505-4
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms. METHODS:The response of breast cancer cell lines (MCF-7 and MDA-MB-231) to doxorubicin was ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3953-6
更新日期:2018-01-06 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract and liver and peritoneum are the main sites of recurrence. Ovarian metastases from GIST are very rare. CASE PRESENTATION:A 50 years-old woman was found to have a pelvic mass on transvaginal ultrasound...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4204-1
更新日期:2018-03-16 00:00:00
abstract:BACKGROUND:Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. However, preclinical experimental data explaining the interaction mechanism(s) are lacking. Our objective is to investig...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-363
更新日期:2013-07-29 00:00:00
abstract:BACKGROUND:Colon cancer patients with the same stage show diverse clinical behavior due to tumor heterogeneity. We aimed to discover distinct classes of tumors based on microarray expression patterns, to analyze whether the molecular classification correlated with the histopathological stages or other clinical paramete...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-260
更新日期:2012-06-19 00:00:00
abstract:BACKGROUND:Breast cancer is the second leading cause of cancer deaths in women in the United States. Although the causes of this disease are incompletely understood, oxidative DNA damage is presumed to play a critical role in breast carcinogenesis. A common oxidatively induced DNA lesion is 8-hydroxyguanine (8-OH-Gua),...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-297
更新日期:2006-12-27 00:00:00
abstract:BACKGROUND:To investigate on expressions and clinical significances of CD133 protein and vasculogenic mimicry (VM) in primary non-small cell lung cancer (NSCLC). METHODS:The specimens of NSCLC from 305 Chinese patients with follow-up were analyzed for CD133 protein expression and VM by immunohistochemical and histoche...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-535
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Cell lines are often poorly characterized from a genetic point of view, reducing their usefulness as tumor models. Our purpose was to assess the genetic background of eight commonly used human thyroid carcinoma models and to compare the findings with those reported for primary tumors of the gland. METHODS:W...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-8-371
更新日期:2008-12-16 00:00:00
abstract:BACKGROUND:Early treatment of patients at risk for developing aggressive prostate cancer is able to delay metastasis and reduce mortality; as such, up-front identification of these patients is critical. Several risk classification systems, including CAPRA-S, are currently used for disease prognostication. However, high...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07438-4
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND:MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. To investigate the progn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2869-x
更新日期:2016-10-28 00:00:00
abstract:BACKGROUND:CST6 promoter is highly methylated in cancer, and its detection can provide important prognostic information in breast cancer patients. The aim of our study was to develop a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation. METHODS:We ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-486
更新日期:2012-10-22 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth most common tumor in human. Research has shown that HPV status HNSCC is a unique prognosis factor, which may due to its immune infiltration landscape. But the underlying mechanism is unclear. METHODS:In this study, we used a combination of several b...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07298-y
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND:In Australia, breast cancer is the most common cancer affecting Australian women. Inequalities in clinical and psychosocial outcomes have existed for some time, affecting particularly women from rural areas and from areas of disadvantage. We have a limited understanding of how individual and area-level facto...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-415
更新日期:2011-09-28 00:00:00
abstract:BACKGROUND:Whether PET scan maximum standard uptake value (SUVmax) could differentiate luminal A from luminal B and help predict the survival of metastatic breast cancer (MBC) patients with luminal subtype is still unknown and need to be investigated. METHODS:305 MBC patients with luminal subtypes were screened with P...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-42
更新日期:2013-01-31 00:00:00