Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis.

abstract：BACKGROUND:In a phase I study of angiotensin-(1-7) [Ang-(1-7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1-7) induced changes in biomarkers according to cancer type and investigates mechanisms of action engaged in vitro. MET...

journal_title：BMC cancer

authors： Petty WJ,Aklilu M,Varela VA,Lovato J,Savage PD,Miller AA

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:Whether PET scan maximum standard uptake value (SUVmax) could differentiate luminal A from luminal B and help predict the survival of metastatic breast cancer (MBC) patients with luminal subtype is still unknown and need to be investigated. METHODS:305 MBC patients with luminal subtypes were screened with P...

journal_title：BMC cancer

authors： Zhang J,Jia Z,Ragaz J,Zhang YJ,Zhou M,Zhang YP,Li G,Wang BY,Wang ZH,Hu XC

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a histologically homogeneous clinical trial cohort that has been treated with a uniform approach. ...

journal_title：BMC cancer

authors： Yoon HH,Catalano PJ,Murphy KM,Skaar TC,Philips S,Powell M,Montgomery EA,Hafez MJ,Offer SM,Liu G,Meltzer SJ,Wu X,Forastiere AA,Benson AB,Kleinberg LR,Gibson MK

更新日期：2011-05-17 00:00:00

abstract：BACKGROUND:The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblasto...

journal_title：BMC cancer

authors： Korja M,Jokilammi A,Salmi TT,Kalimo H,Pelliniemi TT,Isola J,Rantala I,Haapasalo H,Finne J

更新日期：2009-02-17 00:00:00

abstract：BACKGROUND:With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically important. The aim of this study was to analyse EGFR express...

journal_title：BMC cancer

authors： Van Damme N,Deron P,Van Roy N,Demetter P,Bols A,Van Dorpe J,Baert F,Van Laethem JL,Speleman F,Pauwels P,Peeters M

更新日期：2010-05-11 00:00:00

abstract：BACKGROUND:Young age remains a controversial issue as a prognostic factor in breast cancer. Debate includes patients from different parts of the world. Almost 50% of patients with breast cancer seen at the American University of Beirut Medical Center (AUBMC) are below age 50. METHODS:We reviewed 1320 patients seen at ...

journal_title：BMC cancer

authors： El Saghir NS,Seoud M,Khalil MK,Charafeddine M,Salem ZK,Geara FB,Shamseddine AI

更新日期：2006-07-20 00:00:00

abstract：BACKGROUND:Breast cancer is the most common malignancy in women world-wide. Triple negative breast cancer (TNBC) is a highly aggressive subtype that lacks expression of hormone receptors for estrogen, progesterone and human epidermal growth factor 2; and is associated with a high propensity for metastatic spread. Sever...

journal_title：BMC cancer

authors： Avery-Kiejda KA,Braye SG,Forbes JF,Scott RJ

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In this study, we examined the possibility of HemoHIM both to enhance anticancer effect with cisplatin an...

journal_title：BMC cancer

authors： Park HR,Ju EJ,Jo SK,Jung U,Kim SH,Yee ST

更新日期：2009-03-17 00:00:00

abstract：BACKGROUND:High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach, but previous studies suggest that a combined inhibition of Bcl-2 an...

journal_title：BMC cancer

authors： Klenke S,Akdeli N,Stelmach P,Heukamp L,Schulte JH,Bachmann HS

更新日期：2019-03-18 00:00:00

abstract：BACKGROUND:Based on their different mechanisms of action, non-overlapping side effects and radiosensitising potential, combining the antimetabolites pemetrexed (multitargeted antifolate, MTA) and gemcitabine (2',2'-difluorodeoxycytidine, dFdC) with irradiation (RT) seems promising. This in vitro study, for the first ti...

journal_title：BMC cancer

authors： Wouters A,Pauwels B,Lardon F,Pattyn GG,Lambrechts HA,Baay M,Meijnders P,Vermorken JB

更新日期：2010-08-19 00:00:00

abstract：BACKGROUND:The short arm of human chromosome 3 is involved in the development of many cancers including lung cancer. Three bona fide lung cancer tumor suppressor genes namely RBSP3 (AP20 region),NPRL2 and RASSF1A (LUCA region) were identified in the 3p21.3 region. We have shown previously that homozygous deletions in A...

journal_title：BMC cancer

authors： Senchenko VN,Anedchenko EA,Kondratieva TT,Krasnov GS,Dmitriev AA,Zabarovska VI,Pavlova TV,Kashuba VI,Lerman MI,Zabarovsky ER

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Although Temozolomide is effective against glioblastoma, the prognosis remains dismal and new regimens with synergistic activity are sought for. METHODS:In this phase-I/II trial, pegylated liposomal doxorubicin (Caelyx, PEG-Dox) and prolonged administration of Temozolomide in addition to radiotherapy was in...

journal_title：BMC cancer

authors： Beier CP,Schmid C,Gorlia T,Kleinletzenberger C,Beier D,Grauer O,Steinbrecher A,Hirschmann B,Brawanski A,Dietmaier C,Jauch-Worley T,Kölbl O,Pietsch T,Proescholdt M,Rümmele P,Muigg A,Stockhammer G,Hegi M,Bogdahn U,Hau

更新日期：2009-09-02 00:00:00

abstract：BACKGROUND:Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene contributes to the constitutive expression of hypoxia inducible factors 1 and 2 alpha (HIF-α), transcriptional regulators of several genes involved in...

journal_title：BMC cancer

authors： Chintala S,Najrana T,Toth K,Cao S,Durrani FA,Pili R,Rustum YM

更新日期：2012-07-17 00:00:00

abstract：BACKGROUND:Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥...

journal_title：BMC cancer

authors： Seymour JF,Döhner H,Butrym A,Wierzbowska A,Selleslag D,Jang JH,Kumar R,Cavenagh J,Schuh AC,Candoni A,Récher C,Sandhu I,Del Castillo TB,Al-Ali HK,Falantes J,Stone RM,Minden MD,Weaver J,Songer S,Beach CL,Dombret H

更新日期：2017-12-14 00:00:00

abstract：BACKGROUND:Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set up and assay. In this report, we introduce a microfluidic OrganoPlate® platform for extracellular m...

journal_title：BMC cancer

authors： Lanz HL,Saleh A,Kramer B,Cairns J,Ng CP,Yu J,Trietsch SJ,Hankemeier T,Joore J,Vulto P,Weinshilboum R,Wang L

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:Metastatic breast cancer carries a poor prognosis despite the success of newly targeted therapies. Treatment options remain especially limited for the subtype of triple negative breast cancer (TNBC). Several signaling pathways, including NF-κB, are altered in TNBC, and the complexity of this disease implies ...

journal_title：BMC cancer

authors： House CD,Grajales V,Ozaki M,Jordan E,Wubneh H,Kimble DC,James JM,Kim MK,Annunziata CM

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:Cancer of unknown primary remains a mallignancy of elusive biology and grim prognosis that lacks effective therapeutic options. We investigated angiogenesis in cancer of unknown primary to expand our knowledge on the biology of these tumors and identify potential therapeutic targets. METHODS:Paraffin embedd...

journal_title：BMC cancer

authors： Karavasilis V,Malamou-Mitsi V,Briasoulis E,Tsanou E,Kitsou E,Kalofonos H,Fountzilas G,Fotsis T,Pavlidis N

更新日期：2005-03-03 00:00:00

abstract：BACKGROUND:Experimental evidence and clinical studies in breast cancer suggest that some anti-tumor therapy regimens generate stimulation of the immune system that accounts for tumor clinical responses, however, demonstration of the immunostimulatory power of these therapies on cancer patients continues to be a formida...

journal_title：BMC cancer

authors： Bernal-Estévez D,Sánchez R,Tejada RE,Parra-López C

更新日期：2016-08-03 00:00:00

abstract：BACKGROUND:cMyc and p27 are key genes implicated in carcinogenesis. Whether polymorphisms in these genes affect breast cancer risk or prognosis is still unclear. In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and pro...

journal_title：BMC cancer

authors： Figueiredo JC,Knight JA,Cho S,Savas S,Onay UV,Briollais L,Goodwin PJ,McLaughlin JR,Andrulis IL,Ozcelik H

更新日期：2007-06-14 00:00:00

abstract：BACKGROUND:Improving the coordination of cancer care is a priority area for service improvement. However, quality improvement initiatives are hindered by the lack of accurate and reliable measures of this aspect of cancer care. This study was conducted to develop a questionnaire to measures patients' experience of canc...

journal_title：BMC cancer

authors： Young JM,Walsh J,Butow PN,Solomon MJ,Shaw J

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:Helicobacter pylori (H. pylori) is thought to have an oncogenic effect on the development of gastric malignancies. However, the effect of H. pylori status on the prognosis of gastric diffuse large B-cell lymphoma (DLBCL) remains unconfirmed. This study aimed to identify the prognostic importance of H. pylori...

journal_title：BMC cancer

authors： Cheng Y,Xiao Y,Zhou R,Liao Y,Zhou J,Ma X

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:Solid tumours are less oxygenated than normal tissues. This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. The molecular mechanisms underlying such resistance have been investigated in a range of tumour types, including the adult brain tumours glioblastoma, yet little is k...

journal_title：BMC cancer

authors： Cowman S,Fan YN,Pizer B,Sée V

更新日期：2019-04-03 00:00:00

abstract：BACKGROUND:Altered expression of microRNAs (miRNAs) is known to contribute to cancer progression. miR-23b and miR-27b, encoded within the same miRNA cluster, are reported to have both tumor suppressive and oncogenic activity across human cancers, including breast cancer. METHODS:To clarify this dichotomous role in bre...

journal_title：BMC cancer

authors： Hannafon BN,Cai A,Calloway CL,Xu YF,Zhang R,Fung KM,Ding WQ

更新日期：2019-06-28 00:00:00

abstract：BACKGROUND:The epithelial cell adhesion molecule (EpCAM) has been shown to be overexpressed in breast cancer and stem cells and has emerged as an attractive target for immunotherapy of breast cancer patients. This study analyzes the effects of EpCAM on breast cancer cell lines with epithelial or mesenchymal phenotype. ...

journal_title：BMC cancer

authors： Martowicz A,Spizzo G,Gastl G,Untergasser G

更新日期：2012-10-30 00:00:00

abstract：BACKGROUND:In Australia, breast cancer is the most common cancer affecting Australian women. Inequalities in clinical and psychosocial outcomes have existed for some time, affecting particularly women from rural areas and from areas of disadvantage. We have a limited understanding of how individual and area-level facto...

journal_title：BMC cancer

authors： Youl PH,Baade PD,Aitken JF,Chambers SK,Turrell G,Pyke C,Dunn J

更新日期：2011-09-28 00:00:00

abstract：BACKGROUND:The effects of exposure to ultraviolet radiation are a significant concern in Australia which has one of the highest incidences of skin cancer in the world. Despite most skin cancers being preventable by encouraging consistent adoption of sun-protective behaviours, incidence rates are not decreasing. There i...

journal_title：BMC cancer

authors： Cleary CM,White KM,Young RM,Hawkes AL,Leske S,Starfelt LC,Wihardjo K

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the most aggressive cancers lacking efficient early detection biomarkers. Circulating miRNAs are now being considered to have potency to be used as diagnostic and prognostic biomarkers in different diseases as well as cancers. In case of cancer,...

journal_title：BMC cancer

authors： Chhatriya B,Mukherjee M,Ray S,Sarkar P,Chatterjee S,Nath D,Das K,Goswami S

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. SFRP1 (the secreted frizzled-related protein 1), a putative tumor suppressor gene mapped onto chromosome 8p12-p11.1, the frequent loss of heterozygosity (LOH) region in human HCC, encodes a Wingless-type (Wnt) signaling antagonist...

journal_title：BMC cancer

authors： Huang J,Zhang YL,Teng XM,Lin Y,Zheng DL,Yang PY,Han ZG

更新日期：2007-07-12 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), is currently the first-line chemotherapeutic agent for GBM. However, the sensitivity of GBM cells to TMZ is affected by many factors. And, several clinic trials, including co-administration...

journal_title：BMC cancer

authors： Li L,Huang Y,Gao Y,Shi T,Xu Y,Li H,Hyytiäinen M,Keski-Oja J,Jiang Q,Hu Y,Du Z

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available treating options have prolonged patient's survival. However, BRAF-mutated CRC patients remain unres...

journal_title：BMC cancer

authors： Miele E,Abballe L,Spinelli GP,Besharat ZM,Catanzaro G,Chiacchiarini M,Vacca A,Po A,Capalbo C,Ferretti E

更新日期：2020-02-17 00:00:00