Abstract：
BACKGROUND:The purpose of this study was to identify the risk factors associated with fatal pulmonary hemorrhage (PH) in patients with locally advanced non-small cell lung cancer (NSCLC), treated with chemoradiotherapy. METHODS:The medical records of 583 patients with locally advanced NSCLC, who were treated with chemoradiotherapy between July 1992 and December 2009 were reviewed. Fatal PH was defined as PH leading to death within 24 h of its onset. Tumor cavitation size was defined by the cavitation diameter/tumor diameter ratio and was classified as minimum (< 0.25), minor (≥ 0.25, but < 0.5), and major (≥ 0.5). RESULTS:Of the 583 patients, 2.1% suffered a fatal PH. The numbers of patients with minimum, minor, and major cavitations were 13, 11, and 14, respectively. Among the 38 patients with tumor cavitation, all 3 patients who developed fatal PH had major cavitations. On multivariate analysis, the presence of baseline major cavitation (odds ratio, 17.878), and a squamous cell histology (odds ratio, 5.491) proved to be independent significant risk factors for fatal PH. Interestingly, all patients with fatal PH and baseline major cavitation were found to have tumors with squamous cell histology, and the occurrence of fatal PH in patients having both risk factors was 33.3%. CONCLUSIONS:Patients at high risk of fatal PH could be identified using a combination of independent risk factors.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Ito M,Niho S,Nihei K,Yoh K,Ohmatsu H,Ohe Ydoi
10.1186/1471-2407-12-27subject
Has Abstractpub_date
2012-01-20 00:00:00pages
27issn
1471-2407pii
1471-2407-12-27journal_volume
12pub_type
杂志文章相关文献
BMC CANCER文献大全abstract：BACKGROUND:Previous studies on bladder cancer have shown nodal involvement to be an independent indicator of prognosis and survival. This study aimed at developing an objective method for detection of nodal metastasis from molecular profiles of primary urothelial carcinoma tissues. METHODS:The study included primary b...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-6-159
更新日期：2006-06-16 00:00:00
abstract：BACKGROUND:Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nu...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-382
更新日期：2008-12-19 00:00:00
abstract：BACKGROUND:Little is known about the presentation, help seeking behaviour for breast cancer in Singapore. Nor was there a study exploring the experience of patients in their breast cancer journey. METHODS:A qualitative interview study with thematic analysis, conducted with 36 patients. RESULTS:There is no clear patte...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07585-8
更新日期：2020-11-10 00:00:00
abstract：BACKGROUND:MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aimed to investigate the mechanism of miR-200c targets fucosyltransferase 4 (FUT4) on the proliferation...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07670-y
更新日期：2021-01-04 00:00:00
abstract：BACKGROUND:Nicotinamide phosphoribosyltransferase (NAMPT) enzyme acts as the major enzyme in the nicotinamide adenine dinucleotide (NAD) synthesis salvage pathway. Deregulation of NAD could be associated with progression of several cancers such as breast cancer. Here, the consequence of NAMPT inhibition by miR-154 was ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-6221-0
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Cancers of unknown primary origin (CUPs) are reported to be the 3-4th most common causes of cancer death. Recent years have seen advances in mutational analysis and genomics profiling. These advances could improve accuracy of diagnosis of CUPs and might improve the prognosis of patients with CUPs. CASE PRES...
journal_title：BMC cancer
pub_type： 杂志文章,评审
doi：10.1186/s12885-019-5277-1
更新日期：2019-01-11 00:00:00
abstract：BACKGROUND:Spontaneous regression/complete resistance (SR/CR) mice are a unique colony of mice that possess an inheritable, natural cancer resistance mediated primarily by innate cellular immunity. This resistance is effective against sarcoma 180 (S180) at exceptionally high doses and these mice remain healthy. METHOD...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-179
更新日期：2010-05-03 00:00:00
abstract：BACKGROUND:One of the basic prerequisites for generating evidence-based data is the availability of classification systems. Attempts to date to classify breast cancer operations have focussed on specific problems, e.g. the avoidance of secondary corrective surgery for surgical defects, rather than taking a generic appr...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-9-108
更新日期：2009-04-08 00:00:00
abstract：BACKGROUND:The molecular mechanisms of the development and progression of bladder cancer are poorly understood. The objective of this study was to analyze the expression of Bmi-1 protein and its clinical significance in human bladder cancer. METHODS:We examined the expression of Bmi-1 mRNA and Bmi-1 protein by RT-PCR ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-9-61
更新日期：2009-02-19 00:00:00
abstract：BACKGROUND:The EphB4 receptor tyrosine kinase has been reported as increased in tumours originating from several different tissues and its expression in a prostate cancer xenograft model has been reported. METHODS:RT-PCR, western blotting and immunohistochemical techniques were used to examine EphB4 expression and pro...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-5-119
更新日期：2005-09-20 00:00:00
abstract：BACKGROUND:New biomarkers are needed for the prognosis of advanced colorectal cancer, which remains incurable by conventional treatments. O6-methylguanine DNA methyltransferase (MGMT) methylation and protein expression have been related to colorectal cancer treatment failure and tumor progression. Moreover, the presenc...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-511
更新日期：2014-07-11 00:00:00
abstract：BACKGROUND:The historical basis and contemporary evidence for the use of immune strategies for prevention of malignancies are reviewed. Emphasis is focussed on the Febrile Infections and Melanoma (FEBIM) study on melanoma and on malignancies that seem to be related to an overexpression of human endogenous retrovirus K ...
journal_title：BMC cancer
pub_type： 历史文章,杂志文章,评审
doi：10.1186/1471-2407-14-595
更新日期：2014-08-16 00:00:00
abstract：BACKGROUND:For the expanding population of bladder cancer survivors in Korea, the development of subsequent cancers is a significant concern. Here, we provide the second primary cancer incidence rates and types in Korean patients with bladder cancer. METHODS:Using population-based data from the Korea Central Cancer Re...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4530-3
更新日期：2018-05-31 00:00:00
abstract：BACKGROUND:The neural transcription factor SOX11 has been described as a prognostic marker in epithelial ovarian cancers (EOC), however its role in individual histological subtypes and tumour grade requires further clarification. Furthermore, methylation-dependent silencing of SOX11 has been reported for B cell lymphom...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-11-405
更新日期：2011-09-24 00:00:00
abstract：BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynaecological cancers as well, since upregulation of SERBP1 was described in ova...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-597
更新日期：2012-12-13 00:00:00
abstract：BACKGROUND:Human Papillomavirus (HPV) genotyping has an increasingly important role in cervical cancer screening and vaccination monitoring, however, without an internationally agreed standard reference assay. The test results from the most widely used genotyping assays are read manually and hence prone to inter-observ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1223-z
更新日期：2015-04-02 00:00:00
abstract：BACKGROUND:Breast cancer can impact survivors in many aspects of their life. Scarce information is currently available on the quality of life of cancer survivors in Bahrain. The objective of this study is to describe the quality of life of Bahraini women with breast cancer and its association with their sociodemographi...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-212
更新日期：2013-04-28 00:00:00
abstract：BACKGROUND:Pembrolizumab is effective as first-line therapy against advanced non-small cell lung cancer (NSCLC) in patients with programmed death ligand-1 (PD-L1) expression levels ≥50% [1]. However, it is not effective in all patients, and the factors predicting responses among this population remain unknown. METHODS...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/s12885-020-6582-4
更新日期：2020-02-03 00:00:00
abstract：BACKGROUND:To evaluate the effect of Recurrence Score® results (RS; Oncotype DX® multigene assay ODX) on treatment recommendations by Swiss multidisciplinary tumor boards (TB). METHODS:SAKK 26/10 is a multicenter, prospective cohort study of early breast cancer patients: Eligibility: R0-resection, ≥10% ER+ malignant c...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/s12885-017-3261-1
更新日期：2017-04-13 00:00:00
abstract：BACKGROUND:Success of cancer prodrugs relying on a foreign gene requires specific delivery of the gene to the cancer, and improvements such as higher level gene transfer and expression. Attaining these objectives will be facilitated in preclinical studies using our newly discovered CNOB-GDEPT, consisting of the produrg...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2508-6
更新日期：2016-07-25 00:00:00
abstract：BACKGROUND:Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. Several studies have demonstrated discordant HER2 status in the primary and metastatic tumour. However, rates of discordance vary considerably in published report...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-555
更新日期：2012-11-24 00:00:00
abstract：BACKGROUND:Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary lesion may not match with its...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-5217-5
更新日期：2018-12-27 00:00:00
abstract：BACKGROUND:Kidney and renal pelvis cancers account for 4% of all new cancer cases in the United States, among which 85% are renal cell carcinomas (RCC). While cigarette smoking is an established risk factor for RCC, little is known about the contribution of environmental tobacco smoke (ETS) to RCC incidence. This study...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-387
更新日期：2008-12-24 00:00:00
abstract：BACKGROUND:Metastasis is the main cause of death for lung cancer patients. The ex vivo 4D acellular lung model has been shown to mimic this metastatic process. However, the main concern is the model's lack of cellular components of the tumor's microenvironment. In this study, we aim to determine if the intact lung micr...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4358-x
更新日期：2018-04-18 00:00:00
abstract：BACKGROUND:Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2407-13-565
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:The predictive value of thymidylate synthase (TS) for clinical sensitivity to pemetrexed-containing chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis is performed to provide an assessment of whether expression variations of TS are associated with objec...
journal_title：BMC cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1471-2407-14-205
更新日期：2014-03-19 00:00:00
abstract：BACKGROUND:Colorectal-cancer is a leading cause of cancer death in the United States, and Latinos have particularly low rates of screening. Strategies and Opportunities to STOP Colon Cancer in Priority Populations (STOP CRC) is a partnership among two research institutions and a network of safety net clinics to promote...
journal_title：BMC cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1186/1471-2407-14-55
更新日期：2014-02-26 00:00:00
abstract：BACKGROUND:The incidence of papillary thyroid cancer (PTC) is markedly higher in women than men during the reproductive years. In vitro studies have suggested that estrogen may play an important role in the development and progression of PTC through estrogen receptors (ERs). This study aimed to investigate the expressi...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-14-383
更新日期：2014-05-29 00:00:00
abstract：BACKGROUND:Most currently known breast cancer predisposition genes play a role in DNA repair by homologous recombination. Recent studies conducted on RAD51 paralogs, involved in the same DNA repair pathway, have identified rare germline mutations conferring breast and/or ovarian cancer predisposition in the RAD51C, RAD...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-484
更新日期：2013-10-19 00:00:00
abstract：BACKGROUND:Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion. CA IX ectodomain (ECD) is shed from the tumor cell surface to serum/plasma of patients, where it can signify cancer p...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2267-4
更新日期：2016-03-19 00:00:00
