Abstract:
BACKGROUND:The aim of this study was to determine whether early tumor shrinkage (ETS) at 6 weeks after treatment correlates with progression-free survival (PFS) and overall survival (OS) in advanced biliary tract cancer (BTC) patients receiving gemcitabine plus oxaliplatin (GEMOX), with or without erlotinib. METHODS:This was a multicenter, open label, randomized, phase III trial of 103 BTC patients (ClinicalTrials.gov Identifier; NCT01149122, and Rigistration date; January, 7, 2010), comparing GEMOX with GEMOX plus erlotinib. Tumor shrinkage was expressed as a relative decrease compared to baseline and was dichotomized according to a previously reported cutoff value of 10 %. RESULTS:Fifty-four patients (52.4 %) received GEMOX and 49 patients (47.6 %) received GEMOX plus erlotinib. The latter achieved a better overall response rate (RR) (40.8 % vs. 18.6 %, p = 0.02) and showed ETS more frequently (63.2 % vs. 40.7 %, p = 0.03). ETS was significantly correlated with the overall RR (correlation coefficient, 0.53; p < 0.01). The median PFS and OS did not differ according to erlotinib administration. However, the median PFS (7.3 vs. 2.1 months, p < 0.01) and OS (10.7 vs. 5.8 months, p < 0.01) were significantly longer amongst patients with ETS at 6 weeks after treatment, irrespective of erlotinib administration. In patients with wild-type KRAS who were treated with GEMOX plus erlotinib, ETS was a significant prognostic factor for PFS (p < 0.01). CONCLUSIONS:ETS might predict PFS and OS in BTC patients treated with GEMOX with or without erlotinib. Additionally, ETS may be an indication for adding erlotinib to chemotherapy for BTC patients wild-type KRAS. These findings need to be prospectively validated.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Kim ST,Jang KT,Lee SJ,Jang HL,Lee J,Park SH,Park YS,Lim HY,Kang WK,Park JOdoi
10.1186/s12885-015-1552-ysubject
Has Abstractpub_date
2015-07-21 00:00:00pages
530issn
1471-2407pii
10.1186/s12885-015-1552-yjournal_volume
15pub_type
杂志文章,多中心研究,随机对照试验相关文献
BMC CANCER文献大全abstract:BACKGROUND:Improving the coordination of cancer care is a priority area for service improvement. However, quality improvement initiatives are hindered by the lack of accurate and reliable measures of this aspect of cancer care. This study was conducted to develop a questionnaire to measures patients' experience of canc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-298
更新日期:2011-07-15 00:00:00
abstract:BACKGROUND:KIAA1199 is a recently identified novel gene that is up-regulated in human cancer with poor survival. Our proteomic study on signaling polarity in chemotactic cells revealed KIAA1199 as a novel protein target that may be involved in cellular chemotaxis and motility. In the present study, we examined the func...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-194
更新日期:2014-03-15 00:00:00
abstract:BACKGROUND:Preclinical research indicate that vascular disrupting agent (VDA) treatment induces extensive tumor death but also a systemic mobilization of bone marrow derived cells including endothelial progenitor cells (EPC) leading to revascularization and renewed growth within the residual tumor. This study investiga...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2568-7
更新日期:2016-07-26 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the efficacy and safety of everolimus in patients with progressive unresectable adenoid cystic carcinoma (ACC). METHODS:Histologically confirmed ACC patients with documented disease progression within 12 months prior to the study entry were eligible. Everolimus was given...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-795
更新日期:2014-11-03 00:00:00
abstract:BACKGROUND:The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different next-generation sequencing (NGS) pipelines in paired cerebrospinal fluid (CSF) and plasma samples fr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5348-3
更新日期:2019-02-12 00:00:00
abstract:BACKGROUND:It has been shown in several studies that survival in cancer patients who were operated on by a high-volume surgeon was better. Why then do all patients not benefit from treatment by these experienced surgeons? The aim of our work was to study the hypothesis that in breast cancer, geographical isolation and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-351
更新日期:2012-08-13 00:00:00
abstract:BACKGROUND:Breast cancer risk, development, and treatment are influenced by genetic variation in certain genes, namely those involved in cell proliferation, tumor suppression, and drug metabolism. In turn, the relevance of the aforementioned genetic variation to cancer depends on the ethnic group in question, highlight...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6490-7
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization) in PWA in 10 cities in Togo in 2019. METHODS:This is a cross...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07747-8
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:3,3'-diindolylmethane (DIM) is an acid-catalyzed dimer of idole-3-carbinol (I3C), a phytochemical found in cruciferous vegetables that include broccoli, Brussels sprouts and cabbage. DIM is an aryl hydrocarbon receptor (AhR) ligand and a potential anticancer agent, namely for the treatment of breast cancer. ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-524
更新日期:2014-07-21 00:00:00
abstract:CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-017-3767-6
更新日期:2018-01-11 00:00:00
abstract:BACKGROUND:MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. To investigate the progn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2869-x
更新日期:2016-10-28 00:00:00
abstract:BACKGROUND:Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less well characterised. This study aimed to address key information gaps by conducting a systematic revi...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-14-968
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-2-10
更新日期:2002-05-03 00:00:00
abstract:BACKGROUND:The clinical implication of Ras/Raf/ERK pathway activity in breast cancer tissue and its association with response to chemotherapy is controversial. We aimed to explore the value of p90RSK phosphorylation, a downstram molecule of the pathway, in predicting chemotherapy response in breast cancer. METHODS:The...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-585
更新日期:2012-12-10 00:00:00
abstract:BACKGROUND:Studies of human polyomavirus (HPyV) infection and lung cancer are limited and those regarding the association of human papillomavirus (HPV) infection and lung cancer have produced inconsistent results. METHODS:We conducted a nested case-control study to assess the association between incident lung cancer o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2381-3
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Following the recommendation of lung cancer screening in the US, screening committees in several European countries are reviewing the evidence for implementing national programmes. However, inadequate participation from high-risk groups poses a potential barrier to its effectiveness. The present study examin...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4430-6
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of thi...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-019-5579-3
更新日期:2019-04-16 00:00:00
abstract:BACKGROUND:Durvalumab is a standard drug used during maintenance therapy after chemoradiotherapy in patients with locally advanced non-small cell lung cancer (LA-NSCLC). However, little is known about the clinical benefits of durvalumab after chemoradiotherapy in patients with LA-NSCLC with a performance status (PS) of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07406-y
更新日期:2020-10-06 00:00:00
abstract:BACKGROUND:Cervical cancer is the 4th highest cause of female reproductive tract malignancies. Multiple loci have been identified as important determinant factors for tumor susceptibility. In this report, we aimed to explore the roles of gene polymorphisms affecting x-ray repair cross complementing 1 (XRCC1), the tumor...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5149-0
更新日期:2019-01-07 00:00:00
abstract:BACKGROUND:EndoPredict (EP) is a clinically validated multianalyte gene expression test to predict distant metastasis in ER-positive, HER2-negative breast cancer treated with endocrine therapy alone. The test is based on the combined analysis of 12 genes in formalin-fixed, paraffin-embedded (FFPE) tissue by reverse tra...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-456
更新日期:2012-10-05 00:00:00
abstract::Following publication of the original article [1], the authors notified us of a misleading data presentation in Table 4. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-5029-7
更新日期:2018-11-30 00:00:00
abstract:BACKGROUND:Single-cell mRNA profiling of circulating tumour cells may contribute to a better understanding of the biology of these cells and their role in the metastatic process. In addition, such analyses may reveal new knowledge about the mechanisms underlying chemotherapy resistance and tumour progression in patient...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3385-3
更新日期:2017-05-31 00:00:00
abstract:BACKGROUND:Cervical cancer is the most common malignant gynecological cancer, and lymphatic metastasis can occur in the early stage of tumor growth. Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), a marker for lymphatic endothelium, provides powerful tools for studying tumor lymphangiogenesis. The purpose ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-64
更新日期:2009-02-21 00:00:00
abstract:BACKGROUND:Traditional beliefs of androgen's stimulating effects on the growth of prostate cancer (PCa) have been challenged in recent years. Our previous in vitro study indicated that physiological normal levels of androgens inhibited the proliferation of PCa cells. In this in vivo study, the ability of testosterone (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3569-x
更新日期:2017-09-07 00:00:00
abstract:BACKGROUND:Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal as standard size-related response criteria do not necessarily accurately reflect clinical benefit, ...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-017-3371-9
更新日期:2017-06-02 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells, and its expression has been correlated with increased tumour angiogenesis. Although numerous publications dealing with the measurement of circulating VEGF for diagnostic and therapeutic monitoring have been published, the re...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-128
更新日期:2005-10-04 00:00:00
abstract:BACKGROUND:Soft tissue metastases, in particular intraneural metastasis, from any carcinomas seldom occur. To our knowledge, no case of sciatic nerve palsy due to intraneural metastasis of gastric carcinoma is reported in the literature. CASE PRESENTATION:A case is reported of a 82-year old woman with sciatic nerve pa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-313
更新日期:2012-07-25 00:00:00
abstract:BACKGROUND:Alcohol consumption is associated with higher breast cancer risk. While studies suggest a modest association between alcohol intake and mammographic density, few studies have examined the association in racial/ethnic minority populations. METHODS:We assessed dense breast area and total breast area from digi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1094-3
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:To provide estimations of partial and total prevalence of 24 cancer sites in France in 2008. The estimations of partial prevalence were compared with the previous estimations for 2002. METHODS:Nationwide estimations of incidence and survival data from cancer registries were used for partial prevalence. Nati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1168-2
更新日期:2015-03-19 00:00:00
abstract:BACKGROUND:The diagnostic and prognostic significance of increased cathepsin B (CTSB) and cathepsin D (CTSD) concentration in the serum of cancer patients were evaluated for some tumor types. High expression of CTSD and CTSB was detected in biopsy tissues from nasopharyngeal carcinoma (NPC). However, whether CTSD and C...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2283-4
更新日期:2016-03-19 00:00:00